WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation

RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy

(2014) Pengyan Xia et al.   CELL RESEARCH

WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc–dependent manner

(2014) Pengyan Xia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization

(2014) Luis-Alberto Pérez-Quintero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of cryopreservation on effector cells for antibody dependent cell-mediated cytotoxicity (ADCC) and natural killer (NK) cell activity in 51Cr-release and CD107a assays

(2014) Mariana M. Mata et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A

(2014) E. M. Mace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation pathway of Src kinase reveals intermediate states as targets for drug design

(2014) Diwakar Shukla et al.   Nature Communications

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

(2013) Pengyan Xia et al.   EMBO JOURNAL

Phosphoregulation of the WAVE regulatory complex and signal integration

(2013) Michelle C. Mendoza   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control

(2013) Bo Dong et al.   Nature Communications

WASH Knockout T Cells Demonstrate Defective Receptor Trafficking, Proliferation, and Effector Function

(2012) J. T. Piotrowski et al.   MOLECULAR AND CELLULAR BIOLOGY

New insights into the regulation and cellular functions of the ARP2/3 complex

(2012) Jeremy D. Rotty et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human NK cell lytic granules and regulation of their exocytosis

(2012) Konrad Krzewski et al.   Frontiers in Immunology

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis

(2011) Michael Carnell et al.   JOURNAL OF CELL BIOLOGY

Innate or Adaptive Immunity? The Example of Natural Killer Cells

(2011) E. Vivier et al.   SCIENCE

Physical Mechanisms of Signal Integration by WASP Family Proteins

(2010) Shae B. Padrick et al.   Annual Review of Biochemistry

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

WASH and WAVE actin regulators of the Wiskott-Aldrich syndrome protein (WASP) family are controlled by analogous structurally related complexes

(2010) D. Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Phosphorylation of WASp is a key regulator of activity and stability in vivo

(2009) M. P. Blundell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA