EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization

Gene Deregulation and Chronic Activation in Natural Killer Cells Deficient in the Transcription Factor ETS1

(2012) Kevin Ramirez et al.   IMMUNITY

The Adaptor SAP Controls NK Cell Activation by Regulating the Enzymes Vav-1 and SHIP-1 and by Enhancing Conjugates with Target Cells

(2012) Zhongjun Dong et al.   IMMUNITY

Positive and Negative Signaling through SLAM Receptors Regulate Synapse Organization and Thresholds of Cytolysis

(2012) Fang Zhao et al.   IMMUNITY

The Receptor Ly108 Functions as a SAP Adaptor-Dependent On-Off Switch for T Cell Help to B Cells and NKT Cell Development

(2012) Robin Kageyama et al.   IMMUNITY

Expansion of somatically reverted memory CD8+T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus

(2012) Umaimainthan Palendira et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development

(2011) Andre Limnander et al.   NATURE IMMUNOLOGY

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

(2011) Umaimainthan Palendira et al.   PLOS BIOLOGY

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets

(2010) A. D. Hislop et al.   BLOOD

Cutting Edge: The Adapters EAT-2A and -2B Are Positive Regulators of CD244- and CD84-Dependent NK Cell Functions in the C57BL/6 Mouse

(2010) N. Wang et al.   JOURNAL OF IMMUNOLOGY

SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions

(2010) Cynthia Detre et al.   Seminars in Immunopathology

How do SAP family deficiencies compromise immunity?

(2010) Zhongjun Dong et al.   TRENDS IN IMMUNOLOGY

SLAM-Family Receptors: Immune Regulators with or without SAP-Family Adaptors

(2010) A. Veillette   Cold Spring Harbor Perspectives in Biology

Inhibition and Activation by CD244 Depends on CD2 and Phospholipase C-γ1

(2009) Nicholas G. Clarkson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells

(2009) Zhongjun Dong et al.   NATURE IMMUNOLOGY

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

(2009) Mario-Ernesto Cruz-Munoz et al.   NATURE IMMUNOLOGY

Line of attack: NK cell specificity and integration of signals

(2008) Yenan T Bryceson et al.   CURRENT OPINION IN IMMUNOLOGY

Control of T Lymphocyte Signaling by Ly108, a Signaling Lymphocytic Activation Molecule Family Receptor Implicated in Autoimmunity

(2008) Ming-Chao Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

SAP expression in T cells, not in B cells, is required for humoral immunity

(2008) A. Veillette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA