Bile acids evoke placental inflammation by activating Gpbar1/NF-κB pathway in intrahepatic cholestasis of pregnancy

Effect of ursodeoxycholic acid treatment on the altered progesterone and bile acid homeostasis in the mother-placenta-foetus trio during cholestasis of pregnancy

(2015) Maria C. Estiú et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum

(2015) Shadi Abu-Hayyeh et al.   HEPATOLOGY

Placental gene-expression profiles of intrahepatic cholestasis of pregnancy reveal involvement of multiple molecular pathways in blood vessel formation and inflammation

(2014) QiaoLing Du et al.   BMC Medical Genomics

TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation

(2014) Alessia Perino et al.   JOURNAL OF CLINICAL INVESTIGATION

The Reversed Feto-Maternal Bile Acid Gradient in Intrahepatic Cholestasis of Pregnancy Is Corrected by Ursodeoxycholic Acid

(2014) Victoria Geenes et al.   PLoS One

Differential activation of the human farnesoid X receptor depends on the pattern of expressed isoforms and the bile acid pool composition

(2013) Javier Vaquero et al.   BIOCHEMICAL PHARMACOLOGY

Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: A prospective population-based case-control study

(2013) Victoria Geenes et al.   HEPATOLOGY

Primary bile acids as potential biomarkers for the clinical grading of intrahepatic cholestasis of pregnancy

(2013) Jianbo Chen et al.   INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS

Effect of maternal cholestasis on TGR5 expression in human and rat placenta at term

(2013) V. Keitel et al.   PLACENTA

Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype

(2012) Shadi Abu-Hayyeh et al.   HEPATOLOGY

Fetal Outcomes in Pregnancies Complicated by Intrahepatic Cholestasis of Pregnancy in a Northern California Cohort

(2012) Michelle Rook et al.   PLoS One

Effects of Chemical Modification of Ursodeoxycholic Acid on TGR5 Activation

(2011) Yusuke Iguchi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Bile Acid Signaling in Fetal Tissues: Implications for Intrahepatic Cholestasis of Pregnancy

(2011) Catherine Williamson et al.   DIGESTIVE DISEASES

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart

(2011) Michele Miragoli et al.   HEPATOLOGY

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Characterisation of the nuclear receptors FXR, PXR and CAR in normal and cholestatic placenta

(2011) V.L. Geenes et al.   PLACENTA

A placental phenotype for intrahepatic cholestasis of pregnancy

(2011) V.L. Geenes et al.   PLACENTA

Inhibition of Na+-Taurocholate Co-transporting Polypeptide-mediated Bile Acid Transport by Cholestatic Sulfated Progesterone Metabolites

(2010) Shadi Abu-Hayyeh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Longitudinal Profiles of 15 Serum Bile Acids in Patients With Intrahepatic Cholestasis of Pregnancy

(2009) Rachel M Tribe et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Altered gene profile of placenta from women with intrahepatic cholestasis of pregnancy

(2009) Jing Wei et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS