Article
Cell Biology
Xiaobao Gong, Hong Tang, Kai Yang
Summary: This study revealed that PER1 suppresses OSCC progression by inhibiting glycolysis-mediated cell proliferation through the formation of the PER1/RACK1/PI3K complex, regulating the stability of PI3K and the PI3K/AKT pathway-dependent manner. These findings suggest that PER1 could be a valuable therapeutic target in OSCC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Annalucia Carbone, Elisabetta De Santis, Olga Cela, Vincenzo Giambra, Luca Miele, Giuseppe Marrone, Antonio Grieco, Marcus Buschbeck, Nazzareno Capitanio, Tommaso Mazza, Gianluigi Mazzoccoli
Summary: Hepatocellular carcinoma is a major cause of cancer-related death globally, with obesity and metabolic syndrome-related NAFLD and NASH being primary risk factors. Epigenetic mechanisms play a role in NAFLD-associated HCC, with the core circadian protein PER1 potentially modulating liver carcinogenesis in this context.
Article
Medicine, General & Internal
Yinfeng Liu, Jun Hao, Guanli Yuan, Mengyu Wei, Yuhui Bu, Tingting Jin, Li Ma
Summary: The study found that the expression level of the important circadian clock gene PER1 is significantly reduced in breast cancer, and patients with high PER1 expression have a better prognosis. Further research showed that PER1 plays a role in inhibiting tumor growth and metastasis in breast cancer.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ruyi He, Shijie Zhang, Jiale Yu, Xiaojie Yu, Jian Wang, Yi Qiu, Wenting Zhou, Fangyi Wang, Feng Ren, Zhiguo Liu
Summary: Disturbances in circadian rhythms can have long-term impacts on immune functions of the spleen in mice, inducing DNA damage and ferroptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nemanja Milicevic, Ouafa Ait-Hmyed Hakkari, Udita Bagchi, Cristina Sandu, Aldo Jongejan, Perry D. Moerland, Jacoline B. ten Brink, David Hicks, Arthur A. Bergen, Marie-Paule Felder-Schmittbuhl
Summary: The study showed that Per1 and Per2 are essential clock components for driving photoreceptor outer segment phagocytosis, and this process may be transcriptionally driven by the retinal pigment epithelium (RPE). No differentially expressed genes were found in photoreceptors, while several genes were differentially expressed in the RPE, both in wild type and Per1, Per2 double mutant mice. STRING analysis identified a group of interacting genes potentially involved in driving photoreceptor outer segment phagocytosis in the RPE.
Article
Multidisciplinary Sciences
Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz-Josef Lenz, Jeremy N. Rich, Steve A. Kay
Summary: Hepatocellular carcinoma (HCC) is a global health challenge with increasing incidence worldwide. The circadian clock has been shown to play a key role in hepatocarcinogenesis, but the cellular and molecular mechanisms underlying the HCC-clock crosstalk are unknown. In this study, we found that HCC cells rely on the circadian clock transcription factors BMAL1 and CLOCK for cell growth, and down-regulation of these factors induces apoptosis and cell cycle arrest. Mechanistically, inhibiting BMAL1/CLOCK dysregulates cell cycle regulators Wee1 and p21, leading to tumor cell death. Our findings provide insights into the cellular impact of clock proteins in HCC oncogenesis and suggest a potential therapeutic approach based on modulation of the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Qinrui Liu, Hu Wang, Hualin Wang, Na Li, Ruyi He, Zhiguo Liu
Summary: This study found that disruption of the Per1/Per2 genes can decrease the reproductive capacity of elderly male mice. The mechanism involves the reduction of testosterone synthesis and sperm motility through the PKA-StAR pathway, leading to decreased fertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jiao Wang, Qiong Huang, Xingbin Hu, Shuyi Zhang, Yu Jiang, Guangyu Yao, Kongzhen Hu, Xin Xu, Bishan Liang, Qijing Wu, Zhenfeng Ma, Yawen Wang, Chunlin Wang, Zhenzhen Wu, Xiaoxiang Rong, Wangjun Liao, Min Shi
Summary: In trastuzumab-resistant HER2-positive gastric cancer, glycolysis fluctuates with a circadian oscillation regulated by the BMAL1-CLOCK-PER1-HK2 axis, which can be disrupted with a metformin-based chronotherapy to overcome trastuzumab resistance.
Review
Cell Biology
Jing Yao, Chuqi He, Weichao Zhao, Nan Hu, Dingxin Long
Summary: The circadian clock is an internal timing system that influences various physiological processes such as cell metabolism, division, apoptosis, and tumor production, and is closely linked to the cell cycle. Current research focuses on optimizing tumor treatment by adjusting the timing of drug administration based on the circadian clock, which also has effects on cancer and aging.
Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Joseph R. Knoedler, Cristina Saenz de Miera, Arasakumar Subramani, Robert J. Denver
Summary: The gene KLF9 plays an important role in the liver's response to stress-induced Per1 mRNA, while the potential role of B in this response needs further investigation.
Article
Cell Biology
Zeyu Wang, Guanhua Su, Ziyu Dai, Ming Meng, Hao Zhang, Fan Fan, Zhengzheng Liu, Longbo Zhang, Nathaniel Weygant, Fengqiong He, Ning Fang, Liyang Zhang, Quan Cheng
Summary: Circadian clock gene expression in glioma is associated with disease progression, affecting the tumor immune landscape and cell cycle, potentially impacting survival outcomes. A risk model can predict glioma survival outcomes and may be applicable to other types of cancer.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Francesca Battaglin, Priscilla Chan, Yuanzhong Pan, Shivani Soni, Meng Qu, Erin R. Spiller, Sofi Castanon, Evanthia T. Roussos Torres, Shannon M. Mumenthaler, Steve A. Kay, Heinz-Josef Lenz
Summary: Disruption of the circadian clock pathway is associated with cancer risk, development, and progression. Dysregulation of core circadian clock genes is common in human tumors, with varied effects and mechanisms depending on cancer types. Pharmacological modulation of clock components shows promise as a novel anti-cancer therapeutic approach.
Article
Multidisciplinary Sciences
Andrea Brenna, Juergen A. Ripperger, Gabriella Saro, Dominique A. Glauser, Zhihong Yang, Urs Albrecht
Summary: Light influences various physiological processes in mammals, and PER2 has been identified as a co-factor of CREB to facilitate the formation of a transactivation complex on the Per1 gene regulatory region in response to light stimulation.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Nemanja Milicevic, Arthur A. Bergen, Marie-Paule Felder-Schmittbuhl
Summary: Light can synchronize an animal's sleep-wake cycle and directly influence its activity level. High illumination levels decrease activity in mice, and the Per1 gene plays a crucial role in suppressing negative masking responses.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Hua Ye, Kai Yang, Xue-Mei Tan, Xiao-Juan Fu, Han-Xue Li
ONCOTARGETS AND THERAPY
(2015)
Article
Oncology
Han-Xue Li, Xiao-Juan Fu, Kai Yang, Dan Chen, Hong Tang, Qin Zhao
Article
Dentistry, Oral Surgery & Medicine
Xiao-Juan Fu, Wan-shan Li, Li Xiang, Li-Shu Liao
Summary: This retrospective study analyzed the emergency treatment methods and infection prevention measures in the Department of Pediatric Oral and Maxillofacial Surgery at Children's Hospital of Chongqing Medical University during the COVID-19 epidemic. The results showed that effective diagnosis and treatment, along with strict adherence to epidemic prevention procedures, helped prevent the spread of COVID-19.
DENTAL TRAUMATOLOGY
(2022)