Intrinsic reactivity profile of electrophilic moieties to guide covalent drug design: N-α-acetyl-l-lysine as an amine nucleophile

Covalent protein modification: the current landscape of residue-specific electrophiles

(2015) D Alexander Shannon et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

(2014) Mark E. Flanagan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases

(2014) Stefan G. Kathman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinetic Template-Guided Tethering of Fragments

(2012) Rebecca H. Nonoo et al.   ChemMedChem

Application of the Hard and Soft, Acids and Bases (HSAB) Theory to Toxicant–Target Interactions

(2011) Richard M. LoPachin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Measurement and Estimation of Electrophilic Reactivity for Predictive Toxicology

(2011) Johannes A. H. Schwöbel et al.   CHEMICAL REVIEWS

Small Molecule Quantification by Liquid Chromatography-Mass Spectrometry for Metabolites of Drugs and Drug Candidates

(2011) U. P. Dahal et al.   DRUG METABOLISM AND DISPOSITION

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

How essential is the ‘essential’ active-site lysine in dihydrodipicolinate synthase?

(2010) Tatiana P. Soares da Costa et al.   BIOCHIMIE

Review of tyrosine and lysine as new motifs for organophosphate binding to proteins that have no active site serine

(2010) Oksana Lockridge et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Characterization of HKI-272 Covalent Binding to Human Serum Albumin

(2010) J. Wang et al.   DRUG METABOLISM AND DISPOSITION

Involvement of the Immune System in Idiosyncratic Drug Reactions

(2010) Xiachu Zhang et al.   Drug Metabolism and Pharmacokinetics

Strategies for discovering and derisking covalent, irreversible enzyme inhibitors

(2010) Douglas S Johnson et al.   Future Medicinal Chemistry

Discovery of PF-04457845: A Highly Potent, Orally Bioavailable, and Selective Urea FAAH Inhibitor

(2010) Douglas S. Johnson et al.   ACS Medicinal Chemistry Letters

Multiple roles of the active site lysine of Dopa decarboxylase

(2009) Mariarita Bertoldi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Kinetic Glutathione Chemoassay To Quantify Thiol Reactivity of Organic ElectrophilesApplication to α,β-Unsaturated Ketones, Acrylates, and Propiolates

(2009) Alexander Böhme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system

(2008) Yutaka Ishida et al.   ARCHIVES OF ORAL BIOLOGY