Journal
MEDCHEMCOMM
Volume 7, Issue 4, Pages 654-657Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5md00508f
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The new prosthetic group F-18-TEG-DBCO (dibenzocyclooctyne) can be prepared within a total reaction time of 60 min including purification with an overall yield (n.d.c.) of 34 +/- 5%. Copper-free click cycloadditions with an azido-cRGD, a folate-azide and two alpha-MSH analogue azido-peptides resulted in very high RCYs and fast reaction kinetics.
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