Covalent tethering of fragments for covalent probe discovery

Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain

(2015) Danielle McShan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Nedd4 Haploinsufficient Mice Display Moderate Insulin Resistance, Enhanced Lipolysis, and Protection Against High-Fat Diet-Induced Obesity

(2015) Jing Jing Li et al.   ENDOCRINOLOGY

A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism

(2015) Stefan G. Kathman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prolonged and tunable residence time using reversible covalent kinase inhibitors

(2015) J Michael Bradshaw et al.   Nature Chemical Biology

Efficient and Facile Synthesis of Acrylamide Libraries for Protein-Guided Tethering

(2015) Charlotte E. Allen et al.   ORGANIC LETTERS

Covalent Docking of Large Libraries for the Discovery of Chemical Probes

(2015) Nir London et al.   BIOPHYSICAL JOURNAL

Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

(2014) Hao Li et al.   ACS Chemical Biology

Small-Molecule Control of Intracellular Protein Levels through Modulation of the Ubiquitin Proteasome System

(2014) Dennis L. Buckley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

(2014) Mark E. Flanagan et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases

(2014) Stefan G. Kathman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Promiscuity and Selectivity in Covalent Enzyme Inhibition: A Systematic Study of Electrophilic Fragments

(2014) Christian Jöst et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis

(2014) Shyam Krishnan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses

(2014) Z. Han et al.   JOURNAL OF VIROLOGY

Covalent docking of large libraries for the discovery of chemical probes

(2014) Nir London et al.   Nature Chemical Biology

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

(2014) Bryan R Lanning et al.   Nature Chemical Biology

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

PTEN is a protein tyrosine phosphatase for IRS1

(2014) Yuji Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient exploration of chemical space by fragment-based screening

(2014) Richard J. Hall et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

Approaches for enhancing oral bioavailability of peptides and proteins

(2013) Jwala Renukuntla et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Vinyl Sulfone-Based Peptidomimetics as Anti-Trypanosomal Agents: Design, Synthesis, Biological and Computational Evaluation

(2013) Elizabeth Dunny et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Optimization of Novel Epoxide Incorporating Peptidomimetics as Selective Calpain Inhibitors

(2013) Isaac T. Schiefer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Activity-Based Probes for Ubiquitin and Ubiquitin-like Protein Signaling Pathways

(2013) Heeseon An et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Electrophilic Fragment-Based Design of Reversible Covalent Kinase Inhibitors

(2013) Rand M. Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

1,3,5-Triazine as a Modular Scaffold for Covalent Inhibitors with Streamlined Target Identification

(2013) Ranjan Banerjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes

(2013) Kyung Bo Kim et al.   NATURAL PRODUCT REPORTS

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming

(2013) Elena Maspero et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance

(2013) P. A. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

(2013) Hari B Kamadurai et al.   eLife

Kinetic Template-Guided Tethering of Fragments

(2012) Rebecca H. Nonoo et al.   ChemMedChem

Electrophilic natural products and their biological targets

(2012) Malte Gersch et al.   NATURAL PRODUCT REPORTS

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

(2012) Iana M Serafimova et al.   Nature Chemical Biology

Identification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interaction

(2012) Rosa Cardoso et al.   PROTEIN SCIENCE

Development of Small Molecule Inhibitors and Probes of Human SUMO Deconjugating Proteases

(2011) Victoria E. Albrow et al.   CHEMISTRY & BIOLOGY

Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation

(2011) Elena Maspero et al.   EMBO REPORTS

Structure and function of a HECT domain ubiquitin-binding site

(2011) Hyung Cheol Kim et al.   EMBO REPORTS

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Ubiquitin C-Terminal Electrophiles Are Activity-Based Probes for Identification and Mechanistic Study of Ubiquitin Conjugating Machinery

(2009) Kerry Routenberg Love et al.   ACS Chemical Biology

Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database

(2009) Alícia P. Higueruelo et al.   Chemical Biology & Drug Design

Regulation of the RSP5 Ubiquitin Ligase by an Intrinsic Ubiquitin-binding Site

(2009) Michael E. French et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Peptidomimetics Containing a Vinyl Ester Moiety as Highly Potent and Selective Falcipain-2 Inhibitors

(2009) Roberta Ettari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex

(2009) Hari B. Kamadurai et al.   MOLECULAR CELL