Article
Endocrinology & Metabolism
Jacob M. Basak, Macy Falk, Danae N. Mitchell, Kelley A. Coakley, Nidia Quillinan, James E. Orfila, Paco S. Herson
Summary: Post-stroke cognitive impairment and dementia (PSCID) affects survivors of large vessel cerebral ischemia. The molecular pathways underlying PSCID may overlap with neurodegenerative pathophysiology, specifically involving alterations in amyloid beta (A beta) levels. Using a mouse model, this study shows that soluble A beta levels are significantly increased in the hippocampus after a stroke, along with increased activity of BACE1, an enzyme involved in A beta production. Additionally, treatment with a BACE1 inhibitor improves stroke-induced deficits in synaptic plasticity, suggesting a potential therapeutic target for PSCID.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
Daisuke Ibi, Kazuki Hirashima, Yuya Kojima, Kahori Sumiya, Sari Kondo, Mirai Yamamoto, Toshihiro Ando, Masayuki Hiramatsu
Summary: Long-term intake of betaine can prevent cognitive impairment and aberrant expression of genes related to antioxidant activity in the hippocampus of a genetic AD model, suggesting that betaine may be a potential agent for preventing the progression of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Wenwen Yin, Ke Wan, Wenhao Zhu, Xia Zhou, Yating Tang, Wenhui Zheng, Jing Cao, Yu Song, Han Zhao, Xiaoqun Zhu, Zhongwu Sun
Summary: This study aimed to evaluate the correlations between plasma BACE1 concentration, cognition, and hippocampal volume at different stages of the AD continuum. The results showed that BACE1 concentration was elevated in AD continuum patients and correlated with memory function and hippocampal atrophy. Plasma BACE1 concentration may serve as a potential biomarker at the early stage of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Agriculture, Multidisciplinary
Jian Bao, Zheng Liang, Xiaokang Gong, Yanna Zhao, Mengjuan Wu, Wei Liu, Chenyu Tu, Xiaochuan Wang, Xiji Shu
Summary: This study found that Tangeretin (TAN) exhibits antidementia activity in APPswe/PSEN1dE9 transgenic mice, reducing cognitive impairment, synaptic impairments, and beta-amyloid accumulations. TAN also showed powerful inhibitory activity against beta-secretase, suggesting it as a potential drug for preventing Alzheimer's disease pathology.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Neurosciences
Lili Chen, Qin Qin, Panchuan Huang, Fangli Cao, Maojia Yin, Yachen Xie, Wuchao Wang
Summary: Chronic neuropathic pain may lead to cognitive impairment in elderly patients, possibly due to the inhibitory effect of CCL2/CCR2 signaling on hippocampal neurogenesis.
BRAIN RESEARCH BULLETIN
(2023)
Article
Clinical Neurology
Emrah Duezel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schuetze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Bjoern-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H. Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jessen
Summary: This study investigated whether the impact of tau-pathology on memory performance and hippocampal/medial temporal memory function depends on the presence of amyloid pathology. The results showed a linear relationship between amyloid pathology, tau pathology, hippocampal dysfunction, and memory impairment.
Article
Physiology
Sang-Seo Park, Hye-Sang Park, Chang-Ju Kim, Seung-Soo Baek, Song-Young Park, Cody Anderson, Myung-Ki Kim, Ik-Ryeul Park, Tae-Woon Kim
Summary: Exercising in a 40-Hz light flicker environment was found to be more effective than exercise or 40-Hz light flicker alone. This synergistic effect may prevent cognitive dysfunction by inhibiting the Aβ, tau pathway, and neuroinflammation, and enhancing neuroplasticity and mitochondrial functions in the hippocampus during the early stages of Alzheimer's disease.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Neurosciences
Kichang Kwak, Marc Niethammer, Kelly S. Giovanello, Martin Styner, Eran Dayan
Summary: Using deep learning, the researchers delineated the contribution of hippocampal subfields to the progression of MCI and proposed a high-accuracy neural network architecture. They also identified specific regions within the hippocampal subfields that play a crucial role in the model's performance.
Article
Geriatrics & Gerontology
Ingo Kilimann, Diana Wucherer, Till Ittermann, Henry Voelzke, Robin Bulow, Wolfgang Hoffmann, Hans Jorgen Grabe, Katharina Wittfeld, Stefan Johannes Teipel
Summary: The study revealed a significant association between medication anticholinergic burden and hippocampal volume, but not with the cholinergic basal forebrain system. This suggests a potential inverse effect of medication on hippocampal volume, emphasizing the importance of cautious prescription of anticholinergic medication at any age in adults.
Article
Clinical Neurology
Yi Zhang, Chenglin Niu
Summary: The study suggests that CDC42 may be associated with the progression and cognitive decline in Alzheimer's disease, and has the potential to serve as a biomarker for estimating AD risk and progression.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Chemistry, Medicinal
Omid Reza Tamtaji, Reza Heidari-soureshjani, Zatollah Asemi, Ebrahim Kouchaki
Summary: The study aimed to investigate the effects of spirulina intake on cognitive function and metabolic status in patients with Alzheimer's disease (AD). A randomized, double-blind, controlled clinical trial was conducted involving 60 AD patients. The results showed that spirulina intake for 12 weeks significantly improved cognitive function and glucose homeostasis, while reducing high-sensitivity C-reactive protein levels. These findings suggest that spirulina may have beneficial effects in AD patients.
PHYTOTHERAPY RESEARCH
(2023)
Article
Neurosciences
Sydney Y. Schaefer, Michael Malek-Ahmadi, Andrew Hooyman, Jace B. King, Kevin Duff
Summary: Hippocampal atrophy is a common biomarker for Alzheimer's disease, but its use is limited by the cost and contraindications of magnetic resonance imaging (MRI). Recent research has found that a low-cost upper extremity motor task has the potential to identify Alzheimer's disease risk. The study shows that measures of motor task performance can predict hippocampal volume, offering a cost-effective and non-invasive screening method for Alzheimer's disease risk and progression.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Laura Schnoeder, Inge Tomic, Laura Schwindt, Dominic Helm, Mandy Rettel, Walter Schulz-Schaeffer, Elmar Krause, Jens Rettig, Klaus Fassbender, Yang Liu
Summary: Deficiency of p38 alpha-MAPK in neurons leads to increased retrograde transportation of BACE1 in axons, shifting it from axonal terminals to lysosomes in the cell body, which exacerbates amyloid deposition in the brain of Alzheimer's disease.
Review
Zoology
Thomas A. Kim, Michelle D. Syty, Kaitlyn Wu, Shaoyu Ge
Summary: Adult neurogenesis is the creation of new neurons in the adult brain, which play a crucial role in brain functions such as learning and memory. However, diseases like Alzheimer's can impair hippocampal neurogenesis, leading to cognitive decline and memory loss.
ZOOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Marika Marino, Lujia Zhou, Melvin Y. Rincon, Zsuzsanna Callaerts-Vegh, Jens Verhaert, Jerome Wahis, Eline Creemers, Lidia Yshii, Keimpe Wierda, Takashi Saito, Catherine Marneffe, Iryna Voytyuk, Yessica Wouters, Maarten Dewilde, Sandra Duque, Cecile Vincke, Yona Levites, Todd E. Golde, Takaomi C. Saido, Serge Muyldermans, Adrian Liston, Bart De Strooper, Matthew G. Holt
Summary: Single domain antibodies (VHHs) have potential therapeutic value for neurological disorders, but their use in the central nervous system is limited by the blood-brain barrier. This study proposes a gene transfer strategy using BBB-crossing AAV-based vectors to deliver VHH directly into the CNS. The results show that AAV-delivered VHH can effectively inhibit BACE1 and improve cognitive performance in an Alzheimer's disease mouse model, providing a novel therapeutic approach for neurodegenerative diseases.
EMBO MOLECULAR MEDICINE
(2022)
Review
Clinical Neurology
Johanna Andrea Gutierrez-Vargas, Gloria Patricia Cardona-Gomez
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Neurosciences
P. A. Perez-Corredor, J. A. Gutierrez-Vargas, L. Ciro-Ramirez, Norman Balcazar, G. P. Cardona-Gomez
Summary: Obesity induced by a high fructose diet exacerbates neuronal loss, inflammation, and plasticity impairment in the hippocampus after cerebral ischemia.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Engineering, Electrical & Electronic
Julian D. Arias-Londono, Jorge A. Gomez-Garcia, Juan Godino-Llorente
IEEE JOURNAL OF SELECTED TOPICS IN SIGNAL PROCESSING
(2020)
Article
Biochemistry & Molecular Biology
Angelica Maria Sabogal-Guaqueta, Julian David Arias-Londono, Johanna Gutierrez-Vargas, D. Sepulveda-Falla, M. Glatzel, Andres Villegas-Lanau, Gloria Patricia Cardona-Gomez
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Review
Engineering, Biomedical
Laureano Moro-Velazquez, Jorge A. Gomez-Garcia, Julian D. Arias-Londono, Najim Dehak, Juan Godino-Llorente
Summary: Parkinson's Disease affects speech through dysphonia and hypokinetic dysarthria. Recent studies focus on developing new automatic tools for diagnosis and assessment. However, there is currently no standard methodology validated in clinical trials, and further research is needed.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Review
Engineering, Biomedical
J. A. Gomez-Garcia, L. Moro-Velazquez, J. D. Arias-Londono, J. Godino-Llorente
Summary: This paper reviews the current state of automatic voice condition analysis systems, compiling the most significant parameterisation approaches used in the literature. It provides a critical discussion on their usefulness and offers a comprehensive review of the most important techniques used for acoustic modelling in the field.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Neurosciences
P. A. Perez-Corredor, P. Oluwatomilayo-Ojo, J. A. Gutierrez-Vargas, G. P. Cardona-Gomez
Summary: Obesity is associated with worse outcomes after cerebral ischemia, but the cellular mechanisms remain unclear. In this study, rats fed a high fructose diet (HFD) were used as a model of obesity. It was found that obese rats had dyslipidemia and high levels of proinflammatory cytokines. The glia from obese rats showed altered morphology, suggesting hyperreactivity related to neurological and motor deficits. Plasma from obese rats induced activation of endothelial cells and the release of more extracellular vesicles (EVs). These EVs caused an increase in NF-kappa B and astrocyte cytotoxicity. These findings suggest that obesity activates proinflammatory signals in endothelial cells, leading to the release of EVs that contribute to astrocyte activation.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Julian D. Arias-Londono, Alvaro Moure-Prado, Juan I. Godino-Llorente
Summary: This article proposes an alternative approach using deep learning techniques to identify lung lesions associated with COVID-19 from chest X-ray images. The method focuses on a certain region of interest by pre-processing the images and improves model accuracy and interpretability. Results show that the opacities due to COVID-19 can be detected with high accuracy using a semi-supervised training procedure and ensemble of two architectures. The study also suggests the importance of resizing bounding boxes for labeling accuracy, leading to more precise results.
Proceedings Paper
Computer Science, Artificial Intelligence
Catalina Bustamante, Gabriel Castrillon, Julian Arias-Londono
Summary: Focal disturbances in cerebral activity caused by TMS can lead to changes in global brain connectivity, which can be studied using TVFC based on rs-fMRI. This study used HMM to evaluate temporal variations in functional connectivity after stimulation of two different brain areas and built generative models based on HMM to classify different stimuli and achieve high accuracy rates.
APPLICATIONS OF COMPUTATIONAL INTELLIGENCE, COLCACI 2022
(2023)
Article
Biotechnology & Applied Microbiology
Emiro J. Ibarra, Julian D. Arias-Londono, Matias Zanartu, Juan I. Godino-Llorente
Summary: End-to-end deep learning models have shown promise in automatic screening of Parkinson's disease through voice and speech, but struggle with multiple corpora and corpus-dependent clusterings. This study explores the use of domain adversarial training to develop models that can detect Parkinson's disease across diverse datasets, showing that domain adversarial networks can learn common characteristics of Parkinsonian voice and speech, independent of language or corpus.
BIOENGINEERING-BASEL
(2023)
Article
Neurosciences
Oluwatomilayo Patience Ojo, Paula Andrea Perez-Corredor, Johanna Andrea Gutierrez-Vargas, Oluwole Busayo Akinola, Gloria Patricia Cardona-Gomez
Summary: The study evaluated the long-term effects of a high fructose diet and cerebral ischemia on neurological, cognitive, and emotional performance in male rats. Results showed that fructose intake led to weight gain, high blood glucose, and reduced insulin sensitivity. The coexistence of fructose intake and cerebral ischemia worsened neurological performance and resulted in alterations in learning and emotional skills.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Juan Villar-Vesga, Julian Henao-Restrepo, Danielle C. Voshart, David Aguillon, Andres Villegas, Diana Castano, Julian D. Arias-Londono, Inge S. Zuhorn, Lais Ribovski, Lara Barazzuol, Gloria P. Cardona-Gomez, Rafael Posada-Duque
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Pharmacology & Pharmacy
Natalia Lopez-Barbosa, Juan G. Garcia, Javier Cifuentes, Lina M. Castro, Felipe Vargas, Carlos Ostos, Gloria P. Cardona-Gomez, Alher Mauricio Hernandez, Juan C. Cruz
Article
Computer Science, Information Systems
Julian D. Arias-Londono, Jorge A. Gomez-Garcia, Laureano Moro-Velazquez, Juan Godino-Llorente
