Anticancer metallohelices: nanomolar potency and high selectivity

Recognition of DNA/RNA bulges by antimicrobial and antitumor metallohelices

(2015) Jaroslav Malina et al.   DALTON TRANSACTIONS

Metallohelices: potential mimetics of α-helical peptides in cancer treatment?

(2015) Rebecca A Kaner et al.   Future Medicinal Chemistry

Shape-selective recognition of DNA abasic sites by metallohelices: inhibition of human AP endonuclease 1

(2015) J. Malina et al.   NUCLEIC ACIDS RESEARCH

Die another way – non-apoptotic mechanisms of cell death

(2014) Stephen W. G. Tait et al.   JOURNAL OF CELL SCIENCE

Chiral Metallohelical Complexes Enantioselectively Target Amyloid β for Treating Alzheimer’s Disease

(2014) Meng Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric triplex metallohelices with high and selective activity against cancer cells

(2014) Alan D. Faulkner et al.   Nature Chemistry

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53-independent pathways

(2014) S J Allison et al.   Oncogenesis

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

The why and how of phenotypic small-molecule screens

(2013) Ulrike S Eggert   Nature Chemical Biology

Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?

(2013) Viktor Brabec et al.   Chemical Science

Is poor research the cause of the declining productivity of the pharmaceutical industry? An industry in need of a paradigm shift

(2012) Frank Sams-Dodd   DRUG DISCOVERY TODAY

Modern Phenotypic Drug Discovery Is a Viable, Neoclassic Pharma Strategy

(2012) Jonathan A. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metallosupramolecular complex targeting an α/β discordant stretch of amyloid β peptide

(2012) Haijia Yu et al.   Chemical Science

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

(2011) Lucia Cardo et al.   CHEMICAL COMMUNICATIONS

Approaches to the synthesis of optically pure helicates

(2011) Suzanne E. Howson et al.   DALTON TRANSACTIONS

Origins of stereoselectivity in optically pure phenylethaniminopyridine tris-chelates M(NN′)3n+ (M = Mn, Fe, Co, Ni and Zn)

(2011) Suzanne E. Howson et al.   DALTON TRANSACTIONS

Effect of the damping function in dispersion corrected density functional theory

(2011) Stefan Grimme et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity

(2011) Suzanne E. Howson et al.   Nature Chemistry

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Complete Nucleotide Sequence Analysis of Plasmids in Strains ofStaphylococcus aureusClone USA300 Reveals a High Level of Identity among Isolates with Closely Related Core Genome Sequences

(2010) Adam D. Kennedy et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Self-assembling optically pure Fe(A–B)3 chelates

(2009) Suzanne E. Howson et al.   CHEMICAL COMMUNICATIONS

Antimicrobial activity of an iron triple helicate

(2009) Adair D. Richards et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Molecular modelling for transition metal complexes: Dealing with d-electron effects

(2008) Robert J. Deeth et al.   COORDINATION CHEMISTRY REVIEWS

Does the Solid−Liquid Crystal Phase Transition Provoke the Spin-State Change in Spin-Crossover Metallomesogens?

(2008) M. Seredyuk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA binding of dinuclear iron(II) metallosupramolecular cylinders. DNA unwinding and sequence preference

(2008) J. Malina et al.   NUCLEIC ACIDS RESEARCH

Epidemic community-associated methicillin-resistant Staphylococcus aureus: Recent clonal expansion and diversification

(2008) A. D. Kennedy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA