Article
Biochemistry & Molecular Biology
Aiping Zhang, Yucheng Zou, Yuhang Xi, Peng Wang, Yue Zhang, Liangru Wu, Hui Zhang
Summary: This study explored the feasibility of using unmodified bamboo shoot cellulose to produce composite aerogels with sodium alginate for sustained release of curcumin in a fast and green way. The composite aerogels showed promising potential as biocompatible carriers for drug and nutraceutical delivery, with improved thermal stability and mechanical properties induced by calcium ion-induced cross-linking. The study demonstrated the first use of cellulose from bamboo shoot to develop aerogels for drug delivery purposes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Han Liu, Suohui Zhang, Zequan Zhou, Mengzhen Xing, Yunhua Gao
Summary: In this study, two-layer sustained-release microneedles (TS-MNs) were successfully fabricated for the sustained delivery of exenatide (EXT). The TS-MNs showed good mechanical strength and could penetrate the skin for drug release. Moreover, the TS-MNs retained high drug activity during storage and had high relative bioavailability.
Article
Chemistry, Physical
Nitika Mor, Neera Raghav
Summary: Alginate-based hydrogels are promising for drug delivery and biomedical implants due to their structural similarity to body components. This study investigates the use of sodium alginate as a sustained release delivery system for curcumin. The synthesized Curcumin-Alginate ester showed stability in gastric and intestinal fluids during in-vitro simulation. The modified alginate ester released consistent amounts of curcumin in the presence of liver esterases, suggesting its potential as a prodrug system.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pharmacology & Pharmacy
Hassan Ahmad, Tahir Ali Chohan, Jahanzeb Mudassir, Prina Mehta, Bushra Yousef, Aliyah Zaman, Amna Ali, Omar Qutachi, Ming-Wei Chang, Dimitris Fatouros, Muhammad Sohail Arshad, Zeeshan Ahmad
Summary: This study aimed to develop in-situ gels containing naproxen sodium and sodium alginate. The gel formation was studied in different physiological ions, and the gel formulations were evaluated for physical attributes and drug release. In vivo studies showed the potential of the in-situ gel for sustained release of naproxen sodium and treatment of chronic inflammatory conditions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nutrition & Dietetics
Liping Dao, Siyang Chen, Xiangyun Sun, Wenyuan Pang, Hengzhe Zhang, Jun Liao, Jiqiang Yan, Jie Pang
Summary: In this study, natural biological macromolecules were used to load active substances and control their release speed in different environments of the human body. The results showed that the prepared pH-sensitive konjac glucomannan/sodium alginate-mesoporous silica loaded naringin gel spheres exhibited the best release rate under simulated small intestinal fluid.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Applied
Siying Zhang, Xiaorong Deng, Xin Guo, Jian Zhang
Summary: In this study, a new ferritin was successfully extracted, purified, and identified from the liver of Northern pike. The reversible self-assembly characteristics of ferritin were utilized to fabricate chlorogenic acid-loaded apoferritin complex and sodium alginate-apoferritin co-encapsulate system. The prepared composites had improved thermal and UV radiation stability, and the sodium alginate complex showed better sustained-release effect.
Article
Pharmacology & Pharmacy
Cheng-Tang Pan, Ruei-Siang Yu, Chih-Jung Yang, Lih-Ren Chen, Zhi-Hong Wen, Nai-Yu Chen, Hsin-You Ou, Chun-Yen Yu, Yow-Ling Shiue
Summary: This study successfully developed biodegradable calcium alginate microspheres carrying doxorubicin for sustained release and pH regulation therapy. Microspheres with high NaHCO3 concentrations demonstrated enhanced cytotoxicity effects in vitro experiments.
Article
Polymer Science
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi
Summary: This study investigated the enhancement of cytotoxicity of alpha-mangostin (AMG) in breast cancer cells through the modification of chitosan molecular weight. Chitosan-based nanoparticles were developed, and their physicochemical characteristics and cytotoxicity were evaluated. The results showed that the prepared nanoparticles significantly enhanced the cytotoxicity of breast cancer cells compared to the non-nano particle formulation.
Article
Chemistry, Applied
Ling Tang, Yi-Hong Chen, Qiong Wang, Xiao-Hui Wang, Qing-Xi Wu, Zhi-Feng Ding
Summary: The study focused on overcoming the challenges bioactive proteins face in the harsh gastric environment, utilizing microencapsulation as a strategy to protect them. Bovine serum albumin and ovalbumin were used as model proteins, with a polylysine-alginate complex fabricated for microencapsulation. Results showed that the protein-loaded microcapsules exhibited excellent tolerability to the acidic gastric environment, with slow release in simulated gastric fluids and sustained release in intestinal fluids. The developed microcapsules could potentially be used as a vehicle for bioactive proteins in functional foods, health care products, and medical formulations.
Article
Polymer Science
Zhaowen Liu, Xiuqiong Chen, Zhiqin Huang, Hongcai Wang, Shirui Cao, Chunyang Liu, Huiqiong Yan, Qiang Lin
Summary: In this study, an organic solvent-free, eco-friendly and efficient approach for the preparation of amphiphilic conjugates (Ugi-OSAOcT) was developed by grafting octylamine to oxidized sodium alginate. The conjugates self-assembled into stable and spherical micelles and successfully loaded the poorly water-soluble drug ibuprofen. The loaded micelles exhibited sustained and pH-responsive drug release behavior.
Article
Food Science & Technology
Hui Wang, Jinming Liu, Xu Fan, Jing Ren, Qian Liu, Baohua Kong
Summary: In this study, high strength sodium alginate (NaAlg) hydrogel films were obtained using natural crab-shell particles (CSP) and deacetylated crab-shell particles (dCSP) as crosslinking agents. The bi-crosslinked NaAlg hydrogel films demonstrated superior surface hydrophobicity, gel properties, mechanical strength, and thermal stabilities compared to neat NaAlg film and mono-crosslinked NaAlg hydrogel films. Additionally, these hydrogel films exhibited sustained release activity for diclofenac sodium for over 36 hours. This green crosslinking technique shows promise for the development of high-performance NaAlg hydrogel films for food packaging and medical wound dressing applications.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Rui Cui, Bifen Zhu, Jiatong Yan, Yuyue Qin, Mingwei Yuan, Guiguang Cheng, Minglong Yuan
Summary: The study prepared antimicrobial food packaging film with controlled release by loading cinnamaldehyde on etched halloysite nanotubes and adding it to sodium alginate matrix. The film showed improved water vapor barrier properties, tensile strength, and reduced negative effects of UV rays. Controlled release of cinnamaldehyde in the film was confirmed, suggesting broad application prospects in fatty food packaging.
Article
Biochemistry & Molecular Biology
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi
Summary: In this study, folate-conjugated chitosan nanoparticles (F-CS-NPs) were developed as a delivery system for alpha-mangostin (AM) to enhance its cytotoxicity to cancer cells. The use of F-CS-NPs significantly improved the cytotoxicity of AM against MCF-7 breast cancer cells.
Article
Environmental Sciences
Zahra Najahi Mohammadizadeh, Mitra Ahadifar, Mahta Mobinikhaledi, Najmieh Ahadi
Summary: Magnetic nanoparticles with green cover sodium alginate and Ag, MnCoFe2O4@Sodium alginate/Ag (MCF@S-ALG/Ag) MNPs were prepared from Sargassum Vulgare algae. The structure of these nanoparticles was characterized by various techniques. The antibacterial activity of MCF@S-ALG/Ag MNPs was tested against E. coli and S. aureus bacteria, showing significant inhibition.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wenping Wang, Irene Liparulo, Nicola Rizzardi, Paola Bolignano, Natalia Calonghi, Christian Bergamini, Romana Fato
Summary: The study demonstrated that cancer cells can adapt to energetic and oxidative stress caused by mitochondrial dysfunction by reshaping their metabolism. Depletion of CoQ in cells led to upregulation of glycolysis, increased glucose consumption, and changes in enzyme expression related to glutamine metabolism and the TCA cycle. Understanding the metabolic alterations in CoQ-depleted cells provides insights for targeting cancer metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Multidisciplinary
Mona Ebadi, Kalaivani Buskaran, Saifullah Bullo, Mohd Zobir Hussein, Sharida Fakurazi, Giorgia Pastorin
Summary: The study systematically investigated the structural, physicochemical, morphological, and magnetic properties of magnetic drug nanoparticles and their potential in cancer treatment. The coated Fe3O4 magnetite nanoparticles were found to be more effective than sorafenib alone against liver cancer cells, while displaying no cytotoxicity against fibroblasts. These results suggest that the coated Fe3O4 nanoparticles could be a promising drug delivery carrier for biomedical applications.
ALEXANDRIA ENGINEERING JOURNAL
(2021)
Article
Polymer Science
Hamid Zentou, Zurina Zainal Abidin, Robiah Yunus, Dayang Radiah Awang Biak, Mohammed Abdullah Issa
Summary: Response surface methodology was used to optimize the performance of pervaporation of ethanol aqueous solution using polydimethylsiloxane hollow-fiber membrane. The results showed that a quadratic model was suggested for both selectivity and total flux showing a high accuracy with R-2 = 0.9999 and 0.9995, respectively. The developed models indicated a significant effect of the four studied factors on both selectivity and total flux with some significant interactions between these factors.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Correction
Materials Science, Multidisciplinary
Nur Liyana Mohamad Hafiz, Paridah Md Tahir, Lee Seng Hua, Zurina Zainal Abidin, Fatimah Athiyah Sabaruddin, Noryuziah Mohd Yunus, Ummi Hani Abdullah, H. P. S. Abdul Khalil
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Plant Sciences
Xia Hong, Mokrish Ajat, Sharida Fakurazi, Akmal Mohd Noor, Intan Safinar Ismail
Summary: The study demonstrated that Scurrula ferruginea parasitizing on Tecoma stans showed anti-inflammatory activity by inhibiting the production of inflammatory cytokines and regulating gene expression, suggesting its potential as a plant-derived candidate for inflammation treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Green & Sustainable Science & Technology
Jia Boh Tan, Nur Syakina Jamali, Wei En Tan, Hasfalina Che Man, Zurina Zainal Abidin
Summary: The study evaluated the techno-economic feasibility of an on-farm biogas system utilizing cow manure, demonstrating its ability to generate electricity and additional income for farmers.
Article
Chemistry, Multidisciplinary
Hamid Zentou, Zurina Zainal Abidin, Robiah Yunus, Dayang R. Awang Biak, Mohammed Abdullah Issa, Musa Yahaya Pudza
Summary: This study developed a new mathematical model to describe the inhibitory effect of byproducts on alcoholic fermentation. The results showed a linear increase in byproduct concentration with glucose concentration and a significant inhibitory effect on yeast growth. The new model performed better and more accurately than the classical Monod model.
Article
Engineering, Chemical
Hamid Zentou, Zurina Z. Abidin, Robiah Yunus, Dayang Radiah Awang Biak, Mohammed Abdullah Issa, Musa Yahaya Pudza
Summary: The study utilized a solution-diffusion model to investigate the pervaporation process for ethanol recovery from ethanol/water mixture, showing high accuracy and efficiency in optimizing and controlling the process. The model was validated with fermentation broth, demonstrating low mean absolute percentage errors for ethanol, water, and total flux, indicating its potential as an efficient tool for bioethanol production.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2021)
Article
Chemistry, Physical
Noor Amirah Abdul Halim, Zurina Zainal Abidin, Shamsul Izhar Siajam, Chong Gun Hean, Mohd Razif Harun
Summary: Subcritical water extraction of essential oil from Citrus hystrix DC. leaves was optimized using response surface methodology, achieving higher yield and quality of essential oil compounds. The tunable temperatures in SWE not only improved the quantity, but also enhanced the quality and diverse functionalities for nutraceutical sectors compared to conventional hydrodistillation.
JOURNAL OF SUPERCRITICAL FLUIDS
(2021)
Article
Environmental Sciences
Mohammed Abdullah Issa, Hamid Zentou, Zaid H. Jabbar, Zurina Z. Abidin, Haninah Harun, Noor Amirah Abdul Halim, Mohammed M. Alkhabet, Musa Y. Pudza
Summary: In this study, luminescent bio-adsorbent nitrogen-doped carbon dots (N-CDs) were synthesized and used for the removal and detection of Hg (II) from water. The N-CDs displayed excellent stability and adsorption capacity, and the optimal conditions for Hg (II) removal were determined. The research also analyzed the adsorption kinetics and found that N-CDs had a good selectivity for Hg (II).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Polymer Science
Nur Haninah Harun, Zurina Zainal Abidin, Umar Adam Majid, Mohamad Rezi Abdul Hamid, Abdul Halim Abdullah, Rizafizah Othaman, Mohd Yusof Harun
Summary: This study optimized the removal of Cu(II) ions using a Jatropha oil bio-based membrane blended with graphene oxide. The central composite model and response surface methodology were utilized for the optimization. The results demonstrated a high Cu(II) ions removal rate, and the reduced model showed good predictive ability.
Article
Biochemistry & Molecular Biology
Tan Huang, Sharida Fakurazi, Pike-See Cheah, King-Hwa Ling
Summary: In this study, the role of REST-target genes in Down syndrome was investigated in human brain tissues, cerebral organoids, and neural cells. The findings suggest that REST-targeted DEGs are involved in multiple signaling pathways and cellular processes, including nervous system development, cell differentiation, fatty acid metabolism, and inflammation. REST is proposed as a critical regulator and a promising therapeutic target in modulating gene expression in the DS brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Astronomy & Astrophysics
Z. Z. Abidin, A. N. Zulkiplee, V. Epin, F. A. M. Pauzi
Summary: This paper reports a detailed observation of a Type II solar radio burst on November 3, 2010. Data from multiple sources are analyzed, including the Space Weather Prediction Center, National Oceanic and Atmospheric Administration, e-CALLISTO, and Nancay RadioHeliograph. The brightness temperature and degree of circular polarization of the herringbone burst are determined, and correlations between the physical parameters and the herringbone are examined. Based on these findings, it is suggested that this herringbone was generated through fundamental plasma.
RESEARCH IN ASTRONOMY AND ASTROPHYSICS
(2023)
Proceedings Paper
Materials Science, Multidisciplinary
Nor Faeqah Idrus, Robiah Yunus, Zurina Zainal Abidin
Summary: The miscibility and solubility between refrigerant and lubricant play a crucial role in the operation of a refrigeration system. Polyol esters, such as pentaerythritol (PE) esters, are considered to have good miscibility with refrigerants and are used as biolubricants in hydrofluorocarbons (HFCs) refrigerant systems due to their high viscosity. However, the PE ester in this study was found to be partially miscible with HFC R134a refrigerant and required the addition of a suitable surfactant to improve its miscibility and solubility.
MATERIALS TODAY-PROCEEDINGS
(2022)
Article
Engineering, Environmental
Jamila El Gaayda, Fatima Ezzahra Titchou, Issam Barra, Ilham Karmal, Hanane Afanga, Hicham Zazou, Pow-Seng Yap, Zurina Zainal Abidin, Mohamed Hamdani, Rachid Ait Akbour
Summary: This study evaluated the efficiency of Moringa oleifera seed powder (MOSP) as a natural coagulant for removing turbidity and anionic dye from synthetic wastewater. The results showed that MOSP had a high removal efficiency for both turbidity and dye, and could be considered as an alternative to chemical coagulants due to its environmental friendliness.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Materials Science, Paper & Wood
Nuruldiyanah Kamarudin, Dayang Radiah Awang Biak, Zurina Zainal Abidin, Francisco Cardona, S. M. Sapuan
Summary: The study focused on adjusting parameters to maximize dissolution, screening the parameters of the dissolution process using a one factor at a time technique, and obtaining optimal conditions using response surface methodology. The amount of undissolved tannin powder reached its lowest value of 10% in 30 experimental sets.
