Article
Chemistry, Multidisciplinary
Anders Marcher, Minke A. D. Nijenhuis, Kurt V. Gothelf
Summary: An antibody DNA wireframe cube conjugate has been developed for precise control of the drug-to-antibody ratio (DAR) in ADCs for cancer treatment. This method utilizes DNA functionalization to tightly control DAR, with gel electrophoresis and atomic force microscopy used for investigation, and successful application in targeted drug delivery in vitro.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Yunxiao Zhang, Joshua B. Marlow, Wade Millar, Zachary M. Aman, Debbie S. Silvester, Gregory G. Warr, Rob Atkin, Hua Li
Summary: The novel catanionic surface-active ionic liquid (SAIL) exhibits nanostructure in bulk and at the interface, showing good lubricity. The application of potential can alter the interfacial nanostructure and lubricity.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Maria J. Rodriguez-Espinosa, Javier M. Rodriguez, Jose R. Caston, Pedro J. de Pablo
Summary: In this study, we investigated the cargo retention of individual human picobirnavirus virus-like particles with different N-terminal topologies of the capsid protein. Our results show that these different topologies result in distinct cargo release dynamics during mechanical disassembly experiments due to their different interaction with RNA.
NANOSCALE HORIZONS
(2023)
Article
Chemistry, Multidisciplinary
Haruhiko Eki, Katsuhiko Abe, Hiroshi Sugiyama, Masayuki Endo
Summary: This study used atomic force microscopy to directly observe the formation and degradation of tensegrity triangle DNA crystals at a molecular level, visualizing the dynamic process and characterizing them with nanoscale resolution.
CHEMICAL COMMUNICATIONS
(2021)
Article
Polymer Science
Mubashir Shah, Imran Murtaza, Rehan Abid, Ahmed Shuja, Hong Meng, Naeem Ahmed
Summary: The newly designed electrochromic conjugated polymer P(F8-DT6-TT) shows excellent color tuning ability, characterized through NMR, spectroscopy, and AFM techniques. Its stability improves with increasing cycle numbers and exhibits good overall stability.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Chemistry, Physical
Anbazhagan Murugan, Vadivel Siva, Abdul Samad Shameem, Sultan Asath Bahadur
Summary: Nano-crystalline quaternary Cu2ZnSnS4 (CZTS) thin films were deposited on conducting and nonconducting substrates using the SILAR method with varying dipping times. The films were characterized structurally, vibrationally, optically, morphologically, compositionally, and electrochemically. The films exhibited a mingled phase of wurtzite and kesterite structures, with good optical absorption and a wide range of bandgap values.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Engineering, Marine
Andela Bacinic, Petra Vukosav, Ivana Kero, Marina Mlakar
Summary: In this study, natural phospholipids extracted from cultured green algae Dunaliela tertiolecta were used as the main component of cell membranes to investigate their interaction with trace metal Co(II). The phospholipids were selectively extracted from other biological components using a novel protocol. The interaction between Co(II) and phospholipids was observed only in the presence of the chelating ligand 1,10-Phenathroline (Phen). Voltammetric measurements and atomic force microscopy confirmed the interaction between Co(II), Phen, and phospholipids, resulting in structural changes.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
N. E. Benaioun, N. Moulayat, N. E. Hakiki, H. Ramdane, E. Denys, A. Florentin, K. D. Khodja, M. M. Heireche, J. L. Bubendorff
Summary: This study investigates the natural passivation process of two types of stainless steels (AISI 316 and AISI 304) and a nickel-based alloy (Inconel 600) as a function of immersion time in an alkaline medium. The growth of oxide film on each substrate is influenced by trenches formed during the polishing step and does not depend on the chemical composition. The formed film after 3 days of immersion acts as a protective barrier against alloy dissolution.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Marcel Hanke, Niklas Hansen, Emilia Tomm, Guido Grundmeier, Adrian Keller
Summary: The study investigated the denaturation of DNA origami nanostructures by different Gdm salts, with guanidinium thiocyanate being the most potent denaturant. The results also revealed a non-monotonous temperature dependence of DNA origami denaturation in guanidinium sulfate, emphasizing the complexity of Gdm-DNA interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Toshiaki Nakano, Ken Akamatsu, Masataka Tsuda, Ayane Tujimoto, Ryoichi Hirayama, Takeshi Hiromoto, Taro Tamada, Hiroshi Ide, Naoya Shikazono
Summary: This study established a method to evaluate the yield and complexity of clustered DNA damage in irradiated cells using atomic force microscopy. It was found that clustered DNA damage is a signature of ionizing radiation, and Fe ion beams produce clustered DNA damage with high complexity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nanoscience & Nanotechnology
Keivan Asadi, Junghoon Yeom, Hanna Cho
Summary: Investigating internal resonance (IR) mechanisms in micro/nanoresonators reveals that intermodal coupling between second and third flexural modes in asymmetric structures provides an optimal condition for strong IR, with high energy transfer to the resonated mode. This study introduces design strategies that can be easily integrated into typical micro/nanoelectromechanical systems, offering potential for paradigm-shifting applications in micro/nanosystems.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Biophysics
Celia Ferrag, Shaopei Li, Keuna Jeon, Nesha May Andoy, Ruby May A. Sullan, Svetlana Mikhaylichenko, Kagan Kerman
Summary: Incorporating different shapes of silver nanoparticles (AgNPs) into a hydrogel matrix enhanced the mechanical properties of the hydrogels. While spherical and triangular AgNPs showed strong antimicrobial activity, hydrogels with rod AgNPs exhibited relatively lower antimicrobial activity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Editorial Material
Multidisciplinary Sciences
Telmo O. Paiva, Albertus Viljoen, Yves F. Dufrene
Summary: Advancements in atomic force microscopy (AFM) techniques and methodologies in microbiology have enhanced our understanding of microbial cell surfaces. Recent studies have shown that AFM imaging of cells and membranes at or near molecular resolution enables detailed visualization of membrane-drug interactions.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Patrick Lemoine, Chris Dooley, Alessio Morelli, Emma Harrison, Dorian Dixon
Summary: Gold nanoparticles functionalized with PEG and peptide ligands were examined using atomic force microscopy (AFM) to study their morphology and properties. The results showed that PEG and peptide ligands have similar affinity to the gold surface, but exhibit differences in morphology, cohesion, and hydrophilicity at the nanolevel.
APPLIED SURFACE SCIENCE
(2022)
Article
Multidisciplinary Sciences
Alex Evilevitch, Sophia Hohlbauch
Summary: This study investigated the mechanical response of the nucleus during the initial stage of herpesvirus infection by using atomic force microscopy. It was found that the chromatin becomes stiffer while the nuclear lamina becomes softer after the injection of viral DNA, which may contribute to maintaining nuclear integrity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Hyunsik Hong, Sunhong Min, Sagang Koo, Yunjung Lee, Jinho Yoon, Woo Young Jang, Nayeon Kang, Ramar Thangam, Hyojun Choi, Hee Joon Jung, Seong-Beom Han, Qiang Wei, Seung-Ho Yu, Dong-Hwee Kim, Ramasamy Paulmurugan, Woong Kyo Jeong, Ki-Bum Lee, Taeghwan Hyeon, Dokyoon Kim, Heemin Kang
Summary: This study investigates the modulation of stem cell differentiation in the microenvironment using nanoassembly-based magnetic screens. Different sizes of screens can affect the adhesion, mechanotransduction, and differentiation of stem cells by adjusting nanogaps. This regulation mechanism is shown to be effective in vivo, demonstrating the potential for diverse modalities of unscreening RGDs to modulate stem cell differentiation for tissue repair.
ADVANCED MATERIALS
(2022)
Article
Biophysics
Jinho Yoon, Minkyu Shin, Dongyeon Kim, Joungpyo Lim, Hyun-Woong Kim, Taewook Kang, Jeong-Woo Choi
Summary: The study developed a novel bionanohybrid structure to control the intracellular redox states of living cells using the capacitance of MoS2, enabling the construction of a cell-based biomemory device. This innovation offers a new approach to manipulate cellular redox states in cell-based bioelectronic applications.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Chemistry, Multidisciplinary
Jinho Yoon, Minkyu Shin, Ji-Young Lee, Sang-Nam Lee, Jin-Ha Choi, Jeong-Woo Choi
Summary: RNA interference (RNAi)-based therapeutics have not been used for cancer treatment due to their instability and microRNA (miRNA) delivery challenges. Plasmonic nanoparticle-based RNAi nanotherapeutics have been developed with specific properties for accurate cancer diagnosis and strong therapeutic effects. This review presents recent strategies and advances in plasmonic nanoparticle-based miRNA delivery for cancer detection and treatment, and discusses the challenges and potential opportunities in the field of RNAi-based theragnosis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Analytical
Gahyeon Kim, Jinmyeong Kim, Soo Min Kim, Tatsuya Kato, Jinho Yoon, Seungwoo Noh, Enoch Y. Park, Chulhwan Park, Taek Lee, Jeong-Woo Choi
Summary: A MERS-nanovesicle biosensor with multifunctional DNA aptamer was developed for detecting MERS-NVs in different solutions, offering a new approach for MERS-CoV detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Joungpyo Lim, Jinho Yoon, Minkyu Shin, Ki-Bum Lee, Jeong-Woo Choi
Summary: The study introduces a novel cell differentiation biomolecular electron controller, achieving successful spatiotemporal control of SH-SY5Y cell differentiation, providing a promising strategy for regenerative medicine and cell therapy.
Article
Chemistry, Multidisciplinary
Jinho Yoon, Brian M. Conley, Minkyu Shin, Jin-Ha Choi, Cemile Kilic Bektas, Jeong-Woo Choi, Ki-Bum Lee
Summary: The detection of nucleic acids and their mutation derivatives is crucial in biomedical science and applications. Current nucleic acid biosensors often require pretreatment processes and cannot detect specific sequence mutations. To overcome these limitations, a novel electrochemical nano-biosensing system was developed using metal ion intercalation and a gold nanoporous electrode array. This system enables sensitive detection of viral RNA, determination of viral mutation occurrence, and multiplexed detection of multiple RNA targets simultaneously.
Article
Chemistry, Physical
Jinho Yoon, Hyun-Woong Kim, Minkyu Shin, Joungpyo Lim, Ji-Young Lee, Sang-Nam Lee, Jeong-Woo Choi
Summary: This study successfully developed an in vitro 3D neural network composed of a bionanohybrid, 3D neurospheroid, and microelectrode array (MEA). By controlling the electrophysiological states of living cells, the developed network transmitted input signals and exhibited output signals of the 3D neurospheroid. Additionally, the network achieved spatial input signal recognition for the first time. This newly developed 3D neural network has promising applications in brain-on-a-chip, drug efficacy evaluation for brain diseases, bioelectronics, and bioelectronic medicine.
Article
Biophysics
Jinho Yoon, Joungpyo Lim, Minkyu Shin, Ji-Young Lee, Jeong-Woo Choi
Summary: Bioelectronic devices have great potential for developing core electronic components for biocomputing system. Nanomaterials are crucial for overcoming the limitations of biomolecules and developing novel bioelectronic devices. Various nanomaterials are used to create functional bioelectronic devices, such as biomemory and biologic gates.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Multidisciplinary Sciences
Markus Hackl, Edward V. Contrada, Jonathan E. Ash, Atharv Kulkarni, Jinho Yoon, Hyeon-Yeol Cho, Ki-Bum Lee, John M. Yarbrough, Cesar A. Lopez, Sandrasegaram Gnanakaran, Shishir P. S. Chundawat
Summary: Protein adsorption to solid carbohydrate interfaces is crucial in biological processes such as biomass deconstruction. This study focuses on understanding the interactions between carbohydrate-binding modules (CBMs) and polysaccharides to improve enzymatic efficiency in biomass deconstruction. The research presents a method using single-molecule force spectroscopy to study the unbinding behavior of CBMs from polysaccharide surfaces. The results reveal distinct CBM binding conformations and provide insights into the structural mechanisms through molecular dynamics simulations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Letao Yang, Brian M. Conley, Jinho Yoon, Christopher Rathnam, Thanapat Pongkulapa, Brandon Conklin, Yannan Hou, Ki-Bum Lee
Summary: A systematic investigation of stem cell-derived neural interfaces can help uncover the molecular mechanisms behind cell behavior in neurological disorders and expedite the development of stem cell-based therapies. However, the high-throughput investigation of cell-type-specific biophysical cues associated with these neural interfaces remains a significant challenge. Therefore, we developed a combinatorial nanoarray-based method that enables high-throughput investigation of neural interface micro-/nanostructures and their effects on stem cell fate decisions.
Review
Chemistry, Multidisciplinary
Goeun Park, Hanbin Park, Sang-Chan Park, Moonbong Jang, Jinho Yoon, Jae-Hyuk Ahn, Taek Lee
Summary: Zika virus (ZIKV) and dengue virus (DENV) infections are becoming more common due to global warming. Accurate diagnosis is essential for controlling these viral infections. Recent research has focused on developing biosensors for the accurate diagnosis of ZIKV and DENV using DNA nanotechnology. These biosensors offer advantages over traditional diagnostic methods, such as PCR and ELISA. DNA can serve as a bioreceptor and be easily modified with functional groups, making it a valuable tool for the development of specific bioreceptors that bind to viral proteins or nucleic acids. This review discusses advances in DNA-nanotechnology-based biosensors for the detection of ZIKV and DENV.
Review
Chemistry, Analytical
Hye Kyu Choi, Jinho Yoon
Summary: The accurate and rapid diagnosis of viral diseases using biosensors has gained attention in recent years. Nanotechnology offers a promising strategy to overcome the limitations of conventional viral nucleic acid-based biosensors. By implementing nanotechnologies, such as functional nanomaterials and surface nanoengineering, the performance and range of sensing targets of biosensors can be improved. This review provides interdisciplinary information on nanotechnology-assisted biosensors, giving a valuable basis for the development of novel viral nucleic acid biosensors.
Review
Physics, Applied
Jinho Yoon, Joungpyo Lim, Minkyu Shin, Taek Lee, Jeong-Woo Choi
Summary: Bioelectronics is a field that combines biology and electronics to achieve electronic functions in biochips. However, the properties of biomaterials hinder the development of delicate bioelectronic devices due to their low conductivity and durability. Nanomaterials with unique properties such as conductivity and biocompatibility can overcome these limitations. The integration of nanomaterials with biomaterials has led to the development of bionanohybrids, and new nanomaterials like graphene, transition metal dichalcogenides, and MXenes have been developed. This review summarizes recent studies on bionanohybrid-based bioelectronic devices, which improve durability and electrical functions such as conductivity and functional expansion by introducing nanomaterials. It helps to understand the development of bioelectronic devices by integrating biomaterials with nanomaterials.
APPLIED PHYSICS REVIEWS
(2023)
Review
Nanoscience & Nanotechnology
Minkyu Shin, Joungpyo Lim, Joohyun An, Jinho Yoon, Jeong-Woo Choi
Summary: In the field of bioelectronics, organic/inorganic material-based bioelectronics have limitations in terms of stiffness and biocompatibility. To overcome these limitations, researchers have explored the use of hydrogels for bioelectronics, which can bridge the interface between biological materials and electronics. However, hydrogels alone have limitations such as low electrical conductivity and structural stability. To address these issues, studies on biohybrid hydrogels incorporating nanomaterials have been conducted for bioelectronic applications. This review provides recent studies on biohybrid hydrogels and their applications in areas such as flexible/wearable bioelectronic devices, tissue engineering, and biorobotics.
Review
Chemistry, Analytical
Hye Kyu Choi, Jinho Yoon
Summary: The detection of small molecules has attracted a lot of attention in various fields. Enzymatic biosensors, using specific enzymatic reactions, have shown excellent sensing performances. Electrochemical and fluorescence techniques are commonly used for the detection of small molecules due to their advantages. By incorporating nanotechnologies, the detection properties of enzymatic nanobiosensors can be improved. This review provides interdisciplinary information on developing enzymatic nanobiosensors for small molecule detection, aiming to provide a broad perspective and roadmap for developing novel electrochemical and fluorescent enzymatic nanobiosensors.
