Viral RNA Silencing Suppression: The Enigma of Bunyavirus NSs Proteins

Symbiont-mediated RNA interference in insects

(2016) Miranda M. A. Whitten et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cytorhabdovirus P protein suppresses RISC-mediated cleavage and RNA silencing amplification in planta

(2016) Krin S. Mann et al.   VIROLOGY

Comparison of small RNA profiles in Nicotiana benthamiana and Solanum lycopersicum infected by polygonum ringspot tospovirus reveals host-specific responses to viral infection

(2016) Paolo Margaria et al.   VIRUS RESEARCH

Phleboviruses and the Type I Interferon Response

(2016) Jennifer Wuerth et al.   Viruses-Basel

The evolving world of small RNAs from RNA viruses

(2016) Mei-Ling Li et al.   Wiley Interdisciplinary Reviews-RNA

The silencing suppressor (NSs) protein of the plant virus Tomato spotted wilt virus enhances heterologous protein expression and baculovirus pathogenicity in cells and lepidopteran insects

(2015) Virgínia Carla de Oliveira et al.   ARCHIVES OF VIROLOGY

The Non-structural Protein of Crimean-Congo Hemorrhagic Fever Virus Disrupts the Mitochondrial Membrane Potential and Induces Apoptosis

(2015) Bhaskar Barnwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of type I and type III IFN signalling by NSs protein of severe fever with thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation

(2015) Vidyanath Chaudhary et al.   JOURNAL OF GENERAL VIROLOGY

RNA interference tools for the western flower thrips, Frankliniella occidentalis

(2015) Ismael E. Badillo-Vargas et al.   JOURNAL OF INSECT PHYSIOLOGY

Generation of Mutant Uukuniemi Viruses Lacking the Nonstructural Protein NSs by Reverse Genetics Indicates that NSs Is a Weak Interferon Antagonist

(2015) Veronica V. Rezelj et al.   JOURNAL OF VIROLOGY

Disruption of Type I Interferon Signaling by the Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Virus via the Hijacking of STAT2 and STAT1 into Inclusion Bodies

(2015) Yun-Jia Ning et al.   JOURNAL OF VIROLOGY

Small Interfering RNA Pathway Modulates Initial Viral Infection in Midgut Epithelium of Insect after Ingestion of Virus

(2015) Hanhong Lan et al.   JOURNAL OF VIROLOGY

Evolutionary and phenotypic analysis of live virus isolates suggests arthropod origin of a pathogenic RNA virus family

(2015) Marco Marklewitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferons and viruses: an evolutionary arms race of molecular interactions

(2015) Hans-Heinrich Hoffmann et al.   TRENDS IN IMMUNOLOGY

Cytorhabdovirus phosphoprotein shows RNA silencing suppressor activity in plants, but not in insect cells

(2015) Krin S. Mann et al.   VIROLOGY

viral silencing suppressors: Tools forged to fine-tune host-pathogen coexistence

(2015) Tibor Csorba et al.   VIROLOGY

Small RNA profiles of wild-type and silencing suppressor-deficient tomato spotted wilt virus infected Nicotiana benthamiana

(2015) Paolo Margaria et al.   VIRUS RESEARCH

Functional non-coding RNAs derived from the flavivirus 3′ untranslated region

(2015) B.D. Clarke et al.   VIRUS RESEARCH

Tissue Barriers to Arbovirus Infection in Mosquitoes

(2015) Alexander Franz et al.   Viruses-Basel

Insect-Specific Virus Discovery: Significance for the Arbovirus Community

(2015) Bethany Bolling et al.   Viruses-Basel

Suppression of RNAi by dsRNA-Degrading RNaseIII Enzymes of Viruses in Animals and Plants

(2015) Isabel Weinheimer et al.   PLoS Pathogens

Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative-sense RNA viruses

(2015) Ci-Xiu Li et al.   eLife

RNA interference-mediated antiviral defense in insects

(2015) Don B Gammon et al.   Current Opinion in Insect Science

Analysis of Tospovirus NSs Proteins in Suppression of Systemic Silencing

(2015) Marcio Hedil et al.   PLoS One

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

The Diversity, Biogenesis, and Activities of Endogenous Silencing Small RNAs inArabidopsis

(2014) Nicolas G. Bologna et al.   Annual Review of Plant Biology

Traffic into silence: endomembranes and post-transcriptional RNA silencing

(2014) Y. J. Kim et al.   EMBO JOURNAL

Hijacking of RIG-I Signaling Proteins into Virus-Induced Cytoplasmic Structures Correlates with the Inhibition of Type I Interferon Responses

(2014) F. W. Santiago et al.   JOURNAL OF VIROLOGY

The NSs Protein of Tomato spotted wilt virus Is Required for Persistent Infection and Transmission by Frankliniella occidentalis

(2014) P. Margaria et al.   JOURNAL OF VIROLOGY

Orthobunyaviruses: recent genetic and structural insights

(2014) Richard M. Elliott   NATURE REVIEWS MICROBIOLOGY

Analysis of the A-U Rich Hairpin from the Intergenic Region of Tospovirus S RNA as Target and Inducer of RNA Silencing

(2014) Marcio Hedil et al.   PLoS One

Antiviral immunity ofAnopheles gambiaeis highly compartmentalized, with distinct roles for RNA interference and gut microbiota

(2014) Guillaume Carissimo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bunyavirus-Vector Interactions

(2014) Kate Horne et al.   Viruses-Basel

Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform

(2014) Yun-Jia Ning et al.   Journal of Molecular Cell Biology

The long and short of antiviral defense: small RNA-based immunity in insects

(2014) Alfred W Bronkhorst et al.   Current Opinion in Virology

Emerging phleboviruses

(2014) Richard M Elliott et al.   Current Opinion in Virology

Suppression of RNA Silencing by a Plant DNA Virus Satellite Requires a Host Calmodulin-Like Protein to Repress RDR6 Expression

(2014) Fangfang Li et al.   PLoS Pathogens

Dominant resistance against plant viruses

(2014) Dryas de Ronde et al.   Frontiers in Plant Science

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

(2013) Dennis A. Bente et al.   ANTIVIRAL RESEARCH

Is RNA Interference a Physiologically Relevant Innate Antiviral Immune Response in Mammals?

(2013) Bryan R. Cullen et al.   Cell Host & Microbe

RNAi and antiviral defense in Drosophila: Setting up a systemic immune response

(2013) Margot Karlikow et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Identification of the domains of cauliflower mosaic virus protein P6 responsible for suppression of RNA silencing and salicylic acid signalling

(2013) J. Laird et al.   JOURNAL OF GENERAL VIROLOGY

Characterization of a novel Negevirus and a novel Bunyavirus isolated from Culex (Culex) declarator mosquitoes in Trinidad

(2013) A. J. Auguste et al.   JOURNAL OF GENERAL VIROLOGY

Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses

(2013) Marco Marklewitz et al.   JOURNAL OF VIROLOGY

Analysis ofTomato spotted wilt virus NSs protein indicates the importance of the N-terminal domain for avirulence and RNA silencing suppression

(2013) Dryas de Ronde et al.   MOLECULAR PLANT PATHOLOGY

Tswgene-based resistance is triggered by a functional RNA silencing suppressor protein of theTomato spotted wilt virus

(2013) Dryas de Ronde et al.   MOLECULAR PLANT PATHOLOGY

Unrelated viral suppressors of RNA silencing mediate the control of ARGONAUTE1 level

(2013) Éva Várallyay et al.   MOLECULAR PLANT PATHOLOGY

Rice yellow stunt rhabdovirusProtein 6 Suppresses Systemic RNA Silencing by Blocking RDR6-Mediated Secondary siRNA Synthesis

(2013) Hongyan Guo et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

RNA silencing suppression by plant pathogens: defence, counter-defence and counter-counter-defence

(2013) Nathan Pumplin et al.   NATURE REVIEWS MICROBIOLOGY

Independent parallel functions of p19 plant viral suppressor of RNA silencing required for effective suppressor activity

(2013) Éva Várallyay et al.   NUCLEIC ACIDS RESEARCH

Dicer-2 Processes Diverse Viral RNA Species

(2013) Leah R. Sabin et al.   PLoS One

Differential Expression of Tomato Spotted Wilt Virus-Derived Viral Small RNAs in Infected Commercial and Experimental Host Plants

(2013) Neena Mitter et al.   PLoS One

RNA Interference Functions as an Antiviral Immunity Mechanism in Mammals

(2013) Y. Li et al.   SCIENCE

Antiviral RNA Interference in Mammalian Cells

(2013) P. V. Maillard et al.   SCIENCE

The P0 protein encoded by cotton leafroll dwarf virus (CLRDV) inhibits local but not systemic RNA silencing

(2013) Verónica C. Delfosse et al.   VIRUS RESEARCH

Non-Structural Proteins of Arthropod-Borne Bunyaviruses: Roles and Functions

(2013) Saleh Eifan et al.   Viruses-Basel

RNA Interference Targets Arbovirus Replication in Culicoides Cells

(2012) E. Schnettler et al.   JOURNAL OF VIROLOGY

Dicer-2- and Piwi-Mediated RNA Interference in Rift Valley Fever Virus-Infected Mosquito Cells

(2012) P. Léger et al.   JOURNAL OF VIROLOGY

Multiple Domains of the Tobacco mosaic virus p126 Protein Can Independently Suppress Local and Systemic RNA Silencing

(2012) Li-Ya Wang et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Genetic Determinants of Potato virus Y Required to Overcome or Trigger Hypersensitive Resistance to PVY Strain Group O Controlled by the Gene Ny in Potato

(2012) Yan-Ping Tian et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The HC-Pro and P3 Cistrons of an Avirulent Soybean mosaic virus Are Recognized by Different Resistance Genes at the Complex Rsv1 Locus

(2012) R.-H. Wen et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Suppression of Arabidopsis ARGONAUTE1-Mediated Slicing, Transgene-Induced RNA Silencing, and DNA Methylation by Distinct Domains of the Cucumber mosaic virus 2b Protein

(2012) C.-G. Duan et al.   PLANT CELL

Degradation of the antiviral component ARGONAUTE1 by the autophagy pathway

(2012) B. Derrien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Enamovirus P0 protein is a silencing suppressor which inhibits local and systemic RNA silencing through AGO1 degradation

(2012) Adriana F. Fusaro et al.   VIROLOGY

Silencing and Innate Immunity in Plant Defense Against Viral and Non-Viral Pathogens

(2012) Anna Zvereva et al.   Viruses-Basel

Role of Bunyamwera Orthobunyavirus NSs Protein in Infection of Mosquito Cells

(2012) Agnieszka M. Szemiel et al.   PLoS Neglected Tropical Diseases

RNAi in Arthropods: Insight into the Machinery and Applications for Understanding the Pathogen-Vector Interface

(2012) Annette-Christi Barnard et al.   Genes

Mosquito RNAi is the major innate immune pathway controlling arbovirus infection and transmission

(2011) Carol D Blair   Future Microbiology

The helper component-proteinase of the Zucchini yellow mosaic virus inhibits the Hua Enhancer 1 methyltransferase activity in vitro

(2011) R. M. Jamous et al.   JOURNAL OF GENERAL VIROLOGY

Recent advances in the molecular and cellular biology of bunyaviruses

(2011) C. T. Walter et al.   JOURNAL OF GENERAL VIROLOGY

Viral RNAi Suppressor Reversibly Binds siRNA to Outcompete Dicer and RISC via Multiple Turnover

(2011) Renata A. Rawlings et al.   JOURNAL OF MOLECULAR BIOLOGY

Gouleako Virus Isolated from West African Mosquitoes Constitutes a Proposed Novel Genus in the Family Bunyaviridae

(2011) M. Marklewitz et al.   JOURNAL OF VIROLOGY

NSs Protein of Rift Valley Fever Virus Promotes Posttranslational Downregulation of the TFIIH Subunit p62

(2011) B. Kalveram et al.   JOURNAL OF VIROLOGY

Ectopic expression of the p23 silencing suppressor of Citrus tristeza virus differentially modifies viral accumulation and tropism in two transgenic woody hosts

(2011) CARMEN FAGOAGA et al.   MOLECULAR PLANT PATHOLOGY

Massive production of small RNAs from a non-coding region of Cauliflower mosaic virus in plant defense and viral counter-defense

(2011) Todd Blevins et al.   NUCLEIC ACIDS RESEARCH

Cucumber mosaic virus suppressor 2b binds to AGO4-related small RNAs and impairs AGO4 activities

(2011) Sadia Hamera et al.   PLANT JOURNAL

Negative-strand RNA viruses: The plant-infecting counterparts

(2011) Richard Kormelink et al.   VIRUS RESEARCH

Interference in plant defense and development by non-structural protein NSs of Groundnut bud necrosis virus

(2011) Suneha Goswami et al.   VIRUS RESEARCH

The Role of Interferon Antagonist, Non-Structural Proteins in the Pathogenesis and Emergence of Arboviruses

(2011) Bradley S. Hollidge et al.   Viruses-Basel

The RNA interference pathway affects midgut infection- and escape barriers for Sindbis virus in Aedes aegypti

(2010) Cynthia CH Khoo et al.   BMC MICROBIOLOGY

Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation

(2010) Éva Várallyay et al.   EMBO JOURNAL

Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein

(2010) J. Azevedo et al.   GENES & DEVELOPMENT

Size-Independent and Noncooperative Recognition of dsRNA by the Rice Stripe Virus RNA Silencing Suppressor NS3

(2010) Mei Shen et al.   JOURNAL OF MOLECULAR BIOLOGY

Antiviral RNA Interference Responses Induced by Semliki Forest Virus Infection of Mosquito Cells: Characterization, Origin, and Frequency-Dependent Functions of Virus-Derived Small Interfering RNAs

(2010) R. W. C. Siu et al.   JOURNAL OF VIROLOGY

Diverging Affinity of Tospovirus RNA Silencing Suppressor Proteins, NSs, for Various RNA Duplex Molecules

(2010) E. Schnettler et al.   JOURNAL OF VIROLOGY

Cucumber Mosaic Virus 2b Protein Subcellular Targets and Interactions: Their Significance to RNA Silencing Suppressor Activity

(2010) Inmaculada González et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Comparative Analysis of the Capacity of Tombusvirus P22 and P19 Proteins to Function as Avirulence Determinants in Nicotiana species

(2010) Carlos A. Angel et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Small RNA sorting: matchmaking for Argonautes

(2010) Benjamin Czech et al.   NATURE REVIEWS GENETICS

Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila

(2010) Arabinda Nayak et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polerovirus protein P0 prevents the assembly of small RNA-containing RISC complexes and leads to degradation of ARGONAUTE1

(2010) Tibor Csorba et al.   PLANT JOURNAL

Expression, purification and functional characterization of recombinant Zucchini yellow mosaic virus HC-Pro

(2010) Marc W. Fuellgrabe et al.   PROTEIN EXPRESSION AND PURIFICATION

A silencing suppressor protein (NSs) of a tospovirus enhances baculovirus replication in permissive and semipermissive insect cell lines

(2010) Virgínia Carla Oliveira et al.   VIRUS RESEARCH

Viral RNA silencing suppressors (RSS): Novel strategy of viruses to ablate the host RNA interference (RNAi) defense system

(2010) Shalmali Bivalkar-Mehla et al.   VIRUS RESEARCH

C6/36 Aedes albopictus Cells Have a Dysfunctional Antiviral RNA Interference Response

(2010) Doug E. Brackney et al.   PLoS Neglected Tropical Diseases

Two Plant Viral Suppressors of Silencing Require the Ethylene-Inducible Host Transcription Factor RAV2 to Block RNA Silencing

(2010) Matthew W. Endres et al.   PLoS Pathogens

Viral Protein Inhibits RISC Activity by Argonaute Binding through Conserved WG/GW Motifs

(2010) Ana Giner et al.   PLoS Pathogens

Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes

(2009) Chris M Cirimotich et al.   BMC MICROBIOLOGY

dsRNA with 5′ overhangs contributes to endogenous and antiviral RNA silencing pathways in plants

(2009) Ryuya Fukunaga et al.   EMBO JOURNAL

Suppression of RNA silencing by Flock house virus B2 protein is mediated through its interaction with the PAZ domain of Dicer

(2009) Gatikrushna Singh et al.   FASEB JOURNAL

NSs Protein of Rift Valley Fever Virus Induces the Specific Degradation of the Double-Stranded RNA-Dependent Protein Kinase

(2009) M. Habjan et al.   JOURNAL OF VIROLOGY

Elimination of antiviral defense by viral RNase III

(2009) W. J. Cuellar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization and subcellular localization of an RNA silencing suppressor encoded by Rice stripe tenuivirus

(2009) Ruyi Xiong et al.   VIROLOGY

RNAi Targeting of West Nile Virus in Mosquito Midguts Promotes Virus Diversification

(2009) Doug E. Brackney et al.   PLoS Pathogens

Insect Vector Interactions with Persistently Transmitted Viruses

(2008) Saskia A. Hogenhout et al.   Annual Review of Phytopathology

Nuclear import of CaMV P6 is required for infection and suppression of the RNA silencing factor DRB4

(2008) Gabrielle Haas et al.   EMBO JOURNAL

Structural basis for RNA-silencing suppression by Tomato aspermy virus protein 2b

(2008) Hong-Ying Chen et al.   EMBO REPORTS

Inhibition of 3' modification of small RNAs in virus-infected plants require spatial and temporal co-expression of small RNAs and viral silencing-suppressor proteins

(2008) R. Lozsa et al.   NUCLEIC ACIDS RESEARCH

The P0 gene of Sugarcane yellow leaf virus encodes an RNA silencing suppressor with unique activities

(2008) Tichaona Mangwende et al.   VIROLOGY

The NS3 protein of rice hoja blanca virus suppresses RNA silencing in mammalian cells

(2007) E. Schnettler et al.   JOURNAL OF GENERAL VIROLOGY