Article
Multidisciplinary Sciences
Sebastien Bridel, Valerie Bouchez, Bryan Brancotte, Sofia Hauck, Nathalie Armatys, Annie Landier, Estelle Muhle, Sophie Guillot, Julie Toubiana, Martin C. J. Maiden, Keith A. Jolley, Sylvain Brisse
Summary: This study presents a large database of Bordetella isolates and genomes, along with the development of genotyping systems for the whole genus and for the B. pertussis Glade. It provides a valuable resource for evolutionary and epidemiological research on whooping cough and other Bordetella infections.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Laurence Don Wai Luu, Ling Zhong, Sandeep Kaur, Mark J. Raftery, Ruiting Lan
Summary: The Bordetella genus is divided into classical and non-classical groups. Phosphorylation plays a key role in regulating metabolism and virulence pathways in Bordetella. The phosphorylation of key virulence regulator BvgA may be important in fine-tuning virulence gene expression and distinguishing classical from non-classical Bordetella species.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Nicole Wolter, Cheryl Cohen, Stefano Tempia, Sibongile Walaza, Fahima Moosa, Mignon du Plessis, Meredith L. McMorrow, Florette K. Treurnicht, Orienka Hellferscee, Halima Dawood, Ebrahim Variava, Anne von Gottberg
Summary: Pertussis remains a significant cause of illness and hospitalization in South Africa, despite routine vaccination for six decades. Infants are the highest at-risk group for pertussis, while HIV-infected adults were also identified as an important group at risk of infection.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Nicholas J. First, Jose Pedreira-Lopez, Manuel R. F. San-Silvestre, Katelyn M. Parrish, Xiao-Hong Lu, Monica C. Gestal
Summary: In this study, it was found that inhibition of VIP/VPAC2 signaling can promote clearance of Bordetella species and reduce bacterial burden. Treatment with VPAC2 antagonists can decrease lung pathology and suggest that T3SS may serve as a therapeutic target for other gram-negative bacteria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Monica C. Gestal, Laura K. Howard, Kalyan K. Dewan, Eric T. Harvill
Summary: Infectious diseases are a significant health issue in the United States, and finding more effective vaccine strategies is crucial. Bordetella bacteria suppress host immunity to establish persistent colonization, but disrupting these mechanisms could result in stronger immune responses. Current Bordetella vaccines provide only short-term protection, while a universal vaccine could reduce the burden of infection. Research reveals that disrupting bacterial immunomodulatory pathways can generate stronger and more protective immune responses.
Article
Cell Biology
Noemie Lefrancq, Valerie Bouchez, Nadia Fernandes, Alex-Mikael Barkoff, Thijs Bosch, Tine Dalby, Thomas Akerlund, Jessica Darenberg, Katerina Fabianova, Didrik F. Vestrheim, Norman K. Fry, Juan Jose Gonzalez-Lopez, Karolina Gullsby, Adele Habington, Qiushui He, David Litt, Helena Martini, Denis Pierard, Paola Stefanelli, Marc Stegger, Jana Zavadilova, Nathalie Armatys, Annie Landier, Sophie Guillot, Samuel L. Hong, Philippe Lemey, Julian Parkhill, Julie Toubiana, Simon Cauchemez, Henrik Salje, Sylvain Brisse
Summary: This study used 3344 sequences from 23 countries to demonstrate the presence of numerous transmission chains of Bordetella pertussis within a subnational region, and the number of chains was strongly associated with host population size. Vaccine policy has an impact on the genotype dynamics of B. pertussis, which is responsible for 160,000 deaths annually.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Cheryl Keech, Vicki E. Miller, Barbara Rizzardi, Christopher Hoyle, Melinda J. Pryor, Jonathan Ferrand, Ken Solovay, Marcel Thalen, Stephanie Noviello, Peter Goldstein, Andrew Gorringe, Breeze Cavell, Qiushui He, Alex-Mikael Barkoff, Keith Rubin, Camille Locht
Summary: BPZE1, a live attenuated intranasal pertussis vaccine, induces nasal mucosal immunity and functional serum responses. This study demonstrates the potential of BPZE1 to prevent pertussis infection, leading to reduced transmission and diminished epidemic cycles.
Article
Primary Health Care
Jonathan M. Kline, Eleanor A. Smith, Adrienne Zavala
Summary: Pertussis, or whooping cough, remains a public health concern despite expanded immunization recommendations. Polymerase chain reaction testing is recommended for diagnosis. Changes in Tdap immunization recommendations have occurred, and all pregnant patients and patients 11 years or older should receive at least one dose.
AMERICAN FAMILY PHYSICIAN
(2021)
Article
Microbiology
Saidy Vasconez Noguera, Katherine Jaramillo, Andres Zabala, Jose E. Villacis
Summary: This study used PCR to determine the prevalence of Bordetella pertussis and Bordetella parapertussis infections among infants under one year of age in the Ecuadorian highlands. The results showed that 41% of the samples were positive for B. pertussis, with a majority of the cases occurring in infants aged 0-3 months. Additionally, the study highlighted the importance of active national surveillance of pertussis, particularly for laboratory testing.
REVISTA ARGENTINA DE MICROBIOLOGIA
(2021)
Letter
Immunology
Jacky Flipse, Angelino T. Tromp, Janneke Bosman, Christine ten Hove, Hans Beks, Titia Kortbeek, Guido J. H. Bastiaens, Ellen M. Mascini
Summary: An increase in positive Bordetella parapertussis tests among patients in a teaching hospital in the Netherlands led to enhanced infection control and microbiological surveillance. Further analysis revealed that batches of contaminated nasopharyngeal swabs were associated with a pseudo-outbreak, resulting in incorrect diagnoses, antimicrobial treatments, isolation precautions, and public health notifications.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Parul Kapil, Yihui Wang, Lindsey Zimmerman, Mara Gaykema, Tod J. Merkel
Summary: The resurgence of pertussis in the United States is likely due to the failure of acellular pertussis (aP) vaccines to provide long-lasting immunity and prevent infection, carriage, and transmission. By studying baboons, it was found that multiple infections were necessary to induce immune responses and protection in aP-vaccinated animals comparable to those seen in unvaccinated animals after a single challenge. Immunoglobulin G responses to vaccine and nonvaccine antigens were not negatively affected in aP-vaccinated animals. The results suggest the possibility of reprogramming aP-primed immune responses through optimal boosters and multiple doses.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Karen M. Scanlon, Ling Chen, Nicholas H. Carbonetti
Summary: The study revealed that Bordetella pertussis-induced pulmonary hypertension is age-related and depends on the expression of pertussis toxin by the bacterium. Targeting pertussis toxin in treatment may help alleviate pulmonary hypertension and fatal infant infections.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Shuang Wu, Qinghua Hu, Chao Yang, Haijian Zhou, Hongyu Chen, Yanwei Zhang, Min Jiang, Yuxiang He, Xiaolu Shi
Summary: Although pertussis cases have been controlled globally through the Expanded Programme on Immunization, the incidence of pertussis has significantly increased in recent years, especially in developed countries. In Shenzhen, 50 strains of Bordetella pertussis were collected for genotypic and molecular epidemiological analysis, with some strains showing variation possibly associated with the increased incidence. The positive rate of cases under one-year-old was significantly higher, indicating the need for specific monitoring and control measures.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Editorial Material
Microbiology
Nicholas Carbonetti
Summary: This study used a mouse model and cellular studies to investigate the bacterial and host factors that contribute to cough production during Bordetella pertussis infection. The researchers found that bacterial factors pertussis toxin, lipooligosaccharide, and Vag8 function cooperatively to produce cough, and identified the host bradykinin and signaling pathways involved. This finding is highly significant as it enhances our understanding of the pathophysiology of severe cough and may lead to potential new therapeutic approaches for pertussis-induced cough.
Article
Microbiology
Yukihiro Hiramatsu, Koichiro Suzuki, Takashi Nishida, Naoki Onoda, Takashi Satoh, Shizuo Akira, Masahito Ikawa, Hiroko Ikeda, Junzo Kamei, Sandra Derouiche, Makoto Tominaga, Yasuhiko Horiguchi
Summary: The Gram-negative bacterium Bordetella pertussis causes whooping cough, a respiratory disease characterized by paroxysmal coughing. However, the mechanism of coughing has not been extensively studied. In this study, a mouse model was used to reproduce coughing after intranasal inoculation with the bacterium. It was found that lipooligosaccharide, Vag8, and pertussis toxin of the bacteria cooperatively function to cause coughing. Bradykinin and TRPV1 were identified as host factors involved in the coughing mechanism.