Article
Gastroenterology & Hepatology
Shi-Chuan Tang, Kai-Ling Zhang, Kong-Ying Lin, Yi-Dan Tang, Jun Fu, Wei-Ping Zhou, Jian-Xi Zhang, Jie Kong, Xiao-Lu He, Zheng-Hong Sun, Cong Luo, Hong-Zhi Liu, Yong-Ping Lai, Yong-Yi Zeng
Summary: This study demonstrated that anatomical resection decreases the risk of tumor recurrence and improves overall survival (OS) and recurrence-free survival (RFS) in patients with early-stage hepatocellular carcinoma (HCC). Anatomical resection should be adopted as long as such a surgical maneuver is feasible for initial treatment of early-stage HCC.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Qingli Li, Tianqiang Song
Summary: Although adjuvant sorafenib therapy for patients with HCC and high recurrence risk does not reduce the recurrence risk of HCC, it might be associated with longer survival and a lower risk of death.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
J-H Zhong, B-C Xing, W-G Zhang, A. W-H Chan, C. C. N. Chong, M. Serenari, N. Peng, T. Huang, S-D Lu, Z-Y Liang, R-R Huo, Y-Y Wang, M. Cescon, T-Q Liu, L. Li, F-X Wu, L. Ma, M. Ravaioli, J. Neri, A. Cucchetti, P. J. Johnson, L-Q Li, B-D Xiang
Summary: This study investigated the safety and efficacy of repeat hepatic resection (rHR) and radiofrequency ablation (RFA) for recurrent hepatocellular carcinoma (HCC). The results showed that rHR was associated with longer recurrence-free survival compared with RFA, while RFA had lower morbidity and shorter hospital stay.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Liming Zheng, Xi Gu, Guojun Zheng, Xin Li, Meifang He, Longgen Liu, Xike Zhou
Summary: The study constructed a predictive model using various analysis methods to successfully identify high-risk patients for early HCC recurrence, and predict patients' response to adjuvant sorafenib treatment. The model can optimize risk stratification for early HCC recurrence and evaluate patient response to adjuvant sorafenib after liver resection.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seong Eun Ko, Min Woo Lee, Soohyun Ahn, Hyunchul Rhim, Tae Wook Kang, Kyoung Doo Song, Jong Man Kim, Gyu-Seong Choi, Dong Ik Cha, Ji Hye Min, Dong Hyun Sinn, Moon Seok Choi, Hyo Keun Lim
Summary: This study compared the therapeutic outcomes of laparoscopic hepatic resection (LHR) and laparoscopic radiofrequency ablation (LRFA) for single subcapsular hepatocellular carcinoma (HCC) measuring 1-3 cm. The results showed no significant difference in therapeutic outcomes between the two methods.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Nanping Lin, Lei Wang, Qizhen Huang, Weiping Zhou, Xiaolong Liu, Jingfeng Liu
Summary: This study developed a nomogram model to predict the overall survival of hepatocellular carcinoma patients who underwent R0 resection. The model showed good calibration and discriminatory power, and it was found that p-TACE could significantly prolong the median overall survival in high-risk patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sae-Jin Park, Jeong Hee Yoon, Dong Ho Lee, Woo Hyeon Lim, Jeong Min Lee
Summary: The study indicates that tumor stiffness measured by MRE is associated with survival in patients with single nodular hepatocellular carcinoma after hepatic resection. Tumor stiffness, tumor size, and pathological features are significant factors related to overall survival and recurrence-free survival for patients.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Dongsub Jeon, Won-Mook Choi, Jin-Sun Kim, Yusun Jung, Su-Yeon Lee, Haeng Ran Seo, Kang Mo Kim
Summary: This study found that serum sorbitol dehydrogenase (SORD) levels were associated with the length of recurrence-free survival after surgical resection for HCC, with higher SORD levels (>= 15 ng/mL) being linked to a shorter recurrence-free survival. When combined with AFP levels, SORD levels could better predict the prognosis in HCC patients.
Article
Oncology
Kuan-Chun Hsueh, Cheng-Chun Lee, Pi-Teh Huang, Chih-Yu Liang, Shun-Fa Yang
Summary: Multiple studies have found that liver resection (LR) can improve survival outcomes in intermediate- and advanced-stage hepatocellular carcinoma (HCC) patients. However, there is limited knowledge regarding the benefits of LR for recurrent HCC patients who have undergone systemic treatment. This study aimed to evaluate the impact of LR on advanced-stage HCC patients who received sorafenib as a systemic treatment.
Article
Surgery
Haili Zhang, Fei Liu, Ningyuan Wen, Bo Li, Yonggang Wei
Summary: This study found that intrahepatic recurrence was still the most common pattern after LLR for HCC, with most recurrences occurring within 2 years. There were no significant differences in recurrence patterns, timing, or treatment between LLR and OLR, with independent risk factors for recurrence including ALBI grade, postoperative alpha-fetoprotein levels, tumor size, surgical margins, and multiple tumors.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Bin Yu, Han Liang, Qifa Ye, Yanfeng Wang
Summary: This study identified nine dysregulated and prognostic genes related to early recurrence (ER) in hepatocellular carcinoma (HCC) patients after R0 resection, and successfully constructed a prognostic index model based on these genes. The genomic-clinicopathologic nomogram integrating this model showed significantly higher predictive accuracy and clinical application value in predicting ER compared to TNM stage model.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Tao Wei, Xu-Feng Zhang, Fabio Bagante, Francesca Ratti, Hugo P. Marques, Silvia Silva, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Razvan Grigorie, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Yi Lv, Luca Aldrighetti, Timothy M. Pawlik
Summary: The study found that setting the time point for recurrence at 8 months is beneficial for distinguishing early from late recurrence, with early recurrence patients typically having shorter survival time and post-recurrence survival, as well as less likely to receive curative treatment. Curative-intent retreatment for late recurrence patients is associated with similar overall survival compared to patients without recurrence.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Oncology
Shuqi Mao, Xi Yu, Jihan Sun, Yong Yang, Yuying Shan, Jiannan Sun, Joseph Mugaanyi, Rui Fan, Shengdong Wu, Caide Lu
Summary: This study compared the predictive potential of inflammatory markers for overall survival, recurrence-free survival, and 1- and 2-year RFS in hepatocellular carcinoma patients. Nomogram prediction models were established and showed high predictive accuracy. The nomograms can serve as useful clinical tools to guide treatment approaches and prognosis judgement.
Article
Oncology
Yizhen Fu, Xia Li, Zhenyun Yang, Shaoqiang Li, Yangxun Pan, Jinbin Chen, Juncheng Wang, Dandan Hu, Zhongguo Zhou, Li Xu, Minshan Chen, Yaojun Zhang
Summary: This study aimed to establish a risk-based post-resection follow-up strategy for hepatocellular carcinoma (HCC) patients. The results showed that this strategy could detect tumor relapse earlier and reduce the number of follow-ups without compromising on survival.