Article
Oncology
Qu Xie, Zeyin Zhao, Yanzhen Yang, Dan Long, Cong Luo
Summary: This study aimed to construct models using radiomics derived from enhanced computed tomography (CT) imaging to predict the risk of postoperative recurrence in early-stage hepatocellular carcinoma patients. Clinical, radiomic, and combined models were built using four algorithms and evaluated through cross-validation. The results showed that the combined models outperformed those relying solely on clinical or radiomic features. This research provides clinicians with a valuable tool to predict postoperative recurrence and inform early preventive strategies.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yizhen Fu, Xia Li, Zhenyun Yang, Shaoqiang Li, Yangxun Pan, Jinbin Chen, Juncheng Wang, Dandan Hu, Zhongguo Zhou, Li Xu, Minshan Chen, Yaojun Zhang
Summary: This study aimed to establish a risk-based post-resection follow-up strategy for hepatocellular carcinoma (HCC) patients. The results showed that this strategy could detect tumor relapse earlier and reduce the number of follow-ups without compromising on survival.
Article
Surgery
Yueh-Wei Liu, Chee-Chien Yong, Chih-Che Lin, Chih-Chi Wang, Chao-Long Chen, Yu-Fan Cheng, Jing-Houng Wang, Yi-Hao Yen
Summary: In a retrospective study on patients who underwent liver resection for hepatocellular carcinoma, it was found that 6 months was identified as the optimal cutoff time point to differentiate early versus late recurrence. Early recurrence within 6 months was associated with worse post-recurrence survival and overall survival compared to late recurrence beyond 6 months.
UPDATES IN SURGERY
(2021)
Article
Gastroenterology & Hepatology
Shi-Chuan Tang, Kai-Ling Zhang, Kong-Ying Lin, Yi-Dan Tang, Jun Fu, Wei-Ping Zhou, Jian-Xi Zhang, Jie Kong, Xiao-Lu He, Zheng-Hong Sun, Cong Luo, Hong-Zhi Liu, Yong-Ping Lai, Yong-Yi Zeng
Summary: This study demonstrated that anatomical resection decreases the risk of tumor recurrence and improves overall survival (OS) and recurrence-free survival (RFS) in patients with early-stage hepatocellular carcinoma (HCC). Anatomical resection should be adopted as long as such a surgical maneuver is feasible for initial treatment of early-stage HCC.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Oncology
Pinxiong Li, Lei Wu, Zhenhui Li, Jiao Li, Weitao Ye, Zhenwei Shi, Zeyan Xu, Chao Zhu, Huifen Ye, Zaiyi Liu, Changhong Liang
Summary: The study explored the usefulness of spleen radiomics features on predicting early and late recurrences of HCC patients after curative resection. The spleen radiomics signature was identified as an independent risk factor for early recurrence and the mixed model integrating various factors showed improved predictive performance. In late recurrence analysis, the spleen radiomics signature was found to be the only prognostic factor associated with late recurrence of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Riccardo Nevola, Rachele Ruocco, Livio Criscuolo, Angela Villani, Maria Alfano, Domenico Beccia, Simona Imbriani, Ernesto Claar, Domenico Cozzolino, Ferdinando Carlo Sasso, Aldo Marrone, Luigi Elio Adinolfi, Luca Rinaldi
Summary: Hepatocellular carcinoma (HCC) is the most common liver neoplasm with increasing incidence rates. Long-term outcomes of potentially curative treatments are affected by high recurrence rates, with early recurrence being caused by the spread of the primary neoplasm and related to tumor burden, and late recurrence being independent of the primary neoplasm. Early HCC recurrence has a poorer prognosis than late recurrence, and different predictors exist for each type of recurrence. Understanding predictive factors and recurrence risk stratification is important for guiding treatment strategies and post-treatment surveillance.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Bin Yu, Han Liang, Qifa Ye, Yanfeng Wang
Summary: This study identified nine dysregulated and prognostic genes related to early recurrence (ER) in hepatocellular carcinoma (HCC) patients after R0 resection, and successfully constructed a prognostic index model based on these genes. The genomic-clinicopathologic nomogram integrating this model showed significantly higher predictive accuracy and clinical application value in predicting ER compared to TNM stage model.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Jae Hyun Yoon, Sung Kyu Choi, Sung Bum Cho, Hee Joon Kim, Yang Seok Ko, Chung Hwan Jun
Summary: This study found that early extrahepatic recurrence after surgical resection significantly worsens the survival of hepatocellular carcinoma patients, and the identified risk factors may help predict clinical outcomes and improve postoperative survival strategies.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Charlotte Costentin, Etienne Audureau, Young Nyun Park, Serena Langella, Eric Vibert, Alexis Laurent, Francois Cauchy, Olivier Scatton, Mircea Chirica, Rami Rhaiem, Emmanuel Boleslawski, Luca di Tommaso, Alessandro Ferrero, Hirohisa Yano, Jun Akiba, Matteo Donadon, Martina Nebbia, Olivier Detry, Pierre Honore, Marcello Di Martino, Lilian Schwarz, Louise Barbier, Jean-Charles Nault, Hyungjin Rhee, Chetana Lim, Raffaele Brustia, Valerie Paradis, Catherine Guettier, Brigitte Le Bail, Shinya Okumura, Jean-Frederic Blanc, Julien Calderaro
Summary: This study aimed to develop and validate a simple scoring system to predict 2-year recurrence after surgical resection (SR) for hepatocellular carcinoma (HCC). By studying 2359 HCC patients who underwent SR in 17 centers, variables associated with 2-year recurrence were identified and used to create the Early Recurrence Score (ERS). The ERS is a user-friendly staging system that can help design personalized surveillance strategies and adjuvant therapy trials.
LIVER INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Nanping Lin, Lei Wang, Qizhen Huang, Weiping Zhou, Xiaolong Liu, Jingfeng Liu
Summary: This study developed a nomogram model to predict the overall survival of hepatocellular carcinoma patients who underwent R0 resection. The model showed good calibration and discriminatory power, and it was found that p-TACE could significantly prolong the median overall survival in high-risk patients.
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Dongsub Jeon, Won-Mook Choi, Jin-Sun Kim, Yusun Jung, Su-Yeon Lee, Haeng Ran Seo, Kang Mo Kim
Summary: This study found that serum sorbitol dehydrogenase (SORD) levels were associated with the length of recurrence-free survival after surgical resection for HCC, with higher SORD levels (>= 15 ng/mL) being linked to a shorter recurrence-free survival. When combined with AFP levels, SORD levels could better predict the prognosis in HCC patients.
Article
Oncology
Nu Li, Xiaoting Wan, Hong Zhang, Zitian Zhang, Yan Guo, Duo Hong
Summary: This study demonstrates the prognostic value of pretreatment tumor and peritumor contrast-enhanced CT radiomics features for early and late recurrence of hepatocellular carcinoma after liver resection.
Article
Surgery
Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study investigated the relationship between the severity in the grading of microvascular invasion (MVI) and long-term oncological outcomes in patients with early-stage hepatocellular carcinoma (HCC). The results showed that the severity in MVI grading was independently associated with recurrence and survival after HCC resection. Patients with a more severe MVI grading (M2) require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Surgery
Haili Zhang, Fei Liu, Ningyuan Wen, Bo Li, Yonggang Wei
Summary: This study found that intrahepatic recurrence was still the most common pattern after LLR for HCC, with most recurrences occurring within 2 years. There were no significant differences in recurrence patterns, timing, or treatment between LLR and OLR, with independent risk factors for recurrence including ALBI grade, postoperative alpha-fetoprotein levels, tumor size, surgical margins, and multiple tumors.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Yutaka Endo, Laura Alaimo, Henrique A. Lima, Zorays Moazzam, Francesca Ratti, Hugo P. Marques, Olivier Soubrane, Vincent Lam, Minoru Kitago, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Aklile Workneh, Alfredo Guglielmi, Tom Hugh, Luca Aldrighetti, Itaru Endo, Timothy M. Pawlik
Summary: This study aimed to develop and validate a predictive model for microvascular invasion (MVI) and create an online calculator for preoperative assessment in hepatocellular carcinoma (HCC) patients. The study found that alpha-fetoprotein, imaging tumor burden score, and neutrophil-to-lymphocyte ratio were associated with MVI. The developed online tool showed very good accuracy in predicting MVI and had important implications for prognostic stratification in HCC patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Laura Alaimo, Zorays Moazzam, Zachary J. Brown, Yutaka Endo, Andrea Ruzzenente, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Olivier Soubrane, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
Summary: This study aimed to investigate the patterns of recurrence after surgery for intrahepatic cholangiocarcinoma (ICC) in relation to lymph node status, tumor extension, tumor burden score (TBS), and adjuvant chemotherapy. The results showed that the peak of recurrence typically occurred at 6.6 months after surgery. Among patients with negative lymph nodes, T4-category had a higher peak rate of recurrence compared to other T-categories, while high TBS was associated with an earlier peak of recurrence. Among patients with positive lymph nodes, T2-T4 categories had multiple peaks of recurrence with higher hazard rates during the first 3 years after surgery compared to the T1-category, and high TBS groups had an earlier and higher peak rate of recurrence. The administration of adjuvant chemotherapy was associated with delayed hazard rates of recurrence.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Angelo Della Corte, Claudio Sallemi, Francesca Ratti, Lorenzo Monfardini, Simone Gusmini, Federica Cipriani, Renato Pennella, Domenico Santangelo, Valentina Burgio, Andrea Casadei-Gardini, Luca Aldrighetti, Francesco De Cobelli
Summary: This study aims to identify predictors of local tumor progression and post-treatment NLR kinetics after MWA. The increase in NLR after ablation was found to be the only independent predictor of LTP, supporting the role of balance between systemic inflammation and immunity in recurrence after MWA.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Carlo Sposito, Francesca Ratti, Alessandro Cucchetti, Francesco Ardito, Andrea Ruzzenente, Stefano Di Sandro, Marianna Maspero, Giorgio Ercolani, Fabrizio Di Benedetto, Alfredo Guglielmi, Felice Giuliante, Luca Aldrighetti, Vincenzo Mazzaferro
Summary: This study aimed to determine whether lymphadenectomy improves long-term outcomes in patients with clinically node-negative intrahepatic cholangiocarcinoma (iCCA). The results showed that adequate lymphadenectomy significantly improved survival outcomes for patients with clinically node-negative iCCA who were found to be node-positive at pathology. Therefore, routine use of adequate lymphadenectomy is recommended for patients with clinically node-negative iCCA.
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Henrique A. Lima, Yutaka Endo, Zorays Moazzam, Laura Alaimo, Chanza Shaikh, Muhammad M. Munir, Vivian Resende, Alfredo Guglielmi, Hugo P. Marques, Francois Cauchy, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Itaru Endo, Minoru Kitago, Feng Shen, Timothy M. Pawlik
Summary: In hepatocellular carcinoma treatment, heterogeneity still exists within the Barcelona clinic liver cancer subcategories. A simple model was developed to better discriminate and predict prognosis after resection. This model consistently outperformed the existing BCLC model in terms of discrimination power and prognostication.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Correction
Surgery
Nicky van der Heijde, Burak Gorgec, Joal D. Beane, Francesca Ratti, Giulio Belli, Andrea Benedetti Cacciaguerra, Fulvio Calise, Umberto Cillo, Marieke T. De Boer, Alexander M. Fagenson, Asmund A. Fretland, Elizabeth M. Gleeson, Michelle R. de Graaff, Niels F. M. Kok, Kristoffer Lassen, Marcel J. van der Poel, Andrea Ruzzenente, Robert P. Sutcliffe, Bjorn Edwin, Luca Aldrighetti, Henry A. Pitt, Mohammad Abu Hilal, Marc G. Besselink
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Nicky van der Heijde, Burak Gorgec, Joal D. Beane, Francesca Ratti, Giulio Belli, Andrea Benedetti Cacciaguerra, Fulvio Calise, Umberto Cillo, Marieke T. De Boer, Alexander M. Fagenson, Asmund A. Fretland, Elizabeth M. Gleeson, Michelle R. de Graaff, Niels F. M. Kok, Kristoffer Lassen, Marcel J. van der Poel, Andrea Ruzzenente, Robert P. Sutcliffe, Bjorn Edwin, Luca Aldrighetti, Henry A. Pitt, Mohammad Abu Hilal, Marc G. Besselink
Summary: This study compared transatlantic registries focusing on variables collected and differences in baseline characteristics, indications, and treatment in patients undergoing minimally invasive liver surgery (MILS). Despite considerable variation, overall mortality after MILS was consistently below 1.1% in all registries. Harmonization of the registries is needed for future collaborative research on MILS, using the identified 46 key variables.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Henrique A. Lima, Laura Alaimo, Zachary J. Brown, Yutaka Endo, Zorays Moazzam, Diamantis I. Tsilimigras, Chanza Shaikh, Vivian Resende, Alfredo Guglielmi, Francesca Ratti, Luca Aldrighetti, Hugo P. Marques, Olivier Soubrane, Vincent Lam, George A. Poultsides, Irinel Popescu, Sorin Alexandrescu, Guillaume Martel, Tom Hugh, Itaru Endo, Feng Shen, Timothy M. Pawlik
Summary: This study aimed to characterize the peak hazard rates and peak time of recurrence among patients who underwent resection of HCC. The results showed that the hazard of recurrence varied with time and intensity, and the BCLC stage and AFP level significantly impacted the risk of recurrence.
Article
Surgery
Simone Famularo, Matteo Donadon, Federica Cipriani, Federico Fazio, Francesco Ardito, Maurizio Iaria, Pasquale Perri, Simone Conci, Tommaso Dominioni, Quirino Lai, Giuliano La Barba, Stefan Patauner, Sarah Molfino, Paola Germani, Giuseppe Zimmitti, Enrico Pinotti, Matteo Zanello, Luca Fumagalli, Cecilia Ferrari, Maurizio Romano, Antonella Delvecchio, Maria Grazia Valsecchi, Adelmo Antonucci, Fabio Piscaglia, Fabio Farinati, Yoshikuni Kawaguchi, Kiyoshi Hasegawa, Riccardo Memeo, Giacomo Zanus, Guido Griseri, Marco Chiarelli, Elio Jovine, Mauro Zago, Moh'd Abu Hilal, Paola Tarchi, Gian Luca Baiocchi, Antonio Frena, Giorgio Ercolani, Massimo Rossi, Marcello Maestri, Andrea Ruzzenente, Gian Luca Grazi, Raffaele Dalla Valle, Fabrizio Romano, Felice Giuliante, Alessandro Ferrero, Luca Aldrighetti, Davide P. Bernasconi, Guido Torzilli
Summary: This study aimed to create a machine learning predictive model to allocate patients with recurrent hepatocellular carcinoma (HCC) to their best potential treatment based on their specific characteristics. An individualized algorithm for treatment allocation was developed using factors such as age, cirrhosis, number and size of recurrent nodules, extrahepatic spread, and time to recurrence. The algorithm provides recommendations for the best potential treatment according to patients' profiles.
Editorial Material
Oncology
Laura Alaimo, Zorays Moazzam, Yutaka Endo, Henrique A. Lima, Swatika P. Butey, Andrea Ruzzenente, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Minoru Kitago, Alex Kim, Aslam Ejaz, Joal Beane, Jordan Cloyd, Timothy M. Pawlik
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Matteo Serenari, Francesca Ratti, Nicola Guglielmo, Matteo Zanello, Federico Mocchegiani, Jacopo Lenzi, Michele Colledan, Vincenzo Mazzaferro, Umberto Cillo, Alessandro Ferrero, Matteo Cescon, Fabrizio Di Benedetto, Marco Massani, Gianluca Grazi, Raffaele Dalla Valle, Marco Vivarelli, Giuseppe Maria Ettorre, Luca Aldrighetti, Elio Jovine
Summary: This study analyzed the trend and influencing factors of ALPPS in Italy. It was found that the use of ALPPS has slightly declined, but the use of minimally invasive techniques has increased, leading to a reduced 90-day mortality rate. Post-hepatectomy liver failure (PHLF) still remains an unresolved issue.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Bong Jun Kwak, Jae Hoon Lee, Ken Min Chin, Nicholas Syn, Sung Hoon Choi, Tan To Cheung, Adrian K. H. Chiow, Iswanto Sucandy, Marco Marino, Mikel Prieto, Charing Chong, Gi Hong Choi, Mikhail Efanov, T. Peter Kingham, Robert Sutcliffe, Roberto Troisi, Johann Pratschke, Xiaoying Wang, Mathieu D'Hondt, Chung Ngai Tang, Kohei Mishima, Go Wakabayashi, Daniel Cherqui, Davit Aghayan, Bjorn Edwin, Olivier Scatton, Atsushi Sugioka, Tran Cong Duy Long, Constantino Fondevila, Mohammad Alzoubi, Mohammad Abu Hilal, Andrea Ruzzenente, Alessandro Ferrero, Paulo Herman, Boram Lee, David Fuks, Federica Cipriani, Qu Liu, Luca Aldrighetti, Rong Liu, Ho-Seong Han, Brian K. P. Goh
Summary: Minimally invasive liver resection (MILR) is considered safe and beneficial for treating liver diseases. Hepatolithiasis, traditionally limited to East Asia, has become more prevalent worldwide due to increased endoscopic procedures. However, there is a lack of high-quality evidence comparing laparoscopic (LLR) and robotic (RLR) approaches for hepatolithiasis treatment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Yutaka Endo, Zorays Moazzam, Selamawit Woldesenbet, Henrique Araujo Lima, Laura Alaimo, Muhammad Musaab Munir, Chanza F. Shaikh, Alfredo Guglielmi, Luca Aldrighetti, Matthew Weiss, Todd W. Bauer, Sorin Alexandrescu, George A. Poultsides, Minoru Kitago, Shishir K. Maithel, Hugo P. Marques, Guillaume Martel, Carlo Pulitano, Feng Shen, Francois Cauchy, Bas Groot Koerkamp, Itaru Endo, Timothy M. Pawlik
Summary: The prognostic impact of major postoperative complications (POCs) for intrahepatic cholangiocarcinoma (ICC) remains unclear. This study analyzed the relationship between POCs and outcomes relative to lymph node metastases (LNM) and tumor burden score (TBS). The results showed that the presence of POCs was associated with an increased risk of recurrence and death in low TBS/N0 patients, but not in high TBS and/or N1 patients.
WORLD JOURNAL OF SURGERY
(2023)