Article
Environmental Sciences
A. Cibati, R. Gonzalez-Olmos, S. Rodriguez-Mozaz, G. Buttiglieri
Summary: The study found that the complexity of wastewater matrices negatively impacted the efficiency of UV/H2O2 treatment, with urban WWTPs effluents and greywater showing the highest pharmaceutical removal rates, while effluents from hospitals and industries had lower removal rates. The treated wastewater generally showed reduced toxicity, except for industrial wastewater. In terms of removal rates for photo-susceptible, moderately photo-susceptible, and most photo-resistant compounds, urban WWTP effluents and greywater performed the best.
Review
Oncology
Jing Xu, Bo Cao, Chunyu Li, Guohui Li
Summary: Breast cancer is a global health concern. Endocrine therapy is crucial in treating estrogen-positive breast cancer, but it often leads to osteoporosis-related adverse events. These events increase the risk of fractures and reduce the patients' quality of life. This review explores the possibility of endocrine therapy-induced osteoporosis in estrogen-positive breast cancer treatment and discusses the mechanisms involved and the potential of drug therapies and combinations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Environmental
Anaelle Gabet, Christine de Brauer, Gilles Mailhot, Marcello Brigante, Helene Metivier
Summary: This study compares UVA and UVC radiation for the removal of micropollutants in treated wastewater through the activation of H2O2 or S2O82-. The results indicate that UVC radiation leads to faster degradation rates, and S2O82- is photolyzed faster than H2O2. In treated wastewater, the presence of organic matter inhibits the degradation of estrogen, with stronger inhibitions observed in S2O82- processes.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Food Science & Technology
Pranav Vashisht, Brahmaiah Pendyala, Vybhav Vipul Sudhir Gopisetty, Ankit Patras
Summary: This study evaluated the ability of UV-C light to inactivate foodborne pathogens in a simulated opaque fluid and developed a mathematical model for predicting the delivered fluence. The results showed a correlation between REF rates and flow rates, with a linear mathematical model developed to predict REF. The model was tested and validated against independent experiments, showing close agreement between predicted and experimental REF values.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Sen He, Xin Li, Jie-Zhi Ma, Yuan Yang, Shuang Luo, Xian-De Xie, Bing-Hua Yan, Jian Yang, Lin Luo, Lin-Ying Cao
Summary: This study revealed the potential endocrine disruption mechanism of Niclosamide by activating estrogen receptors (ERs) and estrogen-related receptors (ERRs) at environmentally-related nanomolar levels. By fluorescence competitive binding assays and luciferase reporter gene assays, it was found that NIC showed higher binding affinity with ERR gamma than other receptors. Additionally, molecular docking simulations indicated that NIC could bind to ERR gamma with the highest binding energy.
Article
Environmental Sciences
Jiefeng Liang, Qian S. Liu, Zhihua Ren, Ke Min, Xiaoxi Yang, Fang Hao, Qing Zhang, Qian Liu, Qunfang Zhou, Guibin Jiang
Summary: This study systematically investigated the potential endocrine disrupting activities of four common parabens. The results showed that parabens exhibited typical estrogenic effects and could disrupt the endocrine system by activating estrogen receptors and disturbing steroid hormone synthesis and secretion, posing potential risks to the environment and human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Elisabet Perez-Albaladejo, Raquel Pinteno, Maria del Carmen Aznar-Luque, Marta Casado, Cristina Postigo, Cinta Porte
Summary: This study explored the toxicity potential of several haloacetic acids (HAAs) in water, with a focus on their effects on human cells. The results showed that iodoacetic acid (IAA) had the highest cytotoxicity and ability to generate reactive oxygen species (ROS). These substances also caused damage to the endocrine system and genotoxicity. The findings suggest that low concentrations of these substances may have teratogenic and endocrine disruption effects on human health.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Guillermina Canesini, German H. Galoppo, Yamil E. Tavalieri, Gisela P. Lazzarino, Cora Stoker, Enrique H. Luque, Jorge G. Ramos, Monica Munoz-de-Toro
Summary: Environmental exposure to agrochemicals during early development can lead to permanent alterations in normal physiology. This study investigated the effects of atrazine exposure on gonadal development in caiman embryos, and found that it disrupts the expression of biomarkers and genes involved in sex determination and gonadal differentiation. The results suggest that atrazine can interfere with gonadal developmental programming and the observed effects may be present in other vertebrate species.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xuan Liu, Xianyi Xie, Hongling Liu
Summary: Exposure to environmental estrogen during the critical gonadal differentiation period not only affects the development of zebrafish, but also influences the population development, leading to a biased sex ratio in the fish population.
Article
Cell Biology
Fahmida Rasha, Monica Sharma, Kevin Pruitt
Summary: The most common subtype of BC is characterized by ER expression, with treatment typically involving suppression of estrogen production or hindering estrogen binding to its receptors. Despite the benefits of endocrine therapy, overcoming resistance driven by complex changes in the tumor microenvironment remains a clinical challenge, highlighting the need for further investigation into ER modulation mechanisms.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Health Care Sciences & Services
Soyeon Kang, Hagyeong Jo, Mee-Ran Kim
Summary: This study aims to evaluate the effects and safety of menopausal functional health ingredients and medicines as endocrine disruptors on the human body through the literature review and OECD guidelines.
Article
Environmental Sciences
Steve U. Ayobahan, Julia Alvincz, Hannes Reinwald, Jannis Strompen, Gabriela Salinas, Christoph Schaefers, Elke Eilebrecht, Sebastian Eilebrecht
Summary: Endocrine disruptors (EDs) have long-lasting negative effects on reproduction in humans and the environment, making them unsuitable for approval for marketing. However, regulatory testing for endocrine disruption is time-consuming, expensive, and requires animal testing. This study combines sublethal zebrafish embryo assays with transcriptomics and proteomics to identify predictive biomarkers for sexual endocrine disruption. Evaluation of these biomarkers in zebrafish embryo-based bioassays can help identify endocrine disrupting hazards and reduce animal testing.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Engineering, Environmental
Anaelle Gabet, Thomas Monot, Gilles Mailhot, Marcello Brigante, Christine de Brauer, Helene Metivier
Summary: The degradation of a mixture of ibuprofen, naproxen, and diclofenac in different effluents was studied using UVC/H2O2 or UVC/S2O82-. The composition of the effluents and the oxidant precursor had an impact on the process efficiency, with rural constructed wetland effluent showing faster degradation compared to urban conventional WWTP effluent. The stability of the rural effluent composition allowed comparable degradation efficiency, while the dilution effect in the urban effluent led to a significant increase in the degradation rate constants.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Amaral, Georgina Correia-da-Silva, Cristina Ferreira Almeida, Maria Joao Valente, Carla Varela, Elisiario Tavares-da-Silva, Anne Marie Vinggaard, Natercia Teixeira, Fernanda M. F. Roleira
Summary: This study investigates the anti-cancer properties and multi-target potential of compound 1 alpha,2 alpha-epoxy-6-methylenandrost-4-ene-3,17-dione (Oxy) in breast cancer cells. The results show that Oxy acts as an ER alpha antagonist and AR agonist, suggesting it could be a new multi-target drug. Furthermore, Oxy has the ability to sensitize AI-resistant breast cancer cells.
Article
Biochemistry & Molecular Biology
Seok-Hoon Jang, Se Hyun Paek, Jong-Kyu Kim, Je Kyung Seong, Woosung Lim
Summary: Hormone receptor-positive breast cancer cells rely on estrogen and its receptor, but resistance to endocrine therapy is common. By testing different culture conditions, researchers discovered that T47D cells respond well to estrogen under low cell density and medium replacement, which reduces the effectiveness of endocrine therapy. These findings provide new insights into endocrine therapy resistance and offer a new experimental model for future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Irene Carra, Javier Fernandez Lozano, Olivier Autin, James R. Bolton, Peter Jarvis
SCIENCE OF THE TOTAL ENVIRONMENT
(2020)
Article
Environmental Sciences
Khaled Zoroufchi Benis, Mohsen Shakouri, Kerry McPhedran, Jafar Soltan
Summary: Arsenic contamination of water is a global concern, with biosorption proving to be an effective treatment method for arsenate sorption. By optimizing the modification process parameters, such as iron concentration and pH, the sorption capacity of the biosorbent can be significantly enhanced.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
James R. Bolton
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2020)
Article
Environmental Sciences
Mengkai Li, Fei Lou, Zhe Sun, Wentao Li, James R. Bolton, Zhimin Qiang
Summary: Research on simulation models and measurement approaches for fluence rate (FR) distribution in UV reactors were conducted, comparing various simulation models and measurements from MFSD. Factors influencing FR distribution such as reflection, refraction, and turbidity effects were discussed to improve model accuracy and prevent dark regions in reactor design.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2021)
Article
Environmental Sciences
Mohsen Asadi, Kerry McPhedran
Summary: Anaerobic digestion processes produce biogas which can be used as an energy source. Developing data-driven models using operating parameters can increase biogas production rates. The study compared processed and unprocessed input variables to develop regression models for estimating biogas production rates from municipal wastewater treatment plant anaerobic digestors. The results showed that the developed non-linear regression model with unprocessed inputs performed the best, with a balance between accuracy and uncertainty when compared to artificial neural network and adaptive network-based fuzzy inference system models. The models were further optimized using a genetic algorithm, with maximum biogas production rate estimates ranging from 22.0 to 28.6 m3/min.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2021)
Review
Biochemistry & Molecular Biology
Joseph Rabani, Hadas Mamane, Dana Pousty, James R. Bolton
Summary: Actinometers are physical or chemical systems used to determine photon fluxes. This review examines various practical chemical actinometers, such as ferrioxalate, iodide-iodate, and uranyl oxalate, providing recommended conditions for their use.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Environmental Sciences
Abdullah Al Masum, Nathan Bettman, Scott Read, Markus Hecker, Markus Brinkmann, Kerry McPhedran
Summary: This study investigated the stormwater pollutant loadings in seven catchment areas in Saskatoon, SK, Canada. The loadings were predicted using land-use classifications and validated through outfall sampling. The results showed differences between the predicted and actual estimations, emphasizing the importance of assessing and monitoring stormwater outfalls for environmental impacts and treatment technology development.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Hayley Popick, Markus Brinkmann, Kerry McPhedran
Summary: Stormwater from precipitation and snowmelt in urban areas is often released into water bodies without treatment. This study examines the quality of snowmelt in Saskatoon, Canada and finds high concentrations of pollutants exceeding national aquatic toxicity guideline thresholds.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
H. Popick, M. Brinkmann, Kerry McPhedran
Summary: This study examines the quality of stormwater discharge during the summer season in a cold-climate, semi-arid Canadian city. The results show the presence of various contaminants in stormwater, including TSS, COD, DOC, metals, and PAHs. The toxicity of stormwater was also confirmed through toxicity assays.
ENVIRONMENTAL SCIENCES EUROPE
(2022)
Article
Environmental Sciences
Nathan Bettman, Raquibul Alam, Laura Patterson-Fortin, Mohsen Asadi, Kerry McPhedran
Summary: Electrochemical advanced oxidation processes (eAOPs) such as the current advanced oxidation system (AOS) use oxidative species to treat wastewater. This study determined the concentrations of iodide and chloride oxidative species in an AOS and identified the optimal conditions for their creation. The AOS showed good performance in reducing Escherichia coli in synthetic stormwater after optimization.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Green & Sustainable Science & Technology
Khaled Zoroufchi Benis, Jafar Soltan, Kerry N. McPhedran
Summary: This study proposes a novel microwave- and electrochemical-assisted technique to prepare a binary-oxide biochar composite with oxidation and adsorption capabilities. A diffusional mass transfer model combined with a genetic algorithm was used to characterize the adsorption process. The results show that the adsorption capacity of modified biomass significantly increased, indicating the high potential of the proposed procedure for preparation of adsorbents with improved oxidation and adsorption performance.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Engineering, Environmental
Mengkai Li, Fei Lou, Yanyan Huang, Zhe Sun, Wentao Li, James R. Bolton, Zhimin Qiang
Summary: In this study, a method for predicting the electrical energy consumption per order in multiscale UV-AOP reactors for micropollutant removal was developed. The method utilized reaction rate constants determined in a reference reactor and clarified the dependence of energy consumption on reactor properties through a scale-up method.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
Dana Pousty, Hadas Mamane, Vered Cohen-Yaniv, James R. Bolton
Summary: The study focuses on accurately assessing the interaction of light with photochemical and photobiological systems, specifically in terms of incident photon flux and quantum yields. The research demonstrates the calibration of a spectroradiometer using different actinometers and investigates whether UV-LEDs should be considered as monochromatic or polychromatic light sources. The findings indicate consistency in quantum yields between well-researched actinometers and no significant differences between monochromatic and polychromatic analysis.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Instruments & Instrumentation
Mahsa Masjoudi, Madjid Mohseni, James R. Bolton
Summary: This review analyzes fluence data from nearly 250 studies and provides recommended fluence values for specific log reductions, as well as an appendix containing all the collected data. The sensitivity of various organisms to UV radiation exposure is crucial for the design of UV disinfection equipment.
JOURNAL OF RESEARCH OF THE NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Van A. Ortega, David Boyle, Jordan W. Hodgkinson, Denina B. D. Simmons, Miodrag Belosevic, James L. Stafford, Greg G. Goss
Summary: The study found that goldfish exhibited inflammatory responses to injected PAA-TiO2 nanoparticles; there was significant titanium metal deposition in tissues; kidney and spleen tissues experienced damage and lipid peroxidation; immune effector functions of neutrophils were enhanced, and inflammatory-related genes in hematopoietic organs showed significant changes after PAA-TiO2 injection.
ENVIRONMENTAL SCIENCE-NANO
(2021)
Article
Engineering, Environmental
Rong-Gui Zhu, Chang-Gui Pan, Feng-Jiao Peng, Chao-Yang Zhou, Jun-Jie Hu, Kefu Yu
Summary: This comprehensive survey investigated the occurrence, bioaccumulation, and trophic magnification of parabens and their metabolite 4-HB in a marine food web. Results showed that parabens were the predominant pollutants in marine organisms, with significant bioaccumulation from sediments. The estimated trophic magnification factor indicated biomagnification for MeP and trophic dilution for 4-HB. Overall, the risks for humans consuming marine organisms were found to be low.
Article
Engineering, Environmental
Andres F. Torres-Franco, Deborah Leroy-Freitas, Cristina Martinez-Fraile, Elisa Rodriguez, Pedro A. Garcia-Encina, Raul Munoz
Summary: Anaerobic and microalgae-based technologies have emerged as sustainable alternatives for municipal wastewater treatment. However, the presence of viruses in the treated wastewater is a major concern for reuse applications. This study assessed the ability of these technologies to reduce viruses during secondary wastewater treatment. The results showed that all technologies were effective in reducing the concentration of viruses, with microalgae-based treatment exhibiting the highest potential for reducing the disinfection requirements of treated wastewater.
Article
Engineering, Environmental
Young Gwang Kim, Sae Yun Kwon, Spencer J. Washburn, Scott C. Brooks, Ji Won Yoon, Lucien Besnard
Summary: The study uses Hg isotope ratios to identify the sources and exposure pathways of mercury in bivalves, finding that dissolved Hg phases in the water column are the primary source and exposure pathway to bivalves. This provides new insights into using bivalves as bioindicators for sediment quality monitoring.
Article
Engineering, Environmental
Hui Geng, Ying Xu, Rui Liu, Dianhai Yang, Xiaohu Dai
Summary: This study investigates the effect of cation exchange resin (CER) on the sequential recovery of hydrogen and methane from anaerobic digestion (AD) and the corresponding mechanisms. The results show that CER can simultaneously enhance the production of hydrogen and methane by promoting the solubilisation, hydrolysis, and acidification of organic matter. Additionally, CER facilitates effective contact between bacteria and organic particulates and reduces the energy barrier for mass transfer during methane production. The study also reveals changes in the microbial community structure and metagenomics during the AD process.
Article
Engineering, Environmental
Xiaojing Lin, Zhan Jin, Shunfeng Jiang, Zhiquan Wang, Suqing Wu, Ke Bei, Min Zhao, Xiangyong Zheng
Summary: Dehumidification combined with addition of absorbent resin supplement (ARS) was used to achieve rapid evaporation of non-pretreated urine, resulting in high water evaporation efficiency and nutrient recovery.
Article
Engineering, Environmental
Yangli Che, Chaoran Lin, Shen Li, Jiao Liu, Longhai Zhu, Shilei Yu, Nan Wang, Haoshuai Li, Mutai Bao, Yang Zhou, Tonghao Si, Rui Bao
Summary: Hydrodynamic processes play a crucial role in the transmission of sediments, microbial assembly, and organic carbon redistribution in the ocean. Through experiments and analysis, we found that hydrodynamics shape the assembly of microbial communities and control the redistribution of different sourced organic carbon, thereby influencing microbial-mediated biogeochemical transformation.
Article
Engineering, Environmental
Chao Chen, Yu Yang, Nigel J. D. Graham, Zhenyu Li, Xingtao Yang, Zhining Wang, Nadia Farhat, Johannes S. Vrouwenvelder, Li -an Hou
Summary: The fouling of seawater reverse osmosis membranes is a persistent challenge in desalination. This study monitored the operational performance of a desalination plant for 7 years and the fouling development in different areas of membrane modules. The findings showed that operational performance declined over time and fouling mainly occurred at the feed side of the modules, with the highest microbial diversity. Keystone species like Chloroflexi and Planctomycetes played an important role in maintaining community structure and biofilm maturation. Polysaccharides, soluble microbial products, marine humic acid-like substances, and inorganic substances contributed to fouling. Overall, biofouling had a significant impact on membrane fouling after 7 years of operation.
Article
Engineering, Environmental
Dan Li, Jieyi Sun, Yibo Fu, Wentao Hong, Heli Wang, Qian Yang, Junhong Wu, Sen Yang, Jianhui Xu, Yunfei Zhang, Yirong Deng, Yin Zhong, Ping'an Peng
Summary: Sulfidation-oxidation treatment of magnetite (Fe3O4) enhances the production of dark center dot OH, which can efficiently degrade dissolved organic matter (DOM) and accelerate carbon cycling.
Article
Engineering, Environmental
Cheng Yu, Kaijun Wang, Kaiyuan Zhang, Ruiyang Liu, Pingping Zheng
Summary: This study implemented a microaerobic-aerobic configuration in a full-scale municipal wastewater treatment facility and investigated the effects on sludge characteristics, pollutant removal, microbial community, and granulation mechanisms. The results showed successful transition from flocculent-activated sludge to well-defined AGS after two months of operation. The primary pathways for pollutant removal were simultaneous nitrification, denitrification, and phosphorus removal. Moreover, the incorporation of internal separators induced shifts in the flow pattern, which promoted granulation.
Article
Engineering, Environmental
Zhe Zhang, Shaoyang Hu, Guangrong Sun, Wei Wang
Summary: Halogenated aromatic disinfection byproducts (DBPs), such as halogenated phenols, have garnered widespread attention due to their high toxicity and prevalence. This study reports on the analysis, occurrence, and cytotoxicity of a group of emerging halogenated aromatic DBPs, known as halogenated polyhydroxyphenols (HPPs), in drinking water.
Article
Engineering, Environmental
Shengyue Chen, Jinliang Huang, Peng Wang, Xi Tang, Zhenyu Zhang
Summary: Accurate prediction of river water quality is crucial for sustainable water management. This study introduces wavelet analysis and transfer learning techniques to assist LSTM modeling, proposing a newly coupled modeling approach that improves short-term prediction of river water quality.
Article
Engineering, Environmental
Bang Du, Xinmin Zhan, Piet N. L. Lens, Yifeng Zhang, Guangxue Wu
Summary: Efficient anaerobic digestion relies on the cooperation of different microorganisms with different metabolic pathways. This study investigated the effects of different operational modes and the addition of powdered activated carbon (PAC) on ethanol metabolic pathways. The results showed that the SBR mode and the presence of CO2 facilitated ethanol metabolism towards propionate production, while the CFR mode with extended solids retention time enriched Geobacter. Adjusting operational modes and PAC addition can modulate anaerobic ethanol metabolism and enrich Geobacter.
Article
Engineering, Environmental
Wanfa Wang, Si-Liang Li, Jun Zhong, Yuanbi Yi, Fujun Yue, Zenglei Han, Qixin Wu, Ding He, Cong-Qiang Liu
Summary: This study compares the carbon biogeochemical processes in karst and non-karst regions within large thermal stratified river-reservoir systems. The results demonstrate that karst reservoirs have a reduced potential for carbon emissions and highlight the importance of considering geologic settings to improve accuracy in regional and global CO2 emission estimates.
Article
Engineering, Environmental
Chunxia Jiang, Zelong Zhao, Dong Zhu, Xiong Pan, Yuyi Yang
Summary: This study analyzed the occurrence and distribution of antibiotic resistance genes (ARGs) in different environmental media of the Yangtze River using metagenomics. Core resistome dominated by multidrug resistance genes was found in all samples, while rare resistome dominated by various resistance genes was more prevalent in plasmids. Specific bacteria were identified as hosts for both core and rare resistomes, with high clinical concern ARGs found in the rare resistome. Particle-associated environment provided the most ideal conditions for resistome hosts. This study provided insights into the genetic locations of ARGs and the community assembly mechanisms of ARG hosts in freshwater environments.
Article
Engineering, Environmental
Yu Zhang, Yongtao He, Linchun Jia, Lei Xu, Zheng Wang, Yueling He, Ling Xiong, Xumeng Lin, Hong Chen, Gang Xue
Summary: By synergizing organic carbon source, thiosulfate, and zero-valent iron, efficient mixotrophic denitrification of oligotrophic secondary effluent can be achieved. Thiosulfate plays a vital role in promoting TN removal efficiency, while corrosion of Fe0 releases OH- to neutralize H+ from thiosulfate-driven denitrification, creating a suitable environment for denitrification. The coordination of thiosulfate and Fe0 maintains the dominance of Thiobacillus for denitrification.