mtDNA mutations variously impact mtDNA maintenance throughout the human embryofetal development

Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases

(2014) Tian Wang et al.   CELL

A systematic analysis of the suitability of preimplantation genetic diagnosis for mitochondrial diseases in a heteroplasmic mitochondrial mouse model

(2014) J. Neupane et al.   HUMAN REPRODUCTION

Clinical utilisation of a rapid low-pass whole genome sequencing technique for the diagnosis of aneuploidy in human embryos prior to implantation

(2014) Dagan Wells et al.   JOURNAL OF MEDICAL GENETICS

Data from Artificial Models of Mitochondrial DNA Disorders Are Not Always Applicable to Humans

(2014) Julie Steffann et al.   Cell Reports

Mutation dependance of the mitochondrial DNA copy number in the first stages of human embryogenesis

(2013) Sophie Monnot et al.   HUMAN MOLECULAR GENETICS

Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte

(2013) C. M. Dalton et al.   JOURNAL OF CELL SCIENCE

Preimplantation genetic diagnosis in mitochondrial DNA disorders: challenge and success

(2013) Suzanne C E H Sallevelt et al.   JOURNAL OF MEDICAL GENETICS

Mitochondrial DNA variations in ova and blastocyst: Implications in assisted reproduction

(2013) Monis Bilal Shamsi et al.   MITOCHONDRION

Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options

(2013) Ayman W. El-Hattab et al.   Neurotherapeutics

Mitochondrial DNA Haplotypes Define Gene Expression Patterns in Pluripotent and Differentiating Embryonic Stem Cells

(2013) Richard D.W. Kelly et al.   STEM CELLS

Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition

(2012) Mark S. Sharpley et al.   CELL

Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder

(2012) Nathan R. Treff et al.   FERTILITY AND STERILITY

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

(2012) Daniel Paull et al.   NATURE

Towards germline gene therapy of inherited mitochondrial diseases

(2012) Masahito Tachibana et al.   NATURE

Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

(2012) Christoph Freyer et al.   NATURE GENETICS

Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

(2012) Richard D. W. Kelly et al.   NUCLEIC ACIDS RESEARCH

Rapid Mitochondrial DNA Segregation in Primate Preimplantation Embryos Precedes Somatic and Germline Bottleneck

(2012) Hyo-Sang Lee et al.   Cell Reports

Poor Correlations in the Levels of Pathogenic Mitochondrial DNA Mutations in Polar Bodies versus Oocytes and Blastomeres in Humans

(2011) Nadine Gigarel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The association of reproductive senescence with mitochondrial quantity, function, and DNA integrity in human oocytes at different stages of maturation

(2011) Hakan E. Duran et al.   FERTILITY AND STERILITY

The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1

(2010) Timothy Wai et al.   BIOLOGY OF REPRODUCTION

Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system

(2010) Sophie Monnot et al.   HUMAN MUTATION

Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development

(2010) M. Pejznochova et al.   MITOCHONDRION

Mitochondrial function in the human oocyte and embryo and their role in developmental competence

(2010) Jonathan Van Blerkom   MITOCHONDRION

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

(2010) Lyndsey Craven et al.   NATURE

Variations in mouse mitochondrial DNA copy number from fertilization to birth are associated with oxidative stress

(2010) Catherine EM Aiken et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Embryo Mitochondrial DNA Depletion Is Reversed During Early Embryogenesis in Cattle1

(2009) Marcos R. Chiaratti et al.   BIOLOGY OF REPRODUCTION

Pathogenic mitochondrial tRNA mutations - Which mutations are inherited and why?

(2009) Joanna L. Elson et al.   HUMAN MUTATION

Information for genetic management of mtDNA disease: sampling pathogenic mtDNA mutants in the human germline and in placenta

(2009) D. Marchington et al.   JOURNAL OF MEDICAL GENETICS

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

(2009) Liqin Cao et al.   PLoS Genetics

Selection against Pathogenic mtDNA Mutations in a Stem Cell Population Leads to the Loss of the 3243A→G Mutation in Blood

(2008) Harsha Karur Rajasimha et al.   AMERICAN JOURNAL OF HUMAN GENETICS

In vitro–matured rat oocytes have low mitochondrial deoxyribonucleic acid and adenosine triphosphate contents and have abnormal mitochondrial redistribution

(2008) Hai-tao Zeng et al.   FERTILITY AND STERILITY

Mitochondrial respiratory chain complex assembly and function during human fetal development

(2008) Limor Minai et al.   MOLECULAR GENETICS AND METABOLISM

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS

Molecular control of mitochondrial function in developing rhesus monkey oocytes and preimplantation-stage embryos

(2008) N. R. Mtango et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

A Mouse Model of Mitochondrial Disease Reveals Germline Selection Against Severe mtDNA Mutations

(2008) Weiwei Fan et al.   SCIENCE

Strong Purifying Selection in Transmission of Mammalian Mitochondrial DNA

(2008) James Bruce Stewart et al.   PLOS BIOLOGY