Review
Medicine, General & Internal
Angela Zissler, Walter Stoiber, Janine Geissenberger, Peter Steinbacher, Fabio C. Monticelli, Stefan Pittner
Summary: The review provides an overview of the current research status on the effects of influencing factors on postmortem protein degradation for estimating PMI. The diversity of studied factors affects protein degradation, emphasizing the need for thorough screening to improve the method's reliability and precision.
Article
Environmental Sciences
Fei-Xiang Xu, Xu Chen, Heng Zhang, Yi-Jun Fan, Ya-Ping Song, Jin-Wei Lv, Ya-Li Xie, Yichao Huang, Dao-Zhen Chen, Hua Wang, De-Xiang Xu
Summary: Gestational arsenic exposure is associated with intrauterine growth restriction, and this restriction may be related to a reduction in folate content in maternal and umbilical plasma.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Obstetrics & Gynecology
Jaimin S. Shah, Yael Eliner, Denis A. Vaughan, Blair J. Wylie, Ann Korkidakis, Angela Q. Leung, Alan S. Penzias, Denny Sakkas, Thomas L. Toth
Summary: The interpregnancy interval has an impact on perinatal outcomes, and this impact is influenced by the mode of conception. An interpregnancy interval of less than 12 months is associated with an increased risk of preterm birth and low birth weight, while IVF conception is not associated with these increased risks.
FERTILITY AND STERILITY
(2022)
Article
Multidisciplinary Sciences
Francesco D'Ambrosi, Marta Ruggiero, Nicola Cesano, Matteo Di Maso, Giulia Emily Cetera, Beatrice Tassis, Ilma Floriana Carbone, Enrico Ferrazzi
Summary: A study found that in a large population, the rate of stillbirth in singleton pregnancies at term was 0.48 per 1000, with the highest incidence at 38 weeks of gestation. The majority of stillbirths occurred before 39 weeks of gestation, and 6 out of 28 cases were small for gestational age (SGA) fetuses, with the remaining case at the 35th percentile.
Article
Cardiac & Cardiovascular Systems
Maddalena Ardissino, Alec P. Morley, Eric A. W. Slob, Art Schuermans, Bilal Rayes, Zahra Raisi-Estabragh, Antonio de Marvao, Stephen Burgess, Tormod Rogne, Michael C. Honigberg, Fu Siong Ng
Summary: This study found that natural birth weight, independent of the intrauterine environment, is associated with cardiovascular disease and adverse cardiac structure and function.
EUROPEAN HEART JOURNAL
(2023)
Article
Agriculture, Dairy & Animal Science
J. L. Moroni, S. Tsoi, I. I. Wenger, C. Tran, G. S. Plastow, P. Charagu, M. K. Dyck
Summary: This study found that poor placental development in sows with low litter birth weight phenotype may lead to lower birth weights for the entire litter.
ANIMAL REPRODUCTION SCIENCE
(2022)
Review
Endocrinology & Metabolism
Chiara Cauzzo, Valentina Chiavaroli, Susanna Di Valerio, Francesco Chiarelli
Summary: There is a growing body of evidence showing a strong connection between intrauterine growth and the development of chronic diseases in adults. Birth size and growth pattern have significant effects on cardio-metabolic health in childhood and adulthood. Therefore, it is important to closely monitor the growth pattern of children from the intrauterine period onward to detect potential cardio-metabolic risks and intervene early through lifestyle interventions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Jeanette Dawa, Edwin Walong, Clayton Onyango, John Mathaiya, Peter Muturi, Milka Bunei, Washington Ochieng, Walter Barake, Josilene N. Seixas, Lillian Mayieka, Melvin Ochieng, Victor Omballa, Shirley Lidechi, Elizabeth Hunsperger, Nancy A. Otieno, Jana M. Ritter, Marc-Alain Widdowson, Maureen H. Diaz, Jonas M. Winchell, Roosecelis B. Martines, Sherif R. Zaki, Sandra S. Chaves
Summary: Utilizing MITS techniques for analysis of postmortem lung, liver, and blood samples can be extended up to 4 days in adequately preserved bodies. However, inconsistent pathogen detection in samples needs careful consideration.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Brianna C. Aoyama, Jessica L. Rice, Sharon A. McGrath-Morrow, Joseph M. Collaco
Summary: The study examined the demographic and clinical characteristics of preterm infants with bronchopulmonary dysplasia (BPD) and aimed to identify factors predictive of outpatient mortality. The results showed a significantly higher mortality rate among preterm infants with BPD compared to the general population. The need for greater amounts of home supplemental oxygen and the presence of a gastrostomy tube or cerebrospinal fluid shunt were associated with an increased risk of postdischarge mortality.
JOURNAL OF PEDIATRICS
(2022)
Article
Public, Environmental & Occupational Health
Amsalu Taye Wondemagegn, Binalfew Tsehay, Akiloge Lake Mebiratie, Ayenew Negesse
Summary: Inadequate dietary diversity during pregnancy significantly increased the rate of low birth weight and preterm birth.
FRONTIERS IN PUBLIC HEALTH
(2022)
Editorial Material
Biology
Stephanie M. Holm, John Balmes
Summary: Pollution from landscape fires, increasing due to climate change, leads to lower birthweights in babies in low- and middle-income countries.
Article
Obstetrics & Gynecology
Jinfeng Xu, Yuxin Tang, Bing Peng, Wei-Hong Zhang, Xiaodong Wang
Summary: This study investigated the effect of low-molecular-weight heparin (LMWH) on placenta-mediated fetal growth restriction (FGR). The results showed that LMWH use was associated with a decreased risk of intrauterine fetal death and preterm birth, as well as improved neonatal outcomes.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Ecology
Ruina Liu, Qi Wang, Kai Zhang, Hao Wu, Gongji Wang, Wumin Cai, Kai Yu, Qinru Sun, Shuanliang Fan, Zhenyuan Wang
Summary: The study investigated microbial succession patterns during decomposition, identified seven different succession patterns, and developed a random forest regression model to predict postmortem intervals. Lactobacillus, Dubosiella, Enterococcus, and the Lachnospiraceae NK4A136 group were considered significant biomarkers for the model.
Article
Pediatrics
Jing Li, Jing Zhang, Qingfei Hao, Ziyun Shen, Yanna Du, Haoming Chen, Xiuyong Cheng
Summary: This study explored the association between the time from the first extubation to reintubation and the occurrence of moderate-to-severe bronchopulmonary dysplasia (BPD) or death in very low birth weight infants. The findings showed that reintubation within 72 hours after the initial extubation was independently associated with an increased likelihood of moderate-to-severe BPD/death and death, while reintubation within the first 48 hours post-extubation posed the greatest risk.
FRONTIERS IN PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Onesmus Byamukama, Richard Migisha, Paul Kato Kalyebara, Leevan Tibaijuka, Henry Mark Lugobe, Joseph Ngonzi, Onesmus Magezi Ahabwe, Kenia Raquel Martinez Garcia, Godfrey R. Mugyenyi, Adeline Adwoa Boatin, Joy Muhumuza, Wasswa G. M. Ssalongo, Musa Kayondo, Hamson Kanyesigye
Summary: This study investigated the prevalence and associated factors of short interbirth interval among women with previous cesarean deliveries in Mbarara Regional Referral Hospital, Uganda. The study found that factors such as non-use of postpartum family planning, history of still births, unplanned pregnancy, and young maternal age were significantly associated with short interbirth interval.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
M. A. Beesley, J. R. Davidson, F. Panariello, S. Shibuya, D. Scaglioni, B. C. Jones, K. Maksym, O. Ogunbiyi, N. J. Sebire, D. Cacchiarelli, A. L. David, P. De Coppi, M. F. M. Gerli
Summary: The study indicates that fetal lungs are unlikely to be a route of SARS-CoV2 infection, while the gastrointestinal tract of the fetus may be susceptible due to high expression of both proteins and exposure to potentially infected amniotic fluid. Despite having the required proteins, the fetal kidneys are anatomically protected from virus exposure.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
A. Fagan, O. J. Arthurs, N. J. Sebire, S. C. Shelmerdine
Summary: Cinematic rendering (CR) is a novel post-processing technique that allows for more realistic imaging reconstruction by using a complex light modelling algorithm. It has been shown to provide better realism and expressiveness experience compared to volume rendering (VR) techniques in adult imaging. Additionally, CR improves visualization of musculoskeletal and vascular anatomy and may aid non-radiologists in understanding complex patient anatomy. This review focuses on the potential applications of CR in pediatric musculoskeletal imaging, highlighting its advantages over VR and areas for further research.
CLINICAL RADIOLOGY
(2022)
Article
Infectious Diseases
Emma Vestesson, John Booth, James Hatcher, Orlagh McGarrity, Neil J. Sebire, Adam Steventon, Carlos Suarez Alonso, Stephen Tomlin, Joseph F. Standing
Summary: This study evaluated the impact of the COVID-19 pandemic on antibiotic prescribing in a pediatric hospital in London. The results showed an increase in antibiotic usage during the pandemic, but after adjusting for changes in patient characteristics, there was no evidence of a significant impact on antibiotic prescribing.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G. H. Lindeboom, Colin R. Butler, Natsuhiko Kumasaka, Cecilia Dominguez Conde, Lira Mamanova, Liam Bolt, Laura Richardson, Krzysztof Polanski, Elo Madissoon, Josephine L. Barnes, Jessica Allen-Hyttinen, Eliz Kilich, Brendan C. Jones, Angus de Wilton, Anna Wilbrey-Clark, Waradon Sungnak, J. Patrick Pett, Elena Prigmore, Henry Yung, Puja Mehta, Aarash Saleh, Anita Saigal, Vivian Chu, Jonathan M. Cohen, Clare Cane, Aikaterini Iordanidou, Soichi Shibuya, Ann-Kathrin Reuschl, Ivan T. Herczeg, A. Christine Argento, Richard G. Wunderink, Sean B. Smith, Taylor A. Poor, Catherine A. Gao, Jane E. Dematte, Gary Reynolds, Muzlifah Haniffa, Georgina S. Bowyer, Matthew Coates, Menna R. Clatworthy, Fernando J. Calero-Nieto, Berthold Goettgens, Christopher O'Callaghan, Neil J. Sebire, Clare Jolly, Paolo de Coppi, Claire M. Smith, Alexander Misharin, Sam M. Janes, Sarah A. Teichmann, Marko Z. Nikolic, Kerstin B. Meyer
Summary: Higher innate interferon responses in children may restrict viral replication and disease progression, while the response to SARS-CoV-2 infection differs between children and adults.
Letter
Developmental Biology
T. Yee Khong, Neil J. Sebire, Alexander E. P. Heazell, Wessel Ganzevoort, Frank H. Bloomfield, Elisabeth M. W. Kooi, Mauritia C. Marijnen, Sanne J. Gordijn
Article
Obstetrics & Gynecology
Dimitrios Siassakos, Isabella Bourne, Neil Sebire, Lindsay Kindinger, Sara Melissa Whitten, Clarissa Battaglino
Summary: This study found a correlation between distal villous immaturity (DVI) in the placenta and stillbirth, suggesting a link to glucose dysmetabolism. Some women with DVI, despite not being formally diagnosed with diabetes, had high glucose test results during pregnancy, with a higher risk of stillbirth for their babies.
JOURNAL OF PERINATAL MEDICINE
(2022)
Correction
Multidisciplinary Sciences
Tim H. H. Coorens, Thomas R. W. Oliver, Rashesh Sanghvi, Ulla Sovio, Emma Cook, Roser Vento-Tormo, Muzlifah Haniffa, Matthew D. Young, Raheleh Rahbari, Neil Sebire, Peter J. Campbell, D. Stephen Charnock-Jones, Gordon C. S. Smith, Sam Behjati
Article
Pathology
Victoria A. Bryant, Tom S. Jacques, Neil J. Sebire
Summary: This study investigates the causes of sudden unexpected death from natural causes in children aged 1-18 years through retrospective examination of autopsy records. The results show that infections are the most common cause of death, followed by non-infectious diseases, and a portion of deaths remain unexplained. There is no significant difference in the proportions of deaths between previously healthy children and those with pre-existing conditions.
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY
(2022)
Article
Pediatrics
Sheena Visram, Deirdre Leyden, Oceiah Annesley, Dauda Bappa, Neil J. Sebire
Summary: This article investigates the attitudes of children and young people towards the application of Artificial Intelligence (AI) in medicine and healthcare. It found that they were more open to certain applications of AI than others, with a focus on human-centeredness, governance, and trust. The article suggests that educational workshops and practical examples can help address concerns and build trust in AI.
PEDIATRIC RESEARCH
(2023)
Article
Oncology
Laura Privitera, Layla Musleh, Irene Paraboschi, Olumide Ogunlade, Olumide Ogunbiyi, J. Ciaran Hutchinson, Neil Sebire, Paul Beard, Stefano Giuliani
Summary: Neuroblastoma (NB), the most common extracranial tumor in children, can be better treated with the help of imaging techniques such as photoacoustic imaging (PAI) to distinguish viable malignant tissue from necrotic and surrounding healthy tissue. The study found that post-chemotherapy, viable areas of differentiating NBs and ganglioneuroblastomas have higher vascular density, while early necrotic regions have higher vascular density than late necrotic and viable regions. Calcified areas have significantly lower vascular density. The results suggest that PAI can potentially guide surgical resection by identifying different vasculature signatures.
Article
Multidisciplinary Sciences
Bojidar Rangelov, Alexandra Young, Watjana Lilaonitkul, Shahab Aslani, Paul Taylor, Eyjolfur Guomundsson, Qianye Yang, Yipeng Hu, John R. Hurst, David J. Hawkes, Joseph Jacob
Summary: The COVID-19 pandemic has presented a significant challenge to healthcare systems worldwide. This study developed an unsupervised data-driven model called SuStaIn, which can be used to predict short-term infectious diseases like COVID-19 based on commonly recorded clinical measures. The model identified three COVID-19 subtypes and introduced disease severity stages, both of which were predictive of in-hospital mortality or escalation of treatment. This model can be adapted for future outbreaks of COVID-19 or other infectious diseases.
SCIENTIFIC REPORTS
(2023)
Article
Developmental Biology
Nada Mufti, Joanna Chappell, Patrick O'Brien, George Attilakos, Hassna Irzan, Magda Sokolska, Priya Narayanan, Trevor Gaunt, Paul D. Humphries, Premal Patel, Elspeth Whitby, Eric Jauniaux, J. Ciaran Hutchinson, Neil J. Sebire, David Atkinson, Giles Kendall, Sebastien Ourselin, Tom Vercauteren, Anna L. David, Andrew Melbourne
Summary: The study investigates the use of super-resolution reconstruction (SRR) MRI to improve placental assessment and predict adverse maternal outcomes. The results show that SRR imaging and paired imaging can enhance the detection of pathological MRI markers, aiding in surgical planning.
Article
Multidisciplinary Sciences
Taryn D. Treger, John E. G. Lawrence, Nathaniel D. Anderson, Tim H. H. Coorens, Aleksandra Letunovska, Emilie Abby, Henry Lee-Six, Thomas R. W. Oliver, Reem Al-Saadi, Kjell Tullus, Guillaume Morcrette, J. Ciaran Hutchinson, Dyanne Rampling, Neil Sebire, Kathy Pritchard-Jones, Matthew D. Young, Thomas J. Mitchell, Philip H. Jones, Maxine Tran, Sam Behjati, Tanzina Chowdhury
Summary: In this study, we examined somatic changes in reninoma and discovered structural variants involving NOTCH1 and NRARP, resulting in excessive renin and NOTCH1 signaling but normal expression of NRARP. Additionally, our findings were supported by previous studies that also found dysregulated Notch pathway signaling in reninoma.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Rebecca Spencer, Kasia Maksym, Kurt Hecher, Karel Marsal, Francesc Figueras, Gareth Ambler, Harry Whitwell, Nuno Rocha Nene, Neil J. Sebire, Stefan R. Hansson, Anke Diemert, Jana Brodszki, Eduard Gratacos, Yuval Ginsberg, Tal Weissbach, Donald M. Peebles, Ian Zachary, Neil Marlow, Angela Huertas-Ceballos, Anna L. David
Summary: This study investigates the use of maternal serum protein and ultrasound measurements to predict outcomes in pregnancies affected by severe, early-onset fetal growth restriction (FGR). The results demonstrate that ultrasound measurements and maternal serum PlGF concentration can predict important pregnancy outcomes for patients and clinicians.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pediatrics
Milagros Ruiz Nishiki, Melissa Cabecinha, Rachel Knowles, Catherine Peters, Helen Aitkenhead, Adeboye Ifederu, Nadia Schoenmakers, Neil J. Sebire, Erin Walker, Pia Hardelid
Summary: This study aims to determine risk factors for congenital hypothyroidism with gland in situ (CH-GIS) and describe long-term health and education outcomes for affected children using linked administrative health, education and clinical data. Logistic/multinomial regression models will be used to identify risk factors for CH-GIS, while generalised linear models or Cox proportional hazards regression models will assess the association between type of CH and school performance or health outcomes. The study has received ethical approval and its findings will be disseminated through peer-reviewed journals and academic conferences.
BMJ PAEDIATRICS OPEN
(2022)