Emerging tale of UPR and cancer: an essentiality for malignancy

Natural osmolytes alleviate GRP78 and ATF-4 levels: Corroboration for potential modulators of unfolded protein response

(2016) Younis Mohammad Hazari et al.   LIFE SCIENCES

Novel variants of SERPIN1A gene: Interplay between alpha1-antitrypsin deficiency and chronic obstructive pulmonary disease

(2016) Arif Bashir et al.   RESPIRATORY MEDICINE

Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment

(2015) Antonis E. Koromilas   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis

(2015) Patrick A. Carroll et al.   CANCER CELL

A pathway-based approach for identifying biomarkers of tumor progression to trastuzumab-resistant breast cancer

(2015) Seungyoon Nam et al.   CANCER LETTERS

ER proteostasis addiction in cancer biology: Novel concepts

(2015) Estefanie Dufey et al.   SEMINARS IN CANCER BIOLOGY

Novel roles of the unfolded protein response in the control of tumor development and aggressiveness

(2015) Nicolas Dejeans et al.   SEMINARS IN CANCER BIOLOGY

Endoplasmic reticulum quality control in cancer: Friend or foe

(2015) Hana Kim et al.   SEMINARS IN CANCER BIOLOGY

ER stress and hexosamine pathway during tumourigenesis: A pas de deux?

(2015) Sophie Vasseur et al.   SEMINARS IN CANCER BIOLOGY

Oncogenes strike a balance between cellular growth and homeostasis

(2015) Bo Qiu et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Amino Acid Deprivation Promotes Tumor Angiogenesis through the GCN2/ATF4 Pathway

(2015) Yugang Wang et al.   NEOPLASIA

Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

(2014) Martin S. Denzel et al.   CELL

Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway

(2014) Zhao V. Wang et al.   CELL

Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma

(2014) M Corazzari et al.   CELL DEATH AND DIFFERENTIATION

Hypoxic regulation of the PERK/ATF4/LAMP3-arm of the unfolded protein response in head and neck squamous cell carcinoma

(2014) Anika Nagelkerke et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of ER stress–associated IRE-1/XBP-1 pathway reduces leukemic cell survival

(2014) Chih-Hang Anthony Tang et al.   JOURNAL OF CLINICAL INVESTIGATION

VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress

(2014) Evdoxia Karali et al.   MOLECULAR CELL

A Novel ER Stress-Independent Function of the UPR in Angiogenesis

(2014) Hery Urra et al.   MOLECULAR CELL

XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

(2014) Xi Chen et al.   NATURE

Immature truncated O-glycophenotype of cancer directly induces oncogenic features

(2014) Prakash Radhakrishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X Box-Binding Protein 1 Regulates Angiogenesis in Human Pancreatic Adenocarcinomas

(2014) Lorenzo Romero-Ramirez et al.   Translational Oncology

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

Altered Tumor-Cell Glycosylation Promotes Metastasis

(2014) Irina Häuselmann et al.   Frontiers in Oncology

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulatory crosstalk within the mammalian unfolded protein response

(2013) Joseph W. Brewer   CELLULAR AND MOLECULAR LIFE SCIENCES

ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage

(2013) Feng-Jin Guo et al.   CELLULAR SIGNALLING

Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress

(2013) Kwang Hong Tay et al.   CELLULAR SIGNALLING

Hypoxic Activation of the PERK/eIF2  Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

(2013) H. Mujcic et al.   CLINICAL CANCER RESEARCH

ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51

(2013) Tohru Yamamori et al.   FEBS LETTERS

Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)

(2013) Ethel R. Pereira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

(2013) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two phases of disulfide bond formation have differing requirements for oxygen

(2013) Marianne Koritzinsky et al.   JOURNAL OF CELL BIOLOGY

Oncogenic Activation of MEK/ERK Primes Melanoma Cells for Adaptation to Endoplasmic Reticulum Stress

(2013) Amanda Croft et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

(2013) F. Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PERK/eIF2  signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

(2013) K. M. Rouschop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response

(2013) Anika Nagelkerke et al.   RADIOTHERAPY AND ONCOLOGY

Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival

(2012) Luke R. G. Pike et al.   BIOCHEMICAL JOURNAL

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

(2012) Y. Wang et al.   CANCER RESEARCH

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

O-Linked β-N-Acetylglucosaminylation (O-GlcNAcylation) in Primary and Metastatic Colorectal Cancer Clones and Effect ofN-Acetyl-β-d-glucosaminidase Silencing on Cell Phenotype and Transcriptome

(2012) Galit Yehezkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role ofO-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis

(2012) Thomas P. Lynch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autocrine control of glioma cells adhesion and migration through IRE1 -mediated cleavage of SPARC mRNA

(2012) N. Dejeans et al.   JOURNAL OF CELL SCIENCE

ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

(2012) Lori S. Hart et al.   JOURNAL OF CLINICAL INVESTIGATION

O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy

(2011) Wenyi Mi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation

(2011) Qianqian Zhu et al.   MEDICAL ONCOLOGY

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

(2011) N. R. Mahadevan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis

(2010) Y. Gu et al.   CANCER RESEARCH

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition

(2010) Sang Yoon Park et al.   EMBO JOURNAL

Aberrant O-GlcNAcylation characterizes chronic lymphocytic leukemia

(2010) Y Shi et al.   LEUKEMIA

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Transcriptional Regulation of VEGF-A by the Unfolded Protein Response Pathway

(2010) Rajarshi Ghosh et al.   PLoS One

Inositol-requiring enzyme 1  is a key regulator of angiogenesis and invasion in malignant glioma

(2010) G. Auf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Elevated ATF4 Expression, in the Absence of Other Signals, Is Sufficient for Transcriptional Induction via CCAAT Enhancer-binding Protein-activating Transcription Factor Response Elements

(2009) Jixiu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

(2009) Kasper M.A. Rouschop et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3

(2009) Hilda Mujcic et al.   RADIOTHERAPY AND ONCOLOGY

Phosphorylation of eIF2α in response to 26S proteasome inhibition is mediated by the haem-regulated inhibitor (HRI) kinase

(2008) Azmi Yerlikaya et al.   BIOCHEMICAL JOURNAL

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

(2008) Yusuke Adachi et al.   CELL STRUCTURE AND FUNCTION

Is cancer a disease of abnormal cellular metabolism? New angles on an old idea

(2008) Ralph J Deberardinis   GENETICS IN MEDICINE

Cytokine-based transformation of immune surveillance into tumor-promoting inflammation

(2008) J B Mumm et al.   ONCOGENE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA