Article
Chemistry, Multidisciplinary
Anqi Yang, Xiang Lin, Zijian Liu, Xin Duan, Yurou Yuan, Jiaxuan Zhang, Qilin Liang, Xianglin Ji, Nannan Sun, Huajun Yu, Weiwei He, Lili Zhu, Bingzhe Xu, Xudong Lin
Summary: A novel in vivo screening strategy combining hierarchically structured biohybrid triboelectric nano-generators (HB-TENGs) arrays with computational bioinformatics analysis for high-throughput pharmacological evaluation using Caenorhabditis elegans is described. The animals' behaviors are efficiently converted into friction deformation through HB-TENGs, and the resulting triboelectric signals are extracted for various bioinformation of the screened compounds. The information-rich electrical readouts are sufficient to predict a drug's identity by multiple-Gaussian-kernels-based machine learning methods.
Article
Food Science & Technology
WenFeng Shi, HaoXue Zheng, Jing Ming, BiSheng Huang, YuJie Guo, Yan Cao
Summary: The study reveals that Folium Nelumbinis extract has potential neuroprotective effects and can simultaneously target amyloid-beta and acetylcholinesterase, effectively delaying disease progression. The screening of individual components further elucidates the underlying mechanisms. These findings are of great significance in promoting health and preventing Alzheimer's disease.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Environmental Sciences
Jiaying Wu, Yue Gao, Jing Xi, Xinyue You, Xiaohong Zhang, Xinyu Zhang, Yiyi Cao, Peichuan Liu, Xiang Chen, Yang Luan
Summary: In this study, an automated and highly-integrated platform was developed for high-throughput and in situ toxicity testing using Caenorhabditis elegans. The platform combines various modules and devices to achieve efficient worm dispensing, long-term maintenance, toxicity monitoring, imaging, and behavioral analysis. It also enables remote operation and phenotype calculation through connection to the web.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Nutrition & Dietetics
Bipasha Chakravarty
Summary: This article highlights the scope and relevance of using the nematode Caenorhabditis elegans for advancing human nutrition and health studies, providing a simple tool to investigate the nutritional problems facing the world today.
NUTRITION RESEARCH
(2022)
Review
Food Science & Technology
Xu Wang, Guohua Shi, Sufang Fan, Junmei Ma, Yonghuan Yan, Mengtian Wang, Xiaozhi Tang, Pin Lv, Yan Zhang
Summary: With the high incidence of chronic diseases, precise nutrition is a safe and efficient nutritional intervention method to improve human health. Food functional ingredients can be delivered through targeted delivery systems to enhance their bioavailability and provide a controlled release at the targeted action sites in vivo, enabling precise nutritional intervention for various diseases. Recent studies have demonstrated the success of targeted delivery systems for food functional ingredients in the management of inflammatory bowel disease, liver disease, obesity, and cancer.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Yonglu Li, Ping Li, Weixi Zhang, Xiaodong Zheng, Qing Gu
Summary: This review summarizes the research progress of C. elegans models in food toxicology and food function evaluation over the past two decades. The construction methods of C. elegans models are systematically categorized and the applications in food toxicology, such as microbial contamination, food additives, pesticide residues, heavy metals, food packaging, and physical pollution, are summarized. The use of C. elegans models for functional food assessments, including antioxidant, anti-aging, anti-obesity, anti-glucotoxicity, anti-neurodegenerative, and immunoregulation properties are exemplified. The review also discusses the research gaps and future directions in nematode model exploration and multi-model cooperation in food science.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Agricultural Engineering
Sunah Kim, Hidehiro Ishizawa, Daisuke Inoue, Tadashi Toyama, Jaecheul Yu, Kazuhiro Mori, Michihiko Ike, Taeho Lee
Summary: This study reviews the generation and disposal of food processing byproducts (FPBs). The transformation of FPBs into microalgae cultivation can lead to high-value food ingredient production, while reducing costs and increasing productivity. Despite remaining challenges, the microalgal transformation of FPBs shows economic viability and environmental sustainability.
BIORESOURCE TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Brandon M. Murareanu, Noelle Antao, Winnie Zhao, Aurore Dubuffet, Hicham El Alaoui, Jessica Knox, Damian C. Ekiert, Gira Bhabha, Peter J. Roy, Aaron W. Reinke
Summary: In this study, a high-throughput screening method was developed to identify chemical inhibitors of microsporidia infection. Through experiments on Caenorhabditis elegans, 11 potential microsporidia inhibitors were identified, among which five compounds prevent microsporidia infection by inhibiting spore firing.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Xin Zheng, Pei Pu, Botian Ding, Weichen Bo, Dongya Qin, Guizhao Liang
Summary: This study used molecular docking and spectroscopic experiments to screen natural products that can inhibit thrombin and elucidate their interaction mechanism. Some compounds showed effective inhibition, with Van der Waals force playing a key role in driving the interaction.
Article
Biochemistry & Molecular Biology
Sabya Sachi Das, Arunabh Sarkar, Siva Chander Chabattula, Priya Ranjan Prasad Verma, Aamir Nazir, Piyush Kumar Gupta, Janne Ruokolainen, Kavindra Kumar Kesari, Sandeep Kumar Singh
Summary: The developed nanoemulsion system loaded with nanosized food-grade quercetin (QNE) showed significant neuroprotective and cytotoxic effects against Parkinson's disease and human cancer cells, respectively.
Review
Food Science & Technology
Emanuele Zannini, Angela Bravo Nunez, Aylin W. Sahin, Elke K. Arendt
Summary: This article discusses the health benefits and structure of arabinoxylan, a complex fiber found in grains like wheat, barley, and corn. The source and extraction process of arabinoxylan can affect its structure, and further investigation is needed to understand its pure ingredient's benefits on human health. The article also highlights the relationship between arabinoxylan's structure and its functionality in cereal products and emphasizes the importance of studying its health implications in arabinoxylan-rich products.
Review
Cell Biology
Yuting Wang, Wei Wu, Jianke Gong
Summary: Micronutrients have a strong relationship with cell death and play a crucial role in maintaining human body health. Dysregulation of micronutrients can lead to various metabolic or chronic diseases such as obesity, cardiometabolic conditions, neurodegeneration, and cancer. The nematode Caenorhabditis elegans offers a valuable genetic model for studying the effects of micronutrients on metabolism, healthspan, and lifespan. Moreover, its characteristics like specific haem trafficking pathway and ease of studying different forms of cell death make it an excellent tool for understanding the underlying mechanisms. A comprehensive understanding of micronutrient metabolism and cell death not only helps in developing better treatments for micronutrient disorders but also provides insights into human health and aging.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Food Science & Technology
Yanan Wang, Jiachen Shi, Kun Liu, Yu Wang, Yongjiang Xu, Yuanfa Liu
Summary: This study investigated the effects of different edible oils on the aging process and lifespan of Caenorhabditis elegans. The results showed that teaseed oil (TO) could prolong lifespan and slow down aging by regulating lipid metabolism. Furthermore, there were significant differences in gene expression levels and metabolites between the control group and the TO group.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Biotechnology & Applied Microbiology
Sabrina Picciotto, Pamela Santonicola, Angela Paterna, Estella Rao, Samuele Raccosta, Daniele Paolo Romancino, Rosina Noto, Nicolas Touzet, Mauro Manno, Elia Di Schiavi, Antonella Bongiovanni, Giorgia Adamo
Summary: Extracellular vesicles (EVs) are lipid membrane nano-sized vesicles secreted by various cell types for intercellular communication. Nanoalgosomes, a subtype of EVs derived from microalgae, show potential as nanocarriers of bioactive compounds. In this study, it was found that nanoalgosomes can be actively uptaken in vitro by human cells and in vivo by C. elegans cells, offering potential applications for theranostics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Acoustics
Quanxiang Xian, Zhihai Qiu, Shashwati Kala, Kin Fung Wong, Jinghui Guo, Lei Sun
Summary: Ultrasound brain stimulation shows promising effects in activating neuronal activity and modifying behavior in Caenorhabditis elegans, suggesting its potential for probing brain function and treating brain diseases.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Review
Food Science & Technology
Peiling Yan, Weiqing Lan, Jing Xie
Summary: Sodium alginate (SA) is an important marine polysaccharide that has extensive applications in food preservation and quality maintenance. Modification methods can be used to improve the properties of SA and make it compatible with other materials. Solvent-casting films and gels are common methods for using modified SA in food preservation.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)
Article
Food Science & Technology
Zhihui Yu, Yating Gao, Xinyi Jia, Shuai Cui, Li Ma, Dan Zheng, Xin Li, Long Li, Lixin Zhang, Yisheng Chen
Summary: This review provides a new perspective on the state-of-the-art research and application of high-intensity ultrasound (HIU) for modifying blue food proteins (BFPs). The effects of HIU treatment on the functional properties and structural composition of BFPs are comprehensively evaluated.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)
Review
Food Science & Technology
Honghong Zhang, Haoran Fan, Xueming Xu, Dan Xu
Summary: This review provides a comprehensive summary of changes in different components in frozen dough, including starch, gluten protein, lipid, and yeast, from a multiscale perspective. The methods of improving the production process of frozen dough, from main materials to end products, have been discussed. Key findings include the use of high gluten strength wheat flour and composite flour with high dietary fiber to improve the freezing resistance of gluten-starch matrix, as well as various methods to improve yeast freeze tolerance and the effects of different freezing rates.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)
Article
Food Science & Technology
Junhua Xie, Qiqiong Li, Shaoping Nie
Summary: This review provides an overview of bEVs' biology, evidence for their health benefits, and possible molecular pathways involved in their health-promoting effects, as well as perspectives for applications in foods and pharmaceuticals.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)
Article
Food Science & Technology
Jose Bueno-Mancebo, Adriana Artola, Raquel Barrena, Fernando Rivero-Pino
Summary: This review provides an overview of the characterization, production, and applications of sophorolipids (SLs) in the food industry. SLs exhibit bioactivity and environmental friendliness, making them suitable for various applications in food packaging, agriculture, and other areas. The importance of SLs in the context of the One Health approach is emphasized.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)
Letter
Food Science & Technology
Saurabh Singh
Summary: This paper is interesting and relevant to determining the moisture content of food products. However, it lacks the classification of oven drying methods, which are cost-effective and important for drying solids and semisolids.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)
Article
Food Science & Technology
Yong Cheng, Beijun Ang, Chaoyi Xue, Zhenyu Wang, Liduan Yin, Tong Wang, Qiuming Chen, Zhaojun Wang, Maomao Zeng, Wei Zhang, Jie Chen, Zhiyong He
Summary: Pollen fermentation can improve its nutrient profile, degrade allergenic compounds, enhance bioavailability, and promote gut health. Pollen can serve key roles in fermented food production and create opportunities for innovative product development. However, quality and safety considerations are important in pollen fermentation.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)
Review
Food Science & Technology
Fanghua Guo, Fereidoon Shahidi
Summary: This contribution summarizes the potential of anthocyanins as alternatives to antibiotics, focusing on their anti-oxidation, anti-inflammation, absorption, metabolism, antibacterial effects, and the possible mechanisms behind these effects. The use of encapsulation to improve stability and bioavailability of anthocyanins, as well as targeted delivery to the lower digestive tract, shows promise in replacing antibiotics. However, more in vivo studies are needed to further support these findings.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)
Article
Food Science & Technology
Muhammad Rehan Khan, Elena Torrieri, Florent Allais, Sami Fadlallah
Summary: This opinion paper explores the potential of integrating synthetic biology into microbial polymers to produce tailored biopolymers for food packaging applications. By leveraging synthetic biology tools and adopting safety assessment protocols established within the regulatory framework, this innovative approach has the potential to not only replace conventional methods but also address environmental concerns associated with traditional food packaging.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2024)