Article
Environmental Sciences
Parastoo Razmara, Jacob J. Imbery, Emily Koide, Caren C. Helbing, Steve B. Wiseman, Patrick T. Gauthier, Douglas F. Bray, Maurice Needham, Travis Haight, Athanasios Zovoilis, Gregory G. Pyle
Summary: The study found that CuNPs are bioavailable to olfactory mucosal cells and have different effects on rainbow trout compared to Cu2+. RNA-seq analysis revealed distinct mechanisms of action between the two contaminants, with CuNPs affecting olfactory signal transduction, calcium homeostasis, and synaptic vesicular signaling in OSNs. CuNPs also impacted neuroregenerative pathways and suppressed inflammatory signaling, without inducing oxidative stress or apoptosis.
ENVIRONMENTAL POLLUTION
(2021)
Editorial Material
Biochemistry & Molecular Biology
Anita V. Devineni
Summary: A recent study has uncovered a novel form of crosstalk between olfactory pathways in the antennal lobe of the fly brain. This crosstalk has the ability to reshape odor coding and potentially explain why carbon dioxide can elicit both attraction and aversion.
Article
Behavioral Sciences
Hiroyuki Ikushima, Jun Suzuki, Tomotaka Hemmi, Ryoukichi Ikeda, Yuta Kobayashi, Nobuo Ohta, Yukio Katori
Summary: This study used a severe zinc deficiency mouse model to investigate the effects of zinc deficiency on olfactory epithelium regeneration. Zinc deficiency resulted in a decrease in the thickness of the regenerated olfactory epithelium and a failure to increase the numbers of proliferating cells, immature olfactory neurons, and mature olfactory neurons at some time points. Furthermore, RNA sequencing revealed changes in gene expression, such as a decrease in the expression of extracellular matrix-related genes and an increase in that of inflammatory response-related genes, in the zinc-deficient group.
Article
Environmental Sciences
Yun Wang, Haifeng Duan, Jing Zhang, Qingyuan Wang, Tuo Peng, Xujun Ye, Zhenshun Cheng, Xinyi Li
Summary: This study investigates the role of Yes-associated protein 1 (YAP1) in ferroptosis and pyroptosis, as well as its therapeutic potential in PM2.5-induced lung toxicity. The findings suggest that YAP1 deficiency aggravates lung damage caused by PM2.5, while YAP1 overexpression protects lung cells by inhibiting pyroptosis and ferroptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Xuxian Su, Bin Liu, Wen-Jin Wang, Kun Peng, Bing-Bing Liang, Yue Zheng, Qian Cao, Zong-Wan Mao
Summary: This study developed a novel cyclometalated Pt-IV-terthiophene complex, Pt3, that disrupts zinc homeostasis and induces cell apoptosis, thereby activating anti-tumor immunity and eliminating tumors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Dania Jundi, Jean-Pierre Coutanceau, Erika Bullier, Soumaiya Imarraine, Ziad Fajloun, Elim Hong
Summary: The expression of olfactory receptor (OR) genes in non-olfactory tissues has been found in rodents and humans, with over 400 genes in humans and 1000 in rodents. Zebrafish have around 140 OR genes, with 31 genes expressed in various tissues, showing conservation of expression in non-olfactory tissues across vertebrates.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Dania Jundi, Jean-Pierre Coutanceau, Erika Bullier, Soumaiya Imarraine, Ziad Fajloun, Elim Hong
Summary: This study identified the expression of 31 out of 36 olfactory receptor (OR) genes in various tissues in zebrafish larvae, including trunk, pharynx, pancreas, and brain; furthermore, some OR genes exhibited dynamic temporal expression patterns in specific brain regions across different developmental stages of zebrafish, such as the hypothalamus and the habenula.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Guangchan Jing, Huanyuan Wang, Fengwei Nan, Yuqin Liu, Mengren Zhang
Summary: The study demonstrated that Naofucong can inhibit neuronal injury induced by high glucose in HT22 hippocampal neurons, decrease apoptosis, IL-1 beta and IL-18 levels, and suppress NLRP1/caspase-1 mediated neuronal injury with the involvement of P2X7.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Sho Kurihara, Masayoshi Tei, Junichi Hata, Eri Mori, Masato Fujioka, Yoshinori Matsuwaki, Nobuyoshi Otori, Hiromi Kojima, Hirotaka James Okano
Summary: Combined high-field MRI and DTI analyses allow visualization of olfactory sensory neurons and their projections, providing olfactory nerve maps in humans, marmosets, and mice. This technique has the potential to be used clinically for the diagnosis of olfactory dysfunction.
COMMUNICATIONS BIOLOGY
(2022)
Article
Environmental Sciences
Xingyao Pei, Dingkuo Liu, Jianjun Li, Liuan Li, Xiangbin Ding, Wenjuan Zhang, Zibin Li, Gang Xu, Cun Li, Daowen Li
Summary: This study investigates the hepatotoxic mechanism of ZnO NPs and reveals the crosstalk between autophagy and pyroptosis. The findings suggest that autophagy serves as a protective response against pyroptosis induced by ZnO NPs, and the regulation of autophagy and lysosome by TFEB can alleviate the pyroptosis. This study provides new insights for the risk assessment and therapeutic strategy of ZnO NPs-induced pyroptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Nutrition & Dietetics
Francesco Piacenza, Robertina Giacconi, Laura Costarelli, Marco Malavolta
Summary: This preliminary study investigated the fractional Zn absorption (FZA) after the supplementation of three different Zn complexes on eight healthy volunteers. The results showed that the FZA of Zn-Aspartate was significantly higher than other forms of Zn, and the FZA of Zn-Gluconate was significantly higher than ZnSO4. These results suggest that using Zn-Aspartate in individuals at risk of Zn deficiency could improve the Zn absorption rate.
Article
Environmental Sciences
Juan Li, Zhen An, Jie Song, Jinge Du, Lin Zhang, Jing Jiang, Yanmei Ma, Chunzhi Wang, Jingfang Zhang, Weidong Wu
Summary: Exposure to ambient air-borne fine particulate matter (PM2.5) increases respiratory morbidity and mortality. This study uncovered the molecular mechanisms of PM2.5-induced lung toxicity using a mouse model, showing that inhibition of the NALRP3/Caspase-1 signaling pathway ameliorated PM2.5-induced lung injury and inflammation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Neurosciences
Milos Bogdanovic, Hila Asraf, Noa Gottesman, Israel Sekler, Elias Aizenman, Michal Hershfinkel
Summary: Tight regulation of neuronal Zn2+ is critical for physiological function. Multiple Zn2+ transporters, such as ZIP1 and ZIP3, are involved in the uptake and distribution of Zn2+. In this study, we found that the expression of ZIP1 and ZIP3 was developmentally regulated in mouse hippocampal neurons, with higher levels of expression in mature neurons. ZIP1 and ZIP3 were ubiquitously expressed on somas and most neuronal processes in cultured neurons, while in adult mouse hippocampal brain, ZIP1 was predominantly expressed in the CA3 stratum pyramidale, and ZIP3 primarily localized in the stratum lucidum. Silencing of ZIP1 or ZIP3 reduced Zn2+ uptake in vitro, and silencing of ZIP3 protected CA3 neurons from neurodegeneration following seizures in vivo. These findings suggest that distinct Zn2+ transporters play different roles in regulating Zn2+ accumulation and toxicity in different neuronal populations in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Energy & Fuels
Gaigai Duan, Junlei Xiao, Lian Chen, Chunmei Zhang, Shaoju Jian, Shuijian He, Feng Wang
Summary: In this study, a strategy of activated zinc gluconate was proposed to prepare porous carbon with different pore structures. The obtained ZnPCK-3 electrode showed excellent rate performance and cycling stability, thereby providing emerging chances for rational commercial-level design for high performance supercapacitor.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Multidisciplinary Sciences
Carl E. Schoonover, Sarah N. Ohashi, Richard Axel, Andrew J. P. Fink
Summary: The study found that although activity in the primary olfactory cortex could discriminate between odorants at any time, the odor-evoked responses drifted over days to weeks. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This instability may be related to the unstructured connectivity of the piriform cortex.
Meeting Abstract
Rheumatology
D. Choubey
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Article
Pharmacology & Pharmacy
Ravichandran Panchanathan, Hongzhu Liu, Divaker Choubey
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2015)
Letter
Immunology
Divaker Choubey, Ravichandran Panchanathan
JOURNAL OF IMMUNOLOGY
(2015)
Article
Cell Biology
Ravichandran Panchanathan, Hongzhu Liu, Yuet-Kin Leung, Shuk-mei Ho, Divaker Choubey
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2015)
Article
Toxicology
Tilak Khanal, Dasom Kim, Abby Johnson, Divaker Choubey, Kyounghyun Kim
TOXICOLOGY LETTERS
(2015)
Review
Cell Biology
Divaker Choubey, Ravichandran Panchanathan
AGEING RESEARCH REVIEWS
(2016)
Review
Biochemistry & Molecular Biology
Divaker Choubey
CELLULAR AND MOLECULAR LIFE SCIENCES
(2016)
Article
Oncology
Ravichandran Panchanathan, Hongzhu Liu, Divaker Choubey
Article
Biochemistry & Molecular Biology
Ravichandran Panchanathan, Hongzhu Liu, Duan Xin, Divaker Choubey
Article
Oncology
Larissa Ponomareva, Hongzhu Liu, Xin Duan, Eric Dickerson, Hui Shen, Ravichandran Panchanathan, Divaker Choubey
MOLECULAR CANCER RESEARCH
(2013)
Review
Rheumatology
Grant C. Hughes, Divaker Choubey
NATURE REVIEWS RHEUMATOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Divaker Choubey, Ravichandran Panchanathan
Review
Immunology
Divaker Choubey
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Immunology
Divaker Choubey, Ravichandran Panchanathan
CLINICAL IMMUNOLOGY
(2017)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)