Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts

Drug-induced mitochondrial dysfunction and cardiotoxicity

(2015) Zoltán V Varga et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reductive potential — A savior turns stressor in protein aggregation cardiomyopathy

(2015) Madhusudhanan Narasimhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

(2014) Susan P. C. Cole   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca 2+ Regulation by Distinct Mechanisms

(2014) Guo Yin et al.   Journal of the American Heart Association

Targeting Multidrug Resistance Protein 1 (MRP1, ABCC1): Past, Present, and Future

(2013) Susan P.C. Cole   Annual Review of Pharmacology and Toxicology

Glutathione depletion regulates both extrinsic and intrinsic apoptotic signaling cascades independent from multidrug resistance protein 1

(2013) Rodrigo Franco et al.   APOPTOSIS

Reductive Stress Linked to Small HSPs, G6PD, and Nrf2 Pathways in Heart Disease

(2012) Alison C. Brewer et al.   ANTIOXIDANTS & REDOX SIGNALING

Cardiomyocyte-restricted overexpression of extracellular superoxide dismutase increases nitric oxide bioavailability and reduces infarct size after ischemia/reperfusion

(2012) Detlef Obal et al.   BASIC RESEARCH IN CARDIOLOGY

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

(2012) Yanti Octavia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux

(2012) Parameswaran G. Sreekumar et al.   PLoS One

ABCC1polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia

(2011) Agnes F. Semsei et al.   CELL BIOLOGY INTERNATIONAL

Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

(2011) Huali Zhang et al.   FASEB JOURNAL

Nitric Oxide Storage and Transport in Cells Are Mediated by GlutathioneS-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes

(2011) Hiu Chuen Lok et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

(2011) Markus Krohn et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacogenomic Prediction of Anthracycline-Induced Cardiotoxicity in Children

(2011) Henk Visscher et al.   JOURNAL OF CLINICAL ONCOLOGY

In Vitro Effects of Pirfenidone on Cardiac Fibroblasts: Proliferation, Myofibroblast Differentiation, Migration and Cytokine Secretion

(2011) Qiang Shi et al.   PLoS One

Characterization of apical and basal thiol-disulfide redox regulation in human colonic epithelial cells

(2010) Yanci O. Mannery et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice

(2010) Namakkal Soorappan Rajasekaran et al.   ANTIOXIDANTS & REDOX SIGNALING

Involvement of Reductive Stress in the Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Heat Shock Protein 27

(2010) Xia Zhang et al.   HYPERTENSION

Enhanced toxicity and ROS generation by doxorubicin in primary cultures of cardiomyocytes from neonatal metallothionein-I/II null mice

(2010) Ze Fu et al.   TOXICOLOGY IN VITRO

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

(2009) Yi-Wei Zhang et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Cardiac Fibroblast

(2009) Colby A. Souders et al.   CIRCULATION RESEARCH

Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis

(2009) Areeg Faggad et al.   HISTOPATHOLOGY

Extracellular superoxide dismutase regulates cardiac function and fibrosis

(2009) Corrine R. Kliment et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells

(2008) Magdalena L. Circu et al.   BIOCHEMICAL PHARMACOLOGY

Glutathione and apoptosis

(2008) Magdalena L. Circu et al.   FREE RADICAL RESEARCH

Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase

(2008) Christopher C. Franklin et al.   MOLECULAR ASPECTS OF MEDICINE