Minipigs in Translational Immunosafety Sciences

The IL‐33/ST2 axis is specifically required for development of adipose tissue‐resident regulatory T cells

(2015) Zhi‐Qing Hu et al.   Cellular & Molecular Immunology

Natural and inducible Tregs in swine: Helios expression and functional properties

(2015) Tobias Käser et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets

(2015) Hana Potockova et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Human Microbiota-Associated Swine: Current Progress and Future Opportunities

(2015) M. Wang et al.   ILAR JOURNAL

Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation

(2015) Ari B. Molofsky et al.   IMMUNITY

Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences

(2015) Olav Sundnes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phenotypic and functional differentiation of porcine αβ T cells: Current knowledge and available tools

(2015) Wilhelm Gerner et al.   MOLECULAR IMMUNOLOGY

Evidence for a common mucosal immune system in the pig

(2015) Heather L. Wilson et al.   MOLECULAR IMMUNOLOGY

Special issue on non-rodent animal models for immunology research: What can we learn from large animals?

(2015) Maria Montoya et al.   MOLECULAR IMMUNOLOGY

The immunology of the porcine skin and its value as a model for human skin

(2015) Artur Summerfield et al.   MOLECULAR IMMUNOLOGY

Defining Mononuclear Phagocyte Subset Homology Across Several Distant Warm-Blooded Vertebrates Through Comparative Transcriptomics

(2015) Thien-Phong Vu Manh et al.   Frontiers in Immunology

A Hitchhiker’s Guide to Myeloid Cell Subsets: Practical Implementation of a Novel Mononuclear Phagocyte Classification System

(2015) Martin Guilliams et al.   Frontiers in Immunology

Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions

(2015) Thien-Phong Vu Manh et al.   Frontiers in Immunology

Maintenance of Immune Homeostasis through ILC/T Cell Interactions

(2015) Nicole von Burg et al.   Frontiers in Immunology

Efficacy of the porcine species in biomedical research

(2015) Karina Gutierrez et al.   Frontiers in Genetics

Monocyte subsets in man and other species

(2014) Loems Ziegler-Heitbrock   CELLULAR IMMUNOLOGY

CD2 and CD8α define porcine γδ T cells with distinct cytokine production profiles

(2014) Corinna Sedlak et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The porcine innate immune system: An update

(2014) K.H. Mair et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

tTregs, pTregs, and iTregs: similarities and differences

(2014) Ethan M. Shevach et al.   IMMUNOLOGICAL REVIEWS

Pig Skin Includes Dendritic Cell Subsets Transcriptomically Related to Human CD1a and CD14 Dendritic Cells Presenting Different Migrating Behaviors and T Cell Activation Capacities

(2014) Florian Marquet et al.   JOURNAL OF IMMUNOLOGY

The alarmin IL-33 promotes regulatory T-cell function in the intestine

(2014) Chris Schiering et al.   NATURE

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

The peripheral blood transcriptome reflects variations in immunity traits in swine: towards the identification of biomarkers

(2013) Núria Mach et al.   BMC GENOMICS

Structural and functional annotation of the porcine immunome

(2013) Harry D Dawson et al.   BMC GENOMICS

Antigen targeting to APC: From mice to veterinary species

(2013) B. Alvarez et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Phenotypic maturation of porcine NK- and T-cell subsets

(2013) Stephanie C. Talker et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Comparative Analysis of Monocyte Subsets in the Pig

(2013) L. Fairbairn et al.   JOURNAL OF IMMUNOLOGY

Characterization of the T-dependent antibody response (TDAR) to keyhole limpet hemocyanin (KLH) in the Göttingen minipig

(2013) Vanessa L. Peachee et al.   Journal of Immunotoxicology

The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab

(2013) Geertje J. D. van Mierlo et al.   Journal of Immunotoxicology

Use of pigs as a potential model for research into dietary modulation of the human gut microbiota

(2013) Sonja N. Heinritz et al.   NUTRITION RESEARCH REVIEWS

Minipig and beagle animal model genomes aid species selection in pharmaceutical discovery and development

(2013) Jessica J. Vamathevan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Comparative Biology of γδ T Cell Function in Humans, Mice, and Domestic Animals

(2013) Jeff Holderness et al.   Annual Review of Animal Biosciences

Different anti-CD21 antibodies can be used to discriminate developmentally and functionally different subsets of B lymphocytes in circulation of pigs

(2012) Marek Sinkora et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Animal models of toxicology testing: the role of pigs

(2012) Kristi L Helke et al.   Expert Opinion on Drug Metabolism & Toxicology

The Göttingen minipig®as an alternative non-rodent species for immunogenicity testing: A demonstrator study using the IL-1 receptor antagonist anakinra

(2012) Geertje J. D. van Mierlo et al.   Journal of Immunotoxicology

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

(2012) Yanan Zheng et al.   mAbs

The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease

(2011) Lynsey Fairbairn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The pig: a model for human infectious diseases

(2011) François Meurens et al.   TRENDS IN MICROBIOLOGY

Swine as Models in Biomedical Research and Toxicology Testing

(2011) M. M. Swindle et al.   VETERINARY PATHOLOGY

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

Immunophenotyping of lymphocyte, monocyte and dendritic cell subsets in normal rhesus macaques by 12-color flow cytometry: Clarification on DC heterogeneity

(2010) Patrick Autissier et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Acute Lymphoid and Gastrointestinal Toxicity Induced by Selective p38α Map Kinase and Map Kinase–Activated Protein Kinase-2 (MK2) Inhibitors in the Dog

(2010) Dale L. Morris et al.   TOXICOLOGIC PATHOLOGY

The RETHINK project

(2010) Roy Forster et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The minipig as a platform for new technologies in toxicology

(2010) Roy Forster et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The utility of the minipig as an animal model in regulatory toxicology

(2010) Gerd Bode et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Comparison of gene expression profiles between human and mouse monocyte subsets

(2009) M. A. Ingersoll et al.   BLOOD

Molecular genetics of the swine major histocompatibility complex, the SLA complex

(2008) Joan K. Lunney et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Anatomical particularities of the porcine immune system—A physician's view

(2008) Hermann-Josef Rothkötter   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Immunoglobulins, antibody repertoire and B cell development

(2008) J.E. Butler et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Targeting the porcine immune system—Particulate vaccines in the 21st century

(2008) Kenneth C. McCullough et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Porcine host defense peptides: Expanding repertoire and functions

(2008) Yongming Sang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Porcine T lymphocytes and NK cells – An update

(2008) Wilhelm Gerner et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

The piglet as a model for B cell and immune system development

(2008) J.E. Butler et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Membrane markers of the immune cells in swine: an update

(2008) Laurence Piriou-Guzylack et al.   VETERINARY RESEARCH