Redefining critical illness

Clinical trial design during and beyond the pandemic: the I-SPY COVID trial

(2022) et al.   NATURE MEDICINE

Whole genome sequencing reveals host factors underlying critical Covid-19

(2022) Athanasios Kousathanas et al.   NATURE

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

(2021)   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19

(2021)   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Patterns in Acute Pancreatitis Reflect Generalizable Endotypes of the Host Response to Systemic Injury in Humans

(2020) Lucile P. A. Neyton et al.   ANNALS OF SURGERY

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

(2020) Jeong Seok Lee et al.   Science Immunology

Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

(2020) Timothy E. Sweeney et al.   CRITICAL CARE MEDICINE

Genetic mechanisms of critical illness in Covid-19

(2020) Erola Pairo-Castineira et al.   NATURE

Acute respiratory distress syndrome

(2019) Michael A. Matthay et al.   Nature Reviews Disease Primers

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

(2019) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Population enrichment for critical care trials

(2019) Manu Shankar-Hari et al.   Current Opinion in Critical Care

Host-Response Subphenotypes Offer Prognostic Enrichment in Patients With or at Risk for Acute Respiratory Distress Syndrome*

(2019) Georgios D. Kitsios et al.   CRITICAL CARE MEDICINE

Emerging trends in the treatment of advanced basal cell carcinoma

(2018) Michael R. Migden et al.   CANCER TREATMENT REVIEWS

Unsupervised Analysis of Transcriptomics in Bacterial Sepsis Across Multiple Datasets Reveals Three Robust Clusters

(2018) Timothy E. Sweeney et al.   CRITICAL CARE MEDICINE

Outcomes of critical illness

(2018) Ognjen Gajic et al.   Current Opinion in Critical Care

Current Status and Future Opportunities in Lung Precision Medicine Research with a Focus on Biomarkers. An American Thoracic Society/National Heart, Lung, and Blood Institute Research Statement

(2018) Ann Chen Wu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids: From the VANISH Randomized Trial

(2018) David B Antcliffe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS

(2018) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level

(2018) R. Phillip Dellinger et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Mendelian Randomization

(2017) Connor A. Emdin et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study

(2017) Brendon P Scicluna et al.   Lancet Respiratory Medicine

ARDS Subphenotypes Respond Differently to Randomized Fluid Management Strategy

(2016) Katie R Famous et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Opening theDebate on theNewSepsisDefinition. Precision Medicine: An Opportunity to Improve Outcomes of Patients with Sepsis

(2016) Carolyn S. Calfee   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design

(2016) Hallie C. Prescott et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Combining Prognostic and Predictive Enrichment Strategies to Identify Children With Septic Shock Responsive to Corticosteroids*

(2016) Hector R. Wong et al.   CRITICAL CARE MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adaptive Randomization of Neratinib in Early Breast Cancer

(2016) John W. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Developing a Clinically Feasible Personalized Medicine Approach to Pediatric Septic Shock

(2015) Hector R. Wong et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Distinct Molecular Phenotypes of Direct vs Indirect ARDS in Single-Center and Multicenter Studies

(2015) Carolyn S. Calfee et al.   CHEST

The Platform Trial

(2015) Scott M. Berry et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Human Genome Project: Twenty-five years of big biology

(2015) Eric D. Green et al.   NATURE

Fluorescence Immunophenotyping and Interphase Cytogenetics (FICTION) DetectsBCL6Abnormalities, Including Gene Amplification, in Most Cases of Nodular Lymphocyte-Predominant Hodgkin Lymphoma

(2014) Alexei G. Bakhirev et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Gene expression profiling in sepsis: timing, tissue, and translational considerations

(2014) David M. Maslove et al.   TRENDS IN MOLECULAR MEDICINE

Why have clinical trials in sepsis failed?

(2014) John C. Marshall   TRENDS IN MOLECULAR MEDICINE

Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes

(2014) Sarah Kim et al.   Nature Communications

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials

(2014) Carolyn S Calfee et al.   Lancet Respiratory Medicine

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective

(2013) Syed S Mahmood et al.   LANCET

The PIRO (predisposition, insult, response, organ dysfunction) model

(2013) John C Marshall   Virulence

Validation of a gene expression-based subclassification strategy for pediatric septic shock*

(2011) Hector R. Wong et al.   CRITICAL CARE MEDICINE

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toward a clinically feasible gene expression-based subclassification strategy for septic shock: Proof of concept

(2010) Hector R. Wong et al.   CRITICAL CARE MEDICINE

Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?

(2010) Emmanuel Lorne et al.   INTENSIVE CARE MEDICINE

Identification of pediatric septic shock subclasses based on genome-wide expression profiling

(2009) Hector R Wong et al.   BMC Medicine

Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum*

(2009) Hector R. Wong et al.   CRITICAL CARE MEDICINE