Sonidegib: A Review in Locally Advanced Basal Cell Carcinoma

3347 BOLT 18-month analysis: efficacy and safety of sonidegib in patients with locally advanced basal cell carcinoma (laBCC) and evaluation of tumor response using 2 sets of composite assessment criteria

(2015) R. Dummer et al.   EUROPEAN JOURNAL OF CANCER

Hedgehog pathway blockade with the cancer drug LDE225 disrupts taste organs and taste sensation

(2015) Archana Kumari et al.   JOURNAL OF NEUROPHYSIOLOGY

Treatment with two different doses of sonidegib in patients with locally advanced or metastatic basal cell carcinoma (BOLT): a multicentre, randomised, double-blind phase 2 trial

(2015) Michael R Migden et al.   LANCET ONCOLOGY

Vismodegib in patients with advanced basal cell carcinoma (STEVIE): a pre-planned interim analysis of an international, open-label trial

(2015) Nicole Basset-Seguin et al.   LANCET ONCOLOGY

Absorption, distribution, metabolism, and excretion (ADME) of 14C-sonidegib (LDE225) in healthy volunteers

(2014) Markus Zollinger et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

A Phase I Study of PF-04449913, an Oral Hedgehog Inhibitor, in Patients with Advanced Solid Tumors

(2014) A. J. Wagner et al.   CLINICAL CANCER RESEARCH

A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors

(2014) J. Rodon et al.   CLINICAL CANCER RESEARCH

Metastatic basal cell carcinoma: Prognosis dependent on anatomic site and spread of disease

(2014) Margaret McCusker et al.   EUROPEAN JOURNAL OF CANCER

Acquired resistance to the Hedgehog pathway inhibitor vismodegib due to smoothened mutations in treatment of locally advanced basal cell carcinoma

(2014) Tjinta Brinkhuizen et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Smoothened (SMO) receptor mutations dictate resistance to vismodegib in basal cell carcinoma

(2014) Sabrina Pricl et al.   Molecular Oncology

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE