Review
Chemistry, Inorganic & Nuclear
Jan Mohammad Mir, Sheikh Abdul Majid, Aabid Hussain Shalla
Summary: In the current COVID-19 pandemic, the scientific community is focusing on designing antiviral drugs and vaccines, with Schiff bases or azomethine compounds showing promising medicinal and industrial relevance. Studies have indicated that azomethine-metal complexes exhibit superior antimicrobial properties compared to free ligands, suggesting potential for developing new antiviral treatments against COVID-19.
REVIEWS IN INORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Rohini Gupta, Vijay Luxami, Kamaldeep Paul
Summary: 8-Hydroxyquinoline is an important heterocyclic scaffold in organic and analytical chemistry, used for detecting metal ions and anions due to its chromophore properties. Recently, synthetic modification of 8-hydroxyquinoline has garnered attention for developing potent drug molecules for the treatment of diseases like cancer, HIV, and neurodegenerative disorders. The metal chelation properties of 8-hydroxyquinoline and its derivatives also make them potential drug candidates for various diseases.
BIOORGANIC CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Harshad R. Sonawane, Baliram T. Vibhute, Balasaheb D. Aghav, Jaydeep Deore, Sanjay K. Patil
Summary: In the past decade, there has been a significant increase in research on quinoline Schiff base metal complexes due to their versatile applications in various important fields. These complexes are employed in the biological, analytical, and catalytic domains. Researchers have found that Schiff bases exhibit enhanced biological activity when coordinated with metal ions. Quinoline and its derivatives, being heterocyclic compounds, have shown to be crucial in the field of biological sciences. These derivatives have been discovered to possess a broad spectrum of activity, making them effective therapeutic agents for various disorders.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Maha S. A. Abdelrahman, Fouz M. Omar, Akila A. Saleh, Mosad A. El-ghamry
Summary: New nano complexes of Co(II), Ni(II), Cu(II), Zn(II), Fe(III), and oxovanadium(IV), dioxouranium(VI) with a pyridazinone-acid hydrazone ligand, DCNHP (H2L), were synthesized and characterized. The complexes exhibited different geometrical structures and showed thermal stability. The antimicrobial activity study revealed enhanced activity upon complexation, and the antitumor screening indicated inhibition of Hepatocellular carcinoma cell line (HepG-2) viability. Molecular modeling and docking studies indicated strong interactions with the VEGFR-2 enzyme, similar to a known HCC inhibitor, sorafenib. The electrical conductivity study showed that the nano Cu(II) complex displayed higher values than the free ligand, acting as a semiconductor.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Daohong Yu, Yungen Liu, Chi-Ming Che
Summary: A synthetic method for constructing trifluoromethyl-pyrrolo[2,1-a]isoquinolines via decarboxylation and photocatalytic reactions is described. This method exhibits broad substrate compatibility and enables facile access to pharmaceutically active derivatives.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Fatemeh Naderi, Masoumeh Orojloo, Shirin Kamali, Ramin Jannesar, Saeid Amani
Summary: In this study, a new ligand was synthesized and used to prepare metal complexes. Characterization of the complexes revealed high antibacterial activity against Staphylococcus aureus. Additionally, a synergistic effect with three antibiotics was observed.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Review
Chemistry, Medicinal
Zefeng Zhao, Meng Nian, Haifa Qiao, Xiaohang Yang, Shaoping Wu, Xiaohui Zhen
Summary: Baicalein and wogonin, as important flavonoid compounds isolated from Scutellaria baicalensis, have diverse applications in drug discovery. Derivatives of baicalein and wogonin with anticancer, anti-inflammatory, antiviral, antimicrobial, and hypoglycemic activities have been synthesized and extensively studied. This article provides a comprehensive review of the biological activities and structure-activity relationship (SAR) of baicalein and wogonin derivatives, as well as the bioactive molecules reported in patents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Santiago Rostan, Graciela Mahler, Lucia Otero
Summary: The discovery of the anticancer activity of cisplatin has led to the development of modern Inorganic Medicinal Chemistry, focusing on the application of inorganic compounds in therapy or diagnosis of diseases. Metal coordination of bioactive ligands enhances the stability and/or bioavailability of organic drugs, and can achieve a metal-drug synergism. Selenosemicarbazone metal complexes, derived from the isosteric replacement of sulfur by selenium, show various biological activities and have the potential to be used as metal-based drugs. Further exploration is needed for their pharmacological activity.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Applied
Sen Yang, Kuan Li, Yi Tang, Bing Zheng, Wei Wang, Yongjun Wu, Yumei Xiao, Hongchao Guo
Summary: In this paper, we designed and synthesized 4-vinyl-4-butyrolactone as a precursor to generate zwitterionic intermediates, which acted as five-membered all-carbon synthons in palladium-catalyzed (5+3) annulation reactions with azomethine imines, resulting in the formation of eight-membered ring-fused heterocycles.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Biophysics
Emanuelle D. Freitas, Rogerio A. Rataglioli, Josephine Oshodi, Marisa M. Beppu
Summary: The coronavirus pandemic has highlighted the importance of bioactive materials in mitigating viral infections. Bioinspired antimicrobial peptides (AMPs) have emerged as suitable building blocks for antimicrobial coatings due to their versatile design and environmentally friendly features. This review discusses the advances and opportunities in using AMPs to create virucidal coatings, including the fundamental characteristics of peptide structure, advances in coating medical devices, and the role of different materials in designing antiviral coatings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Medicinal
Bahare Salehi, Joara Nalyda Pereira Carneiro, Janaina Esmeraldo Rocha, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais Braga, Javad Sharifi-Rad, Prabhakar Semwal, Sakshi Painuli, Laila Moujir Moujir, Victoria de Zarate Machado, Shriyaa Janakiram, Nanjangud Venkatesh Anil Kumar, Miquel Martorell, Natalia Cruz-Martins, Marc El Beyrouthy, Carmen Sadaka
Summary: Astragalus L. is a widely distributed genus used in folk medicine, dietary supplements, cosmetics, and animal forage. Its major phytoconstituents, including saponins, flavonoids, and polysaccharides, exhibit promising biological activities such as antiaging, antitumor, and immune-enhancing properties. This review provides a comprehensive overview of Astragalus species and their active components for future clinical development.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Physical
Mosad A. El-ghamry, Magdy Shebl, Akila A. Saleh, Saied M. E. Khalil, Magdah Dawy, Amira A. M. Ali
Summary: The study synthesized and characterized several metal complexes and nano complexes, with detailed investigations on their properties, revealing significant potential in antibacterial, antitumor, and catalytic activities.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Chemistry, Inorganic & Nuclear
Federica De Castro, Erik De Luca, Michele Benedetti, Francesco Paolo Fanizzi
Summary: The emergence of new epidemic viruses has raised new questions about viral infection treatment. There are high expectations for answers and fast solutions from scientists. The potential of platinum compounds in viral diseases is an unexplored field that warrants further research.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Chemistry, Applied
Shijie (Gabriel) Kou, Linda Peters, Michael Mucalo
Summary: This article discusses the various applications of chitosan, including its antimicrobial properties, wound healing promotion, and effects on cancer and the immune system. By introducing the molecular chain configuration model, the mechanisms of interactions between chitosan and bacteria, cancer, and wound healing are explained. The article concludes that chitosan is an important polymer with promising potential in medicine due to its multiple beneficial bioactivities and mechanisms of action.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Isabel de la Cueva-Alique, Elena de la Torre-Rubio, Laura Munoz-Moreno, Alicia Calvo-Jareno, Adrian Perez-Redondo, Lourdes Gude, Tomas Cuenca, Eva Royo
Summary: New palladium compounds were synthesized and characterized. Among them, palladium compound 2a' showed the highest anticancer activity in three cancer cell lines, with lower IC50 values compared to cisplatin. Moreover, compounds 2a and 2a' affected the cell cycle and exhibited stereo-dependent cytotoxicity.
DALTON TRANSACTIONS
(2022)
Article
Microbiology
Yara Shamikh, Aliaa A. El Shamy, Yasser Gaber, Usama Ramadan Abdelmohsen, Hashem A. Madkour, Hannes Horn, Hossam M. Hassan, Abeer H. Elmaidomy, Dalal Hussien M. Alkhalifah, Wael N. Hozzein
Review
Plant Sciences
Mohammed I. Rushdi, Iman A. M. Abdel-Rahman, Eman Zekry Attia, Wedad M. Abdelraheem, Hani Saber, Hashem A. Madkour, Elham Amin, Hossam M. Hassan, Usama Ramadan Abdelmohsen
SOUTH AFRICAN JOURNAL OF BOTANY
(2020)
Article
Environmental Sciences
Amr M. Nassar, Nasser F. Alotaibi
Summary: Recycling waste materials, such as chicken eggshells, into useful products like Pd@CaO nanocomposites shows promising environmental benefits by efficiently degrading pollutants like crystal violet dye under solar irradiation. The study highlights the importance of operational conditions and the significant role of the catalyst in the degradation process.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Dina M. Hassan, Lamiaa A. Madkour, Walaa A. Abuelhamd
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Basma A. Elawady, Mona S. Mohamed, Eman H. Elsebaie, Essraa A. Hegazy, Lamiaa A. Madkour
Summary: The study found that while participants had good knowledge and practice, it did not meet the desired standards. Some participants lacked knowledge of infection control instructions, and measures are still needed to improve students' compliance with infection control practices.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2021)
Article
Chemistry, Physical
A. M. Nassar, H. Salah, N. Hashem, M. Khodari, H. F. Assaf
Summary: In this study, a carbon paste electrode based electrochemical sensor was successfully constructed using copper oxide nanoparticles. The modified sensor showed high sensitivity and accuracy in detecting theophylline in actual pharmaceutical samples, with improved selectivity, stability, and reproducibility.
Article
Rheumatology
Hagar L. Mowafy, Maha M. Kotb, Kamal M. Hanna, Fatema T. Elgengehy, Lamiaa A. Madkour
Summary: The study investigated the expression of circPTPN22, microRNA-200a-3p (miR-200a-3p), and interleukin-2 (IL-2) in SLE patients, revealing their potential as non-invasive diagnostic biomarkers for SLE. The results suggest that circPTPN22 and miR-200a-3p could differentiate between patients and controls with high accuracy.
EGYPTIAN RHEUMATOLOGIST
(2022)
Article
Biotechnology & Applied Microbiology
Lamiaa A. Madkour
Summary: This study assessed the anti-clostridial activity of auranofin and baicalin against hypervirulent C. difficile. It found that both drugs significantly reduced C. difficile viable cell and spore counts, with auranofin also reducing toxin production. These findings offer potential for the development of new anti-clostridial drugs.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Laila S. Alqarni, Maha D. Alghamdi, Aisha A. Alshahrani, Amr M. Nassar
Summary: In recent decades, green nanotechnology has gained increasing attention and researchers are developing more sustainable methods for synthesizing nanoparticles. Various biosources have been explored for fabricating nanoparticles of different shapes and sizes. This review highlights the latest studies on synthesizing nanoparticles from biosources and their applications in various fields.
JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Applied
N. F. Alotaibi, M. A. Alsolami, Shaima M. N. Moustafa, Nawaf Bin Darwish, A. M. Nassar
Summary: In this study, desalination of real samples from Dumat Al-Jandal Lake water was conducted using the reverse osmosis (RO) technique. The growth of bacteria on the surface of the RO membrane was found to impact its performance, but the addition of natural materials such as myrrh proved effective in preventing bacterial growth. The modified RO membrane exhibited high resistance against bacterial growth.
ADSORPTION SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shaimaa Hussein, Ayman M. Mahmoud, Hassan A. Elgebaly, Omnia Magdy Hendawy, Emad H. M. Hassanein, Shaima M. N. Moustafa, Nasser F. Alotaibi, Amr M. Nassar
Summary: In this study, the aqueous extract of garlic tunicate leaf was used to synthesize ruthenium/silver/palladium trimetallic nanocomposites (Ru/Ag/Pd)-Np. Various physicochemical tools were employed to characterize the nanocomposites, and the results showed potent antimicrobial and antiproliferative activities of (Ru/Ag/Pd)-Np. The antiproliferative potential of (Ru/Ag/Pd)-Np was significantly enhanced by UV irradiation.
JOURNAL OF CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
N. F. Alotaibi, I. H. Alsohaimi, A. M. Hassan, Modather. F. Hussein, Ahmed E. Taha, Nawaf Bin Darwish, A. M. Nassar
Summary: The synthesis of nanostructured cyclopalladated complex and its nanosilver composite was reported for the first time. The compounds were characterized using spectroscopic and morphological analysis, showing good stability and antimicrobial activity.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
A. M. Nassar, Z. A. Alrowaili, Ahmed A. M. Ahmed, B. A. Cheba, Sultan Akhtar
Summary: A new type of composite Ag-NPs-loaded core/shell mixed oxides NPs, CdO/Co3O4, was successfully synthesized and characterized in this study. The composite materials were found to exhibit higher antibacterial activity against various bacterial strains compared to their precursor materials.
APPLIED NANOSCIENCE
(2021)
Proceedings Paper
Multidisciplinary Sciences
M. Y. A. Mostafa, H. M. H. Zakaly, M. A. M. Uosif, Sh A. M. Issa, H. Madkour, M. Tammam
VII INTERNATIONAL YOUNG RESEARCHERS' CONFERENCE - PHYSICS, TECHNOLOGY, INNOVATIONS (PTI-2020)
(2020)
Article
Medicine, General & Internal
Ahmed Salah Emira, Lamiaa Abd El-Fattah Madkour, Nazmy Edward Seif, Reham Ali Dwedar
ALEXANDRIA JOURNAL OF MEDICINE
(2020)
