Review
Neurosciences
Ying Huang, Zhenzhen Wang, Zhi-Xin Huang, Zhenguo Liu
Summary: This review summarizes a range of important biomarkers, including glutamate, S100B, glial fibrillary acidic protein, receptor for advanced glycation end-products, intercellular adhesion molecule-1, von willebrand factor, matrix metalloproteinase-9, interleukin-6, tumor necrosis factor-a, activated protein C, copeptin, neuron-specific enolase, tau protein, gamma-aminobutyric acid, blood glucose, endothelial progenitor cells, and circulating CD34-positive cells, which may potentially indicate the disease burden and/or predict clinical outcomes of ischemic stroke. The relationship between specific biomarkers, disease burden, and outcomes is examined, along with potential underlying mechanisms. The clinical significance and implications of these biomarkers are also discussed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Qingguang Wang, Haiming Cao, Yan E, Siyu Wang, Shuaiyu Chen, Huiwen Lian, Meng Wang, Junshan Zhou, Yi Xie, Xiaohao Zhang
Summary: The study aimed to investigate the association between serum caveolin-1 (Cav-1) levels and the 3-month functional outcome in patients after mechanical thrombectomy (MT). It was found that higher serum Cav-1 levels were associated with a reduced risk of poor outcome at 3 months, suggesting that Cav-1 may be a potential prognostic biomarker for ischemic stroke after reperfusion therapy.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Shoujiang You, Yucong Bi, Mengyuan Miao, Anran Bao, Jigang Du, Tan Xu, Chun-Feng Liu, Yonghong Zhang, Jiang He, Yongjun Cao, Chongke Zhong
Summary: This study investigated the association between plasma soluble DPP4 (sDPP4) levels and poststroke cognitive impairment (PSCI). The results showed that higher plasma sDPP4 levels were associated with decreased risk of cognitive impairment after noncardioembolic ischemic stroke. Adding sDPP4 to the basic model significantly improved risk reclassification for PSCI. Therefore, plasma sDPP4 levels play an important predictive role in the development of cognitive impairment after noncardioembolic ischemic stroke.
Article
Biochemistry & Molecular Biology
Hailong Yu, Xin Chen, Xin Guo, Danni Chen, Li Jiang, Yajie Qi, Jun Shao, Luhang Tao, Jing Hang, Guangyu Lu, Yingzhu Chen, Yuping Li
Summary: This study aimed to investigate the role of serum xanthine oxidase (XO) levels in the pathogenesis of acute ischemic stroke (AIS). The results showed that the serum level of XO was significantly higher in AIS patients compared to healthy controls and was an independent risk factor for AIS. Serum XO level also had predictive value for stroke progression and prognosis in AIS patients.
Article
Clinical Neurology
Ying Bai, Hui Ren, Yi Zhu, Xufeng Chen, Li Yang, Jiangyan Xia, Guofang Shu, Bing Han
Summary: This study found that circular RNA circDLGAP4 is significantly decreased in the plasma of patients with acute ischemic stroke (AIS), and its level is associated with smoking history and previous transient ischemic attack/stroke/myocardial infarction. CircDLGAP4 has high sensitivity and specificity in diagnosing AIS. Furthermore, the change rate of circDLGAP4 can predict stroke outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zhengbao Zhu, Yan He, Mengyao Shi, Daoxia Guo, Kaixin Zhang, Liyun Ren, Yanbo Peng, Pinni Yang, Jing Chen, Yuhan Zang, Aili Wang, Tan Xu, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
Summary: Elevated plasma osteopontin levels at baseline were found to be associated with increased risks of adverse clinical outcomes at 1 year after ischemic stroke in this study.
Article
Clinical Neurology
Kaixin Zhang, Zhengbao Zhu, Mengyao Shi, Daoxia Guo, Yang Liu, Xiaoqing Bu, Bizhong Che, Tian Xu, Pinni Yang, Jing Chen, Tan Xu, Jiang He, Yonghong Zhang
Summary: This study found that elevated serum Dkk-1 levels after ischemic stroke were independently associated with an increased risk of poststroke depression (PSD).
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Yinwei Zhu, Lulu Sun, Tiansheng Huang, Yiming Jia, Pinni Yang, Qi Zhang, Chongquan Fang, Mengyao Shi, Daoxia Guo, Yanbo Peng, Anushka Aghi, Jing Chen, Aili Wang, Jiang He, Yonghong Zhang, Tan Xu, Zhengbao Zhu
Summary: A multicenter cohort study found that elevated serum BDNF concentrations were associated with decreased risks of adverse outcomes after ischemic stroke, suggesting that serum BDNF may be a potential biomarker for prognosis after ischemic stroke.
Article
Clinical Neurology
Pablo Hervella, Maria Luz Alonso-Alonso, Maria Perez-Mato, Manuel Rodriguez-Yanez, Susana Arias-Rivas, Iria Lopez-Dequidt, Jose M. Pumar, Tomas Sobrino, Francisco Campos, Jose Castillo, Ramon Iglesias-Rey
Summary: Inflammatory biomarkers are strongly associated with wake-up ischemic stroke episodes, while wake-up ischemic stroke is associated with lower levels of vitamin D. These findings suggest that vitamin D deficiency could be a therapeutic target to reduce the occurrence of wake-up ischemic stroke events.
Article
Behavioral Sciences
Meizi Qian, Xinbo Zhou, Beibei Gao, Honghao Huang, Chenguang Yang, Tian Zeng, Jiamin Shen, Jingyu Hu, Fangyue Sun, Shengqi Li, Xuerong Huang, Guangyong Chen
Summary: This study found a significant association between red cell index (RCI) and 3-month mortality in acute ischemic stroke (AIS) patients treated with recombinant tissue plasminogen activator (r-tPA). The results suggest that RCI can serve as a potential predictor for evaluating mortality risk in AIS patients.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Antonela Bicvic, Natalie Scherrer, Juliane Schweizer, Felix Fluri, Mirjam Christ-Crain, Gian Marco De Marchis, Andreas R. Luft, Mira Katan
Summary: This study investigated blood biomarkers associated with ischemic injury and inflammation to predict post-stroke mortality. The researchers identified a novel Biomarker Panel Index (BPI) that improved risk stratification for mortality and was associated with cardioembolic stroke etiology.
EUROPEAN STROKE JOURNAL
(2022)
Article
Medicine, General & Internal
Jixia Wu, Daqing Wu, Youbao Liang, Zhen Zhang, Lei Zhuang, Zhaoping Wang
Summary: The study found that the levels of pNfL in patients with acute ischemic stroke (AIS) have the potential to predict severe outcomes, independently predicting functional outcomes, and may be a promising biomarker.
Article
Clinical Neurology
Kosuke Matsuzono, Takafumi Mashiko, Tadashi Ozawa, Kumiko Miura, Masayuki Suzuki, Yuhei Anan, Reiji Koide, Ryota Tanaka, Tomoaki Kameda, Shigeru Fujimoto
Summary: This study comprehensively analyzes the mortality rate of acute ischemic strokes and reveals real-time survival data during hospitalization and 1 year after the onset of a stroke. The study finds that cardioembolic ischemic strokes are the main cause of death.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Guangyao Wang, Jing Jing, Anxin Wang, Xiaoli Zhang, Xingquan Zhao, Zixiao Li, Chunjuan Wang, Hao Li, Liping Liu, Yongjun Wang, Yilong Wang
Summary: The study suggests that non-high-density lipoprotein cholesterol may be a qualified predictor for recurrent ischemic stroke and all-cause death within 1 year in patients with acute ischemic stroke, but not predictive for intracranial hemorrhage.
Article
Peripheral Vascular Disease
Teppei Komatsu, Motohiro Okumura, Hiroyuki Kida, Masakazu Ozawa, Masahiro Mimori, Tatsushi Kokubu, Junichiro Takahashi, Sumire Kurihara, Takahiro Maku, Haruhiko Motegi, Maki Takahashi, Tomotaka Shiraishi, Ryoji Nakada, Shiho Akiyama, Tomomichi Kitagawa, Takeo Sato, Hiroki Takatsu, Kenichiro Sakai, Tadashi Umehara, Shusaku Omoto, Hidetomo Murakami, Hidetaka Mitsumura, Yasuyuki Iguchi
Summary: Urinary immunoglobulin G may be a stronger marker of atherosclerosis than microalbuminuria. Microalbuminuria is not associated with mild acute ischemic stroke.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)