Predictive value of thrombospondin-1 for outcomes in patients with acute ischemic stroke

Background: Thrombospondin-1 is a potent regulator of angiogenesis. The expression of cerebral thrombospondin-1 is promoted in a rat model of intracerebral hemorrhage. The current study was designed to investigate the change of plasma thrombospondin-1 concentrations and assess the prognostic value of plasma thrombospondin-1 concentrations for long-term mortality and functional outcome of ischemic stroke patients. Methods: This study included 192 patients and 150 healthy controls. The plasma thrombospondin-1 concentrations were measured using enzyme-linked immunosorbent assay. An unfavorable outcome was defined as a modified Rankin Scale score >3. The relationships between plasma thrombospondin-1 concentrations and 6-month clinical outcomes were analyzed using multivariate analysis. Results: Compared with healthy controls, plasma thrombospondin-1 concentrations were statistically significantly elevated in patients. Using multivariate analysis, thrombospondin-1 emerged as an independent predictor for 6-month mortality, 6-month unfavorable outcome and 6-month overall survival. Plasma thrombospondin-1 concentrations possessed high predictive values under receiver operating characteristic curve. Their predictive values were similar to those of National Institutes of Health Stroke Scale scores. Conclusions: Plasma thrombospondin-1 concentrations are elevated obviously and are highly associated with long-term outcome of ischemic stroke. (C) 2015 Elsevier B.V. All rights reserved.