Article
Rheumatology
Johanna E. Gehin, Rolf A. Klaasen, Ellen S. Norli, David J. Warren, Silje W. Syversen, Guro L. Goll, Trine Bjoro, Tore K. Kvien, Maria D. Mjaavatten, Nils Bolstad
Summary: The study found that patients with rheumatoid arthritis (RA) who tested positive for rheumatoid factor (RF) had significantly stronger reactivity to animal antibodies, particularly mouse IgG1 and rabbit IgG, compared to controls. This led to interference in commercial immunoassays, such as the Architect beta-hCG assay, 27-plex cytokine assays, and Elecsys Soluble Transferrin Receptor assay, resulting in falsely elevated test results. Clinicians, laboratorians, researchers, and assay manufacturers need to be aware of the risk of false positives in RF-positive RA patients.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Olga Karapanou, Katerina Saltiki, George Simeakis, Efi Botoula, Stylianos Tsagarakis, Maria Alevizaki, Barbara Vlassopoulou
Summary: This study aimed to identify factors affecting anti-Tg persistence and disease outcome in differentiated thyroid cancer patients. Results showed that worse histological features were more common in patients with anti-Tg persistence, and tumor size and extrathyroidal extension were the main predictors of disease progression. Additional radioiodine administration and/or surgeries did not affect anti-Tg elimination in most cases.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Medical Laboratory Technology
Sara Deza, Julia Maroto, Olaia Tellechea, Natalia Orbegozo, Juana Merino, Juan C. Galofre, Estibaliz Alegre, Alvaro Gonzalez
Summary: This study evaluated the response to treatment in patients with differentiated thyroid cancer and considered the interference of anti-thyroglobulin antibodies. Results showed discrepancies between two different thyroglobulin quantification methods, but the clinical impact on patient management was minimal.
CLINICA CHIMICA ACTA
(2023)
Article
Oncology
Szabina Szujo, Laszlo Bajnok, Beata Bodis, Zsuzsanna Nagy, Orsolya Nemes, Karoly Rucz, Emese Mezosi
Summary: Thyroglobulin (Tg) is a crucial tumor marker in differentiated thyroid cancer (DTC), with non-stimulated Tg values showing excellent accuracy in predicting structural disease. A patient's risk classification can be revised based on a single Tg measurement.
Article
Endocrinology & Metabolism
Julia E. Noel, Priyanka Thatipamala, Kay S. Hung, Julie Chen, Run-Zhang Shi, Lisa A. Orloff
Summary: This study aimed to evaluate the significance of antithyroglobulin and antithyroid peroxidase antibody levels in patients with well-differentiated thyroid cancer. Results showed that elevated TgAb levels were associated with nodal metastases and ENE, while elevated TPOAb levels were correlated with lower T and N stages.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
Chao Meng, Juanjuan Song, Wen Long, Zhuanzhuan Mu, Yuqing Sun, Jun Liang, Yansong Lin
Summary: A convenient nomogram model was developed to predict radioiodine refractory differentiated thyroid cancer. The progression of this cancer can be further stratified as rapidly or slowly progressive based on biochemical markers and age.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medical Laboratory Technology
Caroline M. J. van Kinschot, Robin P. Peeters, Sjoerd A. A. van den Berg, Frederik A. Verburg, Charlotte van Noord, Tessa M. van Ginhoven, W. Edward Visser
Summary: Different assays for thyroglobulin (Tg) and Tg antibodies (TgAb) can result in different classifications of response to therapy for differentiated thyroid cancer (DTC) patients, potentially significantly affecting clinical management. It is important to consider the variations between methods when using recommended Tg cut-offs in guidelines.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alfredo Campenni, Rosaria Maddalena Ruggeri, Massimiliano Siracusa, Alessio Danilo Comis, Davide Romano, Antonio Vento, Helena Lanzafame, Francesca Capoccetti, Angela Alibrandi, Sergio Baldari, Luca Giovanella
Summary: Early-stimulated Tg levels are reliable predictors for response to primary treatment in patients with differentiated thyroid cancer (DTC).
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Endocrinology & Metabolism
Sha Li, Chutong Ren, Yi Gong, Fei Ye, Yulong Tang, Jiangyue Xu, Can Guo, Jiangsheng Huang
Summary: Thyroglobulin (Tg) plays an important role in the evaluation of preoperative and postoperative patients with differentiated thyroid carcinoma (DTC), but its application is limited by factors such as measurement method and the presence of antibodies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Timothy M. Ullmann, Maria Papaleontiou, Julie Ann Sosa
Summary: This review discusses the controversies and difficult decisions in the management of low-risk differentiated thyroid cancer (DTC) and provides recommendations. While overdiagnosis is a concern, the true incidence of DTC has also increased. Treatment options vary, and personalized and nuanced treatment decisions are necessary for clinicians and patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medical Laboratory Technology
Michele Cennamo, Evelina La Civita, Anna Curci, Antonietta Liotti, Umberto Braschi, Daniela Terracciano
Summary: The study compared the performance of the new highly sensitive Liaison Tg II with the well-established Tg Access assay and found a high correlation between the two assays across different concentration ranges. Liaison Tg II demonstrated a good concordance rate for samples with Tg values lower than 0.2 ng/mL and showed excellent performance in discriminating negative and positive results in fine-needle aspiration washout fluids. No interference was observed by Tg auto-antibodies for both assays.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Oncology
Miriam Steinschneider, Jacob Pitaro, Shlomit Koren, Yuval Mizrakli, Carlos Benbassat, Limor Muallem Kalmovich
Summary: Although a portion of patients with differentiated thyroid cancer may progress to structural disease when exhibiting a biochemical incomplete response, the majority of patients present with an indolent disease course. Prediction of progression to structural disease can be facilitated by utilizing the American Thyroid Association's Initial Risk Stratification system and/or the AJCC/TNM staging system.
Review
Endocrinology & Metabolism
Roger Chou, Tracy Dana, Gregory A. Brent, Whitney Goldner, Megan Haymart, Angela M. Leung, Matthew D. Ringel, Julie Ann Sosa
Summary: This systematic review examines the diagnostic accuracy of serum thyroglobulin (Tg) measurement for differentiated thyroid cancer in situations of partial thyroidectomy or total/near-total thyroidectomy without or before radioactive iodine (RAI) treatment. The review finds limited evidence suggesting low utility of Tg measurement for identifying recurrent or metastatic disease following partial thyroidectomy. After total/near-total thyroidectomy without RAI, Tg levels using a cutoff of 1-2.5 ng/mL might identify patients at low risk for persistent or metastatic disease. However, further research is needed to clarify the role of Tg measurement in these settings.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lin Cheng, Ri Sa, Qiong Luo, Hao Fu, Yuchen Jin, Linglin Tang, Yi Yang, Chunjing Yu, Libo Chen
Summary: The study demonstrated that over 90% of TT-DTC patients with unexplained hyperthyroglobulinemia are stratified as being at intermediate to high risk, and RAT using 5.55 GBq of I-131 reveals biochemical, functional, or structural disease and yields a non-structurally or -functionally incomplete response in more than 80% patients, suggesting that TT-DTC patients with unexplained hyperthyroglobulinemia are explicit candidates for RAT.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Carole Ann Spencer
Summary: This review highlights the development of laboratory thyroid tests over the past seven decades, from manual isotopically labeled iodine procedures to automated nonisotopic tests. The introduction of radioimmunoassay techniques and monoclonal antibody technology has played a crucial role in the evolution of thyroid testing. Despite improvements, current tests still face limitations in terms of numerical differences and interferences from reagents and autoantibodies.
Article
Immunology
Julie Oniszczuk, Kelhia Sendeyo, Cerina Chhuon, Berkan Savas, Etienne Cogne, Pauline Vachin, Carole Henique, Ida Chiara Guerrera, Giuseppe Astarita, Vincent Frontera, Andre Pawlak, Vincent Audard, Dil Sahali, Mario Ollero
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Meeting Abstract
Endocrinology & Metabolism
Julie C. Ullman, Alicia A. Nugent, Annie Arguello, Akhil Bhalla, Thomas Sandmann, Steve Lianoglou, Connie Ha, Junhua Wang, Sonnet S. Davis, Jamal Alkabsh, Giuseppe Astarita, Gilbert Di Paolo, Tina Giese, Cathal Mahon, Catherine Bedard, Nicholas Liang, Gunasekaran Kannan, Joesph W. Lewcock, Zachary K. Sweeney, Mihalis S. Kariolis, Dolo Diaz, Anastasia Henry
MOLECULAR GENETICS AND METABOLISM
(2020)
Meeting Abstract
Endocrinology & Metabolism
Anastasia G. Henry, Julie Ullman, Annie Arguello, Jennifer Getz, Akhil Bhalla, Cathal Mahon, Junhua Wang, Tina Giese, Catherine Bedard, Jessica Blumenfeld, Ritesh Ravi, Alicia Nugent, Steve Lianoglou, Mark Dennis, Kannan Gunasekaran, Ankita Srivastava, Kirk Henne, Robert Thorne, Gilbert Di Paolo, Giuseppe Astarita, Dolores Diaz, Adam Silverman, Ryan Watts, Zachary Sweeney, Mihalis Kariolis
MOLECULAR GENETICS AND METABOLISM
(2020)
Article
Neurosciences
Alicia A. Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S. Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C. G. Haddick, Melina Lenser, Timothy K. Earr, Ju Shi, Jason C. Dugas, Benjamin J. Andreone, Todd Logan, Hilda O. Solanoy, Hang Chen, Ankita Srivastava, Suresh B. Poda, Pascal E. Sanchez, Ryan J. Watts, Thomas Sandmann, Giuseppe Astarita, Joseph W. Lewcock, Kathryn M. Monroe, Gilbert Di Paolo
Article
Cell Biology
Julie C. Ullman, Annie Arguello, Jennifer A. Getz, Akhil Bhalla, Cathal S. Mahon, Junhua Wang, Tina Giese, Catherine Bedard, Do Jin Kim, Jessica R. Blumenfeld, Nicholas Liang, Ritesh Ravi, Alicia A. Nugent, Sonnet S. Davis, Connie Ha, Joseph Duque, Hai L. Tran, Robert C. Wells, Steve Lianoglou, Vinay M. Daryani, Wanda Kwan, Hilda Solanoy, Hoang Nguyen, Timothy Earr, Jason C. Dugas, Michael D. Tuck, Jennifer L. Harvey, Michelle L. Reyzer, Richard M. Caprioli, Sejal Hall, Suresh Poda, Pascal E. Sanchez, Mark S. Dennis, Kannan Gunasekaran, Ankita Srivastava, Thomas Sandmann, Kirk R. Henne, Robert G. Thorne, Gilbert Di Paolo, Giuseppe Astarita, Dolores Diaz, Adam P. Silverman, Ryan J. Watts, Zachary K. Sweeney, Mihalis S. Kariolis, Anastasia G. Henry
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Akhil Bhalla, Ritesh Ravi, Meng Fang, Annie Arguello, Sonnet S. Davis, Chi-Lu Chiu, Jessica R. Blumenfeld, Hoang N. Nguyen, Timothy K. Earr, Junhua Wang, Giuseppe Astarita, Yuda Zhu, Damian Fiore, Kimberly Scearce-Levie, Dolores Diaz, Heather Cahan, Matthew D. Troyer, Jeffrey M. Harris, Maria L. Escolar
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Junhua Wang, Akhil Bhalla, Julie C. Ullman, Meng Fang, Ritesh Ravi, Annie Arguello, Elliot Thomsen, Buyankhishig Tsogtbaatar, Jing L. Guo, Lukas L. Skuja, Jason C. Dugas, Sonnet S. Davis, Suresh B. Poda, Kannan Gunasekaran, Simona Costanzo, Zachary K. Sweeney, Anastasia G. Henry, Jeffrey M. Harris, Kirk R. Henne, Giuseppe Astarita
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Neurosciences
Benjamin J. Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S. Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M. Monroe, Joseph W. Lewcock
NATURE NEUROSCIENCE
(2020)
Article
Clinical Neurology
Grace F. Crotty, Romeo Maciuca, Eric A. Macklin, Junhua Wang, Manuel Montalban, Sonnet S. Davis, Jamal Alkabsh, Rachit Bakshi, Xiqun Chen, Alberto Ascherio, Giuseppe Astarita, Sarah Huntwork-Rodriguez, Michael A. Schwarzschild
Review
Biochemistry & Molecular Biology
Berkan Savas, Giuseppe Astarita, Massimo Aureli, Dil Sahali, Mario Ollero
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Spectroscopy
Giuseppe Paglia, Andrew J. Smith, Giuseppe Astarita
Summary: Researchers are utilizing ion mobility mass spectrometry (IM-MS) for metabolomics and lipidomics applications, which offers advantages such as measuring collision cross-section values, improving peak capacity and signal-to-noise ratio, and coupling with various fragmentation modes. These advancements provide a more robust tool for identification, quantification, and structural characterization in the field.
MASS SPECTROMETRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Todd Logan, Matthew J. Simon, Anil Rana, Gerald M. Cherf, Ankita Srivastava, Sonnet S. Davis, Ray Lieh Yoon Low, Chi-Lu Chiu, Meng Fang, Fen Huang, Akhil Bhalla, Ceyda Llapashtica, Rachel Prorok, Michelle E. Pizzo, Meredith E. K. Calvert, Elizabeth W. Sun, Jennifer Hsiao-Nakamoto, Yashas Rajendra, Katrina W. Lexa, Devendra B. Srivastava, Bettina van Lengerich, Junhua Wang, Yaneth Robles-Colmenares, Do Jin Kim, Joseph Duque, Melina Lenser, Timothy K. Earr, Hoang Nguyen, Roni Chau, Buyankhishig Tsogtbaatar, Ritesh Ravi, Lukas L. Skuja, Hilda Solanoy, Howard J. Rosen, Bradley F. Boeve, Adam L. Boxer, Hilary W. Heuer, Mark S. Dennis, Mihalis S. Kariolis, Kathryn M. Monroe, Laralynne Przybyla, Pascal E. Sanchez, Rene Meisner, Dolores Diaz, Kirk R. Henne, Ryan J. Watts, Anastasia G. Henry, Kannan Gunasekaran, Giuseppe Astarita, Jung H. Suh, Joseph W. Lewcock, Sarah L. DeVos, Gilbert Di Paolo
Summary: Mutations in the GRN gene lead to frontotemporal dementia, with a deficiency in the PGRN protein being the cause. Research found various abnormalities in Grn(-/-) mice, including a lack of endolysosomal phospholipids and accumulation of glucocerebrosidase substrate. A protein replacement strategy corrected these abnormalities and may represent a potential biotherapeutic for GRN-FTD.
Article
Neurosciences
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H. Suh, Elliot Thomsen, Jason Dugas, Michelle E. Pizzo, Sarah L. DeVos, Timothy K. Earr, Chia-Ching Lin, Sonnet Davis, Connie Ha, Amy Wing-Sze Leung, Hoang Nguyen, Roni Chau, Ernie Yulyaningsih, Isabel Lopez, Hilda Solanoy, Shababa T. Masoud, Chun-chi Liang, Karin Lin, Giuseppe Astarita, Nathalie Khoury, Joy Yu Zuchero, Robert G. Thorne, Kevin Shen, Stephanie Miller, Jorge J. Palop, Dylan Garceau, Michael Sasner, Jennifer D. Whitesell, Julie A. Harris, Selina Hummel, Johannes Gnorich, Karin Wind, Lea Kunze, Artem Zatcepin, Matthias Brendel, Michael Willem, Christian Haass, Daniel Barnett, Till S. Zimmer, Anna G. Orr, Kimberly Scearce-Levie, Joseph W. Lewcock, Gilbert Di Paolo, Pascal E. Sanchez
Summary: This study created a novel App knock-in mouse model and found that microglia with fibrillar A beta were associated with lipid dyshomeostasis, lysosomal dysfunction, foam cell phenotypes, and immuno-metabolic perturbations, offering new avenues for investigating metabolic pathways in microglia responding to AD-relevant pathogenesis. The in-depth characterization of pathological hallmarks of AD in this model provides a valuable resource for further research on disease-relevant biology.
MOLECULAR NEURODEGENERATION
(2022)
Article
Cell Biology
Danna Jennings, Sarah Huntwork-Rodriguez, Anastasia G. Henry, Jennifer C. Sasaki, Rene Meisner, Dolores Diaz, Hilda Solanoy, Xiang Wang, Elvira Negrou, Vitaliy V. Bondar, Rajarshi Ghosh, Michael T. Maloney, Nicholas E. Propson, Yuda Zhu, Romeo D. Maciuca, Laura Harris, Angela Kay, Peter LeWitt, T. Alex King, Drew Kern, Aaron Ellenbogen, Ira Goodman, Andrew Siderowf, Jason Aldred, Omid Omidvar, Shababa T. Masoud, Sonnet S. Davis, Annie Arguello, Anthony A. Estrada, Javier de Vicente, Zachary K. Sweeney, Giuseppe Astarita, Marie T. Borin, Bradley K. Wong, Harvey Wong, Hoang Nguyen, Kimberly Scearce-Levie, Carole Ho, Matthew D. Troyer
Summary: Mutations in LRRK2 are common genetic risk factors for Parkinson's disease. Inhibition of LRRK2 with DNL201 has shown positive effects in preclinical and clinical trials, improving lysosomal function and demonstrating safety and tolerability. Further development of LRRK2 inhibitors as a therapeutic modality for Parkinson's disease is warranted.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Giuseppe Astarita, Rachel S. Kelly, Jessica Lasky-Su
Summary: Metabolomics and lipidomics play a crucial role in drug discovery and development by providing functional insights through monitoring changes in metabolites and lipids, and promising a transformative impact on precision medicine.
DRUG DISCOVERY TODAY
(2023)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)
