Article
Clinical Neurology
Messoud Ashina, David Dolezil, Jo H. Bonner, Lifen Zhou, Jan Klatt, Hernan Picard, Daniel D. Mikol
Summary: AMG 301 showed no benefit over placebo for migraine prevention in this study, suggesting further research is needed to understand the role of PACAP isoforms and its receptors in migraine pathophysiology.
Article
Clinical Neurology
Nadja Bredo Rasmussen, Christina Deligianni, Casper Emil Christensen, William Kristian Karlsson, Haidar Muhsen Al-Khazali, Tom Van de Casteele, Charlotte Granhall, Faisal Mohammad Amin, Messoud Ashina
Summary: Lu AG09222, an investigational humanized monoclonal antibody, inhibits PACAP38-induced vasodilation and headache, suggesting its potential as a therapy for PACAP-mediated diseases such as migraine.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Biochemistry & Molecular Biology
Areeba Nisar, Zubair Ahmed, Hsiangkuo Yuan
Summary: Migraine is a debilitating neurological condition that affects many patients' quality of life. Despite the success of new therapies, not all patients benefit significantly. Understanding the mechanisms involved in migraine can lead to the discovery of novel therapeutic targets for improved treatment options.
Review
Oncology
Carolyn A. Bernstein
Summary: This review article provides a comprehensive overview of headache evaluation and treatment in cancer patients, including the diagnostic process, common types of headaches, pharmacological treatment, and complementary and integrative therapies.
Article
Anesthesiology
Zhaohua Guo, Katherine Czerpaniak, Jintao Zhang, Yu-Qing Cao
Summary: Studies suggest that blocking both CGRP and PACAP signaling pathways in TG neurons may be more effective in treating chronic migraine and posttraumatic headache than targeting individual pathways.
Article
Pharmacology & Pharmacy
Yuki Kambe, Yu Yamauchi, Trung Thanh Nguyen, Thu Thi Nguyen, Yukio Ago, Norihito Shintani, Hitoshi Hashimoto, Shimako Yoshitake, Takashi Yoshitake, Jan Kehr, Namiko Kawamura, Goro Katsuura, Takashi Kurihara, Atsuro Miyata
Summary: PACAP may enhance lactate production and secretion in astrocytes during the acquisition and recall of fear memories.
PHARMACOLOGICAL REPORTS
(2021)
Article
Medicine, General & Internal
Iwona Rosciszewska-Zukowska, Sabina Galiniak, Halina Bartosik-Psujek
Summary: The aim of this study was to assess the prevalence and characteristics of headaches in Multiple Sclerosis (MS) patients treated with disease-modifying therapies (DMTs). The study found that more than half of MS patients experienced headaches, with the prevalence of migraines being almost three times higher than tension-type headaches. Migraines in MS patients had high severity and typical migraine characteristics.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Nikki Le, Jennifer Hernandez, Cassandra Gastelum, Lynnea Perez, Isabella Vahrson, Sarah Sayers, Edward J. Wagner
Summary: This study demonstrates that PACAP activates PAC1 receptors and K-ATP channels to inhibit A10 dopamine neurons, thereby regulating appetite and suppressing binge-like consumption, in a sex-dependent manner.
Article
Clinical Neurology
Lili Kokoti, Mohammad Al-Mahdi Al-Karagholi, Fatima Azzahra Elbahi, Hande Coskun, Hashmat Ghanizada, Faisal Mohammad Amin, Messoud Ashina
Summary: This study aimed to investigate whether glibenclamide, a non-selective K-ATP channel blocker, could attenuate pituitary adenylate cyclase-activating polypeptide-38 (PACAP38)-induced headache and vascular changes. The results showed that glibenclamide did not reduce the incidence of PACAP38-induced headache or alter the hemodynamic changes in healthy volunteers.
Article
Biochemistry & Molecular Biology
Dora Szabo, Zsolt Sarszegi, Beata Polgar, Eva Saghy, Dora Reglodi, Tunde Toth, Zsofia Onodi, Przemyslaw Leszek, Zoltan V. Varga, Zsuzsanna Helyes, Agnes Kemeny, Peter Ferdinandy, Andrea Tamas
Summary: This study aimed to investigate the presence of PACAP-38 in heart failure (HF) patients and its correlation with HF predictors. The results showed that plasma PACAP-38 immunoreactivity was higher in acute HF patients, while lower in chronic HF patients. In addition, a positive correlation between plasma PACAP-38 and NT-proBNP levels was observed in acute HF, but a negative correlation in chronic HF. The levels of cytokines IL-1 beta, IL-2, IL-4 were lower in chronic HF, and IL-10 was higher in acute HF. PACAP-38 levels in myocardial tissues were lower in all end-stage HF patients. The study suggests that PACAP-38 may be a potential prognostic biomarker in HF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Hangfei Wu, Zhao Dong, Yinglu Liu, Qing Zhang, Mingjie Zhang, Guanqun Hu, Shengyuan Yu, Xun Han
Summary: This study found that PACAP in chronic migraine patients showed exhaustion, while the expression of PACAP and PAC1 receptor in TG showed dynamic changes of increasing first and then decreasing after repeated chemical stimulations. These results suggest that PACAP may play an important role in the pathology of chronic migraine and is associated with CGRP receptor.
Article
Neurosciences
Jerome Ruel, Matthieu J. Guitton, Paul Gratias, Marc Lenoir, Sanbing Shen, Jean-Luc Puel, Philippe Brabet, Jing Wang
Summary: The study explores the potential protective effect of endogenous PACAP against noise-induced hearing loss, showing that PAC1R mutant mice exhibit a more significant elevation in auditory thresholds after acute noise damage, while transgenic mice expressing the human PAC1 receptor show smaller increases. These findings suggest that PACAP could serve as a candidate for endogenous protection against noise-induced hearing loss.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Anesthesiology
Heejin Lee, Saeyoon Kim, Min Cheol Chang
Summary: According to this study, migraine in children and adolescents is more associated with depression, while tension-type headache (TTH) is more associated with anxiety. Therefore, it is important to consider psychological symptoms in the diagnosis and treatment of primary headache disorders.
Review
Neurosciences
A. Y. Sokolov, A. V. Osipchuk, I. B. Skiba, A. V. Amelin
Summary: This review summarizes the experimental and clinical data on the role of PACAP and VIP in the pathophysiology of primary headaches, including migraine. The involvement of these mediators and their receptors in nociception and vascular tone regulation, particularly in the trigeminovascular system, is discussed. The potential of pharmacological agents blocking the PACAP-ergic pathway in relieving headaches is also explored.
NEUROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Lian-Ying Yang, Ji-Ping Hou, En-Kun Han, Gang Qiao, Li-Bin Liu, Xue-Bo Men
Summary: Plasma PACAP levels were found to be significantly decreased in liver cirrhosis patients compared to healthy controls, and may serve as a potential indicator for disease progression. Additionally, PACAP levels were inversely associated with liver inflammation markers and positively related to muscle index scores, indicating its potential role as a biomarker for liver cirrhosis severity assessment.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2021)
Article
Clinical Neurology
Mingjie Zhang, Yufei Liu, Mangsuo Zhao, Wenjing Tang, Xiaolin Wang, Zhao Dong, Shengyuan Yu
JOURNAL OF HEADACHE AND PAIN
(2017)
Article
Clinical Neurology
Yinglu Liu, Zhao Dong, Rongfei Wang, Ran Ao, Xun Han, Wenjing Tang, Shengyuan Yu
Article
Neurosciences
Xun Han, Ye Ran, Min Su, Yinglu Liu, Wenjing Tang, Zhao Dong, Shengyuan Yu
Article
Neurosciences
Zhihua Jia, Wenjing Tang, Dengfa Zhao, Guanqun Hu, Ruisheng Li, Shengyuan Yu
Article
Neurosciences
Zhihua Jia, Xiaoyan Chen, Wenjing Tang, Dengfa Zhao, Shengyuan Yu
Article
Clinical Neurology
Wenjing Tang, Meichen Zhang, Enchao Qiu, Shanshan Kong, Yingji Li, Huanxian Liu, Zhao Dong, Shengyuan Yu
Article
Integrative & Complementary Medicine
Shengyuan Yu, Ye Ran, Wei Xiao, Wenjing Tang, Jianjun Zhao, Wei Chen, Huikui Zhuang, Cun Ouyang, Hai Lin, Dequan Liu, Tongjun Chen, Hui Huang, Baoshen Wang, Yanlei Hao, Zhongrui Yan, Shike Zhao, Yanling Wang, Jinjun Ni, Chaodong Wang, Wentao Ding, Guoqian Li, Jianhua Cao, Shujuan Tian
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Clinical Neurology
Yingji Li, Wenjing Tang, Li Kang, Shanshan Kong, Zhao Dong, Dengfa Zhao, Ruozhuo Liu, Shengyuan Yu
Summary: Mutations in ATP1A2 gene can lead to phenotypes ranging from pure FHM to FHM with epilepsy and intellectual disability due to varying degrees of deficits in the biochemical and electrophysiological properties of Na+/K+-ATPase. Mutations associated with intellectual disability result in severe impairment of Na+/K+-ATPase, while the presence of epilepsy or the type of epilepsy does not seem to affect the degree of pump function impairment.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Clinical Neurology
Li Kang, Wenjing Tang, Yaofen Zhang, Mingjie Zhang, Jing Liu, Yingji Li, Shanshan Kong, Dengfa Zhao, Shengyuan Yu
Summary: The study reveals the involvement of gut microbiome in normal mechanical pain sensation and pathogenesis of migraine, with mice transplanted with gut microbiota from a migraine patient showing exacerbated hyperalgesia.
Article
Clinical Neurology
Leyi Zhang, Chenglong Lu, Li Kang, Yingji Li, Wenjing Tang, Dengfa Zhao, Shengyuan Yu, Ruozhuo Liu
Summary: This study found that recurrent infusion of inflammatory soup in mice resulted in mechanical allodynia in both the periorbital and hind paw regions, with increased and sustained levels of GFAP protein and mRNA in the TNC. Furthermore, the levels of cytokines CCL7, CCL12, and IL-10 may be modulated by astrocytic activation, contributing to the pathology of chronic migraine.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Chemistry, Multidisciplinary
Shiyao Song, Wenjing Tang, Shengyuan Yu, Huwei Liu, Yu Bai
Summary: In this study, the levels of bile acid metabolites were compared in the serum of migraine patients and healthy controls, and it was found that there were differences between male patients and male controls, suggesting a gender-related variation in bile acids. This highlights the importance of gender-stratified analysis in studying diseases with varying morbidity in males and females. Five differential metabolites may serve as potential serum biomarkers for male migraine patients.
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
(2022)
Article
Cell & Tissue Engineering
Tao Wang, Wenjing Tang, Quan Zeng, Shuai Miao, Chenghui Pi, Yingji Li, Wen Yue, Shengyuan Yu
Summary: In this study, peripheral blood mononuclear cells from a healthy 25-year-old Han Chinese man were reprogrammed into induced pluripotent stem cells (iPSCs) using transcription factors. The pluripotency of these iPSC lines was confirmed and they were able to differentiate into all three germ layers, making them suitable for use as control cells in drug development and pathological mechanism studies.
STEM CELL RESEARCH
(2022)
Article
Neurosciences
Zhe Yu, Bozhi Li, Wenjing Tang, Zhao Dong, Ruozhuo Liu, Shengyuan Yu
Summary: Sleep deprivation can significantly prolong the duration of hyperalgesia induced by nitroglycerin and increase the expression of Fos in the brain. This study highlights the importance of sleep disorders for migraine.
Article
Clinical Neurology
Wei Xie, Ruibing Li, Wenjing Tang, Zhenjie Ma, Shuai Miao, Chenhao Li, Chunxiao Yang, Bozhi Li, Tao Wang, Zihua Gong, Yue Zhou, Shengyuan Yu
Summary: This study investigated the role of mitochondria in migraine using a mouse model of chronic migraine. The proteomics profiling revealed mitochondrial dysfunction in key brain regions associated with migraine pathogenesis. Furthermore, the intervention of Urolithin A partially alleviated mitochondrial damage and migraine symptoms.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Medicine, General & Internal
Chunlin Li, Shengyuan Yu, Huiying Li, Jin Zhou, Jieqiong Liu, Wenjing Tang, Lei Zhang
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2017)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)
