A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention

PAC1 receptor blockade reduces central nociceptive activity

(2020) Jan Hoffmann et al.   PAIN

CGRP ligand and receptor monoclonal antibodies for migraine prevention: Evidence review and clinical implications

(2019) David W Dodick   CEPHALALGIA

More precise phenotyping of cluster headache using prospective attack reports

(2019) A.H. Snoer et al.   EUROPEAN JOURNAL OF NEUROLOGY

Calcitonin Gene‐Related Peptide Modulators – The History and Renaissance of a New Migraine Drug Class

(2019) Richard Hargreaves et al.   HEADACHE

PACAP27 induces migraine-like attacks in migraine patients

(2019) Hashmat Ghanizada et al.   CEPHALALGIA

Emerging Treatment Targets for Migraine and Other Headaches

(2019) Zachariah Bertels et al.   HEADACHE

Targeting calcitonin gene-related peptide: a new era in migraine therapy

(2019) Andrew Charles et al.   LANCET

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition

(2018)   CEPHALALGIA

PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache

(2018) Philip R. Holland et al.   JOURNAL OF HEADACHE AND PAIN

Targeted Pituitary Adenylate Cyclase-Activating Peptide Therapies for Migraine

(2018) Anne Luise Haulund Vollesen et al.   Neurotherapeutics

PACAP38 and PAC1 receptor blockade: a new target for headache?

(2018) Eloisa Rubio-Beltrán et al.   JOURNAL OF HEADACHE AND PAIN

Psychometric Evaluation of a Novel Instrument Assessing the Impact of Migraine on Physical Functioning: The Migraine Physical Function Impact Diary

(2017) Ariane K. Kawata et al.   HEADACHE

PACAP38 in human models of primary headaches

(2017) Håkan Ashina et al.   JOURNAL OF HEADACHE AND PAIN

Chronic changes in pituitary adenylate cyclase-activating polypeptide and related receptors in response to repeated chemical dural stimulation in rats

(2017) Xun Han et al.   Molecular Pain

Persistence and switching patterns of oral migraine prophylactic medications among patients with chronic migraine: A retrospective claims analysis

(2016) Zsolt Hepp et al.   CEPHALALGIA

Part II: Biochemical changes after pituitary adenylate cyclase-activating polypeptide-38 infusion in migraine patients

(2016) Song Guo et al.   CEPHALALGIA

Premonitory and nonheadache symptoms induced by CGRP and PACAP38 in patients with migraine

(2016) Song Guo et al.   PAIN

Prevalence of cranial autonomic parasympathetic symptoms in chronic migraine: Usefulness of a new scale

(2015) Nuria Riesco et al.   CEPHALALGIA

Evidence for orexinergic mechanisms in migraine

(2015) Jan Hoffmann et al.   NEUROBIOLOGY OF DISEASE

Neuronal PAC 1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine

(2015) Simon Akerman et al.   Science Translational Medicine

Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38

(2014) Faisal Mohammad Amin et al.   BRAIN

Randomized controlled trial of the orexin receptor antagonist filorexant for migraine prophylaxis

(2014) Almira Chabi et al.   CEPHALALGIA

Preventive treatment in migraine and the new US guidelines

(2013) Emad Estemalik et al.   Neuropsychiatric Disease and Treatment

Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers

(2011) Faisal Mohammad Amin et al.   CEPHALALGIA

The PACAP receptor: A novel target for migraine treatment

(2010) Henrik W. Schytz et al.   Neurotherapeutics

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

(2009) D. Vaudry et al.   PHARMACOLOGICAL REVIEWS

PACAP38 induces migraine-like attacks in patients with migraine without aura

(2008) Henrik Winther Schytz et al.   BRAIN

Vasoactive Intestinal Peptide Causes Marked Cephalic Vasodilation, but does not Induce Migraine

(2008) A Rahmann et al.   CEPHALALGIA