Concise Review: Mechanisms Behind Apoptotic Cell-Based Therapies Against Transplant Rejection and Graft versus Host Disease

The Tolerogenic Function of Annexins on Apoptotic Cells Is Mediated by the Annexin Core Domain

(2015) Björn Linke et al.   JOURNAL OF IMMUNOLOGY

Engulfment of Activated Apoptotic Cells Abolishes TGF-β–Mediated Immunoregulation via the Induction of IL-6

(2015) Clare A. Notley et al.   JOURNAL OF IMMUNOLOGY

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Transforming growth factor-β released by apoptotic white blood cells during red blood cell storage promotes transfusion-induced alloimmunomodulation

(2015) Romain Vallion et al.   TRANSFUSION

Extracorporeal Photopheresis: Tolerogenic or Immunogenic Cell Death? Beyond Current Dogma

(2015) Dalil Hannani   Frontiers in Immunology

Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection

(2014) Fanny Tzelepis et al.   JOURNAL OF CLINICAL INVESTIGATION

The Apoptotic Pathway Contributing to the Deletion of Naive CD8 T Cells during the Induction of Peripheral Tolerance to a Cross-Presented Self-Antigen

(2014) W. L. Redmond et al.   JOURNAL OF IMMUNOLOGY

Experimental Extracorporeal Photopheresis Inhibits the Sensitization and Effector Phases of Contact Hypersensitivity via Two Mechanisms: Generation of IL-10 and Induction of Regulatory T Cells

(2014) A. Maeda et al.   JOURNAL OF IMMUNOLOGY

Apoptotic Cells Induce Immunosuppression through Dendritic Cells: Critical Roles of IFN-  and Nitric Oxide

(2014) G. Ren et al.   JOURNAL OF IMMUNOLOGY

Phagocytosis of apoptotic or necrotic cells differentially regulates the transcriptional expression of IL-12 family members in dendritic cells

(2014) K. O. Dixon et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modified Extracorporeal Photopheresis with Cells from a Healthy Donor for Acute Graft-versus-Host Disease in a Mouse Model

(2014) Holger Budde et al.   PLoS One

Marginal zone CD169+ macrophages coordinate apoptotic cell-driven cellular recruitment and tolerance

(2014) B. Ravishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Infusion of Donor Mononuclear Early Apoptotic Cells as Prophylaxis for Graft-versus-Host Disease in Myeloablative HLA-Matched Allogeneic Bone Marrow Transplantation: A Phase I/IIa Clinical Trial

(2013) Dror Mevorach et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Apoptotic cell administration enhances pancreatic islet engraftment by induction of regulatory T cells and tolerogenic dendritic cells

(2013) Cong Wu et al.   Cellular & Molecular Immunology

Prospects of apoptotic cell-based therapies for transplantation and inflammatory diseases

(2013) Philippe Saas et al.   Immunotherapy

Prolonged Apoptotic Cell Accumulation in Germinal Centers of Mer-Deficient Mice Causes Elevated B Cell and CD4+ Th Cell Responses Leading to Autoantibody Production

(2013) T. N. Khan et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell Therapies in Transplantation Revisited: Deletion of Recipient DCs Deters the Effect of Therapeutic DCs

(2012) Z. Wang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Intravenous infusion of donor apoptotic leukocytes before transplantation delays allogeneic islet graft rejection through regulatory T cells

(2012) F. Mougel et al.   DIABETES & METABOLISM

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

(2012) Stefan Uderhardt et al.   IMMUNITY

Ethylenecarbodiimide-Fixed Donor Splenocyte Infusions Differentially Target Direct and Indirect Pathways of Allorecognition for Induction of Transplant Tolerance

(2012) T. Kheradmand et al.   JOURNAL OF IMMUNOLOGY

Marginal zone macrophages suppress innate and adaptive immunity to apoptotic cells in the spleen

(2011) T. L. McGaha et al.   BLOOD

Cell Death in the Maintenance and Abrogation of Tolerance: The Five Ws of Dying Cells

(2011) Thomas S. Griffith et al.   IMMUNITY

Allogeneic apoptotic thymocyte-stimulated dendritic cells expand functional regulatory T cells

(2011) Thaís Boccia da Costa et al.   IMMUNOLOGY

Plasmacytoid Dendritic Cells Play a Major Role in Apoptotic Leukocyte-Induced Immune Modulation

(2011) F. Bonnefoy et al.   JOURNAL OF IMMUNOLOGY

Natural IgM Is Required for Suppression of Inflammatory Arthritis by Apoptotic Cells

(2011) C. A. Notley et al.   JOURNAL OF IMMUNOLOGY

Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells

(2011) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells

(2011) K. Miles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravenous apoptotic cell infusion as a cell-based therapy toward improving hematopoietic cell transplantation outcome

(2010) Philippe Saas et al.   Annals of the New York Academy of Sciences

Alpha (v) integrins license regulatory T cells to apoptotic cells and self-associated antigens

(2010) Helena Païdassi et al.   Annals of the New York Academy of Sciences

Immune regulation by apoptotic cell clearance

(2010) Masato Tanaka et al.   Annals of the New York Academy of Sciences

Apoptotic cell-based therapies against transplant rejection: role of recipient’s dendritic cells

(2010) Adrian E. Morelli et al.   APOPTOSIS

Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation

(2010) S. J. Divito et al.   BLOOD

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

Extracorporeal photopheresis affects co-stimulatory molecule expression and interleukin-10 production by dendritic cells in graft-versus-host disease patients

(2010) M. Di Renzo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling

(2010) Danute Pupjalis et al.   EMBO Molecular Medicine

Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+Treg

(2010) Rahul Kushwah et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ethylenecarbodiimide-Treated Splenocytes Carrying Male CD4 Epitopes Confer Histocompatability Y Chromosome Antigen Transplant Protection by Inhibiting CD154 Upregulation

(2010) A. J. Martin et al.   JOURNAL OF IMMUNOLOGY

Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor   or Retinoid X Receptor   Deficiency

(2010) T. Roszer et al.   JOURNAL OF IMMUNOLOGY

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Harnessing Naturally Occurring Tumor Immunity: A Clinical Vaccine Trial in Prostate Cancer

(2010) Mayu O. Frank et al.   PLoS One

Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches

(2009) Terry J. Fry et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Activation-Induced CD154 Expression Abrogates Tolerance Induced by Apoptotic Cells

(2009) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Apoptotic Dendritic Cells Induce Tolerance in Mice through Suppression of Dendritic Cell Maturation and Induction of Antigen-Specific Regulatory T Cells

(2009) R. Kushwah et al.   JOURNAL OF IMMUNOLOGY

Novel Subset of CD8 + Dendritic Cells Localized in the Marginal Zone Is Responsible for Tolerance to Cell-Associated Antigens

(2009) C.-H. Qiu et al.   JOURNAL OF IMMUNOLOGY

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

(2009) Miriam Beer Torchinsky et al.   NATURE

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

In Situ-Targeting of Dendritic Cells with Donor-Derived Apoptotic Cells Restrains Indirect Allorecognition and Ameliorates Allograft Vasculopathy

(2009) Zhiliang Wang et al.   PLoS One

Extracorporeal Photophoresis Augments Function of CD4+CD25+FoxP3+ Regulatory T Cells by Triggering Adenosine Production

(2009) Sabrina Schmitt et al.   TRANSPLANTATION

Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells

(2008) E. Gatza et al.   BLOOD

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

A multicenter prospective phase 2 randomized study of extracorporeal photopheresis for treatment of chronic graft-versus-host disease

(2008) M. E. D. Flowers et al.   BLOOD

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

(2008) David R. Gude et al.   FASEB JOURNAL

Constitutive Crosspresentation of Tissue Antigens by Dendritic Cells Controls CD8+ T Cell Tolerance In Vivo

(2008) Nancy Luckashenak et al.   IMMUNITY

Apoptotic cells induce dendritic cell-mediated suppression via interferon-γ-induced IDO

(2008) Charlotte A. Williams et al.   IMMUNOLOGY

Infusion of UVB-treated splenic stromal cells induces suppression of β cell antigen-specific T cell responses in NOD mice

(2008) Chang-Qing Xia et al.   JOURNAL OF AUTOIMMUNITY

MerTK is required for apoptotic cell–induced T cell tolerance

(2008) Mark A. Wallet et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role for CD4+CD25+ T Cells in Inhibition of Graft Rejection by Extracorporeal Photopheresis

(2008) James F. George et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

CD3-specific antibody–induced immune tolerance involves transforming growth factor-β from phagocytes digesting apoptotic T cells

(2008) Sylvain Perruche et al.   NATURE MEDICINE

ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms

(2008) X. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracorporeal Photopheresis After Lung Transplantation: A 10-Year Single-Center Experience

(2008) Christian Benden et al.   TRANSPLANTATION

Potential Applications of Extracorporeal Photopheresis in Liver Transplantation

(2008) L. Urbani et al.   TRANSPLANTATION PROCEEDINGS