Article
Immunology
Yi Zhang, Lei Li, Genevieve Genest, Wei Zhao, Dan Ke, Sabrina Bartolucci, Nils Pavey, Tho-Alfakar Al-Aubodah, Duncan Lejtenyi, Bahar Torabi, Moshe Ben-Shoshan, Bruce Mazer, Ciriaco A. Piccirillo
Summary: In this study, the induction of specific T-REG cells during oral immunotherapy (OIT) in children with cow's milk protein (CMP) allergy was found to be effective in promoting tolerance and reducing Th2 responses. The expansion of these T-REG cells correlated with successful desensitization to CMP and may be a potential marker for predicting the time to reach maintenance phase in OIT.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Nardos Cheru, David A. Hafler, Tomokazu S. Sumida
Summary: Maintenance of peripheral tolerance by CD4(+)Foxp3(+) regulatory T cells is crucial for regulating autoreactive T cells. Dysfunction of Foxp3 leads to autoimmune diseases. Tregs not only maintain immune homeostasis, but also establish tissue microenvironment and homeostasis of non-lymphoid tissues. Tissue resident Tregs show unique profiles and interact with both immune and non-immune cells, exerting suppressive function and adopting to local microenvironment through bidirectional interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Sara Ness, Shiming Lin, John R. Gordon
Summary: Dendritic cells are antigen-presenting cells that interact with T cells to regulate adaptive immune responses. Under certain conditions, dendritic cells can develop into anti-inflammatory cells, inducing immunologic tolerance. Studies have shown that regulatory dendritic cells induce T cell tolerance by suppressing effector T cells and inducing regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Daniel S. Shin, Sneha Ratnapriya, Creel Ng Cashin, Lucy F. Kuhn, Rod A. Rahimi, Robert M. Anthony, James J. Moon
Summary: Self-antigen-specific T cells are regulated through tolerance mechanisms, but tissue injury can disrupt this regulation and trigger autoimmunity. Using mouse models of lung injury, we found that acute injury leads to the expansion of CD4+ regulatory T cells (Tregs) that specifically recognize self-antigen. Conventional CD4+ T cells with the same self-antigen specificity remained unresponsive even after Treg ablation. Therefore, the self-antigen-specific CD4+ T cell repertoire plays a regulatory role in limiting tissue damage and autoimmunity during acute injury.
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jer-Hwa Chang, Hsiao-Chi Chuang, George Hsiao, Tsung-Yun Hou, Ching-Chiung Wang, Shih-Chun Huang, Bo-Yi Li, Yueh-Lun Lee
Summary: Acteoside can suppress the production of proinflammatory mediators by dendritic cells and enhance the secretion of anti-inflammatory cytokines. It can also promote the generation of regulatory T cells through aryl hydrocarbon receptor activation. In a mouse model of allergic asthma, acteoside can reduce Th2-type cytokine levels, increase the levels of anti-inflammatory cytokines and the frequency of regulatory T cells, and ameliorate asthma symptoms and pulmonary inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Jessica G. Lee, Kathleen E. Jaeger, Yoichi Seki, Yi Wei Lim, Christina Cunha, Aleksandra Vuchkovska, Alexander J. Nelson, Anya Nikolai, Dan Kim, Michael Nishimura, Katherine L. Knight, Paula White, Makio Iwashima
Summary: The study reveals that a subset of CD14(+) monocytes can generate regulatory Foxp3(+) T-bet(+) T cells from umbilical cord blood, which suppress T-cell proliferation and ameliorate graft-versus-host disease. Additionally, adult peripheral blood monocytes are capable of inducing Foxp3(+) T cells, but their induction is inhibited by lymphoid cells from adult peripheral blood in neonates. This suggests a novel immunoregulatory role of monocytes in generating regulatory T cells with implications for both neonates and adults.
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhengjuan Li, Xinyuan Liang, Xiaowen Chen, Yuying Chen, Fang Wang, Shuoshi Wang, Yihong Liao, Liping Li
Summary: This study investigated the role of thymus-derived Treg cells and peripherally derived Treg cells in maternal-fetal immune tolerance. It was found that the percentages of Treg cells in the blood and decidua increased during pregnancy, and these cells played an important immunosuppressive role. Thymus and spleen Treg cells showed stronger immune-suppression effects compared to in vitro induced Treg cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Noemi Anna Nagy, Fernando Lozano Vigario, Rinske Sparrius, Toni M. M. van Capel, Ronald W. van Ree, Sander Tas, I. Jolanda M. de Vries, Teunis B. H. Geijtenbeek, Bram C. Slutter, Esther de Jong
Summary: Nanomedicine offers a promising platform for manipulating dendritic cells (DCs) and the adaptive immune response. Liposomal vitamin D3 can induce the development of regulatory CD4+ T cells and inhibit the proliferation of memory T cells. It can also suppress the development of Th1 and Th17 cells and stimulate the migration of CD14+ skin DCs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Shareni Jeyamogan, Joseph R. Leventhal, James M. Mathew, Zheng Jenny Zhang
Summary: Solid organ transplantation (SOT) and vascularized composite allotransplantation (VCA) are the gold-standard treatments for end-stage organ failure and complex tissue defects. However, ischemia reperfusion injury (IRI) is a major factor that can negatively impact transplant outcomes. CD4+CD25+FOXP3+ regulatory T cells (Tregs) have immunomodulatory potential and can prevent and mitigate IRI. Increasing the number of Tregs and targeted delivery can improve the outcomes of SOT and VCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lilian Gomes de Oliveira, Yan de Souza Angelo, Antonio H. Iglesias, Jean Pierre Schatzmann Peron
Summary: Neuroinflammatory and neurodegenerative diseases are major public health issues worldwide, with mitochondrial dysfunction playing a significant role. Regulation of mitochondrial dynamics is essential for CNS health maintenance, impacting the development and progression of neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Sergio M. Borghi, Sandra S. Mizokami, Thacyana T. Carvalho, Fernanda S. Rasquel-Oliveira, Camila R. Ferraz, Victor Fattori, Thiago H. Hayashida, Jean P. S. Peron, Doumit Camilios-Neto, Sergio R. Ambrosio, Nilton S. Arakawa, Rubia Casagrande, Waldiceu A. Verri Jr
Summary: The study demonstrated that KA can inhibit LPS-induced mechanical and thermal hyperalgesia, MPO activity, and modulate redox status in the mice paw. In LPS peritonitis, KA inhibited leukocyte migration, cytokine production, oxidative stress, and NF-κB activation, indicating its potential as a candidate for controlling inflammation and pain during gram-negative bacterial infections.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Infectious Diseases
Igor Salerno Filgueiras, Amanda Torrentes de Carvalho, Daniela Prado Cunha, Dennyson Leandro Mathias da Fonseca, Nadia El Khawanky, Paula Paccielli Freire, Gustavo Cabral-Miranda, Lena F. Schimke, Niels Olsen Saraiva Camara, Hans D. Ochs, Jean Pierre Schatzmann Peron, Otavio Cabral-Marques, Zilton Farias Meira de Vasconcelos
Summary: The outbreak of Zika virus infection led to a public health emergency, causing congenital microcephaly and abnormal neurologic development in newborns as well as neuroimmune disorders in adults. While the number of ZIKV-infected patients has decreased, the potential for new outbreaks remains, highlighting the need for further research and government attention.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Rafael A. Larocca, Peter Abbink, John D. Ventura, Abishek Chandrashekar, Noe Mercado, Zhenfeng Li, Erica Borducchi, Rafael A. de la Barrera, Kenneth H. Eckels, Kayvon Modjarrad, Michael P. Busch, Nelson L. Michael, Dan H. Barouch
Summary: The study shows that baseline immunity induced by DENV vaccination does not significantly enhance ZIKV infection or impair the protective efficacy of ZIKV vaccines.
Article
Clinical Neurology
Yara D. Fragoso, Sidney Gomes, Marcus Vinicius M. Goncalves, Euldes Mendes Junior, Bianca Etelvina S. de Oliveira, Cristiane Franklin Rocha, Gutemberg A. Cruz dos Santos, Carlos Bernardo Tauil, Raquel Vassao Araujo, Jean Pierre S. Peron
Summary: This article reports on nine patients (eight with MS and one with NMOSD) who experienced a disease relapse shortly after receiving their first dose of AZD1222 vaccine against COVID-19. These patients had been stable for six years on average, with no disease activity and unchanged medication. Within a median of 13 days (range 7 to 25 days) after vaccination, they developed new relapses with increased disability and new lesions on magnetic resonance imaging. Although this association may be rare, it suggests a potential adverse event of AZD1222.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Patricia Aparecida Borim, Luiza Ayumi Nishiyama Mimura, Sofia Fernanda Goncalves Zorzella-Pezavent, Carolina Manganeli Polonio, Jean Pierre Schatzmann Peron, Alexandrina Sartori, Thais Fernanda de Campos Fraga-Silva
Summary: In this study, the researchers evaluated the in vitro effect of rapamycin on immune cells in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). The results showed that rapamycin reduced inflammation and activation of immune cells, indicating its potential as a therapeutic drug for multiple sclerosis (MS) and EAE.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Article
Cell Biology
Lena F. Schimke, Alexandre H. C. Marques, Gabriela Crispim Baiocchi, Caroline Aliane de Souza Prado, Dennyson Leandro M. Fonseca, Paula Paccielli Freire, Desiree Rodrigues Placa, Igor Salerno Filgueiras, Ranieri Coelho Salgado, Gabriel Jansen-Marques, Antonio Edson Rocha Oliveira, Jean Pierre Schatzmann Peron, Gustavo Cabral-Miranda, Jose Alexandre Marzagao Barbuto, Niels Olsen Saraiva Camara, Vera Lucia Garcia Calich, Hans D. Ochs, Antonio Condino-Neto, Katherine A. Overmyer, Joshua J. Coon, Joseph Balnis, Ariel Jaitovich, Jonas Schulte-Schrepping, Thomas Ulas, Joachim L. Schultze, Helder I. Nakaya, Igor Jurisica, Otavio Cabral-Marques
Summary: Severe COVID-19 patients show similarities with other hyperinflammatory conditions, such as HLH, in terms of clinical and laboratory features. This study highlights the shared immunological pathways and neutrophil-mediated immune responses between COVID-19 and HLH. Dysregulated neutrophil-associated genes and proteins are observed in COVID-19 patients admitted to the ICU, suggesting a generalized hyperinflammatory state. These findings provide potential therapeutic targets for intervention.
Article
Biochemistry & Molecular Biology
Lilian Gomes de Oliveira, Yan de Souza Angelo, Pedro Yamamoto, Victor Corasolla Carregari, Fernanda Crunfli, Guilherme Reis-de-Oliveira, Licia Costa, Pedro Henrique Vendramini, Erica Almeida Duque, Nilton Barreto dos Santos, Egidi Mayara Firmino, Isadora Marques Paiva, Glaucia Maria Almeida, Adriano Sebollela, Carolina Manganeli Polonio, Nagela Ghabdan Zanluqui, Marilia Garcia de Oliveira, Patrick da Silva, Gustavo Gastao Davanzo, Marina Cacador Ayupe, Caio Loureiro Salgado, Antonio Francisco de Souza Filho, Marcelo Valdemir de Araujo, Taiana Taina Silva-Pereira, Angelica Cristine de Almeida Campos, Luiz Gustavo Bentim Goes, Marielton dos Passos Cunha, Elia Garcia Caldini, Maria Regina D'Imperio Lima, Denise Morais Fonseca, Ana Marcia de Sa Guimaraes, Paola Camargo Minoprio, Carolina Demarchi Munhoz, Claudia Madalena Cabrera Mori, Pedro Manoel Moraes-Vieira, Thiago Mattar Cunha, Daniel Martins-de-Souza, Jean Pierre Schatzmann Peron
Summary: COVID-19 infection alters the immune metabolism and disrupts the balance of important metabolic molecules and neurotransmitters in astrocytes, which may contribute to neurological impairment observed during the disease.
JOURNAL OF NEUROCHEMISTRY
(2022)
Review
Clinical Neurology
Isabelle Pastor Bandeira, Andre Eduardo de Almeida Franzoi, Giulia Murillo Wollmann, Washigton Luiz Gomes de Medeiros Junior, Wesley Nogueira Brandao, Jean Pierre Schatzmann Peron, Jefferson Becker, Osvaldo Jose Moreira Nascimento, Marcus Vinicius Magno Goncalves
Summary: Multiple sclerosis is a chronic autoimmune disease that affects the central nervous system. This review focuses on the potential correlation and positive feedback between interleukin-31 and soluble CD40L in the proinflammatory response of multiple sclerosis, and explores the possibility of using these cytokines as biomarkers for the disease.
NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Carolina M. Polonio, Patrick da Silva, Fabiele B. Russo, Brendo R. N. Hyppolito, Nagela G. Zanluqui, Cecilia Benazzato, Patricia C. B. Beltrao-Braga, Sandra M. Muxel, Jean Pierre S. Peron
Summary: Viral infections, particularly Zika virus, have a significant impact on public health, causing severe fetal neuropathogenesis and microcephaly. MiRNAs play a role in infected neuronal precursor cells and directly contribute to the pathogenesis of fetal microcephaly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Genetics & Heredity
J. P. S. Peron
Summary: Although COVID-19 primarily affects the lungs, it can also have a significant impact on the central nervous system, leading to a range of neurological and psychiatric symptoms. Understanding the relationship between SARS-CoV-2 and the brain is crucial for researchers and healthcare practitioners.
Article
Biochemistry & Molecular Biology
Ivana F. Rosa, Ana P. B. Pecanha, Tabata R. B. Carvalho, Leonardo S. Alexandre, Vinicius G. Ferreira, Lucas B. Doretto, Beatriz M. Souza, Rafael T. Nakajima, Patrick da Silva, Ana P. Barbosa, Leticia Gomes-de-Pontes, Camila G. Bomfim, Glaucia M. Machado-Santelli, Antonio Condino-Neto, Cristiane R. Guzzo, Jean P. S. Peron, Magaiver Andrade-Silva, Niels O. S. Camara, Anali M. B. Garnique, Renata J. Medeiros, Fausto K. Ferraris, Leonardo J. G. Barcellos, Jose D. Correia-Junior, Jorge Galindo-Villegas, Monica F. R. Machado, Angela Castoldi, Susana L. Oliveira, Camila C. Costa, Marco A. A. Belo, Giovane Galdino, German G. Sgro, Natalia F. Bueno, Silas F. Eto, Flavio P. Veras, Bianca H. V. Fernandes, Paulo R. S. Sanches, Eduardo M. Cilli, Guilherme Malafaia, Rafael H. Nobrega, Aguinaldo S. Garcez, Emanuel Carrilho, Ives Charlie-Silva
Summary: The study investigates the potential effect of red photobiomodulation (PBM) as a therapy for COVID-19. The findings suggest that inflammation is a significant feature of the disease, and PBM can help regulate the inflammatory response. Metabolomics analysis also reveals shared impacts on metabolic pathways between PBM and COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jonathan Miguel Zanatta, Stephanie Maia Acuna, Yan de Souza Angelo, Camilla de Almeida Bento, Jean Pierre Schatzman Peron, Beatriz Simonsen Stolf, Sandra Marcia Muxel
Summary: This study investigated the effects of L-arginine and polyamines on L. amazonensis infection and the transcriptional regulation of genes related to arginine metabolism and proinflammatory response in BALB/c macrophages. The results showed that putrescine supplementation reduced the percentage of infected macrophages compared to other supplements. Additionally, the availability of polyamines was found to interfere with cytokine/chemokine production.
Article
Toxicology
Ana Carolina Cardoso dos Santos Durao, Wesley Nogueira Brandao, Vitor Bruno, Lidia Emmanuela W. Spelta, Stephanie de Oliveira Duro, Nilton Barreto dos Santos, Beatriz Aparecida Passos Bismara Paranhos, Nagela Ghabdan Zanluqui, Mauricio Yonamine, Jean Pierre Schatzmann Peron, Carolina Demarchi Munhoz, Tania Marcourakis
Summary: The embryonic stage is the most vulnerable period for congenital abnormalities, and the central nervous system is susceptible to genetic, epigenetic, and environmental influences. This study aimed to evaluate the effects of in utero exposure to environmental tobacco smoke on neuroinflammation in mice offspring. The results showed that exposure to smoke during pregnancy led to increased levels of proinflammatory cytokines and decreased cell viability, potentially affecting fetal programming and leading to more severe neuroinflammation.
FRONTIERS IN TOXICOLOGY
(2022)
Article
Cell & Tissue Engineering
Carla Longo de Freitas, Carolina Manganeli Polonio, Wesley Nogueira Brandao, Cristiano Rossato, Nagela Ghabdan Zanluqui, Lilian Gomes de Oliveira, Marilia Garcia de Oliveira, Lucila Pires Evangelista, Silvio Halpern, Mariangela Maluf, Carlos Eduardo Czresnia, Paulo Perin, Danilo Candido de Almeida, Jean Pierre Schatzmman Peron
Summary: Mesenchymal stem cells, including human tubal mesenchymal stem cells (htMSCs), have been shown to possess immunomodulatory properties and potential in alleviating inflammatory and autoimmune diseases through suppressing dendritic cell activation, altering cytokine secretion, and reducing immune cell infiltration in the central nervous system. Additionally, upregulation of specific molecules like IDO and BDNF indicates the therapeutic potential of htMSCs in treating neurodegenerative diseases.
STEM CELL REVIEWS AND REPORTS
(2022)