Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

While p73 is essential, p63 is completely dispensable for the development of the central nervous system

(2011) Lena Holembowski et al.   CELL CYCLE

HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab

(2011) S. Modi et al.   CLINICAL CANCER RESEARCH

Expression of Macrophage Migration Inhibitory Factor and CD74 in Cervical Squamous Cell Carcinoma

(2011) Rong-jie Cheng et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Elevated expression of macrophage migration inhibitory factor correlates with tumor recurrence and poor prognosis of patients with gliomas

(2011) Xiao-bing Wang et al.   JOURNAL OF NEURO-ONCOLOGY

Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90

(2011) Kamalika Moulick et al.   Nature Chemical Biology

Evaluation of macrophage migration inhibitory factor as an imaging marker for hepatocellular carcinoma in murine models

(2011) Chao Zhang et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Therapeutic Effects of Radiolabeled 17-Allylamino-17-Demethoxygeldanamycin on Human H460 Nonsmall-Cell Lung Carcinoma Xenografts in Mice

(2010) Jin Sun et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Critical Roles of DMP1 in Human Epidermal Growth Factor Receptor 2/neu-Arf-p53 Signaling and Breast Cancer Development

(2010) P. Taneja et al.   CANCER RESEARCH

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link

(2010) H. Conroy et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Histone deacetylase inhibitors repress macrophage migration inhibitory factor (MIF) expression by targeting MIF gene transcription through a local chromatin deacetylation

(2009) Jérôme Lugrin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dual role of macrophage migration inhibitory factor (MIF) in human breast cancer

(2009) Eva Verjans et al.   BMC CANCER

A Tautomerase-Null Macrophage Migration-Inhibitory Factor (MIF) Gene Knock-In Mouse Model Reveals That Protein Interactions and Not Enzymatic Activity Mediate MIF-Dependent Growth Regulation

(2009) G. Fingerle-Rowson et al.   MOLECULAR AND CELLULAR BIOLOGY

Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6

(2009) A. Gibbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligase

(2009) E. S. Ehrlich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat shock protein 90 inhibition abrogates hepatocellular cancer growth through cdc2-mediated G2/M cell cycle arrest and apoptosis

(2008) Go Watanabe et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Overexpression of macrophage migration inhibitory factor induces angiogenesis in human breast cancer

(2008) Xiangdong Xu et al.   CANCER LETTERS

Macrophage migration inhibitory factor (MIF) plays a critical role in pathogenesis of ultraviolet-B (UVB) -induced nonmelanoma skin cancer (NMSC)

(2008) Jason Martin et al.   FASEB JOURNAL

CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins

(2008) Y. Morishima et al.   HUMAN MOLECULAR GENETICS

Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95

(2008) M. A. Park et al.   MOLECULAR CANCER THERAPEUTICS

Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner

(2008) Seiko Oda et al.   PLoS One