Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders

Bipolar disorder

(2016) Iria Grande et al.   LANCET

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Characterization of a subpopulation of developing cortical interneurons from human iPSCs within serum-free embryoid bodies

(2015) Michael W. Nestor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients

(2015) Aaron Topol et al.   BIOLOGICAL PSYCHIATRY

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

rsPSCs: A new type of pluripotent stem cells

(2015) Uri Weissbein et al.   CELL RESEARCH

Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency

(2015) Lorenz Studer et al.   Cell Stem Cell

A Continuous Molecular Roadmap to iPSC Reprogramming through Progression Analysis of Single-Cell Mass Cytometry

(2015) Eli R. Zunder et al.   Cell Stem Cell

Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1

(2015) ChangHui Pak et al.   Cell Stem Cell

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial

(2015) John McNeish et al.   Cell Stem Cell

Common Mechanisms of Excitatory and Inhibitory Imbalance in Schizophrenia and Autism Spectrum Disorders

(2015) R. Gao et al.   CURRENT MOLECULAR MEDICINE

Autism and the synapse

(2015) Darius Ebrahimi-Fakhari et al.   CURRENT OPINION IN NEUROLOGY

In vitro myelin formation using embryonic stem cells

(2015) B. E. Kerman et al.   DEVELOPMENT

Duration of culture and sonic hedgehog signaling differentially specify PV versus SST cortical interneuron fates from embryonic stem cells

(2015) J. A. Tyson et al.   DEVELOPMENT

How to make a midbrain dopaminergic neuron

(2015) E. Arenas et al.   DEVELOPMENT

Genetics and genomics of autism spectrum disorder: embracing complexity

(2015) Silvia De Rubeis et al.   HUMAN MOLECULAR GENETICS

Cellular models to study bipolar disorder: A systematic review

(2015) Biju Viswanath et al.   JOURNAL OF AFFECTIVE DISORDERS

Human-derived neural progenitors functionally replace astrocytes in adult mice

(2015) Hong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Motoneurons Derived from Induced Pluripotent Stem Cells Develop Mature Phenotypes Typical of Endogenous Spinal Motoneurons

(2015) J. S. Toma et al.   JOURNAL OF NEUROSCIENCE

hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells

(2015) Brooke A. DeRosa et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Altered neuronal network and rescue in a human MECP2 duplication model

(2015) S Nageshappa et al.   MOLECULAR PSYCHIATRY

Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking

(2015) S Chanda et al.   MOLECULAR PSYCHIATRY

Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder

(2015) S Bavamian et al.   MOLECULAR PSYCHIATRY

Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities

(2015) J M Madison et al.   MOLECULAR PSYCHIATRY

Direct conversion of human fibroblasts to induced serotonergic neurons

(2015) Z Xu et al.   MOLECULAR PSYCHIATRY

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

(2015) Fadi J. Najm et al.   NATURE

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson's disease model

(2015) Julius A Steinbeck et al.   NATURE BIOTECHNOLOGY

Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells

(2015) Daniel Paull et al.   NATURE METHODS

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

The PsychENCODE project

(2015) Schahram Akbarian et al.   NATURE NEUROSCIENCE

High-throughput functional genomics using CRISPR–Cas9

(2015) Ophir Shalem et al.   NATURE REVIEWS GENETICS

MECP2e1 isoform mutation affects the form and function of neurons derived from Rett syndrome patient iPS cells

(2015) Ugljesa Djuric et al.   NEUROBIOLOGY OF DISEASE

Cell-Based Screening: Extracting Meaning from Complex Data

(2015) Steven Finkbeiner et al.   NEURON

Excitatory/Inhibitory Balance and Circuit Homeostasis in Autism Spectrum Disorders

(2015) Sacha B. Nelson et al.   NEURON

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro

(2015) Cedric Bardy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A survey of human brain transcriptome diversity at the single cell level

(2015) Spyros Darmanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

(2015) Michael P. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation and characterisation of neuromuscular junctions between hiPSC derived motoneurons and myotubes

(2015) M. Demestre et al.   Stem Cell Research

Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells

(2015) Katrina L. Adams et al.   Nature Communications

Path from schizophrenia genomics to biology: gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing

(2015) Jubao Duan   Neuroscience Bulletin

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

(2015) Priya Srikanth et al.   Cell Reports

Advances in Reprogramming to Pluripotency

(2015) Suad Alateeq et al.   Current Stem Cell Research & Therapy

High-Throughput Screening to Identify Compounds That Increase Fragile X Mental Retardation Protein Expression in Neural Stem Cells Differentiated From Fragile X Syndrome Patient-Derived Induced Pluripotent Stem Cells

(2015) Daman Kumari et al.   Stem Cells Translational Medicine

Molecular Mechanisms Regulating the Defects in Fragile X Syndrome Neurons Derived from Human Pluripotent Stem Cells

(2015) Tomer Halevy et al.   Stem Cell Reports

MicroRNA Profiling of Neurons Generated Using Induced Pluripotent Stem Cells Derived from Patients with Schizophrenia and Schizoaffective Disorder, and 22q11.2 Del

(2015) Dejian Zhao et al.   PLoS One

Applications for single cell trajectory analysis in inner ear development and regeneration

(2014) Robert Durruthy-Durruthy et al.   CELL AND TISSUE RESEARCH

Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

(2014) Ki-Jun Yoon et al.   Cell Stem Cell

hPSC-Derived Maturing GABAergic Interneurons Ameliorate Seizures and Abnormal Behavior in Epileptic Mice

(2014) Miles Cunningham et al.   Cell Stem Cell

Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1

(2014) Evangelos Kiskinis et al.   Cell Stem Cell

The developmental transcriptome of the human brain

(2014) Andrew T.N. Tebbenkamp et al.   CURRENT OPINION IN NEUROLOGY

Induced neuronal reprogramming

(2014) Cheen Euong Ang et al.   JOURNAL OF COMPARATIVE NEUROLOGY

A Competitive Advantage by Neonatally Engrafted Human Glial Progenitors Yields Mice Whose Brains Are Chimeric for Human Glia

(2014) M. S. Windrem et al.   JOURNAL OF NEUROSCIENCE

Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

(2014) T Yoshimizu et al.   MOLECULAR PSYCHIATRY

Modeling non-syndromic autism and the impact of TRPC6 disruption in human neurons

(2014) K Griesi-Oliveira et al.   MOLECULAR PSYCHIATRY

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

(2014) K Brennand et al.   MOLECULAR PSYCHIATRY

Rapid neurogenesis through transcriptional activation in human stem cells

(2014) V. Busskamp et al.   Molecular Systems Biology

Transcriptional landscape of the prenatal human brain

(2014) Jeremy A. Miller et al.   NATURE

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Molecular and functional definition of the developing human striatum

(2014) Marco Onorati et al.   NATURE NEUROSCIENCE

Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

(2014) Xinmei Wen et al.   NEURON

A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells

(2014) Jason L. Stein et al.   NEURON

Temporal Specification and Bilaterality of Human Neocortical Topographic Gene Expression

(2014) Mihovil Pletikos et al.   NEURON

Improving and Accelerating Drug Development for Nervous System Disorders

(2014) Diana E. Pankevich et al.   NEURON

Transcription factor induction of human oligodendrocyte progenitor fate and differentiation

(2014) J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome

(2014) Jorge Castro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interneurons from Embryonic Development to Cell-Based Therapy

(2014) D. G. Southwell et al.   SCIENCE

Efficient Specification of Interneurons from Human Pluripotent Stem Cells by Dorsoventral and Rostrocaudal Modulation

(2014) Tae-Gon Kim et al.   STEM CELLS

iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in Initial Neurite Outgrowth

(2014) Matthew E. Doers et al.   STEM CELLS AND DEVELOPMENT

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

(2014) Dae-Sung Kim et al.   Frontiers in Cellular Neuroscience

A Role for Noncoding Variation in Schizophrenia

(2014) Panos Roussos et al.   Cell Reports

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome

(2014) Yuan Tian et al.   Genome Medicine

Transcripts involved in calcium signaling and telencephalic neuronal fate are altered in induced pluripotent stem cells from bipolar disorder patients

(2014) H M Chen et al.   Translational Psychiatry

Epigenetic Characterization of the FMR1 Promoter in Induced Pluripotent Stem Cells from Human Fibroblasts Carrying an Unmethylated Full Mutation

(2014) Celine E.F. de Esch et al.   Stem Cell Reports

Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons

(2014) Vivian Hook et al.   Stem Cell Reports

Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells

(2014) Diana Xuan Yu et al.   Stem Cell Reports

International Coordination of Large-Scale Human Induced Pluripotent Stem Cell Initiatives: Wellcome Trust and ISSCR Workshops White Paper

(2014) Filipa A.C. Soares et al.   Stem Cell Reports

Compartmental Genomics in Living Cells Revealed by Single-Cell Nanobiopsy

(2013) Paolo Actis et al.   ACS Nano

Toward the future of psychiatric diagnosis: the seven pillars of RDoC

(2013) Bruce N Cuthbert et al.   BMC Medicine

New Balance in Pluripotency: Reprogramming with Lineage Specifiers

(2013) Uri Ben-David et al.   CELL

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination

(2013) Su Wang et al.   Cell Stem Cell

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

(2013) Yun Li et al.   Cell Stem Cell

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

Directed Differentiation and Functional Maturation of Cortical Interneurons from Human Embryonic Stem Cells

(2013) Asif M. Maroof et al.   Cell Stem Cell

Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development

(2013) Cory R. Nicholas et al.   Cell Stem Cell

Clinical pharmacology in neuroscience drug discovery: quo vadis?

(2013) David G. Trist et al.   CURRENT OPINION IN PHARMACOLOGY

Altered neural connectivity in excitatory and inhibitory cortical circuits in autism

(2013) Basilis Zikopoulos et al.   Frontiers in Human Neuroscience

Accelerated High-Yield Generation of Limb-Innervating Motor Neurons from Human Stem Cells

(2013) M. W. Amoroso et al.   JOURNAL OF NEUROSCIENCE

The DNA Replication Program Is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells

(2013) Jeannine Gerhardt et al.   MOLECULAR CELL

Abnormal neuronal differentiation and mitochondrial dysfunction in hair follicle-derived induced pluripotent stem cells of schizophrenia patients

(2013) O Robicsek et al.   MOLECULAR PSYCHIATRY

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia

(2013) D M Ruderfer et al.   MOLECULAR PSYCHIATRY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons

(2013) Jocelyn F Krey et al.   NATURE NEUROSCIENCE

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

(2013) Yan Liu et al.   Nature Protocols

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

(2013) Ira Espuny-Camacho et al.   NEURON

Revitalizing Psychiatric Therapeutics

(2013) Steven E Hyman   NEUROPSYCHOPHARMACOLOGY

Use of “MGE Enhancers” for Labeling and Selection of Embryonic Stem Cell-Derived Medial Ganglionic Eminence (MGE) Progenitors and Neurons

(2013) Ying-Jiun J. Chen et al.   PLoS One

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells

(2013) Xin Tang et al.   Stem Cell Research

Production and organization of neocortical interneurons

(2013) Khadeejah T. Sultan et al.   Frontiers in Cellular Neuroscience

Widespread sex differences in gene expression and splicing in the adult human brain

(2013) Daniah Trabzuni et al.   Nature Communications

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline

(2013) Margaret L Sutherland et al.   Stem Cell Research & Therapy

Brain Hyperconnectivity in Children with Autism and its Links to Social Deficits

(2013) Kaustubh Supekar et al.   Cell Reports

Meeting Report: Using Stem Cells for Biological and Therapeutics Discovery in Mental Illness, April 2012

(2013) David M. Panchision   Stem Cells Translational Medicine

Concise Review: The Involvement ofSOX2in Direct Reprogramming of Induced Neural Stem/Precursor Cells

(2013) Christof Maucksch et al.   Stem Cells Translational Medicine

Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay

(2013) Ozlem Bozdagi et al.   Molecular Autism

Differentiation from human pluripotent stem cells of cortical neurons of the superficial layers amenable to psychiatric disease modeling and high-throughput drug screening

(2013) C Boissart et al.   Translational Psychiatry

Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons

(2012) A. D. Carri et al.   DEVELOPMENT

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability

(2012) B. Bilican et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

(2012) N. Egawa et al.   Science Translational Medicine

Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives

(2012) Ori Bar-Nur et al.   Journal of Molecular Cell Biology

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

(2011) Aaron Y.L. Cheung et al.   HUMAN MOLECULAR GENETICS

Spatio-temporal transcriptome of the human brain

(2011) Hyo Jung Kang et al.   NATURE

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome

(2011) Sergiu P Paşca et al.   NATURE MEDICINE

A System for Performing High Throughput Assays of Synaptic Function

(2011) Chris M. Hempel et al.   PLoS One

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

(2011) Steven D. Sheridan et al.   PLoS One

Developmental and Functional Nature of Human iPSC Derived Motoneurons

(2011) Marianne Stockmann et al.   Stem Cell Reviews and Reports

Integrated Brain Circuits: Astrocytic Networks Modulate Neuronal Activity and Behavior

(2010) Michael M. Halassa et al.   Annual Review of Physiology

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

(2010) Achia Urbach et al.   Cell Stem Cell

Animal models of neuropsychiatric disorders

(2010) Eric J Nestler et al.   NATURE NEUROSCIENCE

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

(2009) Daniela Tropea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

(2008) Mototsugu Eiraku et al.   Cell Stem Cell