Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine

Fluid shear stress modulation of hepatocyte-like cell function

(2016) Hassan Rashidi et al.   ARCHIVES OF TOXICOLOGY

Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes

(2016) Xiao-Lei Shi et al.   CELL RESEARCH

Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs

(2016) Dagmara Szkolnicka et al.   Stem Cells Translational Medicine

Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin

(2016) Ali-Reza Sadri et al.   Stem Cells International

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

New markers for tracking endoderm induction and hepatocyte differentiation from human pluripotent stem cells

(2015) A. Holtzinger et al.   DEVELOPMENT

MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells

(2015) Selina Möbus et al.   JOURNAL OF HEPATOLOGY

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells

(2015) Patricio Godoy et al.   JOURNAL OF HEPATOLOGY

Long-term culture and expansion of primary human hepatocytes

(2015) Gahl Levy et al.   NATURE BIOTECHNOLOGY

Hepatic progenitor cells of biliary origin with liver repopulation capacity

(2015) Wei-Yu Lu et al.   NATURE CELL BIOLOGY

Black hole remnants and the information loss paradox

(2015) P. Chen et al.   PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS

A cost-effective and efficient reprogramming platform for large-scale production of integration-free human induced pluripotent stem cells in chemically defined culture

(2015) Jeanette Beers et al.   Scientific Reports

Engraftment of human induced pluripotent stem cell-derived hepatocytes in immunocompetent mice via 3D co-aggregation and encapsulation

(2015) Wei Song et al.   Scientific Reports

Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance

(2015) Baltasar Lucendo Villarin et al.   Advanced Healthcare Materials

CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells

(2015) Taketomo Kido et al.   Stem Cell Reports

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes

(2015) Kate Cameron et al.   Stem Cell Reports

Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

(2015) Richard Siller et al.   Stem Cell Reports

Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming

(2014) Yuanyuan Du et al.   Cell Stem Cell

Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes

(2014) Pengyu Huang et al.   Cell Stem Cell

Strategies for immortalization of primary hepatocytes

(2014) Eva Ramboer et al.   JOURNAL OF HEPATOLOGY

Mouse liver repopulation with hepatocytes generated from human fibroblasts

(2014) Saiyong Zhu et al.   NATURE

Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture

(2014) Richard L. Gieseck III et al.   PLoS One

Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

(2014) Kazuo Takayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Virus associated malignancies: The role of viral hepatitis in hepatocellular carcinoma

(2014) Amir Shlomai et al.   SEMINARS IN CANCER BIOLOGY

Modulating Innate Immunity Improves Hepatitis C Virus Infection and Replication in Stem Cell-Derived Hepatocytes

(2014) Xiaoling Zhou et al.   Stem Cell Reports

Pluripotent Stem Cell–Derived Hepatocytes: Potential and Challenges in Pharmacology

(2013) Dagmara Szkolnicka et al.   Annual Review of Pharmacology and Toxicology

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Identification of small molecules for human hepatocyte expansion and iPS differentiation

(2013) Jing Shan et al.   Nature Chemical Biology

Accurate Prediction of Drug-Induced Liver Injury Using Stem Cell-Derived Populations

(2013) Dagmara Szkolnicka et al.   Stem Cells Translational Medicine

Developing High-Fidelity Hepatotoxicity Models From Pluripotent Stem Cells

(2013) Claire N. Medine et al.   Stem Cells Translational Medicine

Tissue specific synthetic ECM hydrogels for 3-D in vitro maintenance of hepatocyte function

(2012) Aleksander Skardal et al.   BIOMATERIALS

Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells

(2012) Xin Cheng et al.   Cell Stem Cell

JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia

(2012) Max A. Cayo et al.   HEPATOLOGY

Association Between Nucleoside Analogues and Risk of Hepatitis B Virus–Related Hepatocellular Carcinoma Recurrence Following Liver Resection

(2012) Chun-Ying Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus

(2012) Philip Roelandt et al.   JOURNAL OF HEPATOLOGY

Modeling hepatitis C virus infection using human induced pluripotent stem cells

(2012) R. E. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction

(2011) Kazuo Takayama et al.   MOLECULAR THERAPY

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

(2011) Sayaka Sekiya et al.   NATURE

Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells

(2011) Michael D Green et al.   NATURE BIOTECHNOLOGY

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

In Vivo Liver Regeneration Potential of Human Induced Pluripotent Stem Cells from Diverse Origins

(2011) H. Liu et al.   Science Translational Medicine

Hepatic Differentiation of Human Embryonic Stem Cells Is Promoted by Three-Dimensional Dynamic Perfusion Culture Conditions

(2011) Toshio Miki et al.   TISSUE ENGINEERING PART C-METHODS

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells

(2010) Veronika Akopian et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

(2010) S. Tamir Rashid et al.   JOURNAL OF CLINICAL INVESTIGATION

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism

(2010) David C. Hay et al.   Stem Cell Research

Differentiation and Characterization of Metabolically Functioning Hepatocytes from Human Embryonic Stem Cells

(2010) Yuyou Duan et al.   STEM CELLS

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

(2009) Gareth J. Sullivan et al.   HEPATOLOGY

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

(2009) Thomas Touboul et al.   HEPATOLOGY

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

(2009) Keisuke Kaji et al.   NATURE

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

(2009) Knut Woltjen et al.   NATURE

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

(2009) Noemi FUSAKI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Adenoviral Gene Delivery Can Reprogram Human Fibroblasts to Induced Pluripotent Stem Cells

(2009) Wenbo Zhou et al.   STEM CELLS

NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs

(2008) Ren-He Xu et al.   Cell Stem Cell

Cellular and Molecular Mechanisms of Liver Injury

(2008) Harmeet Malhi et al.   GASTROENTEROLOGY

Differentiation and Transplantation of Human Embryonic Stem Cell–Derived Hepatocytes

(2008) Hesham Basma et al.   GASTROENTEROLOGY

Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

(2008) Trond Aasen et al.   NATURE BIOTECHNOLOGY

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

(2008) D. C. Hay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells

(2008) Sadhana Agarwal et al.   STEM CELLS