Review
Physiology
Ian Burton
Summary: Musculoskeletal disorders, including tendinopathy, are increasingly burdening society and health systems. Resistance training has shown short-term effectiveness in treating tendinopathy, but long-term outcomes are poor. Current standardized resistance training protocols have limitations, necessitating the need for better individualized and progressive methods.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Psychology, Multidisciplinary
Bin Yin, Ya-Xin Wang, Cheng-Yang Fei, Ke Jiang
Summary: Personality disorders are often treated through face-to-face sessions or digital mental health services. Schema therapy is a standout therapy that not only targets the symptoms of personality disorders, but also focuses on addressing their underlying causes by healing early maladaptive schemas. This therapy is particularly effective at soothing emotional disturbances before implementing cognitive restructuring, leading to long-term efficacy. However, according to Piaget's genetic epistemology, the formation of adaptive behavioral schemas can only occur through interaction with the real world and feedback from the environment. Therefore, to reshape a patient's schema modes and restore their emotional regulation capabilities, it may be necessary to reconstruct the patient's surroundings. Metaverse, the successor to the Internet with a sense of full presence, can be a powerful tool for this purpose, allowing therapists to transform schema therapy techniques into natural autobiographical experiences within a new virtual environment. This can gradually reshape the patient's schema modes, ultimately enabling more adaptive and inclusive interaction with the real world.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Pharmacology & Pharmacy
Charles P. France, Gerard P. Ahern, Saadyah Averick, Alex Disney, Heather A. Enright, Babak Esmaeli-Azad, Arianna Federico, Lisa R. Gerak, Stephen M. Husbands, Benedict Kolber, Edmond Y. Lau, Victoria Lao, David R. Maguire, Michael A. Malfatti, Girardo Martinez, Brian P. Mayer, Marco Pravetoni, Niaz Sahibzada, Phil Skolnick, Evan Y. Snyder, Nestor Tomycz, Carlos A. Valdez, Jim Zapf
Summary: The only medication available to prevent and treat opioid overdose is naloxone, approved by the FDA nearly 50 years ago. Due to its limitations, a scientific meeting was convened by NIAID/NIH to explore emerging alternative approaches for treating opioid overdose in the event of weaponization of synthetic opioids. This meeting discussed new approaches such as intranasal nalmefene, methocinnamox, covalent naloxone nanoparticles, serotonin receptor agonists, fentanyl-binding cyclodextrin scaffolds, detoxifying biomimetic nanosponge decoy receptors, and antibody-based strategies.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Engineering, Industrial
Peter Jh Beliveau, Heather Johnston, Dwayne Van Eerd, Steven L. Fischer
Summary: This study investigated the use of ergonomics musculoskeletal disorder (MSD) risk assessment tools and its influencing factors among Canadian ergonomics professionals. The majority of tool users in Canada were certified safety professionals rather than ergonomics professionals. The use of tools varied between different professional groups, but the top 10 tools used were similar. Most assessment tools were learned at school, and tool use was not influenced by years of experience or continuing education.
APPLIED ERGONOMICS
(2022)
Article
Multidisciplinary Sciences
Worawan Poochada, Sunisa Chailklieng
Summary: This study aimed to develop an MSDs assessment tool for agriculturists and conducted a tryout using an online database. The online MSFQ showed excellent reliability and user satisfaction, making it suitable for agriculturists to assess their musculoskeletal symptoms.
Article
Medicine, General & Internal
Georgia Stillianesis, Rocco Cavaleri, Simon J. Summers, Clarice Tang
Summary: This study explored the perception of repetitive transcranial magnetic stimulation (rTMS) as a treatment among individuals with chronic musculoskeletal pain. The findings suggest that rTMS is accepted as a treatment option for chronic pain management. Targeted strategies addressing accessibility, funding support, and medical endorsements can encourage the use of rTMS in clinical settings for chronic pain.
Review
Endocrinology & Metabolism
Sarah Mele, Felipe Martelli, Jiayi Lin, Oguz Kanca, John Christodoulou, Hugo J. Bellen, Matthew D. W. Piper, Travis K. Johnson
Summary: Amino acid disorders (AADs) are rare inherited conditions that affect one in 6500 live births, often leading to neurological decline and death in infants. Dietary modification can be an effective treatment for some AADs like phenylketonuria, but the potential for dietary therapy remains largely unexplored for most AADs. Drosophila is a suitable animal model for nutrigenomic disease modeling due to its conserved amino acid pathways, genetic tractability, and the availability of a customizable synthetic diet.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Jessica Wouk, Robert F. H. Dekker, Eveline A. I. F. Queiroz, Aneli M. Barbosa-Dekker
Summary: β-glucans, natural products found in foods like cereals and mushrooms, have shown cardiovascular protective effects by reducing risk factors such as obesity, dyslipidemia, hyperglycemia, and hypertension. Studies have also demonstrated their potential hypoglycemic, hypocholesterolemic, and antiobesogenicity activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Endocrinology & Metabolism
Clarence Hale, Murielle M. Veniant
Summary: Obesity has become a major global health concern, especially in developing countries where resources for surgical treatments are limited. There is a need for safe and effective pharmacological therapies. Recent research suggests that GDF15 holds promise as a novel anti-obesity treatment.
MOLECULAR METABOLISM
(2021)
Article
Medicine, General & Internal
Ning Wei, Xinxin Wang, Ling Chen, Mengyu Lyu
Summary: This study aims to investigate the effects of a 12-week flexi-bar training programme on muscle strength and physical function in older people with dynapenia. The study will include 114 participants randomly divided into flexi-bar, placebo, and control groups. Assessments will include timed-up-and-go test, five-repetition sit-to-stand test, 10-metre walking test, handgrip strength, serum albumin, and haemoglobin levels.
Article
Biochemistry & Molecular Biology
Olaia Martinez-Iglesias, Vinogran Naidoo, Juan Carlos Carril, Silvia Seoane, Natalia Cacabelos, Ramon Cacabelos
Summary: There is a lack of effective diagnostic biomarkers for neurodegenerative disorders (NDDs). Gene expression analysis can provide diagnostic value for NDDs and offers an alternative to current diagnostic methods. This study identified specific gene expressions associated with Alzheimer's disease (AD), Parkinson's disease (PD), and vascular/mixed dementia (VaD). APOE, PSEN1, ABCA7, and SNCA mRNA levels showed high diagnostic accuracy for AD and PD, while PICALM had less accuracy as a biomarker for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Rehabilitation
Ian Burton, Aisling McCormack
Summary: This study aims to evaluate the use of exercise and intervention variables in resistance training interventions for lower limb tendinopathy in randomized controlled trials, as well as assess the reporting completeness and implementation of scientific resistance training principles. The results show that reporting of exercise descriptors and intervention content was generally high, allowing for exercise replication. However, reporting for some specific tendinopathies and content items like adherence was poor, limiting the optimal translation to clinical practice.
CLINICAL REHABILITATION
(2022)
Article
Medicine, General & Internal
Thomas Frydendal, Robin Christensen, Inger Mechlenburg, Lone Ramer Mikkelsen, Soren Overgaard, Kim Gordon Ingwersen
Summary: This study aims to investigate whether THA followed by standard care is superior to 12 weeks of supervised PRT followed by 12 weeks of optional unsupervised PRT for improving hip pain and function in patients with severe hip OA.
Article
Behavioral Sciences
Chrystiane V. A. Toscano, Leonardo Barros, Ahlan B. Lima, Thiago Nunes, Humberto M. Carvalho, Joana M. Gaspar
Summary: The global prevalence of autism spectrum disorder (ASD) is around 1%, with a combination of genetic, environmental factors, and immune system dysfunction believed to play a role in its development. Individuals with ASD show increased neuroinflammation in the brain, and currently there are no pharmacological treatments available, but pedagogical and psychotherapeutic therapies can help manage behavioral symptoms. Exercise intervention programs have shown potential in improving cognitive and behavioral symptoms in children with ASD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Medicine, General & Internal
Maria Popp, Stefanie Reis, Selina Schiesser, Renate Ilona Hausinger, Miriam Stegemann, Maria-Inti Metzendorf, Peter Kranke, Patrick Meybohm, Nicole Skoetz, Stephanie Weibel
Summary: The evidence on the efficacy and safety of ivermectin for treating COVID-19 is conflicting. Results suggest uncertainty in the effectiveness of ivermectin for treating severe cases and limited effects for mild cases.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Peripheral Vascular Disease
Isabela R. Marcal, Awassi Y. Ngomane, Fernanda B. Souza, Emmanuel G. Ciolac
Summary: The study evaluated the responses of blood pressure, heart rate, arterial stiffness, and endothelial reactivity to heated water immersion in older individuals with hypertension. The results showed differences in heart rate and blood pressure responses, but no significant changes in arterial stiffness and endothelial reactivity.
BLOOD PRESSURE MONITORING
(2021)
Review
Immunology
Guilherme Veiga Guimaraes, Fernando Ribeiro, Fernanda Zane Arthuso, Rafael Ertner Castro, Veronique Cornelissen, Emmanuel Gomes Ciolac
Summary: Heart transplantation is a therapeutic option for end-stage heart failure patients, and exercise therapy can improve their exercise capacity, cardiovascular health, and quality of life. High-intensity interval training and patients with cardiac reinnervation benefit more, while aerobic exercise can lead to reductions in blood pressure.
TRANSPLANTATION REVIEWS
(2021)
Article
Sport Sciences
Isabela R. Marcal, Pedro G. Falqueiro, Bianca Fernandes, Awassi Y. Ngomane, Vanessa T. Amaral, Guilherme Guimaraes, Emmanuel G. Ciolac
Summary: The study showed that RPE is a cost-effective tool for prescribing and self-regulating high-intensity interval exercise, leading to improvements in health-related variables in young individuals.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2021)
Article
Endocrinology & Metabolism
Alessandro Domingues Heubel, Ariane Aparecida Viana, Stephanie Nogueira Linares, Vanessa Teixeira do Amaral, Nathany Souza Schafauser, Gustavo Yudi Orikassa de Oliveira, Paula Camila Ramirez, Bruno Martinelli, Tiago da Silva Alexandre, Audrey Borghi-Silva, Emmanuel Gomes Ciolac, Renata Goncalves Mendes
Summary: The study identified increased BMI as the major factor associated with endothelial dysfunction in noncritically hospitalized COVID-19 patients. Other factors associated with FMD were baseline artery diameter and blood levels of creatinine.
Article
Pharmacology & Pharmacy
Awassi Yuphiwa Ngomane, Raphael Martins de Abreu, Bianca Fernandes, Isabela Roque Marcal, Guilherme Veiga Guimaraes, Emmanuel Gomes Ciolac
Summary: Individuals with type 2 diabetes mellitus showed impaired levels of cardiac autonomic markers compared to individuals with systemic arterial hypertension and Parkinson's disease, despite having lower levels of blood pressure and arterial stiffness.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Geriatrics & Gerontology
Vanessa Teixeira do Amaral, Bianca Fernandes, Awassi Yuphiwa Ngomane, Isabela Roque Marcal, Gabriel de Souza Zanini, Emmanuel Gomes Ciolac
Summary: The study found that low-income older women can improve anthropometric, hemodynamic, and functional capacity variables by participating in twice-weekly short-term CBEP (i.e.: 12 weeks). However, the effects on hemodynamic and functional capacity appear to be affected by exercise intensity and modality.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Sport Sciences
Bianca Fernandes, Fabio A. Barbieri, Isabela R. Marcal, Vanessa T. Do Amaral, Lucas Simieli, Tiago Penedo, Emmanuel G. Ciolac
Summary: The aim of this study was to assess the hemodynamic and cardiac autonomic response to high-intensity interval exercise (HIIE) versus moderate-intensity continuous exercise (MICE) in individuals with Parkinson's disease (PD). The results show that the hemodynamic response to exercise is impaired in individuals with PD.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2022)
Article
Physiology
Cristian Alvarez, Emmanuel Gomes Ciolac, Guilherme Veiga Guimaraes, David C. Andrade, Manuel Vasquez-Munoz, Matias Monsalves-Alvarez, Pedro Delgado-Floody, Alicia M. Alonso-Martinez, Mikel Izquierdo
Summary: The study aimed to assess the residual effects of high-intensity interval training and resistance training on fasting plasma glucose and fasting insulin in women with insulin resistance. The results showed that both types of training had better residual effects compared to concurrent training.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Education & Educational Research
Vanessa Teixeira do Amaral, Isabela Roque Marcal, Thiago da Cruz Silva, Fernanda Bianchi Souza, Yacco Volpato Munhoz, Pedro Henrique Camprigher Witzler, Matheus Monge Soares Correa, Bianca Fernandes, Emmanuel Gomes Ciolac
Summary: This study investigated the impact of COVID-19 home confinement on physical activity levels, sedentary behavior, and health-related quality of life (HRQL) in older women. The results showed that home confinement led to a decrease in physical activity levels, an increase in sedentary behavior, but no significant changes in HRQL. Educational programs promoting healthy behaviors may help attenuate the impact of home confinement on older women.
EDUCATIONAL GERONTOLOGY
(2022)
Article
Pharmacology & Pharmacy
Isabela Roque Marcal, Vanessa Teixeira Do Amaral, Bianca Fernandes, Raphael Martins de Abreu, Cristian Alvarez, Guilherme Veiga Guimaraes, Veronique A. Cornelissen, Emmanuel Gomes Ciolac
Summary: This study aimed to assess the effects of high-intensity interval exercise and moderate-intensity continuous exercise on hemodynamic, cardiac autonomic, and vascular responses in older individuals with hypertension. The results showed that high-intensity interval exercise was more effective in improving parasympathetic modulation compared to moderate-intensity continuous exercise and control.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Biotechnology & Applied Microbiology
Ariane Aparecida Viana, Alessandro Domingues Heubel, Vanessa Teixeira do Amaral, Stephanie Nogueira Linares, Gustavo Yudi Orikassa de Oliveira, Bruno Martinelli, Audrey Borghi Silva, Renata Goncalves Mendes, Emmanuel Gomes Ciolac
Summary: This study aimed to evaluate the influence of previous levels of physical activity on hemodynamic, vascular, ventilatory, and functional outcomes after COVID-19 hospitalization. The results showed that individuals with lower levels of physical activity had impaired pulmonary function and walking performance compared to those with higher levels of physical activity.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Sport Sciences
Vanessa Teixeira Do Amaral, Ariane Aparecida Viana, Alessandro Domingues Heubel, Stephanie Nogueira Linares, Bruno Martinelli, Pedro Henrique Camprigher Witzler, Gustavo Yudi Orikassa De Oliveira, Gabriel De Souza Zanini, Audrey Borghi Silva, Renata Goncalves Mendes, Emmanuel Gomes Ciolac
Summary: This study suggests that tele-supervised home-based exercise training may be a potential adjunct therapeutic for rehabilitating individuals who were hospitalized due to COVID-19. After treatment, the exercise group showed improvements in certain parameters, while the control group did not show significant changes.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Geriatrics & Gerontology
Isabela Roque Marcal, Bianca Fernandes, Vanessa Teixeira do Amaral, Renato Lopes Pelaquim, Emmanuel Gomes Ciolac
Summary: The usefulness of the 6-20 rating of perceived exertion (RPE) scale for prescribing and self-regulating high-intensity interval (HIIE) and moderate-intensity continuous (MICE) aerobic exercise in a heated swimming pool was analyzed. The study found that using the RPE scale at 15-17 is an effective tool for prescribing and self-regulating heated water-based HIIE, which is important for water-based exercise in older individuals with hypertension.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2022)
Article
Physiology
Cristian Alvarez, Francisco Guede-Rojas, Rodrigo Ramirez-Campillo, David C. Andrade, Jaime Vasquez-Gomez, Fernando Rodriguez-Rodriguez, Emmanuel Gomes Ciolac, Felipe Caamano-Navarrete, Pedro Delgado-Floody
Summary: This study examined the response of postexercise hypotension in morbidly obese patients and investigated the effect of concurrent training order on blood pressure changes. The results showed that both ET + RT and RT + ET orders induced similar postexercise hypotensive effects during the training period. The study also identified predictors of responders and nonresponders based on body composition, metabolic, and physical fitness outcomes.
FRONTIERS IN PHYSIOLOGY
(2022)
Letter
Sport Sciences
Emmanuel Gomes Ciolac
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
