Article
Neurosciences
Mizuki Sugiyama, Ichiko Nishijima, Wataru Nakamura, Takahiro J. Nakamura
Summary: The suprachiasmatic nucleus (SCN) is important for regulating circadian rhythms, while the food-entrainable oscillator (FEO) also plays a role in circadian regulation. This study found that secretin receptor signaling is not essential for the timekeeping mechanism of FEO.
NEUROSCIENCE LETTERS
(2022)
Article
Nutrition & Dietetics
Anna Magdalena Sanetra, Katarzyna Palus-Chramiec, Lukasz Chrobok, Jagoda Stanislawa Jeczmien-Lazur, Emilia Gawron, Jasmin Daniela Klich, Kamil Pradel, Marian Henryk Lewandowski
Summary: Obesity is a growing health problem and studying its developmental mechanism is crucial. This study found that a high-fat diet disrupts the circadian rhythmicity of the dorsomedial hypothalamus (DMH) in male rats, indicating its possible role in obesity development. Additionally, time-restricted feeding can prevent the disruptive effects of a high-fat diet on the DMH clock.
Article
Cell Biology
Daniel S. Whittaker, Laila Akhmetova, Daniel Carlin, Haylie Romero, David K. Welsh, Christopher S. Colwell, Paula Desplats
Summary: This study reveals the pleiotropic effects of time-restricted feeding on Alzheimer's disease, including improvements in pathology and memory, as well as normalization of gene transcription patterns. This intervention has significant translational potential for reducing or halting AD progression.
Article
Physiology
Caitlin M. Daimon, Shane T. Hentges
Summary: Inhibition of POMC neurons reduces the severity of activity-based anorexia (ABA) without affecting body weight or food intake. POMC neurons may contribute to excessive exercise habits in patients with AN, while metabolic control during ABA appears to occur through mechanisms independent of POMC neurons.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ashleigh G. Wilcox, R. Sonia Bains, Debbie Williams, Elizabeth Joynson, Lucie Vizor, Peter L. Oliver, Elizabeth S. Maywood, Michael H. Hastings, Gareth Banks, Patrick M. Nolan
Summary: The study describes a mouse mutant with the central pacemaker SCN genetically ablated, leading to arrhythmicity in circadian rhythms and metabolic parameters, although the mutants could still anticipate food availability. Despite disruptions to SCN cell identity and circuitry, the mutants' activity levels were altered and other zeitgebers could not restore rhythmicity.
Article
Physiology
David E. Ehichioya, S. K. Tahajjul Taufique, Isabel Magana, Sofia Farah, Yuuki Obata, Shin Yamazaki
Summary: The gut microbiota plays a critical role in regulating circadian rhythms in mice, but depleting the gut microbiota with antibiotics does not significantly impact voluntary wheel running activity and food anticipatory activity.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Nutrition & Dietetics
Debra K. M. Tacad, Ashley P. Tovar, Christine E. Richardson, William F. Horn, Nancy L. Keim, Giri P. Krishnan, Sridevi Krishnan
Summary: This review summarizes the current knowledge on how time-restricted feeding and continuous caloric restriction affect central neuroendocrine systems involved in regulating satiety. The findings suggest that both approaches have similar effects on hunger and satiety signals, but time-restricted feeding may improve energy balance signals and reduce hyperphagia through ghrelin and leptin signaling. In addition, both approaches influence circadian rhythms, but time-restricted feeding appears to have a broader impact on peripheral clocks. Further research is needed to confirm these preliminary observations.
ADVANCES IN NUTRITION
(2022)
Review
Endocrinology & Metabolism
Jonathan R. Roth, Shweta Varshney, Ruan Carlos Macedo de Moraes, Girish C. Melkani
Summary: Circadian rhythms exist from the molecular level to complex behaviors, driven by molecular clocks within cells. Disruption of circadian rhythms can trigger metabolic disorders such as obesity, aging, diabetes, and cardiovascular disease. Feeding and fasting rhythms play important roles in circadian rhythms, highlighting the bidirectional relationship between metabolism and circadian rhythms. Studying circadian rhythms may provide new insights into the etiology and management of obesity.
Article
Neurosciences
Lukasz Chrobok, Kamil Pradel, Marcelina Elzbieta Janik, Anna Magdalena Sanetra, Monika Bubka, Jihwan Myung, Amalia Ridla Rahim, Jasmin Daniela Klich, Jagoda Stanislawa Jeczmien-Lazur, Katarzyna Palus-Chramiec, Marian Henryk Lewandowski
Summary: This study demonstrates the intrinsic clock properties of the lateral geniculate nucleus (LGN) in male rats and mice, suggesting it may function as a light-entrainable oscillator with autonomous timekeeping mechanisms. The research identifies specific nuclei within the LGN showing core clock gene expression and circadian variation in neuronal activity, implying a more complex circadian timekeeping system beyond the central brain clock.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Fabrics Bertile, Marine Plumel, Pauline Maes, Aurelie Hirschler, Etienne Challet
Summary: The study identified day-night variations in the cerebellar proteome of mice fed during daytime or nighttime, showing changes in proteins related to heat-shock proteins, enzymes, and neuronal activity in daytime food-restricted mice. Additionally, a significant feeding x time-of-day interaction was found for changes in the intensity of 20 spots.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Nuria Saiz, Cristina Velasco, Nuria de Pedro, Jose Luis Soengas, Esther Isorna
Summary: This study aimed to investigate the potential role of insulin as an intake signal mediating liver entrainment in fish. The experiments showed that the presence of insulin directly increased the abundance of per1a and per2 transcripts in the fish liver. It was found that the involvement of the PI3K/AKT pathway is crucial for insulin-mediated liver entrainment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Qijun Tang, Elizabeth Godschall, Charles D. Brennan, Qi Zhang, Ruei-Jen Abraham-Fan, Sydney P. Williams, Taha Bugra Guenguel, Roberta Onoharigho, Aleyna Buyukaksakal, Ricardo Salinas, Isabelle R. Sajonia, Joey J. Olivieri, O. Yipkin Calhan, Christopher D. Deppmann, John N. Campbell, Brandon Podyma, Ali D. Guler
Summary: This study identified a population of neurons in the dorsomedial hypothalamus that showed calcium activity and up-regulated circadian entrainment genes before an anticipated meal. These neurons can influence the phase of the circadian clock through a direct connection to the suprachiasmatic nucleus (SCN), allowing for mealtime anticipation.
Article
Endocrinology & Metabolism
Haoran Xin, Rongfeng Huang, Meiyu Zhou, Jianghui Chen, Jianxin Zhang, Tingting Zhou, Shushen Ji, Xiao Liu, He Tian, Sin Man Lam, Xinyu Bao, Lihua Li, Shifei Tong, Fang Deng, Guanghou Shui, Zhihui Zhang, Catherine C. L. Wong, Min-Dian Li
Summary: Meal timing, specifically day/sleep time-restricted feeding, enhances running endurance and regulates muscle diurnal rhythms in mice. The circadian clock and a mitochondrial oxidative metabolism-centric network play key roles in mediating the effects of meal timing on physical endurance. Knockdown of the myocyte lipid droplet protein perilipin-5 in muscle tissues mimics the effects of day/sleep time-restricted feeding.
Article
Biochemistry & Molecular Biology
Sensen Chi, Taoyuan Zhang, Yu Pan, Shenghui Niu, Lin Zhao, Zili Gu, Qi Liu, Aishun Jin, Wang Wang, Shuai Tan
Summary: Individuals with rotating and night shift work are prone to metabolic disorders, and time-restricted feeding (tRF) can alleviate metabolic abnormalities caused by circadian rhythm disruption through regulating gut hormone release and activating brown fat thermogenesis.
Article
Endocrinology & Metabolism
Molly R. Gallop, Selene Y. Tobin, Amandine Chaix
Summary: The ability to store energy and maintain energy balance is crucial for mammalian survival. Time-restricted feeding (TRF), a dietary intervention that limits feeding to the active phase, has shown potential in preventing and treating obesity and metabolic dysfunction in rodents. However, the mechanisms behind the effects of TRF on energy balance and metabolic adaptation are still not fully understood.
Article
Genetics & Heredity
Junpei Tanigawa, Haruka Mimatsu, Seiji Mizuno, Nobuhiko Okamoto, Daisuke Fukushi, Koji Tominaga, Hiroyuki Kidokoro, Yukako Muramatsu, Eriko Nishi, Shota Nakamura, Daisuke Motooka, Noriko Nomura, Kiyoshi Hayasaka, Tetsuya Niihori, Yoko Aoki, Shin Nabatame, Masahiro Hayakawa, Jun Natsume, Keiichi Ozono, Taroh Kinoshita, Nobuaki Wakamatsu, Yoshiko Murakami
Article
Endocrinology & Metabolism
Kiyoshi Hayasaka, Chikahiko Numakura, Mitsunori Yamakawa, Tetsuo Mitsui, Hisayoshi Watanabe, Hiroaki Haga, Masahide Yazaki, Hiromasa Ohira, Yasuo Ochiai, Toshiyuki Tahara, Tamio Nakahara, Noriyo Yamashiki, Takahiro Nakayama, Takashi Kon, Hiroshi Mitsubuchi, Hiroshi Yoshida
JOURNAL OF INHERITED METABOLIC DISEASE
(2018)
Article
Genetics & Heredity
Yuichiro Miura, Tatsuya Watanabe, Toshihiko Uchida, Tatsuro Nawa, Naobumi Endo, Taichi Fukuzawa, Ryuji Ohkubo, Junji Takeyama, Ayako Sasaki, Kiyoshi Hayasaka
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2019)
Article
Endocrinology & Metabolism
Chikahiko Numakura, Gen Tamiya, Masao Ueki, Tomoo Okada, Shun-ichi Maisawa, Kanako Kojima-Ishii, Jun Murakami, Reiko Horikawa, Daisuke Tokuhara, Koichi Ito, Masanori Adachi, Takahiro Abiko, Tetsuo Mitsui, Kiyoshi Hayasaka
JOURNAL OF INHERITED METABOLIC DISEASE
(2019)
Article
Pediatrics
Ayako Sasaki, Yumiko Kishikawa, Reisuke Imaji, Yu Fukushima, Yukiko Nakamura, Yutaka Nishimura, Megumi Yamada, Yoichi Mino, Tetsuo Mitsui, Kiyoshi Hayasaka
PEDIATRICS INTERNATIONAL
(2019)
Article
Endocrinology & Metabolism
Yoriko Watanabe, Chikahiko Numakura, Toshiyuki Tahara, Kaori Fukui, Takuji Torimura, Yuji Hiromatsu, Ken Tomotsune, Mitsunori Yamakawa, Kiyoshi Hayasaka
DIABETES RESEARCH AND CLINICAL PRACTICE
(2020)
Article
Clinical Neurology
Aoi Hino, Jiro Terada, Hajime Kasai, Hikaru Shojima, Keiko Ohgino, Ayako Sasaki, Kiyoshi Hayasaka, Koichiro Tatsumi
JOURNAL OF CLINICAL SLEEP MEDICINE
(2020)
Review
Endocrinology & Metabolism
Kiyoshi Hayasaka
Summary: Citrin deficiency is a hereditary disorder caused by SLC25A13 mutations, affecting the energy metabolism of hepatocytes. MCT supplementation therapy is recommended for NICCD and CTLN2 patients to provide energy, promote lipogenesis, and improve ammonia detoxification.
JOURNAL OF INHERITED METABOLIC DISEASE
(2021)
Article
Genetics & Heredity
Tetsuo Mitsui, Satoshi Makino, Gen Tamiya, Hiroko Sato, Yuki Kawakami, Yoshitaka Takahashi, Toru Meguro, Hiroko Izumino, Yosuke Sudo, Ikuo Norota, Kuniaki Ishii, Kiyoshi Hayasaka
Summary: The study reveals the significant role of ALOX12 in platelet aggregation and calcium signaling, suggesting that defects in ALOX12 could lead to abnormal platelet aggregation. A heterozygous c.1946A > G ALOX12 mutation may be a disease-causing mutation contributing to inherited bleeding diathesis.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Genetics & Heredity
Miyako Kanno, Mitsuyoshi Suzuki, Ken Tanikawa, Chikahiko Numakura, Shu-ichi Matsuzawa, Tetsuya Niihori, Yoko Aoki, Yoichi Matsubara, Satoshi Makino, Gen Tamiya, Satoshi Nakano, Ryo Funayama, Matsuyuki Shirota, Keiko Nakayama, Tetsuo Mitsui, Kiyoshi Hayasaka
Summary: PILBD is a heterogeneous disorder classified into syndromic and non-syndromic categories. In a family with dominantly inherited PILBD, a pathogenic variant CACYBP/SIP p.E177Q was found, leading to enhanced degradation of beta-catenin and delayed intrahepatic bile duct maturation. This discovery suggests that accurate regulation of beta-catenin concentration is crucial for bile duct development.
JOURNAL OF HUMAN GENETICS
(2022)
Article
Genetics & Heredity
Satoko Miyatake, Eriko Koshimizu, Atsushi Fujita, Hiroshi Doi, Masaki Okubo, Taishi Wada, Kohei Hamanaka, Naohisa Ueda, Hitaru Kishida, Gaku Minase, Atsuhiro Matsuno, Minori Kodaira, Katsuhisa Ogata, Rumiko Kato, Atsuhiko Sugiyama, Ayako Sasaki, Takabumi Miyama, Mai Satoh, Yuri Uchiyama, Naomi Tsuchida, Haruka Hamanoue, Kazuharu Misawa, Kiyoshi Hayasaka, Yoshiki Sekijima, Hiroaki Adachi, Kunihiro Yoshida, Fumiaki Tanaka, Takeshi Mizuguchi, Naomichi Matsumoto
Summary: We developed a diagnostic method for repeat expansion diseases that is faster, more accurate, and more comprehensive compared to conventional methods.
NPJ GENOMIC MEDICINE
(2022)
Article
Urology & Nephrology
Taeko Hashimoto, Yutaka Harita, Keiichi Takizawa, Seiya Urae, Kiyonobu Ishizuka, Kenichiro Miura, Shigeru Horita, Daisuke Ogino, Gen Tamiya, Hideki Ishida, Tetsuo Mitsui, Kiyoshi Hayasaka, Motoshi Hattori
KIDNEY INTERNATIONAL REPORTS
(2019)
Meeting Abstract
Pediatrics
Ayako Sasaki, Kiyoshi Hayasaka
PEDIATRIC PULMONOLOGY
(2019)
Review
Genetics & Heredity
Kiyoshi Hayasaka, Chikahiko Numakura
APPLICATION OF CLINICAL GENETICS
(2018)