Review
Medicine, Research & Experimental
Matthew E. Long, Rama K. Mallampalli, Jeffrey C. Horowitz
Summary: Pneumonia and acute lung injury present challenges for healthcare professionals, and understanding their pathogenesis can help improve clinical interventions.
Article
Oncology
Huirong Fu, Xuanqi Liu, Lin Shi, Lingyan Wang, Hao Fang, Xiangdong Wang, Dongli Song
Summary: This study aimed to explore the potential mechanisms by which OPN regulates lung epithelial inflammation and the interaction of epithelial cells with TCs. The findings showed that OPN played a regulatory role in lung epithelial inflammation and injury, as well as in the communication between epithelial cells and TCs. Controlling lung epithelial OPN could be an alternative approach for preventing and treating epithelial-origin lung inflammation and injury.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Book Review
Multidisciplinary Sciences
Hugh Pennington
Summary: Pathogens and pandemics have had a significant impact on human history, including the current COVID-19 pandemic, but the exact effects of these events are still highly disputed.
Article
Biochemistry & Molecular Biology
Suphagan Boonpethkaew, Jitlada Meephansan, Onjira Jumlongpim, Pattarin Tangtanatakul, Wipasiri Soonthornchai, Jongkonnee Wongpiyabovorn, Ratchanee Vipanurat, Mayumi Komine
Summary: Exploring the transcriptome in the peripheral edge of lesional skin is crucial for understanding the molecules and signaling pathways that contribute to inflammation. The study identified differentially expressed genes in the lesional skin, which enhanced functions related to tissue growth, cell migration, and immune response. The findings suggest that inflammation in the lesional skin may be driven by specific signaling pathways, potentially leading to the discovery of new therapeutic targets for psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xunyao Wu, Anqi Wang, Sumei Zhang, Xiaoxi Wang, Dan Guo, Weiguo Zhu, Yang Jiao, Jiaxin Zhou, Wen Zhang, Linyi Peng, Minghui Duan, Yunyun Fei
Summary: Kimura's disease is a rare chronic inflammatory disorder characterized by subcutaneous masses, lymphadenopathy, and peripheral eosinophilia. Recent studies have found that the activation of the extracellular-signal-regulated kinase/mitogen-activated protein kinases (Erk/MAPK) signaling pathway is increased in eosinophils of Kimura's disease patients compared to healthy controls. Flow cytometry analysis shows similar compositions of lymphocytes, monocytes, and dendritic cell subsets between Kimura's disease and healthy individuals, suggesting that this signaling pathway may be a potential therapeutic target for Kimura's disease.
Article
Multidisciplinary Sciences
Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D. Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobu Morone, Marco Sereno, Claire P. Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodosio, Catherine Ficken, Maria Guerra Martin, Ruth V. Spriggs, Xiao-Ming Sun, Martin Bushell, Owen J. Sansom, Daniel Murphy, Marion MacFarlane, John P. C. Le Quesne, Anne E. Willis
Summary: The study identifies mRNA translation dysregulation in malignant pleural mesothelioma (MpM) cell lines through polysome profiling, and highlights mTORC1 and 2 as potential pharmacological targets. This dysregulation leads to accelerated protein biosynthesis, abnormal mitochondrial morphology, increased oxygen consumption, and ultimately drives cell growth and disease progression. Inhibition of mRNA translation, especially through targeting mTORC1 and 2, has been shown to reverse these effects and inhibit malignant cell growth, providing a promising therapeutic option for patients with MpM.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Wenjing Zhang, Yu Sun, Lu Bai, Lili Zhi, Yun Yang, Qingzhi Zhao, Chaoqun Chen, Yangfan Qi, Wenting Gao, Wenxia He, Luning Wang, Dan Chen, Shujun Fan, Huan Chen, Hai-Long Piao, Qinglong Qiao, Zhaochao Xu, Jinrui Zhang, Jinyao Zhao, Sirui Zhang, Yue Yin, Chao Peng, Xiaoling Li, Quentin Liu, Han Liu, Yang Wang
Summary: RBMS1 is a key regulator of ferroptosis in lung cancer development and its high expression is associated with reduced patient survival. Depletion or inhibition of RBMS1 can promote ferroptosis and sensitize radioresistant lung cancer cells to radiotherapy. RBMS1 interacts with eIF3d to regulate translation of SLC7A11, playing a critical role in ferroptosis evasion during lung cancer progression.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Yin-cui Wu, Yan Yao, Liang-song Tao, Shu-xian Wang, Ying Hu, Liang-yun Li, Shuang Hu, Xiang Meng, Da-Shuai Yang, He Li, Tao Xu
Summary: Common liver tissue damage is caused by the accumulation of toxic aldehydes in lipid peroxidation under oxidative stress. Acetaldehyde dehydrogenase 2 (ALDH2) can effectively metabolize these toxic aldehydes, alleviating various liver diseases. This review explores the relationship between ALDH2 and liver diseases such as alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and hepatocellular carcinoma (HCC), as well as the regulatory mechanism of ALDH2 in these diseases.
CELLULAR SIGNALLING
(2023)
Review
Immunology
Yinlan Wu, Yanhong Li, Yubin Luo, Yu Zhou, Xiuping Liang, Lu Cheng, Tong Wu, Ji Wen, Chunyu Tan, Yi Liu
Summary: This paper reviews the application of proteomics in different subtypes of connective tissue disease-related interstitial lung disease (CTD-ILD), discussing the role of differentially expressed proteins in the development of pulmonary fibrosis and their potential clinical applications.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Daniel Dumitru Banciu, Dragos Cretoiu, Sanda Maria Cretoiu, Adela Banciu, Daniel Popa, Rodica David, Cristian Stefan Berghea-Neamtu, Calin Remus Cipaian, Mihai Octavian Negrea, Mihaela Gheonea, Bogdan Neamtu
Summary: This review article discusses the roles of telocytes in inflammatory bowel diseases (IBD) and presents the mechanisms and hypotheses related to their impact on epithelial regeneration, progressive fibrosis, and dysmotility. The article aims to provide a functional model to illustrate the possible roles of telocytes in the normal and pathological functioning of the digestive tract. Telocytes are influenced by nearby blood vessel compression and the degree of fibrosis in surrounding tissues, and they mediate these processes accordingly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Jing Zhao, Anahid A. Birjandi, Mohi Ahmed, Yushi Redhead, Jose Villagomez Olea, Paul Sharpe
Summary: This study identifies the role of telocytes in regulating macrophage activity in the periodontium. In periodontitis, telocytes proliferate and produce HGF signals, which cause macrophages to shift from an M1 to an M1/M2 state.
Review
Cell Biology
Elena N. Huang, Henry Quach, Jin-A Lee, Joshua Dierolf, Theo J. Moraes, Amy P. Wong
Summary: Cystic fibrosis is a disease caused by mutations in the CFTR protein, leading to abnormal fluid and ion transport, reduced lung function, and increased mortality rate. Although progress has been made in CF research, clinical outcomes may not be mutation-specific. Research suggests that CFTR protein plays an important role in early lung development and mutant CFTR proteins may impact CF airway disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Leyu Hu, Tongtong Wang, Huiying Ren, Wenqiang Liu, Yubao Li, Changfa Wang, Liangliang Li
Summary: Equine herpesvirus 8 (EHV-8) is an important pathogen in the horse and donkey industry, but little is known about its pathogenicity and immune response in a mouse model. This study aimed to investigate the pathogenicity and immune response in the lung during EHV-8 infection in BALB/c mice. The results showed that EHV-8 effectively replicated and elicited a strong proinflammatory response in the lung tissues of the mouse model. This mouse model provides valuable insights into the pathogenicity of EHV-8 and can be used to study respiratory diseases.
Review
Medicine, General & Internal
Clara Bernardelli, Anna Caretti, Elena Lesma
Summary: Chronic inflammatory lung diseases are characterized by altered lipids metabolism and mTORC1 deregulation, leading to pro-inflammatory and senescent phenotypes. LAM, a rare pulmonary disease, is driven by dysregulated lipid metabolism and mTORC1 inhibition, resulting in cystic remodeling and loss of lung function. Understanding the role of lipids in LAM pathogenesis may lead to the discovery of biomarkers and innovative therapeutic approaches.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, Research & Experimental
Jingyi Li, Chunfen Mo, Yifan Guo, Bowen Zhang, Xiao Feng, Qiuyue Si, Xiaobo Wu, Zhe Zhao, Lixin Gong, Dan He, Jichun Shao
Summary: Pin1, a member of the PPIases superfamily, catalyzes the cis-trans conversion of proline in target substrates to modulate cellular functions, and its dysregulation is closely related to the occurrence and development of various diseases. This review summarizes the current knowledge of Pin1 in disease pathogenesis.
Article
Materials Science, Multidisciplinary
Wang Zhao, Hao Su, Weifeng He, Xiaorong Wang, Xiaoyu Cui, Sihai Luo
Summary: Electro-spark deposition (ESD) is an effective method for welding and fabricating coatings, but it can introduce severe surface defects that deteriorate the material performance. This study investigated the effect of key factors on surface features of WC-10 wt.% Co coatings and found that pulse energy, deposition layers, and their interaction significantly affect coating defects. It was also discovered that ultra-low efficiency deposition in the later stage of ESD can effectively repair coating defects.
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
(2023)
Article
Rheumatology
Baozhen Huang, Xinning Wang, Yanlin Niu, Yuchuan Ding, Xiaolei Wang, Qingqing Tan, Yucong Li, Yuan Liu, Ying Chi, Yuan Wang, Zhixuan Zhou, Jianguo Li
Summary: This study evaluated the use of JAKi in treating JDM and found it to be a relatively safe and effective alternative. Cytokine profiles were able to reflect the inflammatory status of JDM patients.
Article
Economics
Zuhao Zou, Xiaoping Wang
Summary: This study analyzes the investment opportunities in the medical sector before and after the COVID-19 outbreak and finds that the actual expected yield of China's medical sector is higher than calculated, indicating an undervaluation of the market. The study also highlights the stable systemic risk premium of the medical sector. Therefore, investors should allocate stocks in the medical and pharmaceutical sectors to improve portfolio income and diversify investment risk in the post-pandemic era.
ECONOMIC RESEARCH-EKONOMSKA ISTRAZIVANJA
(2023)
Article
Chemistry, Applied
Xiongfa Yang, Yan Song, Yaohuang Jiang, Xiaoling Wang, Yina Yang, Jianhua Wang, Xiaojia Wang, Na He, Guoqiao Lai, Yanchun Yu
Summary: UV-curable silicone modified antibacterial materials containing Schiff base were prepared and showed good antimicrobial activity against E. coli and Neurospora crassa. A contact-kill antibacterial mechanism was proposed. These materials also exhibited high transparency and hardness. Their mechanical performance was also good with a tensile strength of 11.6 MPa. These UV-curable Schiff base-containing antibacterial silicone modified materials may be a promising candidate for antibacterial materials.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Psychiatry
Jingjing Shi, Xiaohong Wang, Na Zhao, Chuanyi Kang, Liying Yang, Yue Zheng, Jiacheng Liu, Lei Feng, Xuequan Zhu, Caina Ma, Wenyuan Wu, Gang Wang, Jian Hu
Summary: This study compared the sex differences of residual somatic symptoms (RSS) in patients with first-episode depression (FED). The results showed that RSS is common in FED patients, with females more likely to experience stomach pain and males more likely to experience trouble sleeping. Additionally, quality of life plays an essential role in RSS in both genders. Therefore, sex differences should be considered when assessing the relationship between RSS and therapeutic effect in depression.
Article
Chemistry, Applied
Xue Zhang, Xueya Xu, Xiaoying Wang, Yajuan Lin, Yaling Zheng, Wen Xu, Jian Liu, Wei Xu
Summary: A glycyrrhetinic acid-modified carboxymethyl chitosan-thioketal-rhein (GCTR) conjugate was synthesized for the in vivo delivery of celastrol. Celastrol was encapsulated into polymeric micelles formed by GCTR conjugates self-assembly in water, resulting in celastrol/GCTR PMs with high drug loading capacity and small particle size. Celastrol/GCTR PMs exhibited sustained-release in the blood environment and rapid-release in the tumor microenvironment, showing significant proliferation inhibitory effect on HepG2 and BEL-7402 cells and negligible impact on L-02 cells at low concentrations. The reactive oxygen species (ROS)-responsive properties of celastrol/GCTR PMs improved the bioavailability of celastrol and showed remarkable hepatoma-targeting properties. Celastrol/GCTR PMs effectively inhibited tumor growth with no apparent damage to different organs.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Environmental
Chen Hao, Chenghao Ni, Xiaokun Wang, Yun Pan, Qianqian Wu, Jingbo Wu, Xiaohong Wang
Summary: In this work, a unique three-dimensional core-shell cathode material CuS2@CoNi2S4 and a porous rod-like anode material thistlederived carbon (TDC) are synthesized for hybrid capacitors. The cathode CuS2@CoNi2S4 shows excellent specific capacitance (1191.6 Cg-1 at 1 A g-1) and enhanced cyclic stability (85.7% after 10,000 cycles) prepared by in-situ growth and solvothermal method. The anode TDC exhibits better double-layer energy storage behavior compared with activated carbon. The assembled hybrid capacitors with the synergistic effect of the cathode core and shell and the porous structure of the anode show high energy density (79.5 Wh kg-1 at 800 W kg-1) and long cycle performance (84.5% after 10,000 cycles), indicating great application potential in the realm of supercapacitors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Immunology
Yang Zhou, Guo-Hong Zheng, Na Li, Jing-Jing Liu, Xiao-Hong Wang, Yu-Feng Li
Summary: Immune checkpoint inhibitors (ICIs) have shown revolutionary efficacy in the treatment of multiple cancers. Cytokine-release syndrome (CRS) is a common and lethal adverse event in chimeric antigen receptor T-cell therapy but rare in ICI therapy. This case report describes a patient with hypopharyngeal squamous cell carcinoma who developed CRS after receiving toripalimab combined with chemotherapy, leading to rapid progression and death.
Article
Automation & Control Systems
Weijia Zheng, YangQuan Chen, Xiaohong Wang, Runquan Huang, Meijin Lin, Fang Guo
Summary: This paper proposes a fractional order sliding mode control (FOSMC) method for the control problem of permanent magnet synchronous motor (PMSM) speed servo system subject to multiple disturbances. By using an improved disturbance observer (DO) and an extended state observer (ESO), the lumped exogenous disturbances and uncertainties of the PMSM speed servo are estimated. A novel FOSMC law is developed by incorporating feedforward compensation and a fractional order switching law, improving tracking performance and robustness of the PMSM servo system.
INTERNATIONAL JOURNAL OF CONTROL AUTOMATION AND SYSTEMS
(2023)
Article
Physics, Fluids & Plasmas
W. Zhang, G. -h. Zhu, X. -j. Zhang, G. -q. Zhong, L. Ai, Y. -q. Chu, T. -s. Fan, H. -c. Fan, Y. -y. Guo, B. -l. Hao, J. Huang, Y. -f. Jin, L. -n. Liu, L. -y. Liao, Y. -h. Li, Q. -c. Liang, Y. -x. Sun, G. X. Wang, D. -k. Yang, H. Yang, H. -p. Zhang
Summary: ICRF heating and NBI can synergistically accelerate beam ions and generate fusion neutrons. The synergy improves plasma performance and increases parameters such as poloidal beta, plasma stored energy, core ion temperature, neutron yield, and kinetic pressure. Various parameter scans show that decreasing minority ion concentration or the distance between resonance and magnetic axis, as well as increasing ICRF heating power or NBI beam energy can enhance the synergetic effects and result in higher energy fast ions.
Article
Physics, Fluids & Plasmas
L. F. Lu, B. Lu, X. J. Zhang, L. Colas, G. Urbanczyk, Z. Wang, Z. J. Li, B. L. Hao, L. Xue, M. Xue, S. Wang, A. P. Sun
Summary: The HL-2M tokamak is a new medium-sized tokamak that aims to achieve 10 keV ion temperature and investigate energetic particles relevant to burning plasmas. This paper analyzes the main ICRF heating schemes for HL-2M and proposes optimal RF frequency and antenna parameters for ion heating and energetic ion generation. Simulation results suggest that ICRF heating can significantly contribute to ion heating and the production of energetic ions in HL-2M.
Article
Oceanography
Li Li, Yihan Ren, Taoyan Ye, Xiao Hua Wang, Jianyu Hu, Yuezhang Xia
Summary: Curvature variations in tidal flats have a strong influence on sediment dynamics in macro-tidal turbid bays. This study used a validated 3D sediment model to investigate the interactions between tidal flats and sediment dynamics in Hangzhou Bay. The results showed that the geometry of the tidal flats greatly affects hydrodynamics and sediment transport processes. Tidal flat reclamation alters the curvature of tidal channels and subsequently influences the circulation and sediment transport. The study highlights the importance of anthropogenic activities in shaping the geomorphological evolution of estuaries.
JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
(2023)
Article
Chemistry, Multidisciplinary
Jia-Tong Ren, Ding Wei, Bo-Jun Tan, Rui Hu, Yu-Chen Gao, Xiao-Hong Wang, Wei-Tao Yang
Summary: Developing MOF-based catalysts with superior catalytic properties for the thermal decomposition of RDX is crucial for efficient combustion of RDX-based propellants. In this study, micro-sized Co-ZIF-L with star-like morphology exhibited remarkable catalytic capability, lowering the RDX decomposition temperature by 42.9°C and increasing the heat release by 50.8% compared to all previously reported MOFs and even ZIF-67. The unique structure of SL-Co-ZIF-L activated the exothermic C-N fission pathway, promoting the decomposition process at low temperatures.
Article
Environmental Sciences
Fei Peng, Xiaolei Wang, Guodong Fang, Yanzheng Gao, Xinglun Yang, Juan Gao, Yujun Wang, Dongmei Zhou
Summary: In this study, various soil model minerals were investigated for their effects on PS decomposition and free radical evolution. It was found that the efficiency of PS decomposition varied among different minerals, involving both radical and non-radical processes. This study provides a deeper understanding of the interactions between PS and minerals during PS-based ISCO in soil remediation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Orthopedics
Daoqiang Huang, Zhiqiang Hu, Weili Feng, Xiaoping Wang
Summary: This study investigated the biomechanical properties of dual plate fixation technique for unstable distal clavicle fractures using finite element analysis. The results showed that dual plate fixation had better biomechanical stability and lower risk of implant failure, making it an alternative technique for treating unstable distal clavicle fractures.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Review
Cell Biology
Alyssa Kearly, Andrew D. L. Nelson, Aleksandra Skirycz, Monika Chodasiewicz
Summary: Stress Granules (SGs) and Processing-bodies (P-bodies) are important biomolecular condensates that play crucial roles in maintaining mRNA balance and regulating stress responses. They are composed of proteins and RNAs involved in translation, protein folding, and energy metabolism.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
P. Lemonnier, T. Lawson
Summary: Stomatal conductance plays a crucial role in determining CO2 uptake and water loss in plants, affecting overall water status and productivity. However, the signals coordinating mesophyll demands for CO2, the role of chloroplasts in stomatal function, and other GC metabolic processes in stomatal function remain poorly understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Matteo Gionfriddo, Timothy Rhodes, Spencer M. Whitney
Summary: Rubisco is a key enzyme that facilitates the entry of CO2 into the biosphere, but its catalytic properties are slow and error-prone. More effective Rubisco variants have been discovered in certain algae, offering the potential to significantly improve crop productivity. However, incompatibilities in protein folding have hindered the transplantation of these variants into plants. Directed evolution is now being explored to enhance Rubisco catalysis.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Vittoria Clapero, Stephanie Arrivault, Mark Stitt
Summary: The Calvin-Benson cycle has undergone massive selection and co-evolution with carbon-concentrating mechanisms due to changing environmental factors. Metabolite profiling reveals species-specific variations in the operation of the cycle, indicating the influence of different modes of photosynthesis. Connectivity analysis identifies constraints and driving factors for cross-species diversity in the cycle.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Sukhbir Kaur, David D. Roberts
Summary: Thrombospondin-1 modulates cell behavior by interacting with components of the extracellular matrix and cell surface receptors. Its release and expression are influenced by injuries and various diseases, while its sustained presence in the extracellular space is regulated by receptor-mediated clearance. Thrombospondin-1 plays important roles in immune responses.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Richard P. Tucker, Josephine C. Adams
Summary: Thrombospondins (TSPs) play diverse roles in animals and have been found to belong to a superfamily that includes different subgroups such as mega-TSPs, sushi-TSPs, and poriferan-TSPs. Invertebrates encode a greater diversity of TSP superfamily members than vertebrates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
James Petrik, Sylvia Lauks, Bianca Garlisi, Jack Lawler
Summary: Many cancers start with a small nest of transformed cells that can remain dormant. Thrombospondin-1 (TSP-1) initially promotes dormancy by suppressing angiogenesis, but over time, factors promoting angiogenesis become dominant and recruit various cells to form a complex tumor microenvironment. TSPs play a role in the proliferation, migration, and invasion of cells in the tumor microenvironment, as well as influencing the immune characteristics and phenotype of tumor-associated macrophages.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hana Fakim, Christine Vande Velde
Summary: There has been increasing attention to the role of phase-separated biomolecular condensates, specifically stress granules, in neurodegenerative diseases like ALS. ALS-associated mutations in genes involved in stress granule assembly have been found, and stress granule proteins have been detected in pathological inclusions in ALS patient neurons. However, protein components of stress granules are also present in other physiological biomolecular condensates, which have not been adequately discussed in relation to ALS. This review explores the functions of TDP-43 and FUS in physiological condensates occurring in the nucleus and neurites beyond stress granules, and discusses the impact of ALS-linked mutations on their ability to phase separate and perform their functions in stress-independent biomolecular condensates.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Alexander Lin, Yogambha Ramaswamy, Ashish Misra
Summary: Smooth muscle cells, endothelial cells, and macrophages in blood vessels display remarkable heterogeneity, and their developmental origins may influence their plasticity. Unbiased single cell whole transcriptome analysis techniques are revolutionizing the understanding of cellular diversity and plasticity, providing insights for therapeutic research.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Elton P. Hudson
Summary: The Calvin Benson cycle plays a crucial role in the ecological and biotechnological aspects of bacteria. Recent studies have shed light on the regulation of this cycle in bacteria, with post-transcriptional and post-translational regulation being important in phototrophic bacteria, and transcriptional regulation being prominent in chemolithoautotrophic bacteria. Understanding the regulation of the Calvin Benson cycle has implications for enhancing CO2 fixation and improving the synthesis of desired products. Non-canonical cycles may offer potential benefits for industrial applications.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Xin-Guang Zhu, Haim Treves, Honglong Zhao
Summary: This paper discusses the major regulatory mechanisms over the Calvin Benson Cycle (CBC) that maintain homeostasis of metabolite levels. These mechanisms include redox regulation of enzymes, metabolite regulations (especially allosteric regulations), and balanced activities of enzymes. These regulatory mechanisms are crucial for maintaining high flux and photosynthetic efficiency in CBC.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Hunter C. Herriage, Yi-Ting Huang, Brian R. Calvi
Summary: Apoptosis prevents the inappropriate acquisition of extra copies of the genome, known as polyploidy, but the polyploid state can suppress apoptosis. The mechanisms linking apoptosis and polyploid cell cycles are still largely unknown, and studying the regulation of apoptosis in development and cancer could lead to more effective therapies.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Daniel Campbell, Steven Zuryn
Summary: Mitochondrial dynamics play a crucial role in regulating cellular and organismal homeostasis, impacting various aspects of an organism's healthspan. By studying the nematode Caenorhabditis elegans, a comprehensive understanding of the impact of mitochondrial dynamics on homeostasis over a lifetime can be obtained.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Diba Borgmann, Henning Fenselau
Summary: Maintaining blood glucose at an appropriate physiological level requires coordination of multiple organs and tissues, with the vagus nerve playing a key role in central control. Recent studies have revealed the cellular identity, neuroanatomical organization, and functional contributions of vagal neurons in the regulation of systemic glucose metabolism. These findings provide new insights into the precise roles of vagal neurons in coordinating glucose levels and offer potential avenues for treating glucose metabolism disorders.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
Review
Cell Biology
Tatiana C. Coverdell, Stephen B. G. Abbott, John N. Campbell
Summary: In this article, we review how genetic technology and single-cell genomics are revealing the organizational principles of the efferent vagus in unprecedented detail.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2024)
