Article
Rheumatology
Renske C. F. Hebing, Marry Lin, Maja Bulatovic Calasan, Ittai B. Muller, Sohaila Mahmoud, Sandra Heil, Eduard A. Struys, Bart J. F. van den Bemt, Jos W. R. Twisk, Willem Lems, Michael T. Nurmohamed, Gerrit Jansen, Robert de Jonge
Summary: This study investigates the pharmacokinetics of methotrexate polyglutamate (MTX-PG) accumulation in red blood cells (RBCs) and peripheral blood mononuclear cells (PBMCs) in patients with early rheumatoid arthritis (RA) after oral and subcutaneous MTX treatment. The results show that there are disparate pharmacokinetic profiles between PBMCs and RBCs, with higher accumulation of MTX-PG in PBMCs. The distribution profile of MTX-PG in PBMCs remains constant over 6 months, while in RBCs, the main PG-moiety changes from MTX-PG(1) to MTX-PG(3).
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Janne Heuvelmans, Nathan den Broeder, Geke A. H. van den Elsen, Alfons A. den Broeder, Bart J. F. van den Bemt
Summary: This study aimed to compare the effectiveness and tolerability of oral MTX and s.c. MTX in RA patients. The results showed that oral MTX was non-inferior to s.c. MTX in terms of disease activity control, with a slightly lower dose and better tolerability.
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Eva Vermeer, Renske C. F. Hebing, Maartje M. van de Meeberg, Marry Lin, Tim G. J. de Meij, Eduard A. Struys, Gerrit Jansen, Michael T. Nurmohamed, Maja Bulatovic Calasan, Robert de Jonge
Summary: There is no conclusive evidence supporting the superiority of either oral or subcutaneous administration of methotrexate (MTX) in immune-mediated inflammatory disorders (IMIDs). Subcutaneous administration leads to higher plasma bioavailability and initial accumulation of MTX-polyglutamates (MTX-PGs) in red blood cells (RBCs), but the difference seems to disappear over time. The choice of administration route may be based on shared decision-making, offering patients the option of either oral or subcutaneous administration of MTX based on individual preferences and tolerability.
CURRENT RHEUMATOLOGY REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Fangke Zhang, Yawei Du, Jiancheng Zheng, Zhengwei Cai, Tao Ding, Pengzhen Zhuang, Ding Yang, Fangling Liao, Yu Zhang, Wu Yang, Yafang Xiao, Weiling He, Wenguo Cui, Weisheng Guo
Summary: Researchers have developed multi-stage albumin nanomedicine depot (MAND) for the treatment of chronic inflammatory diseases by encapsulating MTX-loaded human serum albumin nanoparticles (MTX@HSA NPs) in calcium alginate chitosan microcapsules. MANDs provide protection to MTX@HSA NPs against gastric acid erosion and allow specific release of the nanoparticles in the intestine. Animal experiments demonstrate improved therapeutic efficacy and reduced intestinal side effects compared to free MTX by oral administration.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, General & Internal
Eric Senbel, Sonia Trope, Helene Herman-Demars, Elena Zinovieva, Agnes Courbeyrette, Pierre Clerson, Yann Fardini, Rene-Marc Flipo
Summary: The APRIM study aimed to investigate the impact of switching from oral to subcutaneous methotrexate on treatment adherence, disease control, and quality of life in rheumatoid arthritis patients. Results demonstrated that the transition to subcutaneous route improved adherence, disease activity control, and quality of life for patients.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Rheumatology
Delila Singh, Nina Hesse, Alla Skapenko, Hendrik Schulze-Koops
Summary: Methotrexate is associated with rare bone lesions that are often misdiagnosed as osteoporotic fractures. Early diagnosis is crucial for treatment and prevention of further osteopathology. This case highlights the importance of raising awareness and taking appropriate therapeutic measures, including discontinuing methotrexate.
Article
Chemistry, Analytical
Junqing He, Junyan Wang, Min Zhang, Guoyue Shi
Summary: As a folate antagonist, methotrexate (MTX) has been widely used in clinics for treating various tumors and inflammatory diseases. However, the dosage and clearance of MTX vary between individuals, and it may cause life-threatening side effects at high doses. Therefore, a convenient and simple method for MTX sensing is highly demanded.
Article
Chemistry, Multidisciplinary
Parvathy Suresh, Mounir M. Salem-Bekhit, Hafsa Palathum Veedu, Sultan Alshehri, Sreeja Chandrasekhar Nair, Sarah Bukhari, Vidya Viswanad, Ehab Taha, Ram Kumar Sahu, Mohammed M. Ghoneim, Ibrahim Elbagory
Summary: A novel formulation of methotrexate-loaded nanoemulsion was developed to deliver methotrexate into the system via the lymph for the treatment of rheumatoid arthritis. The optimized nanoemulsion showed excellent physicochemical properties, significant anti-arthritic activity, and stability when stored at a low temperature.
Article
Chemistry, Multidisciplinary
Tingting Guo, Xu Kang, Sifan Ren, Xianjin Ouyang, Mingming Chang
Summary: A drug delivery system was designed for treating rheumatoid arthritis through local percutaneous administration and nano-controlled release of methotrexate. The system exhibited good pH sensitivity and release behavior. In vitro and in vivo experiments showed promising results in reducing arthritis symptoms and maintaining cure stability.
Article
Rheumatology
Clement Triaille, Gaelle Tilman, Tatiana Sokolova, Axelle Loriot, Joelle Marchandise, Stephanie De Montjoye, Adrien Nzeusseu-Toukap, Laurent Meric de Bellefon, Caroline Bouzin, Christine Galant, Patrick Durez, Bernard R. Lauwerys, Nisha Limaye
Summary: This study used transcriptomic profiling to explore clinically relevant subgroups in early, untreated rheumatoid arthritis (RA) patients. The synovial transcriptome closely mirrored clinical disease activity, and the ratio of M2:M1 macrophages was inversely correlated with inflammation and disease activity, suggesting a protective role for tissue resident macrophages in RA.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Claire Daien, Marek Krogulec, Paul Gineste, Jean-Marc Steens, Laurence Desroys du Roure, Sophie Biguenet, Didier Scherrer, Julien Santo, Hartmut Ehrlich, Patrick Durez
Summary: This study evaluated the safety and efficacy of ABX464 in patients with moderate-to-severe active rheumatoid arthritis. The results showed that ABX464 at a 50 mg dose was safe, well tolerated, and showed promising efficacy. The 100 mg dose had a high dropout rate due to gastrointestinal adverse events.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Siddharth Jain, Varun Dhir, Amita Aggarwal, Ranjan Gupta, Bidyalaxmi Leishangthem, Shankar Naidu, Aastha Khullar, Supriya Maurya, Veena Dhawan, Shefali Khanna Sharma, Aman Sharma, Sanjay Jain
Summary: This study compared the efficacy and safety of different dose escalation strategies of oral MTX in RA patients over a period of 16-24 weeks. The results showed that a faster escalation strategy was not more effective than the usual strategy, but was associated with higher gastrointestinal adverse events in the initial phase.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Multidisciplinary Sciences
Helen R. Gosselt, Costanza L. Vallerga, Pooja R. Mandaviya, Erik Lubberts, Johanna M. W. Hazes, Robert de Jonge, Sandra G. Heil
Summary: The study did not identify genome-wide significant differences as biomarkers for Methotrexate (MTX) therapy response, necessitating meta-analyses.
Article
Rheumatology
Ulf Lindstrom, Daniela di Giuseppe, Sofia Exarchou, Gerd-Marie Alenius, Tor Olofsson, Eva Klingberg, Lennart Jacobsson, Johan Askling, Johan K. Wallman
Summary: This study aimed to compare the treatment outcomes of patients with newly diagnosed psoriatic arthritis (PsA) and rheumatoid arthritis (RA) using methotrexate (MTX) monotherapy. The results showed that PsA patients were less likely to continue the use of MTX compared to RA patients, and the effectiveness of MTX was also lower in PsA.
Article
Orthopedics
Donghai Li, Zhen Tan, Pengde Kang, Bin Shen, Fuxing Pei
INTERNATIONAL ORTHOPAEDICS
(2017)
Article
Anesthesiology
Donghai Li, Changde Wang, Zhouyuan Yang, Pengde Kang
Article
Medicine, General & Internal
Donghai Li, Qinsheng Hu, Gang Tan, Xiaowei Xie, Zhouyuan Yang, Pengde Kang
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2018)
Article
Orthopedics
Donghai Li, Qinsheng Hu, Pengde Kang, Jing Yang, Zongke Zhou, Bin Shen, Fuxing Pei
INTERNATIONAL ORTHOPAEDICS
(2018)
Article
Multidisciplinary Sciences
Donghai Li, Zhouyuan Yang, Zhun Wei, Pengde Kang
SCIENTIFIC REPORTS
(2018)
Article
Materials Science, Biomaterials
Donghai Li, Xiaowei Xie, Zhouyuan Yang, Changde Wang, Zhun Wei, Pengde Kang
BIOMATERIALS SCIENCE
(2018)
Article
Cell & Tissue Engineering
Wei Zhun, Li Donghai, Yang Zhouyuan, Zhao Haiyan, Kang Pengde
STEM CELLS INTERNATIONAL
(2018)
Article
Orthopedics
Donghai Li, Jinhai Zhao, Zhouyuan Yang, Pengde Kang, Bin Shen, Fuxing Pei
JOURNAL OF KNEE SURGERY
(2019)
Article
Engineering, Biomedical
Yue Luo, Donghai Li, Jinhai Zhao, Zhouyuan Yang, PengDe Kang
BIO-MEDICAL MATERIALS AND ENGINEERING
(2018)
Article
Engineering, Biomedical
Yue Luo, Donghai Li, Xiaowei Xie, PengDe Kang
BIOMEDICAL MATERIALS
(2019)
Article
Orthopedics
Qiuru Wang, Donghai Li, Zhouyuan Yang, Pengde Kang
JOURNAL OF ARTHROPLASTY
(2020)
Article
Orthopedics
Donghai Li, Mohammed Alqwbani, Qiuru Wang, Ren Liao, Jing Yang, Pengde Kang
JOURNAL OF ARTHROPLASTY
(2020)
Article
Engineering, Biomedical
Donghai Li, Liu Huifang, Jinhai Zhao, Zhouyuan Yang, Xiaowei Xie, Zhun Wei, Dongzhe Li, Pengde Kang
BIOMEDICAL MATERIALS
(2018)
Article
Engineering, Biomedical
Liqing Deng, Donghai Li, Zhouyuan Yang, Xiaowei Xie, Pengde Kang
BIO-MEDICAL MATERIALS AND ENGINEERING
(2017)
Review
Rehabilitation
Donghai Li, Zhouyuan Yang, Pengde Kang, Xiaowei Xie
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2017)
Article
Rheumatology
Walter P. Maksymowych, Nele Herregods, Nisha Varma, Arthur B. Meyers, Jennifer Stimec, Andrea S. Doria, Nikolay Tzaribachev, Tarimobo M. Otobo, Marion A. van Rossum, Joel Paschke, Stephanie Wichuk, Robert G. Lambert
Summary: This study aimed to investigate whether systematic calibration improves the scoring proficiency of JAMRIS-SIJ and whether contrast-enhancement enhances its performance. The results showed that calibrated readers achieved greater reliability in scoring specific inflammatory and structural lesions. Sensitivity and reliability for scoring inflammatory lesions were higher on fluid-sensitive sequences compared to contrast-enhanced sequences. Therefore, systematic calibration should be implemented before using JAMRIS-SIJ in clinical trials, and it is unlikely that contrast-enhanced MRI will improve the performance of this method.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
L. van Ouwerkerk, S. A. Bergstra, T. D. Maarseveen, T. W. J. Huizinga, R. Knevel, C. F. Allaart
Summary: This study evaluated whether the initial use of glucocorticoid (GC) bridging in RA patients leads to a higher probability of long-term GC and bDMARD use. The results showed that patients who initially started GC had a higher risk of later GC use, but the risk of bDMARD use was not significantly increased.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)
Article
Rheumatology
ShuangHua Liu, YiMei Tan, WeiDong Huang, HongSheng Luo, BingCheng Pan, Shuan Wu
Summary: This study assessed the cardiovascular safety of zoledronic acid in the treatment of primary osteoporosis. The results showed that in women with primary osteoporosis, zoledronic acid may increase the risk of atrial fibrillation and arrhythmias, but the cardiovascular risk in men with osteoporosis is uncertain.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2024)