NIX initiates mitochondrial fragmentation via DRP1 to drive epidermal differentiation

Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery

(2020) Mija Marinković et al.   Autophagy

Liquid-liquid phase separation drives skin barrier formation

(2020) Felipe Garcia Quiroz et al.   SCIENCE

Live imaging of alterations in cellular morphology and organelles during cornification using an epidermal equivalent model

(2020) Sari Ipponjima et al.   Scientific Reports

Autophagy in Skin Diseases

(2019) Yeye Guo et al.   DERMATOLOGY

A reversible autophagy inhibitor blocks autophagosome–lysosome fusion by preventing Stx17 loading onto autophagosomes

(2019) Somya Vats et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Dynamics and Its Involvement in Disease

(2019) David C. Chan   Annual Review of Pathology-Mechanisms of Disease

A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway

(2019) Vladimir Kirkin et al.   MOLECULAR CELL

Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa

(2018) Mrinal K Sarkar et al.   ANNALS OF THE RHEUMATIC DISEASES

Calcium Signaling and Reactive Oxygen Species in Mitochondria

(2018) Edoardo Bertero et al.   CIRCULATION RESEARCH

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation

(2018) Daniela Weiland et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function

(2018) Bhupendra Singh et al.   Cell Death & Disease

More Than Skin Deep: Autophagy Is Vital for Skin Barrier Function

(2018) Payel Sil et al.   Frontiers in Immunology

Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma

(2018) Teruki Yanagi et al.   Frontiers in Oncology

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity

(2018) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

No Parkin Zone: Mitophagy without Parkin

(2018) Elodie Villa et al.   TRENDS IN CELL BIOLOGY

Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage

(2018) Rhonda M. Brand et al.   Frontiers in Pharmacology

Mitochondrial dysfunction in affected skin and increased mitochondrial DNA in serum from patients with psoriasis

(2018) Anastasia Therianou et al.   EXPERIMENTAL DERMATOLOGY

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division

(2017) Rajarshi Chakrabarti et al.   JOURNAL OF CELL BIOLOGY

Epidermal iron metabolism for iron salvage

(2017) Masayuki Asano et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Drp1 regulates mitochondrial morphology and cell proliferation in cutaneous squamous cell carcinoma

(2017) Shinya Kitamura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Fragmentation of the mitochondrial network in skin in vivo

(2017) Daniel Mellem et al.   PLoS One

Targeted deletion of Crif1 in mouse epidermis impairs skin homeostasis and hair morphogenesis

(2017) Jung-Min Shin et al.   Scientific Reports

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

(2017) Vladimir V. Rogov et al.   Scientific Reports

Endoplasmic Reticulum Calcium Regulates Epidermal Barrier Response and Desmosomal Structure

(2016) Anna Celli et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Constitutive Autophagy and Nucleophagy during Epidermal Differentiation

(2016) Olufolake Akinduro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mechanisms of Selective Autophagy in Normal Physiology and Cancer

(2016) Joseph D. Mancias et al.   JOURNAL OF MOLECULAR BIOLOGY

The Emerging Network of Mitochondria-Organelle Contacts

(2016) Andrew Murley et al.   MOLECULAR CELL

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia

(2016) Robert B. Hamanaka et al.   Cell Reports

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

(2016) Rebecca Rojansky et al.   eLife

Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity

(2016) Simon Joost et al.   Cell Systems

Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX

(2015) Paul A. Ney   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR

(2015) Aparna Bhaduri et al.   DEVELOPMENTAL CELL

Dissecting the formation, structure and barrier function of the stratum corneum

(2015) Takeshi Matsui et al.   INTERNATIONAL IMMUNOLOGY

Autophagosome dynamics in neurodegeneration at a glance

(2015) Y. C. Wong et al.   JOURNAL OF CELL SCIENCE

Development of autophagy inducers in clinical medicine

(2015) Beth Levine et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-Inducible Factors Regulate Filaggrin Expression and Epidermal Barrier Function

(2015) Waihay J. Wong et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention

(2015) Andrew C. Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagosome–lysosome fusion is independent of V-ATPase-mediated acidification

(2015) Caroline Mauvezin et al.   Nature Communications

The significant role of autophagy in the granular layer in normal skin differentiation and hair growth

(2014) Nagisa Yoshihara et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Atypical BH3-domains of BNIP3 and BNIP3L lead to autophagy in hypoxia

(2014) Nathalie M. Mazure et al.   Autophagy

BNIP3 Plays Crucial Roles in the Differentiation and Maintenance of Epidermal Keratinocytes

(2014) Mariko Moriyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Loss of iron triggers PINK1/Parkin-independent mitophagy

(2013) George F G Allen et al.   EMBO REPORTS

Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission

(2013) Oliver C. Losón et al.   MOLECULAR BIOLOGY OF THE CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

(2013) R. B. Hamanaka et al.   Science Signaling

Polymorphisms in the ATG16L1 Gene are Associated with Psoriasis Vulgaris

(2012) K Douroudis et al.   ACTA DERMATO-VENEREOLOGICA

A short linear motif in BNIP3L (NIX) mediates mitochondrial clearance in reticulocytes

(2012) Ji Zhang et al.   Autophagy

Epidermal barrier function and systemic diseases

(2012) Marcia Ramos-e-Silva et al.   CLINICS IN DERMATOLOGY

PINK1- and Parkin-mediated mitophagy at a glance

(2012) Seok Min Jin et al.   JOURNAL OF CELL SCIENCE

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

Polarity and stratification of the epidermis

(2012) Andrew Muroyama et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Induction of hypoxia inducible factor (HIF-1α) in rat kidneys by iron chelation with the hydroxypyridinone, CP94

(2011) Jin Hyen Baek et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HIF-1α in Epidermis: Oxygen Sensing, Cutaneous Angiogenesis, Cancer, and Non-Cancer Disorders

(2011) Hamid R. Rezvani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nanoscale Organization of Mitochondrial Microcompartments Revealed by Combining Tracking and Localization Microscopy

(2011) Timo Appelhans et al.   NANO LETTERS

Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis

(2011) Cory L. Simpson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine

(2010) Laura L. Lackner et al.   CHEMISTRY & BIOLOGY

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo measurement of epidermal thickness changes associated with tumor promotion in murine models

(2010) Kevin G. Phillips et al.   JOURNAL OF BIOMEDICAL OPTICS

5-ALA mediated photodynamic therapy induces autophagic cell death via AMP-activated protein kinase

(2010) Hong-Tai Ji et al.   Molecular Cancer

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Epidermal Sensing of Oxygen Is Essential for Systemic Hypoxic Response

(2008) Adam T. Boutin et al.   CELL