Article
Biochemistry & Molecular Biology
Martha Cecilia Rosales-Hernandez, Martiniano Bello, Jazziel Velazquez Toledano, Barbara Citlali Escudero Feregrino, Jose Correa Basurto, Leticia Guadalupe Fragoso Morales, Monica Adriana Torres-Ramos
Summary: The 3D structure of the aryl hydrocarbon receptor (AhR) was studied using in silico methods. Molecular dynamics simulations revealed that HSP90 interacts with AhR when agonists bind, but not when antagonists bind. This study provides insights into the activity and interactions of AhR.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Biochemistry & Molecular Biology
Marco Gargaro, Giulia Scalisi, Giorgia Manni, Giada Mondanelli, Ursula Grohmann, Francesca Fallarino
Summary: The aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates various cellular responses and has attracted significant attention in the field of immunology in recent years. In addition to its role in toxicology, AhR also plays a crucial role in normal cell physiology, mediating toxic or physiologic effects in response to multiple exogenous and endogenous molecules. Various factors, such as the nature of the ligand, its metabolism by AhR-induced enzymes, tissue microenvironment, and the presence of coregulators or specific transcription factors, contribute to the outcome of gene transcriptional regulation by AhR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Biochemistry & Molecular Biology
Xiao-Jing Guan, You-Ying Zhang, Xiao Zheng, Hai-Ping Hao
Summary: Host-microbiota interactions are essential for various physiological events, and harnessing the sensory machinery mediated by nuclear receptors could offer an innovative strategy for drug discovery targeted towards gut microbiota.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Energy & Fuels
Sivakumar Ellappan, Silambarasan Rajendran
Summary: This review highlights the use of eucalyptus oil as a primary biodiesel and biodiesel as a secondary fuel in low heat rejection engines to improve brake thermal efficiency and reduce emissions. The higher density and cetane index of eucalyptus oil compared to diesel are addressed by adding diethyl ether to the blend. The study aims to enhance the BTE equivalent and decrease emissions compared to traditional diesel fuel.
Review
Pharmacology & Pharmacy
Natalie C. Sondermann, Sonja Fassbender, Frederick Hartung, Anna M. Hatala, Katharina M. Rolfes, Christoph F. A. Vogel, Thomas Haarmann-Stemmann
Summary: The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that plays a critical role in the pathogenesis of various diseases. AHR can interact with other transcription factors and signaling molecules to regulate gene expression and associated physiological or pathophysiological functions. Understanding the non-canonical functions of AHR is important for disease prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Renata P. Gabardo, Natalie P. Toyama, Bianca do Amaral, Marcela Boroski, Aline T. Toci, Simone F. Benassi, Patricio G. Peralta-Zamora, Gilcelia A. Cordeiro, Marcus de Liz
Summary: This study aims to establish a method for determining atrazine and its degradation byproducts in surface water samples, which was successfully applied in the analysis of natural waters from the Parana 3 River Basin in a region with large soybean and corn production. The method was proven to be efficient in cleaning up samples from rivers with a strong impact of anthropic activity.
MICROCHEMICAL JOURNAL
(2021)
Article
Toxicology
Haibo Jin, Minghao Yan, Chun Pan, Zhenyu Liu, Xiaoxuan Sha, Chengyue Jiang, Luxi Li, Mengge Pan, Dongmei Li, Xiaodong Han, Jie Ding
Summary: Chronic exposure to microplastics can lead to reproductive abnormalities in mammals, including changes in testicular morphology, abnormal spermatogenesis, and interference with hormone secretion in the serum.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Review
Chemistry, Medicinal
Li Lin, Yue Dai, Yufeng Xia
Summary: This review provides an overview of the recent advances in the aryl hydrocarbon receptor (AhR) field, covering articles published between 2002 and 2022. AhR plays a crucial role in health and diseases, and it has been associated with various conditions such as cancer, autoimmune disorders, and inflammatory bowel diseases. The review highlights the diverse range of potential ligands for AhR, including amino acid metabolites, polyphenols, and flavonoids. It emphasizes the opportunities and challenges in targeting AhR for drug development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pediatrics
M. Sourouni, L. Haisch, K. Oelmeier, M. Moellers, D. Willy, K. Sondern, H. Koester, J. Steinhard, J. Sandkoetter, W. Klockenbusch, R. Schmitz, J. Potratz
Summary: O/E LHR alone cannot serve as a predictive marker for fetal outcome in pregnancies complicated by CAKUT, but it might still be a helpful parameter together with detailed renal ultrasound evaluation, onset of amniotic fluid abnormality, and SDP.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Emrah Aydin, Nilhan Torlak, Beth Haberman, Foong-Yen Lim, Jose L. Peiro
Summary: This study analyzed the effects of various parameters on the timing of death in congenital diaphragmatic hernia (CDH) patients and found that ECMO need and O/E LHR values were independent predictors. Prenatal pulmonary measurements are the major predictors determining the severity of the disease in CDH patients.
Article
Pharmacology & Pharmacy
Evangel Kummari, Erin Rushing, Ashleigh Nicaise, Amye McDonald, Barbara L. F. Kaplan
Summary: Although TCDD modestly increased the percentage of FasL + B cells in the spleen and spinal cord in EAE mice, it did not significantly induce FasL + B cells in vitro. TCDD primarily suppressed IgG production in B cells systemically and in spleen and spinal cord in EAE, rather than inducing FasL + Bregs.
Article
Biochemistry & Molecular Biology
Peng Chen, Shaobing Wang, Chenyang Cao, Wenchong Ye, Meizhu Wang, Cui Zhou, Wenming Chen, Xu Zhang, Keyu Zhang, Wen Zhou
Summary: Efforts were made to develop promising ANF-derived chimeras for degrading CYP1B1 and overcoming drug resistance. The study showed that modification in the ANF structure and linker type significantly affected the potency of the degraders in eliminating drug resistance in CYP1B1-expressing cells.
BIOORGANIC CHEMISTRY
(2021)
Article
Engineering, Environmental
Yu Zhang, Guanyu Wu, Yun Chen, Pengcheng Yan, Li Xu, Junchao Qian, Feng Chen, Yuting Yan, Henan Li
Summary: In this study, a photoelectrochemical (PEC) aptasensor was developed using Co(II) doped g-C3N4 nanotubes for the specific detection of Atrazine (ATZ). The aptamer improved the selectivity of the sensor through specific recognition with ATZ. The PEC aptasensor showed excellent selectivity and stability in real water samples. This work provides a simplified and cost-effective method for detecting ATZ and insights into the detection of other pollutants.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Environmental Sciences
Tengteng Xia, Jiqiao Liu, Zheng Liu, Fangxin Yue, Fu Yang, Xiaopeng Zhu, Weibiao Chen
Summary: The laser heterodyne radiometer (LHR), with its advantages of miniaturization, low cost, and high spectral-resolution, is a ground-verification instrument for satellite observation of atmospheric trace-gas concentration. This study presents a new performance evaluation method for LHR measurements, based on an ASE source and a CO2 absorption cell in the laboratory. Simulation analysis shows that LHR can achieve an accuracy of 1 ppm within the photodetector bandwidth range when calibrated with instrument line shape (ILS), and the maximum error without ILS correction does not exceed 0.07 ppm with a filter bandwidth of less than 200 MHz. Experimental results confirm the accuracy of LHR with an error of less than 1 ppm and an SNR of 100.
Review
Biochemistry & Molecular Biology
Zhongyan Wang, Megan Snyder, Jessica E. Kenison, Kangkang Yang, Brian Lara, Emily Lydell, Kawtar Bennani, Olga Novikov, Anthony Federico, Stefano Monti, David H. Sherr
Summary: The aryl hydrocarbon receptor (AHR) was initially studied for its role in environmental chemical toxicity, but further research has revealed it to be a key regulator of malignant cell progression and cancer aggression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
Bojana Stanic, Dunja Kokai, Biljana Tesic, Svetlana Fa, Dragana Samardzija Nenadov, Kristina Pogrmic-Majkic, Nebojsa Andric
Summary: By integrating experimental and in silico approaches, this study investigated the underlying mechanisms of dibutyl phthalate (DBP) induced vascular dysfunction. The findings suggest that DBP exposure can affect extracellular matrix, cell adhesion, and migration, which are associated with cardiovascular, cerebrovascular, and immune system diseases.
TOXICOLOGY LETTERS
(2022)
Article
Toxicology
Kristina Pogrmic-Majkic, Dragana Samardzija Nenadov, Biljana Tesic, Svetlana Fa Nedeljkovic, Dunja Kokai, Bojana Stanic, Nebojsa Andric
Summary: This study utilized AOPs and AOP networks to understand the impact of chemicals on human health. It derived the HFRT-AOP network and mapped DEHP to this network, providing insights into the toxic mechanism of DEHP-induced human female reproductive toxicity.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Cell Biology
Biljana Tesic, Dragana Samardzija Nenadov, Tamara Tomanic, SvetlanaFa Nedeljkovic, Stevan Milatovic, Bojana Stanic, Kristina Pogrmic-Majkic, Nebojsa Andric
Summary: DEHP is an endocrine disruptor that affects steroidogenesis in human and rodent granulosa cells. This study analyzed the mechanism by which DEHP affects steroidogenesis in FSH-stimulated human granulosa cells. The results showed that DEHP decreased FSH-stimulated STAR and CYP19A1 expression, leading to a decrease in progesterone and estradiol production. DEHP also inhibited the cAMP and ERK1/2 signaling pathways, resulting in the inhibition of steroidogenesis.
Article
Toxicology
Bojana Stanic, Nemanja Milosevic, Natasa Sukur, Dragana Samardzija Nenadov, Svetlana Fa Nedeljkovic, Srdan Skrbic, Nebojsa Andric
Summary: By analyzing toxicogenomic data, we inferred the molecular pathway network involved in hepatocellular carcinoma (HCC) induced by aflatoxin B1 (AFB1). Computational tools were utilized to identify protein-protein interaction network, hub genes, transcription factors (TFs), upstream kinases, and biological processes (BPs). Our results revealed an association between AFB1 and hub genes involved in the cell cycle, and we identified TFs that regulate these hub genes and linked them with upstream kinases. This study provides important insights into the signaling hierarchy and information flow contributing to AFB1-induced HCC.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Medicine, General & Internal
Natasa Nikolic, Branka Basica, Aljosa Mandic, Nela Surla, Vera Gusman, Deana Medic, Tamas Petrovic, Mirjana Strbac, Vladimir Petrovic
Summary: Cervical cancer caused by persistent infection with HR HPV genotypes is a significant cause of death among women aged 15 to 44 in Serbia. The expression of E6 and E7 HPV oncogenes can be used as a biomarker for diagnosing high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate the diagnostic potential of HPV mRNA and DNA tests for HSIL.
Article
Biochemistry & Molecular Biology
Bojana Stanic, Dunja Kokai, Jelena Markovic Filipovic, Dragana Samardzija Nenadov, Kristina Pogrmic-Majkic, Nebojsa Andric
Summary: This study investigates the effects of long-term low-level exposure to BPA on gene expression in human endothelial cells. The results indicate that BPA exposure leads to concentration-specific changes in gene expression, which are controlled by transcription factors rather than the estrogen receptor pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Food Science & Technology
Natasa Sukur, Nemanja Milosevic, Kristina Pogrmic-Majkic, Bojana Stanic, Nebojsa Andric
Summary: Experimental evidence suggests that certain chemicals, especially endocrine disruptors, can have negative effects on the female reproductive system and decrease fertility in women. However, there is limited or no experimental data available for many chemicals regarding their impact and mechanisms of action in the female reproductive system. To predict the hazards of chemicals to the female reproductive system, a previously defined adverse outcome pathway (AOP) and Convolutional Deep Neural Network models were used. The models, trained using CompTox assays with intended molecular and biological targets corresponding to AOP7, achieved high performance in identifying potentially harmful chemicals. This approach provides a solution for quickly analyzing data and generating machine learning models to identify active chemicals in the female reproductive system. It may also be applicable to other chemicals and adverse outcome pathways if sufficient data is available.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Reproductive Biology
Dragana Samardzija Nenadov, Biljana Tesic, Tamara Tomanic, Marija Opacic, Bojana Stanic, Kristina Pogrmic-Majkic, Nebojsa Andric
Summary: This study examined the effects of different concentrations of DEHP exposure on human granulosa cells. The results showed that low concentration did not affect gene expression, while high concentration only affected the expression of nine genes. Despite these changes, progesterone production was not affected in both low and high concentration DEHP-exposed cells. Overall, this study suggests that acute exposure to low concentration of DEHP does not compromise the function of human granulosa cells, while high concentration only causes subtle effects. The identified nine novel targets of high-dose DEHP require further investigation for their role and importance in DEHP-exposed human granulosa cells.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
