Editorial Material
Medicine, Research & Experimental
Jose Maria Lamo-Espinosa, Felipe Prosper, Juan F. Blanco, Fermin Sanchez-Guijo, Mercedes Alberca, Veronica Garcia, Margarita Gonzalez-Vallinas, Javier Garcia-Sancho
Summary: The study found that using 10, 40, and 100 million autologous cells for knee osteoarthritis treatment provided similar and long-lasting results, providing strong evidence for the efficacy of single-cell injection therapy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Michela Mocchi, Elia Bari, Silvia Dotti, Riccardo Villa, Priscilla Berni, Virna Conti, Maurizio Del Bue, Gian Paolo Squassino, Lorena Segale, Roberto Ramoni, Maria Luisa Torre, Sara Perteghella, Stefano Grolli
Summary: The study demonstrates the safety and potential efficacy of canine mesenchymal stromal cells-secretome in treating osteoarthritis through both in vitro experiments and clinical trials on dogs.
Review
Cell Biology
Timothy P. Liu, Pin Ha, Crystal Y. Xiao, Sang Yub Kim, Andrew R. Jensen, Jeremiah Easley, Qingqiang Yao, Xinli Zhang
Summary: There is a need for novel therapeutics for regenerating injured articular cartilage. Mesenchymal stem cells (MSCs) show promise in chondrogenic differentiation and healing, but further investigation in large animal models is needed. Large animal models play a critical role in studying human MSCs in an osteochondral microenvironment and identifying promising approaches for clinical investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fenglei Chen, Shan Wang, Chenying Zeng, Su'an Tang, Huimin Gu, Ziming Wang, Jinteng Li, Pei Feng, Yunhui Zhang, Peng Wang, Yanfeng Wu, Huiyong Shen
Summary: This study reveals that circSERPINE2 plays a regulatory role in stem cell senescence and has therapeutic potential in alleviating aging-related disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Zehao Zhang, Sheng Zhao, Zhaofeng Sun, Chuanxing Zhai, Jiang Xia, Caining Wen, Yuge Zhang, Yuanmin Zhang
Summary: Osteoarthritis (OA) is a common joint disorder causing pain and disability, with unsatisfactory current treatment outcomes. Recent studies have shown that mesenchymal stem cell-derived exosomes (MSC-Exos) have a significant impact on OA and could be a potential cell-free therapy. This review provides an overview of the synthesis, composition, and mechanisms of action of MSC-Exos in OA, and discusses their potential as a therapeutic tool and bioengineering approaches to enhance their therapeutic potential.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Pengxu Wei, Ruixue Bao
Summary: Knee osteoarthritis is a common problem, especially in older individuals, and can eventually lead to disability. Injecting mesenchymal stem cells (MSCs) into the knee joint has been shown to induce cartilage regeneration in several studies. Additionally, understanding the anatomical, biomechanical, and biochemical changes associated with knee osteoarthritis can help develop appropriate interventions to delay disease progression and improve cartilage repair induced by MSC injection. Post-injection rehabilitation programs and related mechanisms are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Gi Beom Kim, Oog-Jin Shon, Min-Soo Seo, Young Choi, Wook Tae Park, Gun Woo Lee
Summary: Although conventional MSC-based therapies have limitations, MSC-derived exosomes offer advantages such as small dimensions, low immunogenicity, and potent therapeutic effects for osteoarthritis treatment. Exosomes are nano-sized vesicles containing nucleic acids, functional proteins, and bioactive lipids, secreted by various cell types. They play a role in tissue repair, immune regulation, and inflammation reduction, demonstrating potential for a new therapeutic approach in osteoarthritis. Further research is needed to confirm their clinical effectiveness and feasibility.
Article
Engineering, Biomedical
Bin Wang, Wei Liu, Jiao Jiao Li, Senlin Chai, Dan Xing, Hongsheng Yu, Yuanyuan Zhang, Wenjin Yan, Zhihong Xu, Bin Zhao, Yanan Du, Qing Jiang
Summary: In the treatment of osteoarthritis, delivering low doses of MSCs through microcarriers can achieve similar reparative effects as repeated high doses. Mechanistic investigations reveal that 3D growth of MSCs reduces inflammatory factors, enhances early chondrogenesis and extracellular matrix interactions, and maintains the phenotype of co-cultured chondrocytes.
BIOACTIVE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Natalia Linkova, Vladimir Khavinson, Anastasiia Diatlova, Svetlana Myakisheva, Galina Ryzhak
Summary: Finding innovative ways to treat osteoarthritis (OA) is a pressing task in molecular medicine and biogerontology. Directed differentiation of mesenchymal stem cells (MSCs) into chondrocytes is considered a potential method for OA treatment. This review examines the main molecules involved in the chondrogenic differentiation of MSCs, with peptides derived from growth factors' structures and components of cartilage tissue showing promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Liying Pang, Hong Jin, Zhengmao Lu, Fangyuan Xie, Huaxing Shen, Xinying Li, Xinyi Zhang, Xianghe Jiang, Lili Wu, Mengya Zhang, Tinglin Zhang, Yonghua Zhai, Yuanyuan Zhang, Huilin Guan, Jiacan Su, Meng Li, Jie Gao
Summary: Osteoarthritis is a serious joint disorder, and new treatment strategies are needed. Mesenchymal stem cell (MSC)-derived exosomes offer a promising therapeutic strategy. However, the limited yield of exosomes is a challenge. This study developed a high-yield exosome-mimicking nanovesicles (MSC-NVs) with enhanced regenerative and anti-inflammatory properties.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Orthopedics
Sara Sadat Nabavizadeh, Tahereh Talaei-Khozani, Moein Zarei, Shahrokh Zare, Omid Koohi Hosseinabadi, Nader Tanideh, Sajad Daneshi
Summary: The study evaluated the effects of SMMSCs, PRP, and secretome on collagenase II-induced rat knee osteoarthritis. Results showed that the combination of SMMSCs/secretome/PRP had a significant effect on glycosaminoglycans and collagen II contents, indicating better therapeutic efficacy.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Multidisciplinary Sciences
Shu-Fen Sun, Guan-Chyun Lin, Chien-Wei Hsu, Huey-Shyan Lin, I-H Siu Liou, Shin-Yi Wu
Summary: The study compared the efficacy of combined injections of HYAJOINT Plus and PRP with single PRP injections in patients with knee osteoarthritis. The results showed that the combined injection group achieved better pain reduction on the VAS scale at 6 months.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Multidisciplinary
Marius Ionitescu, Dinu Vermesan, Bogdan Andor, Cristian Dumitrascu, Musab Al-Qatawneh, Vlad Bloanca, Andrei Dumitrascu, Radu Prejbeanu
Summary: The study found that ongoing studies for knee osteoarthritis represent a small fraction of registered clinical trials, but they make up over a quarter of all knee trials and over two thirds of all osteoarthritis studies. These studies primarily focus on arthroplasty and intraarticular injections for treatment.
APPLIED SCIENCES-BASEL
(2021)
Article
Orthopedics
Andrea Pintore, Donato Notarfrancesco, Arnaldo Zara, Antonio Oliviero, Filippo Migliorini, Francesco Oliva, Nicola Maffulli
Summary: The study found that autologous mesenchymal stem cell (MSC) injections can improve clinical and functional outcomes in knee osteoarthritis (KOA) patients, with similar results between autologous bone marrow cells (BMAC) and adipose-derived stromal cells (ADSCs). Measurements of Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS), and visual analog scale (VAS) were collected from 102 patients with KOA before the procedures, at one month, and at six months post-injection.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Philippe Hernigou, Jerome Delambre, Steffen Quiennec, Alexandre Poignard
Summary: The study indicated that bone marrow lesions can serve as predictive factors for future knee arthroplasty in the knee treated with subchondral cell therapy at the ten-year follow-up.
INTERNATIONAL ORTHOPAEDICS
(2021)