Review
Medicine, Research & Experimental
Xueru Wang, Gang Xu, Hanyu Liu, Zhengtao Chen, Susu Huang, Jiushu Yuan, Chunguang Xie, Lian Du
Summary: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes, and finding effective treatments for DPN is crucial. Schwann cells (SCs) play an important role in the development of DPN by inhibiting apoptosis. Previous studies have shown the potential of Chinese herbal medicine (CHM) in treating DPN. This review explores the effects of CHM on SCs apoptosis through different pathological pathways and provides new insights for treating DPN.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Qingqing Yuan, Xiang Zhang, Wandi Wei, Jialing Zhao, Yuhao Wu, Song Zhao, Lin Zhu, Peiran Wang, Jun Hao
Summary: In this study, lycorine was identified as a potential drug for diabetic peripheral neuropathy. It was found that lycorine promoted autophagy in Schwann cells through AMPK pathway activation and MMP9 downregulation.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Plant Sciences
Yundong Yin, Hua Qu, Qiaoning Yang, Zhaohui Fang, Rui Gao
Summary: The study demonstrated that AST can promote autophagy activity in DPN Schwann cells by regulating the miR-155-mediated PI3K/Akt/mTOR signaling pathway, thus alleviating neuronal cell damage. Treatment with AST in DPN rats resulted in decreased blood glucose levels, improved neurological function, and reduced peripheral nerve myelin sheath injury, attributed to the inhibition of cell apoptosis through the suppression of the PI3K/Akt/mTOR signaling pathway.
Article
Neurosciences
Baoyan Fan, Michael Chopp, Yi Zhang, Xinli Wang, Amy Kemper, Zheng Gang Zhang, Xian Shuang Liu
Summary: The study found that knockout of the Ago2 gene in PLP lineage Schwann cells (SCs) led to a reduction in nerve conduction velocities and impairments of thermal and mechanical sensitivities. It was also observed that Ago2 knockout induced demyelination and neurodegeneration. These results suggest that Ago2 in SCs is essential for maintaining peripheral nerve function and its loss exacerbates nerve damage in diabetic peripheral neuropathy (DPN).
Article
Pharmacology & Pharmacy
Yuan Yuan, Jinmeng Li, Yanhong Chen, Qingshan Cai, Yingying Xu, Luting Lin, Yazhen Lang, Suhang Guo, Ruoying Zhang, Xinjun Cai
Summary: This study investigates the mechanism of linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis (MDR-TB). The results show that linezolid inhibits autophagy flux, leading to the development of peripheral neuropathy. The findings suggest a potential neuroprotective role of autophagy in preventing linezolid-induced neuropathy in MDR-TB patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiahui An, Xiang Zhang, Keqi Jia, Cuihong Zhang, Lin Zhu, Meijuan Cheng, Fan Li, Song Zhao, Jun Hao
Summary: TSA promotes nerve conduction and BDNF expression in diabetic peripheral neuropathy by modulating GRP78, improving nerve cell function under high glucose conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Neurosciences
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Zhong-Ya Wei
Summary: Peripheral neuropathy is a common neurological issue with limited treatment options. Schwann cell transplantation plays a crucial role in resolving peripheral neuropathy, and stem cells have the potential to differentiate into Schwann-like cells. These studies provide insights into cell therapy and uncover prospective therapeutic strategies for peripheral neuropathy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jiayue Zhu, Xinwei Yang, Xiao Li, Shuo Han, Yanbo Zhu, Liping Xu
Summary: Tang Luo Ning (TLN), a traditional Chinese compound prescription, has been used to treat diabetic peripheral neuropathy (DPN) in China. This study aimed to investigate the effects of TLN on mitochondrial dynamics in rat models and Schwann cells. TLN was found to improve mitochondrial function, maintain balance in dynamics, and improve schwannopathy. Study results suggest that TLN may hold promise for clinical application in treating DPN.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jiayang Li, Guangzhi Wu, Weiye Li, Xiongyao Zhou, Weizhen Li, Xiong Xu, Ke Xu, Rangjuan Cao, Shusen Cui
Summary: This study found significant differences in miRNA expression between plasma exosomes of DPN and age-matched healthy rats. MiR-20b-3p was enriched in hplasma-exos and both of them alleviated DPN symptoms. MiR-20b-3p regulated autophagy in Schwann cells by targeting Stat3, inhibiting the progression of DPN.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Young Rae Jo, Yuna Oh, Young Hee Kim, Yoon Kyung Shin, Hye Ran Kim, Hana Go, Jaekyoon Shin, Hye Ji Park, Hyongjong Koh, Jong Kuk Kim, Jung Eun Shin, Kyung Eun Lee, Hwan Tae Park
Summary: DSCs utilize autophagy-related genes to form secretory phagophores and tubular phagophores, enabling the exocytosis of large myelin chambers. This autophagy-mediated myelin clearance mechanism is a novel response of DSCs to nerve damage.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Guangjun Song, Junmiao Zhuang, Xingrong Wang
Summary: This retrospective study evaluated the clinical efficacy of Chinese herbal footbath plus traditional Chinese medicine (TCM) decoction in diabetic peripheral neuropathy. The results showed that this treatment can significantly improve nerve conduction velocity, reduce blood glucose levels, alleviate symptoms, and enhance clinical efficacy.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Cuneyd Parlayan, Yunus Sahin, Zekiye Altan, Kaifee Arman, Masa-Aki Ikeda, Khandakar A. S. M. Saadat
Summary: The study focused on the role of ARID3A in osteosarcoma progression, revealing its impact on BECN1 expression and cell proliferation. Findings suggest that ARID3A may act as a tumor suppressor and influence the expression level of BECN1 in U-2 OS cells, shedding light on potential treatment strategies for osteosarcoma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Meijian Wang, Min Xie, Shuyan Yu, Pan Shang, Cong Zhang, Xiaolin Han, Cuiqin Fan, Li Chen, Xianghua Zhuang, Shihong Chen
Summary: Studies have shown that Lipin1 is involved in the pathogenesis of DPN, playing a role in regulating autophagy and maintaining normal peripheral nerve conduction function. Upregulation of Lipin1 can ameliorate autophagic disorders and pathological changes in nerves, leading to an increase in nerve conduction velocity in DPN rats.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Alan Pestronk, Robert E. Schmidt, Robert Bucelli, Julia Sim
Summary: This study examined the protein components of Schwann cells and myelin in normal and diseased human peripheral nerves, and found that the molecular composition of the central nervous system varies with age, axon size, and nerve pathology.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Toxicology
Zhanxun Wu, Wenping Yan, Ke Wang, Genghua Xu, Danyan Zhu, Xuyun Li, Huafeng Wang, Min Yang, Xiangnan Zhang, Jiaying Wu
Summary: Bortezomib (BTZ) is an effective drug for multiple myeloma treatment, but it often leads to BTZ-induced peripheral neuropathy (BIPN). In this study, it was found that BTZ caused demyelination in sciatic nerves, leading to mechanical hyperalgesia and impaired nerve conduction. The mechanism was identified as the dysfunction of lysosomes and autophagy blockage in Schwann cells. However, the use of the lysosomal activator Torin1 reversed the autophagy blockage and improved the BIPN pathology.
ARCHIVES OF TOXICOLOGY
(2023)