Intestinal bile acid receptors are key regulators of glucose homeostasis

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice

(2016) Joseph F. Pierre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile salts in control of lipid metabolism

(2016) Marleen Schonewille et al.   CURRENT OPINION IN LIPIDOLOGY

Postprandial Plasma Concentrations of Individual Bile Acids and FGF-19 in Patients With Type 2 Diabetes

(2016) David P. Sonne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis

(2016) Kathleen R. Markan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Bile Routing Modification Reproduces Key Features of Gastric Bypass in Rat

(2015) Daisy Goncalves et al.   ANNALS OF SURGERY

Regulators of Gut Motility Revealed by a Gnotobiotic Model of Diet-Microbiome Interactions Related to Travel

(2015) Neelendu Dey et al.   CELL

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

(2015) Cheryl A. Brighton et al.   ENDOCRINOLOGY

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21

(2015) Bryn M. Owen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

(2015) Mohamed-Sami Trabelsi et al.   Nature Communications

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery

(2015) Charles Robb Flynn et al.   Nature Communications

Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice

(2015) Daniel A. Briere et al.   PLoS One

Nuclear bile acid signaling through the farnesoid X receptor

(2014) Claire Mazuy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine

(2014) Rune E. Kuhre et al.   DIABETES

FXR is a molecular target for the effects of vertical sleeve gastrectomy

(2014) Karen K. Ryan et al.   NATURE

GPBAR1/TGR5 Mediates Bile Acid-Induced Cytokine Expression in Murine Kupffer Cells

(2014) Guiyu Lou et al.   PLoS One

Glucose-lowering effects of intestinal bile acid sequestration through enhancement of splanchnic glucose utilization

(2014) Janne Prawitt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Pleiotropic Roles of Bile Acids in Metabolism

(2013) Thomas Q. de Aguiar Vallim et al.   Cell Metabolism

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12 -Hydroxylated Bile Acids

(2013) R. A. Haeusler et al.   DIABETES

Muricholic bile acids are potent regulators of bile acid synthesis via a positive feedback mechanism

(2013) X. Hu et al.   JOURNAL OF INTERNAL MEDICINE

Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes

(2013) S. Caron et al.   MOLECULAR AND CELLULAR BIOLOGY

Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance

(2013) Yongjie Ma et al.   PHARMACEUTICAL RESEARCH

Ageing Fxr Deficient Mice Develop Increased Energy Expenditure, Improved Glucose Control and Liver Damage Resembling NASH

(2013) Mikael Bjursell et al.   PLoS One

Novel insights into ChREBP regulation and function

(2013) Gaëlle Filhoulaud et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice

(2012) Matthew J. Potthoff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of rectal administration of taurocholic acid on glucagon-like peptide-1 and peptide YY secretion in healthy humans

(2012) T. Wu et al.   DIABETES OBESITY & METABOLISM

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion

(2012) H. E. Parker et al.   DIABETOLOGIA

Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers

(2012) T. E. Adrian et al.   DIABETOLOGIA

Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry

(2012) Abdella M. Habib et al.   ENDOCRINOLOGY

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

TGR5 potentiates GLP-1 secretion in response to anionic exchange resins

(2012) Taoufiq Harach et al.   Scientific Reports

Bile Acid Metabolism and the Pathogenesis of Type 2 Diabetes

(2011) Janne Prawitt et al.   Current Diabetes Reports

Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

(2011) J. Prawitt et al.   DIABETES

Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

(2011) V. Gorboulev et al.   DIABETES

Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study

(2011) C. Beysen et al.   DIABETOLOGIA

PPARβ/δ Activation Induces Enteroendocrine L Cell GLP-1 Production

(2011) Mehdi Daoudi et al.   GASTROENTEROLOGY

Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure

(2011) Mitsuhiro Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

(2011) Tingting Li et al.   MOLECULAR ENDOCRINOLOGY

Colesevelam improves insulin resistance in a diet-induced obesity (F-DIO) rat model by increasing the release of GLP-1

(2010) Quan Shang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities

(2010) Rohit Kohli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Improved glycemic control with colesevelam treatment in patients with type 2 diabetes is not directly associated with changes in bile acid metabolism

(2010) Gemma Brufau et al.   HEPATOLOGY

Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice

(2010) Galya Vassileva et al.   JOURNAL OF ENDOCRINOLOGY

Metabolic Footprint of Diabetes: A Multiplatform Metabolomics Study in an Epidemiological Setting

(2010) Karsten Suhre et al.   PLoS One

Bile Acids Have the Gall to Function as Hormones

(2009) Thomas Quad de Aguiar Vallim et al.   Cell Metabolism

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

A comprehensive definition for metabolic syndrome

(2009) P. L. Huang   Disease Models & Mechanisms

Bile salt sequestration induces hepaticde novolipogenesis through farnesoid X receptor- and liver X receptorα-controlled metabolic pathways in mice

(2009) Hilde Herrema et al.   HEPATOLOGY

An Increased Flux through the Glucose 6-Phosphate Pool in Enterocytes Delays Glucose Absorption inFxr–/–Mice

(2009) Theo H. van Dijk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Bile-acid-induced cell injury and protection

(2009) Maria J Perez et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants

(2008) Mark Kidd et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Glucose Sensing in L Cells: A Primary Cell Study

(2008) Frank Reimann et al.   Cell Metabolism

The use of High Performance Thin-Layer Chromatography to determine the role of membrane lipid composition in bile salt-induced kidney cell damage

(2007) Winston A. Morgan et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS