Fatty acid synthase causes drug resistance by inhibiting TNF-α and ceramide production

Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells

(2011) Christopher J. Clarke et al.   BIOCHEMICAL JOURNAL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

(2010) Carlos A. Castaneda et al.   CANCER AND METASTASIS REVIEWS

Ubiquitin-Specific Protease 8 Links the PTEN-Akt-AIP4 Pathway to the Control of FLIPSStability and TRAIL Sensitivity in Glioblastoma Multiforme

(2010) Amith Panner et al.   CANCER RESEARCH

Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells

(2010) A. Vazquez-Martin et al.   CELL PROLIFERATION

Mammalian Neutral Sphingomyelinases: Regulation and Roles in Cell Signaling Responses

(2010) Bill X. Wu et al.   NEUROMOLECULAR MEDICINE

Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin

(2009) Hiromi Ito et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Novel PTEN-Dependent Link to Ubiquitination Controls FLIPS Stability and TRAIL Sensitivity in Glioblastoma Multiforme

(2009) A. Panner et al.   CANCER RESEARCH

Sphingosine Kinase Isoforms Regulate Oxaliplatin Sensitivity of Human Colon Cancer Cells through Ceramide Accumulation and Akt Activation

(2009) Satoshi Nemoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor-α-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

(2009) David Wheeler et al.   JOURNAL OF NEUROCHEMISTRY

Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer

(2009) Toshiro Migita et al.   JNCI-Journal of the National Cancer Institute

Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction

(2008) A. Cogolludo et al.   CARDIOVASCULAR RESEARCH

Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4

(2008) Lynn M. Knowles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new mechanism of drug resistance in breast cancer cells: fatty acid synthase overexpression-mediated palmitate overproduction

(2008) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS