Article
Immunology
Xiaoying Shang, Lisheng Ren, Guirong Sun, Teng Yu, Yuan Yao, Lin Wang, Fenghai Liu, Lijun Zhang, Xiaqin He, Mingjun Liu
Summary: The study showed that anti-C1q, anti-dsDNA, anti-Nucleosome, and anti-Histone antibodies are valuable in diagnosing active lupus nephritis and monitoring systemic lupus erythematosus disease activity. These antibodies correlated positively with SLE disease activity index, with anti-Nucleosome showing the highest correlation coefficient. The levels of these antibodies decreased following treatment and the changes were positively correlated with SLE disease activity index variations.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Immunology
Cristina Cocco, Elias Manca, Giulia Corda, Maria Maddalena Angioni, Barbara Noli, Mattia Congia, Francesco Loy, Michela Isola, Elisabetta Chessa, Alberto Floris, Lorena Lorefice, Luca Saba, Alessandro Mathieu, Gian Luca Ferri, Alberto Cauli, Matteo Piga
Summary: Brain-reactive autoantibodies are found in patients with SLE and NPSLE, with higher frequency and titers observed in NPSLE patients. The target antigens of these autoantibodies are still undetermined, but they likely include β2GPI.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Jiangbiao Xiong, Gang Wang, Tian Xu, Ren Liu, Shujiao Yu, Yan Wang, Rui Wu
Summary: This study aimed to explore the risk factors for osteonecrosis in patients with SLE. The results showed that the score of ECLAM at SLE onset, a cumulative dose of prednisone above 10 g, and positive anti-RNP antibodies were significantly associated with osteonecrosis in SLE. It was also found that anti-RNP antibodies might be a novel predictor for osteonecrosis in SLE patients.
FRONTIERS IN MEDICINE
(2022)
Article
Rheumatology
May Yee Choi, Ann Elaine Clarke, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Ken Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, Karen H. Costenbader, Marvin J. Fritzler
Summary: In a longitudinal analysis of a large international incident SLE cohort, three ANA assays demonstrated high positivity rates and commutability. However, over a 5-year follow-up, there was a modest variation in ANA assay performance.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Kyoko Kawahara, Tomoyuki Mukai, Masanori Iseki, Akiko Nagasu, Hajime Nagasu, Takahiko Akagi, Shoko Tsuji, Sumie Hiramatsu-Asano, Yasuyoshi Ueki, Katsuhiko Ishihara, Naoki Kashihara, Yoshitaka Morita
Summary: SH3BP2 deficiency improved lupus-like manifestations, including reduced splenomegaly, renal involvement, elevated serum anti-dsDNA antibody levels, and increased splenic B220(+)CD4(-)CD8(-) T cells. Interestingly, deficiency of SH3BP2 in B cells did not alleviate lupus-like phenotypes. Additionally, SH3BP2 deficiency did not have a significant impact on T cells and macrophages in vitro, but it suppressed dendritic cell differentiation and reduced dendritic cell numbers in the spleen of lupus-prone mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Diane M. Spencer, Elisabet Svenungsson, Iva Gunnarsson, Roberto Caricchio, David S. Pisetsky
Summary: This study investigates the antibody response to Z-DNA in patients with systemic lupus erythematosus (SLE) and healthy individuals. The results show that SLE patients commonly produce antibodies to Z-DNA, and healthy individuals also exhibit binding in the assay. The levels of antibodies to Z-DNA in SLE blood are related to those to B-DNA, and cross-reactivity is demonstrated through adsorption experiments. The binding of SLE anti-Z-DNA antibodies is sensitive to the effects of ionic strength, suggesting electrostatic binding.
CLINICAL IMMUNOLOGY
(2023)
Article
Rheumatology
May Yee Choi, Irene Chen, Ann Elaine Clarke, Marvin J. Fritzler, Katherine A. Buhler, Murray Urowitz, John Hanly, Yvan St-Pierre, Caroline Gordon, Sang-Cheol Bae, Juanita Romero-Diaz, Jorge Sanchez-Guerrero, Sasha Bernatsky, Daniel J. Wallace, David Alan Isenberg, Anisur Rahman, Joan T. Merrill, Paul R. Fortin, Dafna D. Gladman, Ian N. Bruce, Michelle Petri, Ellen M. Ginzler, Mary Anne Dooley, Rosalind Ramsey-Goldman, Susan Manzi, Andreas Jonsen, Graciela S. Alarcon, Ronald F. van Vollenhoven, Cynthia Aranow, Meggan Mackay, Guillermo Ruiz-Irastorza, Sam Lim, Murat Inanc, Kenneth Kalunian, Soren Jacobsen, Christine Peschken, Diane L. Kamen, Anca Askanase, Jill P. Buyon, David Sontag, Karen H. Costenbader
Summary: A novel longitudinal clustering technique was used to analyze comprehensive autoantibody data from a large, well-characterised, multinational inception SLE cohort, in order to determine predictive profiles of clinical outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Yingxin Dai, Enling Li, Dandan Chen, Xiangyu Niu, Zhiqing Wang, Liangjing Lu, Bing Zheng
Summary: Monospecific autoantibodies to dense fine speckles 70 (DFS70) antigen are prevalent in Chinese SLE patients and are positively associated with anti-dsDNA. There is consistent dynamic variation between anti-DFS70 and anti-dsDNA during follow-up.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Viktoryia Laurynenka, Lili Ding, Kenneth M. Kaufman, Judith A. James, John B. Harley
Summary: The association between EBV infection and SLE is reconfirmed, and the presence of anti-EBNA1 antibodies in SLE cases is more frequent than in EBV-infected controls, supporting the hypothesis that anti-EBNA1 contributes to SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yingkun Nie, Chunyan Li, Ni Sun
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune abnormalities leading to multi-organ damage. The effects of Ophiopogonin D (OP-D) on B cell activation and autoantibody production as well as renal injury in the pathogenesis of SLE were investigated using MRL/lpr mice. OP-D treatment prolonged survival, reduced proteinuria and serum creatinine levels, mitigated renal pathological alteration, and decreased serum levels of autoantibodies and B cell numbers.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Rheumatology
Mary K. Crow
Summary: Research has identified type I interferon (IFN-I) and autoantibodies targeting nucleic acids and nucleic acid-binding proteins as fundamental contributors to the pathogenesis of systemic lupus erythematosus (SLE). This review summarizes recent genetic analyses of SLE patients and current studies on innate and adaptive immune function, which contribute to sustained IFN-I pathway activation, immune activation, autoantibody production, inflammatory mediator generation, and tissue damage. The goal of these studies is to understand disease mechanisms, identify therapeutic targets, and develop better treatments for patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Tetsuo Kubota
Summary: Anti-DNA antibodies play an important role in SLE by entering cells and affecting the pathophysiology. Activated circulating neutrophils in SLE release immunogenic NETs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Christina Adamichou, Irini Genitsaridi, Dionysis Nikolopoulos, Myrto Nikoloudaki, Argyro Repa, Alessandra Bortoluzzi, Antonis Fanouriakis, Prodromos Sidiropoulos, Dimitrios T. Boumpas, George K. Bertsias
Summary: A machine learning algorithm was developed to assist in the diagnosis of SLE by analyzing patient data sets, leading to improved diagnostic and treatment outcomes.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Review
Immunology
Gabriela Guzman-Martinez, Concepcion Maranon
Summary: Patients with systemic lupus erythematosus (SLE) have an increased risk of cardiovascular disease (CVD), which is becoming one of the most relevant complications and a significant factor causing morbidity and mortality in SLE. Immune constituents, including specific circulating cell populations, autoantibodies, and inflammatory mediators, play a role in the pathogenesis of atherosclerosis and endothelial damage in SLE patients. This review summarizes the presentation of CVD in SLE, the role of autoimmune responses in inducing atherogenesis, endothelial impairment, and cardiac disease, and discusses the utility of immune mediators as early CVD biomarkers and targets for clinical intervention in SLE patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jessica S. Kleer, Pascal A. Rabatscher, Jessica Weiss, Joel Leonardi, Severin B. Vogt, Andrea Kieninger-Grafitsch, Carlo Chizzolini, Uyen Huynh-Do, Camillo Ribi, Marten Trendelenburg
Summary: The study found that epitope-specific anti-C1q in SLE patients is associated with specific disease manifestations, providing more diagnostic value than conventional anti-C1q.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Pablo Martinez-Vicente, Domenec Farre, Pablo Engel, Ana Angulo
Article
Biology
Guillem Angulo, Jelena Zeleznjak, Pablo Martinez-Vicente, Joan Punet-Ortiz, Hartmut Hengel, Martin Messerle, Annette Oxenius, Stipan Jonjic, Astrid Krmpotic, Pablo Engel, Ana Angulo
Summary: Viral infections are often controlled by activated T lymphocytes through ICOS, which enhances T-cell activation. During herpesvirus infections, ICOSL is downregulated, leading to impaired T-cell responses. The viral protein m138/fcr-1 interacts with ICOSL in MCMV, affecting T-cell function and immune surveillance.
Article
Immunology
Manuel Saez Moya, Rebeca Gutierrez-Cozar, Joan Punet-Ortiz, Maria Luisa Rodriguez de la Concepcion, Julia Blanco, Jorge Carrillo, Pablo Engel
Summary: In a study using NOD.H-2 (h4) mice as a model for spontaneous SjS, it was found that these mice have a higher frequency of self-reactive B-cell clones, and with age, there is an increase in polyreactive and autoreactive IgG clones. Furthermore, in these mice, there is a trend towards oligoclonality in IgG B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Hematology
Patricia Balsas, Luis Veloza, Guillem Clot, Marta Sureda-Gomez, Marta-Leonor Rodriguez, Christos Masaoutis, Gerard Frigola, Alba Navarro, Silvia Bea, Ferran Nadeu, Eva Gine, Armando Lopez-Guillermo, Antonio Martinez, Inmaculada Ribera-Cortada, Pablo Engel, Leticia Quintanilla-Martinez, Wolfram Klapper, Elias Campo, Virginia Amador
Summary: Mantle cell lymphoma (MCL) with SOX11 expression is associated with a lower T-cell infiltration, poor clinical outcome, and an immunosuppressive microenvironment characterized by CD70 overexpression. This suggests that CD70 could be a potential target for tailored therapies targeting the immune microenvironment in MCL.
Article
Multidisciplinary Sciences
Natalia Ortega, Marta Ribes, Marta Vidal, Rocio Rubio, Ruth Aguilar, Sarah Williams, Diana Barrios, Selena Alonso, Pablo Hernandez-Luis, Robert A. Mitchell, Chenjerai Jairoce, Angeline Cruz, Alfons Jimenez, Rebeca Santano, Susana Mendez, Montserrat Lamoglia, Neus Rosell, Anna Llupia, Laura Puyol, Jordi Chi, Natalia Rodrigo Melero, Daniel Parras, Pau Serra, Edwards Pradenas, Benjamin Trinite, Julia Blanco, Alfredo Mayor, Sonia Barroso, Pilar Varela, Anna Vilella, Antoni Trilla, Pere Santamaria, Carlo Carolis, Marta Tortajada, Luis Izquierdo, Ana Angulo, Pablo Engel, Alberto L. Garcia-Basteiro, Gemma Moncunill, Carlota Dobano
Summary: Long-term kinetics of antibodies to SARS-CoV-2 were examined in a cohort of health care workers, showing stable levels over time with an increase in anti-spike antibody levels around 150 days post-symptom onset. Additionally, asymptomatic individuals had significantly higher levels of IgG and IgA to HCoV compared to symptomatic individuals, suggesting a potential protective effect of pre-existing cross-reactive HCoVs antibodies against SARS-CoV-2 infection and COVID-19 disease.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Chaowen Zheng, Jerec Ricci, Qinqin Zhang, Ali Alawieh, Xiaofeng Yang, Satish Nadig, Songqing He, Pablo Engel, Junfei Jin, Carl Atkinson, Stephen Tomlinson
Summary: Constructs targeting P-selectin and complement inhibition demonstrate enhanced efficacy in hindlimb ischemia/reperfusion injury model, with reduced myeloid cell infiltration, improved tissue perfusion, and anti-thrombotic activity. These constructs show potential for differential application in thrombotic versus hemorrhagic conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Daniela Kuzilkova, Joan Punet-Ortiz, Pei M. Aui, Javier Fernandez, Karel Fiser, Pablo Engel, Menno C. van Zelm, Tomas Kalina
Summary: This study developed a flow cytometric procedure for standardized quantitative expression profiling of surface antigens on blood leukocyte subsets across multiple research laboratories. The designed tubes can discriminate 27 leukocyte subsets and detect the expression of PE-conjugated CD markers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Gemma Moncunill, Ruth Aguilar, Marta Ribes, Natalia Ortega, Rocio Rubio, Gemma Salmeron, Maria Jose Molina, Marta Vidal, Diana Barrios, Robert A. Mitchell, Alfons Jimenez, Cristina Castellana, Pablo Hernandez-Luis, Pau Rodo, Susana Mendez, Anna Llupia, Laura Puyol, Natalia Rodrigo Melero, Carlo Carolis, Alfredo Mayor, Luis Izquierdo, Pilar Varela, Antoni Trilla, Anna Vilella, Sonia Barroso, Ana Angulo, Pablo Engel, Marta Tortajada, Alberto L. Garcia-Basteiro, Carlota Dobano
Summary: The study suggests that a single dose of vaccine may be sufficient for previously exposed healthy individuals. However, personalized recommendations may be necessary based on COVID-19 history and lifestyle due to individual variability in immune responses. The mRNA-1273 vaccine shows higher immunogenicity, which could be beneficial for individuals expected to have a poorer response to vaccination and in the face of immunity-evading variants such as Omicron. Antibody levels in previously exposed unvaccinated individuals can persist for up to one year.
Article
Immunology
Pablo Hernandez-Luis, Ruth Aguilar, Judit Pelegrin-Perez, Gemma Ruiz-Olalla, Alberto L. Garcia-Basteiro, Marta Tortajada, Gemma Moncunill, Carlota Dobano, Ana Angulo, Pablo Engel
Summary: This study assessed the neutralization capacity of antibodies against different variants of the SARS-CoV-2 virus. The research found that after receiving mRNA vaccines, neutralizing antibody activity significantly increased. However, fully vaccinated individuals showed partially impaired neutralizing responses against most variants.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Giovanna Roncador, Joan Punet-Ortiz, Lorena Maestre, Luis Gerardo Rodriguez-Lobato, Scherezade Jimenez, Ana Isabel Reyes-Garcia, Alvaro Garcia-Gonzalez, Juan F. Garcia, Miguel Angel Piris, Santiago Montes-Moreno, Manuel Rodriguez-Justo, Mari-Pau Mena, Carlos Fernandez de Larrea, Pablo Engel
Summary: CD229 is a cell-surface molecule predominantly expressed on lymphocytes. This study investigated the expression of CD229 on various malignancies and normal tissues, showing that it is restricted to hematopoietic cells. The researchers also discovered that the presence of soluble CD229 in the sera of multiple myeloma patients could serve as a prognostic biomarker. These findings suggest that CD229 may be both a useful disease biomarker and a potential therapeutic target.
Article
Cell Biology
Alba Sabate-Perez, Montserrat Romero, Paula Sanchez-Fernandez-de-Landa, Stefania Carobbio, Michail Mouratidis, David Sala, Pablo Engel, Josep A. Villena, Sam Virtue, Antonio Vidal-Puig, Manuel Palacin, Xavier Testar, Antonio Zorzano
Summary: The study reveals a novel molecular mechanism by which TP53INP2 regulates PPARG activity and brown adipogenesis through autophagy, and demonstrates the importance of TP53INP2 in maintaining thermogenic capacity and preventing lipid accumulation in brown adipose tissue. These findings provide insights into the therapeutic strategies against obesity and its metabolic complications.
Article
Immunology
Pablo Martinez-Vicente, Francesc Poblador, Judith Leitner, Domenec Farre, Peter Steinberger, Pablo Engel, Ana Angulo
Summary: This study identifies a functional PD-L1 homolog gene (De2) in a pathogen, which interacts with host PD-1 to attenuate T-cell responses and promote viral replication. The findings suggest a novel viral immunosuppressive strategy and highlight the importance of modulating the PD-1/PD-L1 axis during viral infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sergi Casado-Llombart, Maria Velasco-de Andres, Cristina Catala, Alejandra Leyton-Pereira, Rebeca Gutierrez-Cozar, Belen Suarez, Noelia Armiger, Esther Carreras, Miriam Esteller, Elena Ricart, Ingrid Ordas, Javier P. Gisbert, Maria Chaparro, Maria Esteve, Lucia Marquez, David Busquets, Eva Iglesias, Esther Garcia-Planella, Maria Dolores Martin-Arranz, Juliane Lohmann, C. Korcan Ayata, Jan Hendrik Niess, Pablo Engel, Julian Panes, Azucena Salas, Eugeni Domenech, Francisco Lozano
Summary: The expression and variation of CD5 and CD6 may play a role in the pathophysiology of inflammatory bowel diseases, affecting their clinical manifestations and therapeutic requirements.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Cristina Catala, Maria Velasco-de Andres, Alejandra Leyton-Pereira, Sergi Casado-Llombart, Manuel Saez Moya, Rebeca Gutierrez-Cozar, Joaquin Garcia-Luna, Marta Consuegra-Fernandez, Marcos Isamat, Fernando Aranda, Mario Martinez-Florensa, Pablo Engel, Gustavo Mourglia-Ettlin, Francisco Lozano
Summary: CD6 plays a crucial role in the early response to bacterial infection, affecting natural polyreactive antibody levels and cell counts of spleen B1a and marginal zone B cells in Cd6(-/-) mice, thus impacting survival rates.
Article
Microbiology
Ruth Aguilar, Xue Li, Claudia S. Crowell, Teresa Burrell, Marta Vidal, Rocio Rubio, Alfons Jimenez, Pablo Hernandez-Luis, Dieter Hofmann, Hrvoje Mijocevic, Samuel Jeske, Catharina Christa, Elvira D'Ippolito, Paul Lingor, Percy A. Knolle, Hedwig Roggendorf, Alina Priller, Sarah Yazici, Carlo Carolis, Alfredo Mayor, Patrik Schreiner, Holger Poppert, Henriette Beyer, Sophia E. Schambeck, Luis Izquierdo, Marta Tortajada, Ana Angulo, Erwin Soutschek, Pablo Engel, Alberto Garcia-Basteiro, Dirk H. Busch, Gemma Moncunill, Ulrike Protzer, Carlota Dobano, Markus Gerhard
Summary: This study found a strong positive correlation between neutralizing antibody levels and IgG levels, especially against RBD, in response to SARS-CoV-2 infection. Additionally, symptomatic infection was positively associated with antibody levels and neutralizing activity. These findings suggest that relatively simple and high-throughput serological assays can be used to assess levels of protection against SARS-CoV-2 infection.
MICROBIOLOGY SPECTRUM
(2023)