Connectivity mapping (ssCMap) to predict A20-inducing drugs and their antiinflammatory action in cystic fibrosis

Increased Inflammatory Response Both in Brain and in Periphery in Presenilin 1 and Presenilin 2 Conditional Double Knock-Out Mice

(2017) Xu Jiang et al.   JOURNAL OF ALZHEIMERS DISEASE

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy

(2015) Yu Matsuzawa et al.   Autophagy

Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells

(2015) J A Reihill et al.   BRITISH JOURNAL OF PHARMACOLOGY

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

Nuclear-cytoplasmatic shuttling of proteins in control of cellular oxygen sensing

(2015) Reinhard Depping et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

Lumacaftor/ivacaftor for patients homozygous for Phe508del-CFTR: should we curb our enthusiasm?

(2015) A. M. Jones et al.   THORAX

A20 deficiency sensitizes pancreatic beta cells to cytokine-induced apoptosis in vitro but does not influence type 1 diabetes development in vivo

(2015) L Catrysse et al.   Cell Death & Disease

Clinical Mechanism of the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor in G551D-mediated Cystic Fibrosis

(2014) Steven M. Rowe et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ATF3 is a novel regulator of mouse neutrophil migration

(2014) Nicholas D. Boespflug et al.   BLOOD

Understanding and checking the assumptions of linear regression: a primer for medical researchers

(2014) Robert J Casson et al.   CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis

(2014) M.W. Konstan et al.   Journal of Cystic Fibrosis

The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation

(2014) Chinnaswamy Tiruppathi et al.   NATURE IMMUNOLOGY

Acquired Deficiency of A20 Results in Rapid Apoptosis, Systemic Inflammation, and Abnormal Hematopoietic Stem Cell Function

(2014) Akiko Nagamachi et al.   PLoS One

Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells

(2013) Catriona Kelly et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Ubiquitin E3 Ligase A20 is Required in Degradation of Microbial Superantigens in Vascular Endothelial Cells

(2013) Guoqiang Gu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Entinostat Prevents Leukemia Maintenance in a Collaborating Oncogene-Dependent Model of Cytogenetically Normal Acute Myeloid Leukemia

(2013) Joanne M. Ramsey et al.   STEM CELLS

A20 in inflammation and autoimmunity

(2013) Leen Catrysse et al.   TRENDS IN IMMUNOLOGY

HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway

(2013) X-F Qi et al.   Cell Death & Disease

Development of primary human nasal epithelial cell cultures for the study of cystic fibrosis pathophysiology

(2012) F. de Courcey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Does the ΔF508-CFTR mutation induce a proinflammatory response in human airway epithelial cells?

(2012) Thomas H. Hampton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Applications of Connectivity Map in drug discovery and development

(2012) Xiaoyan A. Qu et al.   DRUG DISCOVERY TODAY

Expression of the nuclear factor-κB inhibitor A20 is altered in the cystic fibrosis epithelium

(2012) Catriona Kelly et al.   EUROPEAN RESPIRATORY JOURNAL

Ubiquitin E3 Ligase A20 Facilitates Processing Microbial Product in Nasal Epithelial Cells

(2012) Yun-Fang An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the inflammatory regulator A20 correlates with lung function in patients with cystic fibrosis

(2012) Catriona Kelly et al.   Journal of Cystic Fibrosis

Life or death: Neuroprotective and anticancer effects of quercetin

(2012) Federico Dajas   JOURNAL OF ETHNOPHARMACOLOGY

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

(2012) Anja Zeigerer et al.   NATURE

Cystic fibrosis: a mucosal immunodeficiency syndrome

(2012) Taylor Sitarik Cohen et al.   NATURE MEDICINE

Ikarugamycin induces DNA damage, intracellular calcium increase, p38 MAP kinase activation and apoptosis in HL-60 human promyelocytic leukemia cells

(2011) Ruxandra Popescu et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Identification of Candidate Small-Molecule Therapeutics to Cancer by Gene-Signature Perturbation in Connectivity Mapping

(2011) Darragh G. McArt et al.   PLoS One

Anti-Inflammatory Effect of Fluvastatin on IL-8 Production Induced by Pseudomonas aeruginosa and Aspergillus fumigatus Antigens in Cystic Fibrosis

(2011) Stéphane Jouneau et al.   PLoS One

ATF3, a Hub of the Cellular Adaptive-Response Network, in the Pathogenesis of Diseases: Is Modulation of Inflammation a Unifying Component?

(2010) TSONWIN HAI et al.   GENE EXPRESSION

Role of the A20-TRAF6 Axis in Lipopolysaccharide-mediated Osteoclastogenesis

(2010) Guillaume Mabilleau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

sscMap: An extensible Java application for connecting small-molecule drugs using gene-expression signatures

(2009) Shu-Dong Zhang et al.   BMC BIOINFORMATICS

Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions

(2009) A. J. Robinson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A20 Attenuates Allergic Airway Inflammation in Mice

(2009) N.-I. Kang et al.   JOURNAL OF IMMUNOLOGY

A simple and robust method for connecting small-molecule drugs using gene-expression signatures

(2008) Shu-Dong Zhang et al.   BMC BIOINFORMATICS

Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways

(2008) Binwu Ying et al.   MOLECULAR BIOLOGY REPORTS