NMD: a multifaceted response to premature translational termination

Testing the faux-UTR model for NMD: Analysis of Upf1p and Pab1p competition for binding to eRF3/Sup35p

(2012) Stephanie Kervestin et al.   BIOCHIMIE

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea

(2012) Thomas Becker et al.   NATURE

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

The cryo-EM structure of the UPF–EJC complex shows UPF1 poised toward the RNA 3′ end

(2012) Roberto Melero et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Translation drives mRNA quality control

(2012) Christopher J Shoemaker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6

(2012) K. A. Frizzell et al.   RNA

Degradation of mRNAs that lack a stop codon: a decade of nonstop progress

(2012) A. Alejandra Klauer et al.   Wiley Interdisciplinary Reviews-RNA

Promoter Elements Regulate Cytoplasmic mRNA Decay

(2011) Almog Bregman et al.   CELL

Single-Molecule mRNA Decay Measurements Reveal Promoter- Regulated mRNA Stability in Yeast

(2011) Tatjana Trcek et al.   CELL

Copper tolerance of Saccharomyces cerevisiae nonsense-mediated mRNA decay mutants

(2011) Rafael Deliz-Aguirre et al.   CURRENT GENETICS

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8

(2011) E. Arias-Palomo et al.   GENES & DEVELOPMENT

Molecular Mechanisms for the RNA-Dependent ATPase Activity of Upf1 and Its Regulation by Upf2

(2011) Sutapa Chakrabarti et al.   MOLECULAR CELL

Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations

(2011) I. Peixeiro et al.   NUCLEIC ACIDS RESEARCH

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

(2011) Yukiko Okada-Katsuhata et al.   NUCLEIC ACIDS RESEARCH

Interactions between Upf1 and the Decapping Factors Edc3 and Pat1 in Saccharomyces cerevisiae

(2011) Kylie D. Swisher et al.   PLoS One

Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs

(2011) D. Schaeffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosome recycling depends on a mechanistic link between the FeS cluster domain and a conformational switch of the twin-ATPase ABCE1

(2011) D. Barthelme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implication of Ccr4-Not complex function in mRNA quality control in Saccharomyces cerevisiae

(2011) J. Assenholt et al.   RNA

Cotranscriptional effect of a premature termination codon revealed by live-cell imaging

(2011) V. de Turris et al.   RNA

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

(2011) H. Yepiskoposyan et al.   RNA

Suppression of nonsense mutations as a therapeutic approach to treat genetic diseases

(2011) Kim M. Keeling et al.   Wiley Interdisciplinary Reviews-RNA

Cutting the nonsense: the degradation of PTC-containing mRNAs

(2010) Pamela Nicholson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Upf1 ATPase-Dependent mRNP Disassembly Is Required for Completion of Nonsense- Mediated mRNA Decay

(2010) Tobias M. Franks et al.   CELL

Upf1 Senses 3′UTR Length to Potentiate mRNA Decay

(2010) J. Robert Hogg et al.   CELL

RNA Polymerase II Subunits Link Transcription and mRNA Decay to Translation

(2010) Liat Harel-Sharvit et al.   CELL

Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe

(2010) Jikai Wen et al.   EMBO JOURNAL

The iron–sulphur protein RNase L inhibitor functions in translation termination

(2010) Sohail Khoshnevis et al.   EMBO REPORTS

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

(2010) I. Kashima et al.   GENES & DEVELOPMENT

Nonsense-mediated mRNA decay maintains translational fidelity by limiting magnesium uptake

(2010) M. J. O. Johansson et al.   GENES & DEVELOPMENT

The Role of ABCE1 in Eukaryotic Posttermination Ribosomal Recycling

(2010) Andrey V. Pisarev et al.   MOLECULAR CELL

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

(2010) G. Buchwald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How and where are nonsense mRNAs degraded in mammalian cells?

(2010) Oliver Mühlemann et al.   RNA Biology

Translational competence of ribosomes released from a premature termination codon is modulated by NMD factors

(2010) S. Ghosh et al.   RNA

Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay

(2010) C. J. Shoemaker et al.   SCIENCE

RNA decay modulates gene expression and controls its fidelity

(2010) Shubhendu Ghosh et al.   Wiley Interdisciplinary Reviews-RNA

Execution of nonsense-mediated mRNA decay: what defines a substrate?

(2009) Indrani Rebbapragada et al.   CURRENT OPINION IN CELL BIOLOGY

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

(2009) Marcello Clerici et al.   EMBO JOURNAL

Upf1 stimulates degradation of the product derived from aberrant messenger RNA containing a specific nonsense mutation by the proteasome

(2009) Kazushige Kuroha et al.   EMBO REPORTS

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

(2009) A. Yamashita et al.   GENES & DEVELOPMENT

Structural insights into eRF3 and stop codon recognition by eRF1

(2009) Z. Cheng et al.   GENES & DEVELOPMENT

The Shuttling Protein Npl3 Promotes Translation Termination Accuracy in Saccharomyces cerevisiae

(2009) Luis A. Estrella et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Proline-Rich Nuclear Receptor Coregulatory Protein 2 Mediates an Interaction between mRNA Surveillance Machinery and Decapping Complex

(2009) Hana Cho et al.   MOLECULAR CELL

Co-translational mRNA decay in Saccharomyces cerevisiae

(2009) Wenqian Hu et al.   NATURE

Long 3′-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae

(2009) Bessie W. Kebaara et al.   NUCLEIC ACIDS RESEARCH

Processing bodies are not required for mammalian nonsense-mediated mRNA decay

(2009) L. Stalder et al.   RNA

Upf1 Phosphorylation Triggers Translational Repression during Nonsense-Mediated mRNA Decay

(2008) Olaf Isken et al.   CELL

The mRNA Export Factor Gle1 and Inositol Hexakisphosphate Regulate Distinct Stages of Translation

(2008) Timothy A. Bolger et al.   CELL

Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay

(2008) Zoltán Kerényi et al.   EMBO JOURNAL

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

(2008) Pavel V Ivanov et al.   EMBO JOURNAL

Nonsense-Mediated mRNA Decay in Yeast Does Not Require PAB1 or a Poly(A) Tail

(2008) Stacie Meaux et al.   MOLECULAR CELL

The multiple lives of NMD factors: balancing roles in gene and genome regulation

(2008) Olaf Isken et al.   NATURE REVIEWS GENETICS

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

(2008) Andrea B Eberle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

(2008) E. Huntzinger et al.   RNA

Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast

(2008) S. Takahashi et al.   RNA

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

(2008) Guramrit Singh et al.   PLOS BIOLOGY

Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region

(2008) Andrea B Eberle et al.   PLOS BIOLOGY