Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase

Monogenic neurological disorders of sphingolipid metabolism

(2015) Frédérique Sabourdy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Metabolic and cellular bases of sphingolipidoses

(2015) Konrad Sandhoff   BIOCHEMICAL SOCIETY TRANSACTIONS

Substrate trajectory through phospholipid-transporting P4-ATPases: Figure 1

(2014) Patrick Williamson   BIOCHEMICAL SOCIETY TRANSACTIONS

Comparing crystal structures of Ca2+-ATPase in the presence of different lipids

(2014) Nikolaj D. Drachmann et al.   FEBS Journal

Mice Deficient in the Putative Phospholipid Flippase ATP11C Exhibit Altered Erythrocyte Shape, Anemia, and Reduced Erythrocyte Life Span

(2014) Mehmet Yabas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

(2014) A. L. Vestergaard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type IV P-type ATPases Distinguish Mono-versusDiacyl Phosphatidylserine Using a Cytofacial Exit Gate in the Membrane Domain

(2013) Ryan D. Baldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylserine flipping enhances membrane curvature and negative charge required for vesicular transport

(2013) Peng Xu et al.   JOURNAL OF CELL BIOLOGY

Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state

(2013) Chikashi Toyoshima et al.   NATURE

Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases

(2013) R. D. Baldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of Na + , K + -ATPase in the Na + -Bound State

(2013) Maria Nyblom et al.   SCIENCE

Phospholipid flippases: Building asymmetric membranes and transport vesicles

(2012) Tessy T. Sebastian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion

(2012) Onur Emre Onat et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Biochemical Characterization of P4-ATPase Mutations Identified in Patients with Progressive Familial Intrahepatic Cholestasis

(2012) Alex Stone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flippase-mediated phospholipid asymmetry promotes fast Cdc42 recycling in dynamic maintenance of cell polarity

(2012) Arupratan Das et al.   NATURE CELL BIOLOGY

Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2

(2012) J. A. Coleman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases

(2012) R. D. Baldridge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in a P-Type ATPase Gene Cause Axonal Degeneration

(2012) Xianjun Zhu et al.   PLoS Genetics

P-Type ATPases

(2011) Michael G. Palmgren et al.   Annual Review of Biophysics

High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine

(2011) Gregory D. Fairn et al.   JOURNAL OF CELL BIOLOGY

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

(2011) Mehmet Yabas et al.   NATURE IMMUNOLOGY

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

(2011) Owen M Siggs et al.   NATURE IMMUNOLOGY

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C

(2011) O. M. Siggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of the ATP8A2 gene in a patient with a t(10;13) de novo balanced translocation and a severe neurological phenotype

(2010) Pierre Cacciagli et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells

(2010) Patricia M. Verhulst et al.   HEPATOLOGY

Avoiding Twisted Pixels: Ethical Guidelines for the Appropriate Use and Manipulation of Scientific Digital Images

(2010) Douglas W. Cromey   SCIENCE AND ENGINEERING ETHICS

Endocytic Sorting and Recycling Require Membrane Phosphatidylserine Asymmetry Maintained by TAT-1/CHAT-1

(2010) Baohui Chen et al.   PLoS Genetics

The C Terminus of Na+,K+-ATPase Controls Na+Affinity on Both Sides of the Membrane through Arg935

(2009) Mads S. Toustrup-Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP8B1 is essential for maintaining normal hearing

(2009) J. M. Stapelbroek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Ca2+-ATPase pumps ions across the sarcoplasmic reticulum membrane

(2008) Chikashi Toyoshima   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

P4-ATPase Requirement for AP-1/Clathrin Function in Protein Transport from the trans-Golgi Network and Early Endosomes

(2008) Ke Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY